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Gutuo Jiejiu decoction improves survival of patients with severe alcoholic hepatitis: A retrospective cohort study

World Journal of Gastroenterology 2017年第16期23卷 2957-2963页

作者： hong-yuan mou hong-Ming Nie Xiao-Yu Hu Department of Infectious Diseases School of Clinical Medicine Teaching Hospital of Chengdu University of Traditional Chinese Medicine Department of Liver Diseases Shuguang Hospital Shanghai University of Traditional Chinese Medicine

AIM To verify the value of Gutuo Jiejiu decoction in improving the survival of patients with severe alcoholic hepatitis(SAH).METHODS We performed a retrospective cohort study in consecutive patients diagnosed with SAH at the Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine. The traditional Chinese medicine formula Gutuo Jiejiu decoction was employed as an exposure factor. Patients from the Teaching Hospital of Chengdu University of Traditional Chinese Medicine who had been treated with Gutuo Jiejiu decoction + prednisone were assigned to an observation group, and patients from Shuguang Hospital, Shanghai University of Traditional Chinese Medicine who had been treated with prednisone alone were selected as a control group. A retrospective analysis was performed by comparing age, alcohol intake, and clinical parameters of liver injury beforeand after treatment. Additionally, the 3-and 12-mo survival rates and the occurrence of complications were *** One hundred and twenty-eight eligible patients were selected from 175 cases with SAH, of which 68 were assigned to the observation group and the other 60 to the control group. No significant difference was found in the patients' baseline characteristics(P > 0.05). However, significant improvements of 90-d survival rate [56/68(82.4%) vs 27/60(45.0%), P = 0.0000] and 365-d survival rate [48/68(70.6%) vs 13/60(21.7%), P = 00000] were observed in the observation group after treatment. After the first 3 mo of treatment, more improvements in the clinical parameters and scoring systems related to liver injury occurred in the observation group than in the control group(P < 0.05). After treatment for 12 mo, the differences in the clinical parameters and scoring systems related to liver injury between the two groups were more significant(P < 0.05). No significant differences in complications and adverse effects were found b

关键词： Severe alcoholic hepatitis Survival rate Prednisone Traditional Chinese medicine therapy Retrospective study

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Different methods of acupuncture for relief of pain due to liver cancer:A network meta-analysis

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World Journal of Meta-Analysis 2022年第2期10卷 52-62页

作者： hong-yuan mou Jing Chen Zuo-Yun Chen hong Du Department of Traditional Chinese Medicine People’s Hospital of LichuanLichuan 445400Hubei ProvinceChina Preventive Treatment Center Central Hospital of Enshi PrefectureEnshi 445000Hubei ProvinceChina

BACKGROUND Pain in the liver is a common symptom of liver cancer in late stages,and the pain incidence rate exceeds 50%[1].In serious cancer pain,morphine and other major analgesics have been commonly administrated for clinical treatments,and their effects are accurate,but with a high incidence of side effects,such as nausea,vomiting,constipation,and other *** is a traditional Chinese medicine *** have been many randomized controlled trials addressing the safety and usefulness of different methods of acupuncture in alleviating liver cancer ***,which of these methods is the most effective method is still *** To compare the effectiveness of different acupuncture methods for alleviating pain due to liver *** Eligible studies were retrieved from eight databases(the Cochrane Library,PubMed,EMBASE,Medline,CNKI,CBM,Chongqing VIP,and Wan Fang Database)up to March 31,2021 and screened based on the established inclusion and exclusion *** quality of the include studies was *** software was applied for statistical *** bias of the included studies was also ***,the network meta-analysis was carried out to evaluate the efficacy of acupuncture methods for relief of pain due to liver *** A total of eight randomized controlled trials were included in the network *** trials(covering 5 treatments and 734 patients)provided data suitable for *** trials focused on short-term effects and many were classed as being of poor quality with a high risk of bias,commonly associated with lack of blinding(which was sometimes impossible to achieve).End of treatment results showed that four interventions,including wrist-ankle acupuncture,triple puncture and remaining needle acupuncture,Tian yuan acupuncture,and block acupuncture,produced a statistically significant reduction in pain when compared with the three-step analgesic ladder *** surface under

关键词： Pain Liver cancer Acupuncture Network meta-analysis Effectiveness Three-step analgesic ladder

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青年与老年人脊柱黄韧带黏弹性实验研究

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医用生物力学 2011年第1期26卷 75-80页

作者：王溪原苑福生张远石袁宏谋冯晰民中国医科大学附属第四医院骨科沈阳110032

目的比较青年与老年人脊柱黄韧带的应力松弛和蠕变黏弹性力学性质,为黄韧带退变的黏弹性力学机制提供依据。方法 20例老年腰椎退变病人黄韧带标本为老年退变组,20例青年腰椎外伤病人黄韧带为青年组,黄韧带标本均取自L4～L5间黄韧带。以1... 详细信息

目的比较青年与老年人脊柱黄韧带的应力松弛和蠕变黏弹性力学性质,为黄韧带退变的黏弹性力学机制提供依据。方法 20例老年腰椎退变病人黄韧带标本为老年退变组,20例青年腰椎外伤病人黄韧带为青年组,黄韧带标本均取自L4～L5间黄韧带。以1%/s的应变增加速度和0.5 MPa/s的应力增加速度分别对试样进行应力松弛和蠕变实验,实验温度设定为(36.5±0.5)℃。设定试验时间为7 200 s,采集90个应力松弛和蠕变数据。以统计分析和归一化的方法处理实验数据。结果青年组黄韧带7 200 s应力下降了1.42 MPa,老年组黄韧带7 200 s应力下降了1.91 MPa。青年组黄韧带7 200 s应变上升了3.39%,老年组黄韧带7 200 s应变上升了2.07%,两组7 200 s应力均下降,应变上升数据均有统计学意义(P<0.05)。应力松弛曲线是以对数关系变化的,蠕变曲线是以指数关系变化的。结论老年退变组黄韧带和青年组黄韧带相比,7 200 s应力松弛量和蠕变量降低,黏弹性力学性能发生改变。

关键词：黄韧带应力松弛蠕变黏弹性力学性能

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牛磺酸对环磷酰胺增效减毒作用的研究

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癌症 2009年第3期28卷 244-248页

作者：赵娜王蕾牟红元梁梅岳旺青岛大学医学院药学系山东青岛266021

背景与目的:环磷酰胺(cyclophosphamide,CTX)是临床常用的抗肿瘤药物,但是不良反应较大,因此,寻找实现增效减毒的辅助药物有重要意义。本研究探讨两种给药途径下牛磺酸(taurine,Tau)对CTX的增效减毒作用。方法:以S180荷瘤小鼠为模型,Ta... 详细信息

背景与目的:环磷酰胺(cyclophosphamide,CTX)是临床常用的抗肿瘤药物,但是不良反应较大,因此,寻找实现增效减毒的辅助药物有重要意义。本研究探讨两种给药途径下牛磺酸(taurine,Tau)对CTX的增效减毒作用。方法:以S180荷瘤小鼠为模型,Tau采用灌胃和静脉注射两种给药途径与CTX联合用药。检测各组小鼠的抑瘤率、骨髓有核细胞数、外周血白细胞数、脾指数、胸腺指数、脾淋巴细胞增殖活性和腹腔巨噬细胞吞噬能力等指标,分析Tau对CTX的增效减毒作用。结果:Tau(40mg·kg-1、80mg·kg-1、160mg·kg-1)静脉注射或Tau(160mg·kg-1、320mg·kg-1、640mg·kg-1)灌胃联合应用CTX(20mg·kg-1)腹腔注射对S180肉瘤的抑瘤率均比单一使用CTX高,CTX组抑瘤率为55.8%,而Tau(静脉注射)+CTX低、中、高各剂量组的抑瘤率分别是66.4%、74.5%和84.6%,Tau(灌胃)+CTX低、中、高各剂量组的抑瘤率分别是60.1%、69.7%和81.2%;与CTX组比较,Tau(静脉注射)+CTX各剂量组和Tau(灌胃)+CTX各剂量组外周血白细胞数、骨髓有核细胞数、胸腺指数、脾指数、脾淋巴细胞增殖活性和腹腔巨噬细胞吞噬能力均增高。结论:两种给药途径下Tau对CTX均具有增效减毒作用。

关键词：肉瘤 S180细胞株牛磺酸环磷酰胺增效减毒小鼠

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5G基站的开关电源设计方案

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通信电源技术 2020年第3期37卷 214-215,220页

作者：袁宏谋广西通信规划设计咨询有限公司

确保开关电源以及远程直流供电电源系统高效运行最为关键的一点就是5G时代的基站新型开关的设计。因此,主要分析了5G基站的开关电源设计方案,以供参考。

关键词： 5G基站开关电源直流远供 HVDC(高压直流)

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基于对5G组网的基础资源改造的探讨

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通信电源技术 2019年第12期36卷 184-185,187页

作者：袁宏谋广西通信规划设计咨询有限公司

首先对5G组网过程中核心的技术进行了深入的研究与分析,然后研究探讨了机房与天面等配套设施,最后以当前的实际情况为基础提出了有关问题的改进措施与整改意见。

关键词： 5G组网基础资源改造

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腓总神经损伤18例修复与功能重建的回顾性分析(英文)

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中国临床康复 2005年第29期9卷 174-175页

作者：袁宏谋冯晰民王溪原安久力中国医科大学第四附属医院骨科辽宁省沈阳市110032

背景:伤后手术时间、手术方法选择对周围神经损伤后修复与功能恢复程度具有一定参考价值。目的:探讨相关因素对腓总神经损伤后修复与功能重建的影响。设计:病例分析。单位:中国医科大学第四附属医院骨外科。对象:选择1991-01/2001-01在... 详细信息

背景:伤后手术时间、手术方法选择对周围神经损伤后修复与功能恢复程度具有一定参考价值。目的:探讨相关因素对腓总神经损伤后修复与功能重建的影响。设计:病例分析。单位:中国医科大学第四附属医院骨外科。对象:选择1991-01/2001-01在中国医科大学第四附属医院骨外科病房住院治疗的单纯腓总神经损伤患者18例。男15例,女3例;年龄12～61岁,平均26.5岁;完全断裂9例,不完全断裂3例,卡压1例,挫伤4例,不可逆损伤1例;伤后0.5h～6个月入院。方法:患者入院后均行腓总神经探查术。行神经吻合12例,神经松解2例,肌腱移位1例,3例保守治疗。术后常规应用抗生素,活血药物及神经营养药物,并指导患者被动功能锻炼,防止关节僵硬及肌肉萎缩。主要观察指标:术后6个月时对腓总神经功能恢复进行评定(优:同侧胫前肌肌力4以上;良:同侧胫前肌肌力3级;可:同侧胫前肌肌力2级;差:同侧胫前肌肌力1级或0级)。结果:18例患者均进入结果分析。其中优10例,良6例,可2例,优良率为89%(16/18)。结论:对腓总神经损伤患者,确诊后应尽早行一期修复断裂神经,有利于肢体的功能恢复。

关键词：腓神经/损伤功能恢建回顾性研究

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Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine

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Chinese Journal of Integrative Medicine 2025年第1期31卷 39-48页

作者： WU Wen-bin GAO Fan TANG Yue-heng WANG hong-zhan DONG Hui LU Fu-er yuan Fen Institution of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(GLP-1)/GLP-1 receptor(GLP-1R) in both islet and intestine. Methods: The db/db mice were divided into the model(distilled water), low-dose HRD(LHRD, 3 g/kg), high-dose HRD(HHRD, 6 g/kg), and liraglutide(400 μg/kg) groups using a random number table, 8 mice in each group. The db/m mice were used as the control group(n=8, distilled water). The entire treatment of mice lasted for 6 weeks. Blood insulin, glucose, and GLP-1levels were quantified using enzyme-linked immunosorbent assay kits. The proliferation and apoptosis factors of islet cells were determined by immunohistochemistry(IHC) and immunofluorescence(IF) staining. Then,GLP-1, GLP-1R, prohormone convertase 1/3(PC1/3), PC2, v-maf musculoaponeurotic fibrosarcoma oncogene homologue A(MafA), and pancreatic and duodenal homeobox 1(PDX1) were detected by Western blot, IHC,IF, and real-time quantitative polymerase chain reaction, respectively. Results: HRD reduced the weight and blood glucose of the db/db mice, and improved insulin sensitivity at the same time(P<0.05 or P<0.01). HRD also promoted mice to secrete more insulin and less glucagon(P<0.05 or P<0.01). Moreover, it also increased the number of islet β cell and decreased islet α cell mass(P<0.01). After HRD treatment, the levels of GLP-1,GLP-1R, PC1/3, PC2, MafA, and PDX1 in the pancreas and intestine significantly increased(P<0.05 or P<0.01).Conclusion: HRD can maintain the normal function and identity of islet β cell, and the underlying mechanism is related to promoting the paracrine and endocrine activation of GLP-1 in pancreas and intestine.

关键词： type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine

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负压引流与皮片引流对跟骨骨折手术切口愈合的影响

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昆明医科大学学报 2015年第10期36卷 83-85页

作者：袁宏谋张伟中国医科大学附属四院骨外科辽宁沈阳110032

目的对比分析负压引流与皮片引流对跟骨骨折手术切口愈合的影响.方法选取中国医科大学附属四院收治的98例跟骨骨折手术患者作为研究对象,使用随机数字表法,将其分为A、B组,各49例,B组进行皮片引流,A组进行负压引流,比较2组患者的引流量... 详细信息

目的对比分析负压引流与皮片引流对跟骨骨折手术切口愈合的影响.方法选取中国医科大学附属四院收治的98例跟骨骨折手术患者作为研究对象,使用随机数字表法,将其分为A、B组,各49例,B组进行皮片引流,A组进行负压引流,比较2组患者的引流量、并发症发生率、切口愈合时间等.结果 A组患者的切口干燥时间、切口愈合时间均显著短于B组,P<0.05,差异有统计学意义;A组患者的引流物放置时间明显长于B组,引流量明显多于B组,P<0.05,差异均有统计学意义.术后,A组仅有1例发生切口开裂,并发症发生率为2.04%,B组共有13例发生并发症,并发症发生率为26.53%,其中切口皮肤开裂8例,切口感染5例.A组患者的并发症发生率显著低于B组,χ2=24.491,P<0.05,差异具有统计学意义.结论与皮片引流相比,负压引流的引流量更多,切口并发症发生率更低,切口愈合更快,临床应用优势显著,值得推广应用.

关键词：皮片引流负压引流跟骨骨折

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Methanol steam mediated corrosion engineering towards high-entropy NiFe layered double hydroxide for ultra-stable oxygen evolution

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Chinese Chemical Letters 2025年第1期36卷 338-343页

作者： Jinqiang Gao Haifeng yuan Xinjuan Du Feng Dong Yu Zhou Shengnan Na Yanpeng Chen Mingyu Hu Mei hong Shihe Yang Guangdong Provincial Key Laboratory of Nano-Micro Materials Research School of Advanced MaterialsPeking University Shenzhen Graduate School(PKUSZ)Shenzhen 518055China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China Department of Physics Hong Kong Baptist UniversityHong Kong 999077China

Rational design of viable routes to obtain efficient and stable oxygen evolution reaction(OER)electrocatalysts remains challenging,especially under industrial ***,we provide a solvent-steam assisted corrosion engineering strategy to directly fabricate high-entropy NiF e-LDH with spatially resolved structural *** fluoride in methanol steam enables the formation of nanosheets while Fe^(3+)effectively enhances their adhesion to the semi-sacrificial nickel-iron foam(NFF),thereby conjuring up a Ni Fe-LDH@NFF catalyst that exhibits remarkable adaptability to robust electrochemical activation yet with excellent *** measurements reveal the in-situ formation of high-valance metal oxyhydroxide and the enhancement of adsorption-desorption *** the industrial condition(6 mol/L KOH,60℃),the Ni Fe-LDH@NFF exhibits excellent activity of 50 mA/cm^(2) at 1.55 V and high durability of over 120 h at 200 mA/cm^(2).We anticipate that the steam assisted strategy could promote the development of efficient non-precious electrocatalysts for hydrogen energy.

关键词： High-entropy material Corrosion engineering NiFe-LDH Oxygen evolution reaction Stability

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