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A quantitative study of airway ultrasound in predicting difficult laryngoscopy:A prospective study

Chinese Journal of Traumatology 2023年第6期26卷 351-356页

作者： Lin Ning Xing Zhu hong-Chao Li Shi-Jie Zhou Qi-Wei Zhang hong-yu zou Qing-Xiang Mao hong Yan Department of Anaesthesiology Army Medical Center of PLADaping Hospital of Army Medical UniversityChongqingChina Laboratory of Anaesthesia Center Army Medical Center of PLADaping Hospital of Army Medical UniversityChongqingChina Anaesthesia Center Army Medical Center of PLADaping Hospital of Army Medical UniversityChongqingChina

Purpose:As common clinical screening tests cannot effectively predict a difficult airway,and unanticipated difficult laryngoscopy remains a challenge for physicians.We herein used ultrasound to develop some point-of-care predictors for difficult laryngoscopy.Methods:This prospective observational study included 502 patients who underwent laryngoscopy and a detailed sonographic assessment.Patients under 18 years old,or with maxillofacial deformities or fractures,limited mouth opening,limited neck movement or history of neck surgery were excluded from the study.Laryngoscopic views of all patients were scored and grouping using the modified Cormack-Lehane(CL)scoring system.The measurements acquired comprised tongue width,the longitudinal cross-sectional area of the tongue,tongue volume,the mandible-hyoid bone distance,the hyoid boneglottis distance,the mandible-hyoid bone-glottis angle,the skin-thyrohyoid membrane distance,the glottis-superior edge of the thyroid cartilage distance(DGTC),the skin-hyoid bone distance,and the epiglottis midway-skin distance.ANOVA and Chi-square were used to compare differences between groups.Logistic regression was used to identify risk factors for difficult laryngoscopy and it was visualized by receiver operating characteristic curves and nomogram.R version 3.6.3 and SPSS version 26.0 were used for statistical analyses.Results:Difficult laryngoscopy was indicated in 49 patients(CL grade III-IV)and easy laryngoscopy in 453 patients(CL grade I-II).The ultrasound-measured mandible-hyoid bone-glottis angle and DGTC significantly differed between the 2 groups(p<0.001).Difficult laryngoscopy was predicted by an area under the curve(AUC)of 0.930 with a threshold mandible-hyoid bone-glottis angle of 125.5and by an AUC of 0.722 with a threshold DGTC of 1.22 cm.The longitudinal cross-sectional area of the tongue,tongue width,tongue volume,the mandible-hyoid distance,and the hyoid-glottis distance did not significantly differ between the groups.Conclusion:Difficult laryngoscopy may be anticipa

关键词： Airway management Intubation Ultrasonography Airway Difficult laryngoscopy

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In vitro degradation,photo-dynamic and thermal antibacterial activities of Cu-bearing chlorophyllin-induced Ca-P coating on magnesium alloy AZ31

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Bioactive Materials 2022年第12期7卷 284-299页

作者： Zhen-yu Zhang Yan-Lin An Xiao-Shi Wang Lan-yue Cui Shuo-Qi Li Cheng-Bao Liu yu-hong zou Fen Zhang Rong-Chang Zeng College of Materials Science and Engineering Shandong University of Science and TechnologyQingdao266590China College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China

Surgical failures,caused by postoperative infections of bone implants,are commonly met,which cannot be treated precisely with intravenous antibiotics.Photothermal therapy(PTT)and photodynamic therapy(PDT)have attracted widespread attention due to their non-invasive antibacterial effects on tissues and no bacterial resistance,which may be an excellent approach to solve infections related to bone implants for biodegradable magnesium alloys.Herein,a sodium copper chlorophyllin(SCC)with a porphyrin ring induced Ca-P coating was prepared on AZ31 magnesium alloy via layer-by-layer(LbL)assembly.The morphology and composition of the samples were characterized through field emission scanning electron microscope(FE-SEM)with affiliated energy dispersive spectrometer(EDS),X-ray diffractometer(XRD),and Fourier infrared spectrometer(FTIR)and X-ray photoelectron spectrometer(XPS)as well.Potentiodynamic polarization,electrochemical impedance spectroscopy(EIS)and hydrogen evolution experiments were employed to evaluate the corrosion behavior of the samples.Atomic absorption spectrophotometer was used to measure Cu elemental content of different immersion periods.Cytocompatibility and antibacterial performance of the coatings were probed using in vitro cytotoxicity tests(MTT assay),live/dead cell staining and plate counting method.The results showed that the obtained(Ca-P/SCC)10 coating exhibited good corrosion resistance,antimicrobial activity(especially under 808 nm irradiation)and biocompatibility.The antibacterial rates for E.coli and S.aureus were 99.9%and 99.8%,respectively;and the photothermal conversion efficiency was as high as 42.1%.Triple antibacterial mechanisms including photodynamic,photothermal reactions and copper-ions release were proposed.This coating exhibited a promising application for biodegradable magnesium alloys.

关键词： Magnesium alloy Coating Degradable biomaterial Biocompatibility Antibacterial activity

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In vitro degradation and multi-antibacterial mechanisms ofβ-cyclodextrin@curcumin embodied Mg(OH)_(2)/MAO coating on AZ31 magnesium alloy

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Journal of Materials Science & Technology 2023年第1期132卷 179-192页

作者： Kui Xue Pei-hong Tan Ze-Hui Zhao Lan-yue Cui M Bobby Kannan Shuo-Qi Li Cheng-Bao Liu yu-hong zou Fen Zhang Zhuo-yuan Chen Rong-Chang Zeng Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China School of Engineering The University of NewcastleCallaghanNSW 2308Australia College of Chemical and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China School of Materials Science and Energy Engineering Foshan UniversityFoshan 528000China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China

It is a challenging task to prepare a coating on Mg alloys for desirable corrosion resistance,good antibac-terial ability and biocompatibility.In this research work,an in-situ Mg(OH)_(2)coating incorporated with sodium alginate(SA)andβ-cyclodextrin(β-CD)@curcumin(Cur)was formed on the surface of micro arc oxidation(MAO)coated AZ31 alloy via a low temperature hydrothermal method.Characterization tech-niques such as X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectrometer(FT-IR)and scanning electron microscope(SEM)were employed to characterize the chemi-cal composition and surface morphology of the coatings.The corrosion protection ability of the coatings was monitored via electrochemical polarization,hydrogen evolution and immersion tests.Photothermal antibacterial ability and cytocompatibility of the coatings were evaluated by plate counting method under the irradiation of 808 nm-near infrared light,in vitro cytotoxicity tests(MTT)and live/dead cell staining.The results indicate that a chelation of the organic molecules led to the formation of a MAO/(β-CD@Cur)-SA-Mg(OH)_(2)coating with excellent corrosion protection,multi-antibacterial ability and almost no toxic-ity to the cells.Especially,the coating provided photothermal performance through the light absorption of Cur,which was encapsulated byβ-CD to improve its bioavailability.SA enhanced the binding force between the drug and the substrate.This novel coating designated the potential application on bioab-sorbable magnesium alloys.

关键词： Magnesium alloys Photothermal ability Antibacterial coating Corrosion Biomaterials

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Corrosion resistance of Mg-Al-LDH steam coating on AZ80 Mg alloy:Effects of citric acid pretreatment and intermetallic compounds

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Journal of Magnesium and Alloys 2023年第8期11卷 2967-2979页

作者： Jin-Meng Wang Xiang Sun Liang Song M.Bobby Kannan Fen Zhang Lan-yue Cui yu-hong zou Shuo-Qi Li Rong-Chang Zeng Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China School of Engineering University of NewcastleCallaghanNew South Wales 2308Australia College of Science and Engineering James Cook UniversityTownsvilleQueensland 4811Australia College of Chemical and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China

In this study,the effects of intermetallic compounds(Mg_(17)Al_(12)and Al_(8)Mn_(5))on the Mg-Al layered double hydroxide(LDH)formation mechanism and corrosion behavior of an in-situ LDH/Mg(OH)_(2)steam coatings on AZ80 Mg alloy were investigated.Citric acid(CA)was used to activate the alloy surface during the pretreatment process.The alloy was first pretreated with CA and then subjected to a hydrothermal process using ultrapure water to produce Mg-Al-LDH/Mg(OH)_(2)steam coating.The effect of different time of acid pretreatment on the activation of the intermetallic compounds was investigated.The microstructure and elemental composition of the obtained coatings were analyzed using FE-SEM,EDS,XRD and FT-IR.The corrosion resistance of the coated samples was evaluated using different techniques,i.e.,potentiodynamic polarization(PDP),electrochemical impedance spectrum(EIS)and hydrogen evolution test.The results indicated that the CA pretreatment significantly influenced the activity of the alloy surface by exposing the intermetallic compounds.The surface area fraction of Mg_(17)Al_(12)and Al_(8)Mn_(5)phases on the surface of the alloy was significantly higher after the CA pretreatment,and thus promoted the growth of the subsequent Mg-Al-LDH coatings.The CA pretreatment for 30 s resulted in a denser and thicker LDH coating.Increase in the CA pretreatment time significantly led to the improvement in corrosion resistance of the coated AZ80 alloy.The corrosion current density of the coated alloy was lower by three orders of magnitude as compared to the uncoated alloy.

关键词： Magnesium alloy Citric acid pretreatment Steam coating Layered double hydroxide Intermetallic compounds Corrosion resistance

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草酸预处理AM50镁合金表面快速原位制备蒸汽Mg−Al LDH涂层的耐蚀性

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Transactions of Nonferrous Metals Society of China 2024年第6期34卷 1843-1863页

作者：潘仕琪王金梦张芬解浩峰崔蓝月 MBOBBY KANNAN 邹玉红曾荣昌山东科技大学材料科学与工程学院轻金属腐蚀实验室青岛266590 有研工程技术研究院有限公司有色金属材料制备加工国家重点实验室北京100088 School of Engineering University of NewcastleCallaghanNew South Wales2308Australia 山东科技大学化学与环境工程学院青岛266590 郑州大学材料科学与工程学院郑州450002

通过暴露合金表面的金属间化合物(β-Mg17Al12和AlMn),研究草酸(OA)酸洗对AM50镁合金表面原位蒸汽Mg−Al层状双氢氧化物(LDH)涂层成膜机制和耐蚀性的影响。结果表明,OA预处理使镁合金表面金属间化合物比例显著增加,Mg−Al LDH在Al−Mn相周... 详细信息

通过暴露合金表面的金属间化合物(β-Mg17Al12和AlMn),研究草酸(OA)酸洗对AM50镁合金表面原位蒸汽Mg−Al层状双氢氧化物(LDH)涂层成膜机制和耐蚀性的影响。结果表明,OA预处理使镁合金表面金属间化合物比例显著增加,Mg−Al LDH在Al−Mn相周围成核并生长。当酸洗时间为45 s时,所得LDH涂层的厚度最大、耐蚀性最佳,与基体相比,其腐蚀电流密度降低3个数量级。最后,提出了AM50镁合金表面Mg−Al LDH涂层的成膜机制。

关键词：镁合金草酸金属间化合物蒸汽涂层层状双氢氧化物耐蚀性

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Glymphatic system:a gateway for neuroinflammation

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Neural Regeneration Research 2024年第12期19卷 2661-2672页

作者： Kailu zou Qingwei Deng hong Zhang Changsheng Huang Department of Anesthesiology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Xiangya School of Medicine Central South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

The glymphatic system is a relatively recently identified fluid exchange and transpo rt system in the brain.Accumulating evidence indicates thatglymphatic function is impaired not only in central nervous system disorders but also in systemic diseases.Systemic diseases can trigger the inflammatory responses in the central nervous system,occasionally leading to sustained inflammation and functional disturbance of the central nervous system.This review summarizes the current knowledge on the association between glymphatic dysfunction and central nervous system inflammation.In addition,we discuss the hypothesis that disease conditions initially associated with peripheral inflammation ove rwhelm the performance of the glymphatic system,thereby triggering central nervous system dysfun ction,chronic neuroinflammation,and neurodegeneration.Future research investigating the role of the glymphatic system in neuroinflammation may offer innovative therapeutic approaches for central nervous system disorders.

关键词： aquaporin-4 central nervous system disease cerebrospinal fluid chronic neuroinflammation glymphatic dysfunction neurodegeneration peripheral nerve injury perivascular space systemic disease vicious cycle

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Metabolic derivatives of alcohol and the molecular culpritsof fibro-hepatocarcinogenesis:Allies or enemies?

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World Journal of Gastroenterology 2016年第1期22卷 50-71页

作者： Alex Boye yu-hong zou Yan Yang Department of Pharmacology and Institute of Natural Medicine Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Medical Laboratory Science College of Allied Health SciencesUniversity of Cape CoastCape Coast 25064Ghana Department of Biology School of ScienceCenter for Regenerative Biology and MedicineIndiana University-Purdue University IndianapolisIndianapolisIN 46202United States

Chronic intake of alcohol undoubtedly overwhelms the structural and functional capacity of the liver by initiating complex pathological events characterized by steatosis,steatohepatitis,hepatic fibrosis and cirrhosis.Subsequently,these initial pathological events are sustained and ushered into a more complex and progressive liver disease,increasing the risk of fibrohepatocarcinogenesis.These coordinated pathological events mainly result from buildup of toxic metabolic derivatives of alcohol including but not limited to acetaldehyde(AA),malondialdehyde(MDA),CYP2E1-generated reactive oxygen species,alcohol-induced gut-derived lipopolysaccharide,AA/MDA protein and DNA adducts.The metabolic derivatives of alcohol together with other comorbidity factors,including hepatitis B and C viral infections,dysregulated iron metabolism,abuse of antibiotics,schistosomiasis,toxic drug metabolites,autoimmune disease and other non-specific factors,have been shown to underlie liver diseases.In view of the multiple etiology of liver diseases,attempts to delineate the mechanism by which each etiological factor causes liver disease has always proved cumbersome if not impossible.In the case of alcoholic liver disease(ALD),it is even more cumbersome and complicated as a result of the many toxic metabolic derivatives of alcohol with their varying liver-specific toxicities.In spite of all these hurdles,researchers and experts in hepatology have strived to expand knowledge and scientific discourse,particularly on ALD and its associated complications through the medium of scientific research,reviews and commentaries.Nonetheless,the molecularmechanisms underpinning ALD,particularly those underlying toxic effects of metabolic derivatives of alcohol on parenchymal and non-parenchymal hepatic cells leading to increased risk of alcohol-induced fibrohepatocarcinogenesis,are still incompletely elucidated.In this review,we examined published scientific findings on how alcohol and its metabolic derivatives mount cellular attack on each hepatic cell a

关键词： Alcoholic hepatitis Lipopolysaccharide Fibro-hepatocarcinogenesis Mitogen activated proteinkinase Transforming growth factor beta Small motheragainst decapentaplegic

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Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration

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National Science Review 2024年第3期11卷 215-226页

作者： Jian-hong Xiao Zhen-Bang Zhang JiaHao Li Si-Ming Chen Huai-Ling Gao YinXiu Liao Lu Chen ZiShuo Wang YiFan Lu yuanZhen Hou HengAn Wu Duohong zou Shu-hong yu Department of Chemistry New Cornerstone Science Laboratory Institute of Biomimetic Materials&Chemistry Anhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Department of Dental Implant Center Stomatologic Hospital and College Key Laboratory of Oral Diseases Research of Anhui Province Anhui Medical University CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Department of Oral Surgery College of Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Institute of Innovative Materials(I2M) Department of Chemistry Department of Materials Science and Engineering Southern University of Science and Technology

Polysaccharide-based membranes with excellent mechanical properties are highly desired. However, severe mechanical deterioration under wet conditions limits their biomedical applications. Here, inspired by the structural heterogeneity of strong yet hydrated biological materials, we propose a strategy based on heterogeneous crosslink-and-hydration（HCH） of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties. The heterogeneity lies in that the crosslink-and-hydration occurs in the molecule-network while the stress-bearing nanofiber-network remains unaffected. As one demonstration, a membrane assembled by bacterial cellulose nanofiber-network and Ca2+-crosslinked and hydrated sodium alginate molecule-network is designed. Studies show that the crosslinked-and-hydrated molecule-network restricts water invasion and boosts stress transfer of the nanofiber-network by serving as interfibrous bridge. Overall, the molecule-network makes the membrane hydrated and flexible; the nanofiber-network as stress-bearing component provides strength and toughness.The HCH dual-scale network featuring a cooperative effect stimulates the design of advanced biomaterials applied under wet conditions such as guided bone regeneration membranes.

关键词： bioinspiration heterogeneous crosslink-and-hydration dual-scale network nanocomposite membrane wet mechanical properties guided bone regeneration

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103 GHz germanium-on-silicon photodiode enabled by an optimized U-shaped electrode

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Photonics Research 2024年第1期12卷 1-6页

作者： Yang Shi Xiang Li Mingjie zou yu yu Xinliang Zhang Wuhan National Laboratory for Optoelectronics&School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China Optics Valley Laboratory Wuhan 430074China Xidian University Xi’an 710126China

High-performance germanium photodiodes are crucial components in silicon photonic integrated circuits for large-capacity data communication.However,the bandwidths of most germanium photodiodes are limited by the intractable resistance–capacitance parasitic effect.Here,we introduce a unique U-shaped electrode to alleviate this issue,reducing the parasitic effect by 36%without compromising any other performance.Experimentally,a large bandwidth of 103 GHz,an optical responsivity of 0.95 A/W at 1550 nm,and a dark current as low as 1.3 nA are achieved,leading to a record high specific detectivity.This is the first breakthrough to 100 GHz bandwidth among all vertical germanium photodiodes,to the best of our knowledge.Open eye diagrams of 120 Gb/s on-off keying and 200 Gb/s four-level pulse amplitude signals are well received.This work provides a promising solution for chip-based ultra-fast photodetection.

关键词： Gb/s shaped electrode

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Management with the insufficient proximal landing zone for endovascular repair in aortic dissection

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Chinese Medical Journal 2011年第19期124卷 3003-3007页

作者： MA Hao YANG hong-yu zou Jun-jie ZHANG Xi-wei Department of General Surgery the First Affiliated HospitalNanjing Medical University Department of General Surgery Jiangsu Province Hospital Nanjing Jiangsu 210029 China

Background Sufficient length of the proximal landing zone （PLZ） is the key for a successful thoracic endovascular aortic repair （TEVAR） of an aortic lesion. The aim of this research was to investigate the safety, feasibility, efficacy, and problems of endovascular repair for aortic dissection with insufficient PLZ.Methods The clinical data between August 2005 and February 2010 from patients with insufficient PLZ for endovascular repair of aortic dissection were retrospectively reviewed. According to the classification proposed by Ishimaru, aortic zone 0 was involved in 3 cases, zone 1 in 10 cases, and zone 2 in 11 cases. A hybrid surgical procedure of supraortic debranching and revascularization, directly coverage the orifice of left subclavian artery, or a left common carotid artery chimney graft technique were performed to obtain an adequate proximal aortic landing zone.Results There was no significant difference in risk factors and diameter of the PLZ between Zone 0, Zone 1, and Zone 2. But the length of the PLZ was significantly different in the three groups （P 〈0.01）. There was no significant difference in technical and clinical success rate between the groups.Conclusions The procedure for extending an insufficient PLZ for endovascular repair for aortic arch pathology is feasible and relatively safe. The applicability of TEVAR in such aortic disorders may be expanded.

关键词： endovascular procedures aortic dissection proximal landing zone aorta, thoracic

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