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Global-local combined features to detect pain intensity from facial expression images with attention mechanism

Journal of Electronic Science and Technology 2024年第3期22卷 80-93页

作者： Jiang Wu Yi shi Shun Yan hong-Mei Yan Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China MOE Key Laboratory for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China College of Engineering University of California at Santa BarbaraSanta Barbara93106USA

The estimation of pain intensity is critical for medical diagnosis and treatment of *** the development of image monitoring technology and artificial intelligence,automatic pain assessment based on facial expression and behavioral analysis shows a potential value in clinical *** paper reports a framework of convolutional neural network with global and local attention mechanism(GLA-CNN)for the effective detection of pain intensity at four-level thresholds using facial expression ***-CNN includes two modules,namely global attention network(GANet)and local attention network(LANet).LANet is responsible for extracting representative local patch features of faces,while GANet extracts whole facial features to compensate for the ignored correlative features between *** the end,the global correlational and local subtle features are fused for the final estimation of pain *** under the UNBC-McMaster Shoulder Pain database demonstrate that GLA-CNN outperforms other state-of-the-art ***,a visualization analysis is conducted to present the feature map of GLA-CNN,intuitively showing that it can extract not only local pain features but also global correlative facial *** study demonstrates that pain assessment based on facial expression is a non-invasive and feasible method,and can be employed as an auxiliary pain assessment tool in clinical practice.

关键词： Attention Convolutional neural network Facial expression Pain intensity

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Research on intelligent search-and-secure technology in accelerator hazardous areas based on machine vision

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Nuclear Science and Techniques 2024年第4期35卷 96-107页

作者： Ying-Lin Ma Yao Wang hong-Mei shi Hui-Jie Zhang School of Traffic and Transportation Beijing Jiaotong UniversityBeijing 100044China School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Prompt radiation emitted during accelerator operation poses a significant health risk,necessitating a thorough search and securing of hazardous areas prior to ***,manual sweep methods are ***,the limitations of manual sweeps have become increasingly evident with the implementation of large-scale *** leveraging advancements in machine vision technology,the automatic identification of stranded personnel in controlled areas through camera imagery presents a viable solution for efficient search and *** the criticality of personal safety for stranded individuals,search and security processes must be sufficiently *** ensure comprehensive coverage,180°camera groups were strategically positioned on both sides of the accelerator tunnel to eliminate blind spots within the monitoring *** YOLOV8 network model was modified to enable the detection of small targets,such as hands and feet,as well as larger targets formed by individuals near the ***,the system incorporates a pedestrian recognition model that detects human body parts,and an information fusion strategy is used to integrate the detected head,hands,and feet with the identified pedestrians as a cohesive *** strategy enhanced the capability of the model to identify pedestrians obstructed by equipment,resulting in a notable improvement in the recall ***,recall rates of 0.915 and 0.82were obtained for Datasets 1 and 2,*** there was a slight decrease in accuracy,it aligned with the intended purpose of the search-and-secure software *** tests conducted within an accelerator tunnel demonstrated the effectiveness of this approach in achieving reliable recognition outcomes.

关键词： Search and secure Machine vision Camera Human body parts recognition Particle accelerator Hazardous area

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Reoxidation of liquid steel and evolution of inclusions during protective atmosphere electroslag remelting of Ce-containing heat-resistant stainless steel

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Journal of Iron and Steel Research International 2024年第8期31卷 1923-1935页

作者： yu Zhao Cheng-bin shi shijun Wang Peng Ren Jing Li State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing(USTB)Beijing 100083China

The evolution of Ce-containing inclusions and its correlation with the reoxidation of liquid steel during protective atmosphere electroslag remelting(ESR)of heat-resistant steel were *** reoxidation of liquid steel took place during the ESR,resulting in the oxygen pickup from 0.0014 to 0.0053 wt.%.The inclusions in the consumable electrode,liquid metal pool and remelted ingot are Ce_(2)O_(2)S and Ce_(2)O,inclusions *** inclusions in the remelted ingot are originated from three ways:(I)the original inclusions from the electrode;(Il)the newly formed Ce_(2)O_(2)S and Ce_(2)O_(3) inclusions in the liquid metal pool by reoxidation remaining still in remelted ingot;(IlI)the newly generated Ce2O2S and Ce_(2)O_(3) inclusions during cooling and solidification of liquid *** relative proportions of Ce_(2)O_(3) inclusions in liquid metal pool and remelted ingot are 41% and 76.5%,*** inclusions ranging from 2 to 5μm in the remelted ingot take up 55%,followed by the inclusions smaller than 2μm(43%of total inclusions).The number proportion of the Ce_(2)0,inclusions in the liquid metal pool which were removed by floating up into slag is 1.96×10-5%.

关键词： Non-metallic inclusion Electroslag remelting Rare earth cerium Reoxidation Inclusion evolution

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Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

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Chinese Medical Journal 2011年第2期124卷 246-252页

作者： CHEN Huan LIU Kai-yan XU Lan-ping LIU Dai-hong CHEN yu-hong shi hong-xia HAN Wei ZHAN Xiao-hui WANG yu ZHAO Ting HUANG Xiao-jun Peking University Institute of Hematology Peking University People's Hospital Beijing 100044 China

Background Relapse happens frequently after allogeneic hematopoietic cell transplantation （alIo-HCT） in the patients with Philadelphia chromosome-positive acute lymphoblastic leukemia （Ph^＋ ALL）. Detection of the minimal residual disease （MRD） before and after alIo-HCT is associated with higher relapse rate. Early administration of imatinib after alIo-HCT may prevent recurrent Ph^＋ ALL. The aim of this study was to evaluate the safety and efficacy of imatinib in preventing hematological relapse when imatinib was administrated in the first 90 days after alIo-HCT. Methods Patients with Ph^＋ ALL that underwent alIo-HCT were enrolled in a prospective study. A TaqMan-based real-time quantitative polymerase chain reaction （RQ-PCR） technique was used to detect the MRD （bcr-abl transcript levels）. Imatinib therapy was initiated prior to 90 days after alIo-HCT if the patient＇s absolute neutrophil count （ANC） was above 1.0×10^9/L （without granulocyte colony-stimulating factor （G-CSF） administration） and the platelet count was greater than 50.0×10^9/L, or if the bcr-abl transcript levels were elevated in two consecutive tests, or if the bcr-abl transcript levels were 〉10.2 after the initial engraftment. The initial daily dose of imatinib was 400 mg/d for adults and 260 mg/m^2 for children （younger than 17 years）. Imatinib was administered for at least I month and the bcr-abl TaqMan results were negative for 3 consecutive tests, or complete molecular remission （CR^mol） was sustained for at least 3 months. Results From May 2005 to October 2008, 29 patients were enrolled in this study, of whom, 19 patients were male and 10 were female. The median age of the enrolled patients was 33 years （range 6-50 years）. Imatinib therapy was started at a median time of 60 days （range 20-122 days） post HCT （only one patient started Imatinib therapy at 122nd day after HCT）. Twenty-five adult patients could tolerate a dose of 300-400 mg/d of imatinib, and three children tolerated a dose of 260 mg

关键词： Philadelphia chromosome acute lymphoblastic leukemia allogeneic hematopoietic cell transplantation minimal residual disease

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Xiao Tan San Jie Fang Hampers the Growth of Colon Cancer Stem Cells through the Wnt/β-catenin Signaling Pathway

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 171-179页

作者： yu-Qi Zhou Jun-Fei yuan hong-shi Shen Ya-Ping Wang Han-Fei shi De-Jian Pan Min Ye Department of Hematology and Oncology The 904^(th) Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Clinical Laboratory The 904^(th)Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical UniversityShanghaiChina

Objective: The purpose of this research was to examine the potential anticancer properties of Xiao Tan San Jie Fang(XTSJF) and its potential mechanism of action against colorectal cancer. Materials and Methods: HCT116 cells were induced into HCT116 spheres in DMEM/F12 medium by treatment with epidermal growth factor + fibroblast growth factor + leukemia inhibitory factor + B27. The proliferation ability and stemness of HCT116 spheres was examined. Various concentrations of XTSJF were used to treat HCT116 spheres to observe the impact on proliferation, apoptosis, and expression of stem cell markers. Next, Wnt/β-catenin pathway-related factor proteins were detected. Results: The findings revealed that XTSJF suppressed cell growth and induced cell death in HCT116 cells in a dosage-dependent manner. Similarly, XTSJF promotes apoptosis, inhibits cell proliferation, prolongs survival, and maintains the expression of stem cells through the Wnt/-catenin/TCF4 axis. XTSJF also inhibits AKT activity and subsequently activates glycogen synthesis kinase-3β expression, inhibiting Wnt/beta-catenin pathway activity and downstream target gene transcript expression. The Wnt/β-catenin signaling pathway is inhibited by the XTSJF, leading to the suppression of colon cancer stem cell proliferation. Conclusion: Xiaotan Sanjie Prescription inhibited colon cancer stem cell growth through Wnt/β-catenin signaling pathway.

关键词： Apoptosis colorectal cancer proliferation traditional Chinese medicine Wnt/β-catenin signaling

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Comparative Transcriptome Analysis of Shell-Matrix-Protein Genes and Observation of the Shell Microstructure in the Deep-Sea Clam Calyptogena marissinica

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Journal of Ocean University of China 2024年第3期23卷 797-810页

作者： shi yu LIU Dongting YAO Gaoyou HE Maoxian CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Provincial Key Laboratory of Applied Marine BiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China University of Chinese Academy of Sciences Beijing 100049China

The deep-sea clam Calyptogena marissinica is widely distributed in the Haima cold seep ecosystem on the northwes-tern slope of the South China Sea with low pH values,low temperature and high *** information is available on the biomineralization of this *** this research,we generated a comprehensive transcript dataset of ***’s mantle tissue,and a total of 19821 unigenes were *** shell matrix proteins(SMP)-related genes were *** qPCR results showed that four out of six prismatic matrix genes(MSP2,MSP5,prisilkin-39,and shematrin),four out of the six nacreous matrix genes(perlucin,pif,pif97,and papilin),and two extrapallial fluid proteins(SPARC and calmodulin)were significantly expressed in the *** the nacreous and the prismatic layers are chrysanthemum-shaped,which are stacked on the top of each other to form a laminated nacreous *** alignment and phylogenetic analysis of MSP-5,Prisilkin-39,Perlucin,and Pif homologues showed that some amino acids of *** that differed from those detected in other molluscs may cause the different shape of the nacreous and prismatic layers,but do not lead to a change in the species’evolutionary *** results indicated the conservation of the functions of SMP-related genes in ***,and the specific shape of the prismatic and nacreous layers of this deep-sea mollusc,which will contribute to the research on the molecular regulation mechanisms of biomineralization in *** and provide a new perspective to investigate biomineralization in deep-sea clams in general.

关键词： transcriptome biomineralization mantle tissue shell Calyptogena marissinica

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Recent progress of MgO-based materials in CO_(2) adsorption and conversion:Modification methods,reaction condition,and CO_(2) hydrogenation

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Chinese Chemical Letters 2024年第5期35卷 57-65页

作者： Zixuan Zhu Xianjin shi Yongfang Rao yu Huang Key Laboratory of Aerosol Chemistry&Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of Sciences(CAS)Xi’an 710061China Center for Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

Integrated CO_(2) capture and conversion of(ICCC)is one of the most effective solutions to reduce anthropogenic CO_(2) emissions,which has attracted extensive public *** functional materials(DFMs),including adsorbent and catalyst,are the key components to achieve *** oxide(MgO)is an ideal adsorbent for ICCC,since it is characterized by high theoretical adsorption capacity,low cost,low energy consumption and extensive *** can also be used as DFMs in combination with the Ni *** not only can act as an adsorbent in DFMs but also enhance the catalytic performance of *** review summarizes the advantages and modification methods of MgO as adsorbent and the influence of its adsorption conditions on the adsorption ***,the important role of MgO in facilitating the catalytic conversion of CO_(2) is *** research focuses are proposed for the development of MgO based DFMs with high adsorption capacity,high stability,conversion,and selectivity as well as low cost and energy consumption.

关键词： CO_(2) ICCC MgO Adsorption Conversion

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Primordial black holes and curvature perturbations from false vacuum islands

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 58-72页

作者： Rong-Gen Cai yu-shi Hao Shao-Jiang Wang School of Physical Science and Technology Ningbo UniversityNingbo 315211China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Asia Pacific Center for Theoretical Physics Pohang 37673Republic of Korea

Recently,much attention has been focused on the false vacuum islands that are flooded by an expanding ocean of true-vacuum bubbles slightly later than most of the other parts of the *** delayed decay regions will accumulate locally larger vacuum energy density by staying in the false vacuum longer than those already transited into the true vacuum.A false vacuum island with thus acquired density contrast of a super-horizon size will evolve locally from radiation dominance to vacuum dominance,creating a local baby Universe that can be regarded effectively as a local closed *** such density contrasts of super-horizon sizes can ever grow large enough to exceed the threshold of gravitational collapse,primordial black holes will form similar to those collapsing curvature perturbations on super-horizon scales induced by small-scale enhancements during *** not,such density contrasts can still induce curvature perturbations potentially observable *** this paper,we revisit and elaborate on the generations of primordial black holes and curvature perturbations from delayed-decayed false vacuum islands during asynchronous first-order phase transitions with fitting formulas convenient for future model-independent studies.

关键词： first-order phase transitions primordial black holes curvature perturbations

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Promoted surface charge density from interlayer Zn–N_(4) configuration in carbon nitride for enhanced CO_(2) photoreduction

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Nano Research 2024年第4期17卷 2400-2409页

作者： Xianjin shi yu Huang Gangqiang Zhu Wei Peng Meijuan Chen State Key Laboratory of Loess and Quaternary Geology(SKLLQG) Key Laboratory of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Center of Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China

The solar-driven reduction of CO_(2) into valuable products is a promising method to alleviate global environmental problems and energy ***,the low surface charge density limits the photocatalytic conversion performance of CO_(2).Herein,a polymeric carbon nitride(PCN)photocatalyst with Zn single atoms(Zn1/CN)was designed and synthesized for CO_(2) *** results of the CO_(2) photoreduction studies show that the CO and CH_(4) yields of Zn1/CN increased fivefold,reaching 76.9 and 22.9μmol/(g·h),respectively,in contrast to the unmodified ***+plasma-etched X-ray photoelectron spectroscopy and synchrotron radiation-based X-ray absorption fine structure results reveal that Zn single atom is mainly present in the interlayer space of PCN in the Zn–N_(4) *** characterizations indicate that the interlayer Zn–N_(4) configuration can amplify light absorption and establish an interlayer charge transfer ***-assisted Kelvin probe force microscopy confirms that more photogenerated electrons are delivered to the catalyst surface through interlayer Zn–N_(4) configuration,which increases its surface charge ***,in-situ infrared spectroscopy combined with density functional theory calculation reveals that promoted surface charge density accelerates key intermediates(*COOH)conversion,thus achieving efficient CO_(2) *** work elucidates the role of internal single atoms in catalytic surface reactions,which provides important implications for the design of single-atom catalysts.

关键词： single-atom catalysts photocatalytic CO_(2)reduction interlayer modification charge transfer dynamics surface charge density

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Performance and enhanced oil recovery efficiency of an acid-resistant polymer microspheres of anti-CO2 channeling in low-permeability reservoirs

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Petroleum Science 2024年第4期21卷 2420-2432页

作者： Hai-Zhuang Jiang hong-Bin Yang Ruo-Sheng Pan Zhen-yu Ren Wan-Li Kang Jun-Yi Zhang shi-Long Pan Bauyrzhan Sarsenbekuly State Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) School of Petroleum Engineering China University of Petroleum (East China) Oil and Gas Engineering Research Institute School of Energy and Petroleum Industry Kazakh-British Technical University

CO2flooding is a vital development method for enhanced oil recovery in low-permeability reservoirs,However,micro-fractures are developed in low-permeability reservoirs,which are essential oil flow channels but can also cause severe CO2gas channeling ***,anti-gas channeling is a necessary measure to improve the effect of *** kind of anti-gas channeling refers to the plugging of fractures in the deep formation to prevent CO2gas channeling,which is different from the wellbore *** microspheres have the characteristics of controllable deep plugging,which can achieve the profile control of low-permeability fractured *** acidic environments with supercritical CO2,traditional polymer microspheres have poor expandability and plugging *** on previous work,a systematic evaluation of the expansion performance,dispersion rheological properties,stability,deep migration,anti-CO2channeling and enhanced oil recovery ability of a novel acid-resistant polymer microsphere（DCNPM-A） was carried out under CQ oilifield conditions（salinity of85,000 mg/L,80℃,pH=3）.The results show that the DCNPM-A microsphere had a better expansion performance than the traditional microsphere,with a swelling rate of *** microsphere dispersion with a concentration of 0.1%-0.5% had the advantages of low viscosity,high dispersion and good injectability in the low permeability fractured *** the acidic environment of supercritical CO2,DCNPM-A microspheres showed excellent stability and could maintain strength for over 60 d with less *** core experiments,DCNPM-A microspheres exhibited delayed swelling characteristics and could effectively plug deep *** a plugging rate of 95%,the subsequent enhanced oil recovery of CO2flooding could reach 21.03%.The experimental results can provide a theoretical basis for anti-CO2channeling and enhanced oil recovery in low-permeability fractured reservoirs.

关键词： Low-permeability reservoir Anti-CO2 channeling Polymer microsphere Acid resistance

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