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Performance of the walking trail making test in older adults with white matter hyperintensities

World Journal of Psychiatry 2024年第1期14卷 102-110页

作者： hong-Yi zhao Zhi-Qiang Zhang yong-Hua Huang hong Li Fang-Yuan Wei Department of Neurology No.984 Hospital of PLABeijing 100094China Department of Neurology The Seventh Medical Center of PLA General HospitalBeijing 100700China Mental Health Institute of Inner Mongolia Autonomous Region The Third Hospital of Inner Mongolia Autonomous RegionHohhot 010010Inner Mongolia Autonomous RegionChina Department of Neurosurgery No.984 Hospital of PLABeijing 100094China Department of Hand and Foot Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Engineering Research Center of Chinese Orthopaedic and Sports Rehabilitation Artificial Intelligent Ministry of EducationBeijing 100029China

BACKGROUND Several studies have reported that the walking trail making test(WTMT)completion time is significantly higher in patients with developmental coordination disorders and mild cognitive impairments.We hypothesized that WTMT performance would be altered in older adults with white matter hyperintensities(WMH).AIM To explore the performance in the WTMT in older people with WMH.METHODS In this single-center,observational study,25 elderly WMH patients admitted to our hospital from June 2019 to June 2020 served as the WMH group and 20 participants matched for age,gender,and educational level who were undergoing physical examination in our hospital during the same period served as the control group.The participants completed the WTMT-A and WTMT-B to obtain their gait parameters,including WTMT-A completion time,WTMT-B completion time,speed,step length,cadence,and stance phase percent.White matter lesions were scored according to the Fazekas scale.Multiple neuropsychological assessments were carried out to assess cognitive function.The relationships between WTMT performance and cognition and motion in elderly patients with WMH were analyzed by partial Pearson correlation analysis.RESULTS Patients with WMH performed significantly worse on the choice reaction test(CRT)(0.51±0.09 s vs 0.44±0.06 s,P=0.007),verbal fluency test(VFT,14.2±2.75 vs 16.65±3.54,P=0.012),and digit symbol substitution test(16.00±2.75 vs 18.40±3.27,P=0.010)than participants in the control group.The WMH group also required significantly more time to complete the WTMT-A(93.00±10.76 s vs 70.55±11.28 s,P<0.001)and WTMT-B(109.72±12.26 s vs 82.85±7.90 s,P<0.001).WTMT-A completion time was positively correlated with CRT time(r=0.460,P=0.001),while WTMT-B completion time was negatively correlated with VFT(r=-0.391,P=0.008).On the WTMT-A,only speed was found to statistically differ between the WMH and control groups(0.803±0.096 vs 0.975±0.050 m/s,P<0.001),whereas on the WTMT-B,the WMH group exhibited a significantly lower speed(0.778±0.111 vs 0.970±0.053

关键词： White matter hyperintensities Cognitive dysfunction Motor deficits Gait analysis Trail making test Small vessel disease

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Improved Convolutional Neural Network for Traffic Scene Segmentation

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2691-2708页

作者： Fuliang Xu yong Luo Chuanlong Sun hong zhao College of Mechanical and Electrical Engineering Qingdao UniversityQingdao266071China

In actual traffic scenarios,precise recognition of traffic participants,such as vehicles and pedestrians,is crucial for intelligent transportation.This study proposes an improved algorithm built on Mask-RCNN to enhance the ability of autonomous driving systems to recognize traffic participants.The algorithmincorporates long and shortterm memory networks and the fused attention module(GSAM,GCT,and Spatial Attention Module)to enhance the algorithm’s capability to process both global and local information.Additionally,to increase the network’s initial operation stability,the original network activation function was replaced with Gaussian error linear unit.Experiments were conducted using the publicly available Cityscapes dataset.Comparing the test results,it was observed that the revised algorithmoutperformed the original algorithmin terms of AP_(50),AP_(75),and othermetrics by 8.7%and 9.6%for target detection and 12.5%and 13.3%for segmentation.

关键词： Instance segmentation deep learning convolutional neural network attention mechanism

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Dynamic plugging regulating strategy of pipeline robot based on reinforcement learning

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Petroleum Science 2024年第1期21卷 597-608页

作者： Xing-Yuan Miao hong zhao College of Mechanical and Transportation Engineering China University of PetroleumBeijing102249China

Pipeline isolation plugging robot (PIPR) is an important tool in pipeline maintenance operation. During the plugging process, the violent vibration will occur by the flow field, which can cause serious damage to the pipeline and PIPR. In this paper, we propose a dynamic regulating strategy to reduce the plugging-induced vibration by regulating the spoiler angle and plugging velocity. Firstly, the dynamic plugging simulation and experiment are performed to study the flow field changes during dynamic plugging. And the pressure difference is proposed to evaluate the degree of flow field vibration. Secondly, the mathematical models of pressure difference with plugging states and spoiler angles are established based on the extreme learning machine (ELM) optimized by improved sparrow search algorithm (ISSA). Finally, a modified Q-learning algorithm based on simulated annealing is applied to determine the optimal strategy for the spoiler angle and plugging velocity in real time. The results show that the proposed method can reduce the plugging-induced vibration by 19.9% and 32.7% on average, compared with single-regulating methods. This study can effectively ensure the stability of the plugging process.

关键词： Pipeline isolation plugging robot Plugging-induced vibration Dynamic regulating strategy Extreme learning machine Improved sparrow search algorithm Modified Q-learning algorithm

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Current understanding of ELF4 deficiency:a novel inborn error of immunity

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World Journal of Pediatrics 2024年第5期20卷 444-450页

作者： hong-Qiang Du Xiao-Dong zhao Department of Rheumatology&Immunology National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Child Rare Diseases in Infection and ImmunityChildren’s Hospital of Chongqing Medical UniversityZhongshan Er Road 136Yuzhong DistrictChongqingChina

Background ELF4 deficiency has been recently recognized as a novel disorder within the spectrum of inborn errors of immunity(IEIs),specifically categorized as a“disease of immune dysregulation.”Cases of this condition,reported by our team and others,are very limited worldwide.As such,our current knowledge of this new disease remains preliminary.This review aims to provide a brief overview of the clinical manifestations,pathogenesis,and treatment strategies for this novel IEI.Data sources A comprehensive review was conducted after an extensive literature search in the PubMed/Medline database and websites concerning transcriptional factor ELF4 and reports concerning patients with ELF4 deficiency.Our search strategy was“ELF4 OR ETS-related transcription factor Elf-4 OR EL4-like factor 4 OR myeloid Elf-1-like factor”as of the time of manuscript submission.Results The current signature manifestations of ELF4 deficiency disorder are recurrent and prolonged oral ulcer,abdominal pain,and diarrhea in pediatric males.In some cases,immunodeficiency and autoimmunity can also be prominent.Targeted Sanger sequencing or whole exome sequencing can be used to detect variation in ELF4 gene.Western blotting for ELF4 expression of the patient’s cells can confirm the pathogenic effect of the variant.To fully confirm the pathogenicity of the variant,further functional test is strongly advised.Glucocorticoid and biologics are the mainstream management of ELF4 deficiency disorder.Conclusions Pediatric males presenting with recurring ulcerations in digestive tract epithelium with or without recurrent fever should be suspected of DEX.When atypical presentations are prominent,variations in ELF4 gene should be carefully evaluated functionally due to the complex nature of ELF4 function.Experience of treating DEX includes use of glucocorticoid and biologics and more precise treatment needs more patients to identify and further mechanistic study.

关键词： ELF4 transcription factor Immune dysregulation Inborn errors of immunity Mechanism Recurrent infections

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Homological Transfer between Additive Categories and Higher Differential Additive Categories

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1325-1344页

作者： Xi TANG zhao yong HUANG School of Science Guilin University of Aerospace TechnologyGuilin 541004P.R.China Department of Mathematics Nanjing UniversityNanjing 210093P.R.China

Given an additive category C and an integer n≥2.The higher differential additive category consists of objects X in C equipped with an endomorphism ϵ_(X)satisfying ϵ_(X)^(n).Let R be a,finite-dimensional basic algebra over an algebraically closed field and T the augmenting functor from the category of finitely generated left R-modules to that of finitely generated left R/(t^(n))-modules.It is proved that a finitely generated left R-module M isτ-rigid(respectively,(support)τ-tilting,almost completeτ-tilting)if and only if so is T(M)as a left R[t]/(t^(n))-module.Moreover,R isτm-selfinjective if and only if so is R[t]/(t^(n)).

关键词： Higher differential objects Wakamatsu tilting subcategories G_(ω)-projective modules sup-portτ-tilting modules τ_(m)-selfinjective algebras precluster tilting subcategories

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Annexin A1 in the nervous and ocular systems

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Neural Regeneration Research 2024年第3期19卷 591-597页

作者： Aijia Wang hong Zhang Xing Li Yin zhao Department of Ophthalmology 2Department of AnesthesiologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

The therapeutic potential of Annexin A1,an important member of the Annexin superfamily,has become evident in results of experiments with multiple human systems and animal models.The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous system.In this review,we initially describe the expression sites of Annexin A1,then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches;and,finally,we discuss the neuroregenerative potential qualities of Annexin A1.The eye and the nervous system are anatomically and functionally connected,but the association between visual system pathogenesis,especially in the retina,and Annexin A1 alterations has not been well summarized.Therefore,we explain the beneficial effects of Annexin A1 for ocular diseases,especially for retinal diseases and glaucoma on the basis of published findings,and we explore present and future delivery strategies for Annexin A1 to the retina.

关键词： Annexin A1(ANXA1) glaucoma nervous system neuroprotection neuroregeneration ocular disease retina

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Barrier Option Pricing in Regime Switching Models with Rebates

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 849-861页

作者： Yue-xu zhao Jia-yong BAO School of Economics Hangzhou Dianzi UniversityHangzhou 310018China School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China

This paper is concerned with the valuation of single and double barrier knock-out call options in a Markovian regime switching model with specific rebates.The integral formulas of the rebates are derived via matrix Wiener-Hopf factorizations and Fourier transform techniques,also,the integral representations of the option prices are constructed.Moreover,the first-passage time density functions in two-state regime model are derived.As applications,several numerical algorithms and numerical examples are presented.

关键词： option pricing Markovian regime switching Wiener-Hopf factorization Fourier transform

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Interface engineering of Co_(9)S_(8)/SnS heterostructure as a high-performance anode for lithium/sodium-ion batteries

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Rare Metals 2024年第2期43卷 612-623页

作者： Jia Luo Shi-Li Xiang Dan-Yang Han An Liu João Cunha Gang-yong Li zhao-Hui Hou hong Yin School of Chemistry and Chemical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional MaterialsHunan Institute of Science and TechnologyYueyang414006China Hubei Jiufengshan Laboratory Wuhan430206China International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga4715-330BragaPortugal

Transition metal sulfide(TMS)anodes exhibit the characteristics of phase stability and high capacity for lithium/sodium-ion batteries(LIBs/SIBs).However,the TMS anodes often suffer from poor electronic conductivity,low ionic diffusion and large volume expansion during Li/Na-ion intercalation significantly impairing the Li/Na-storage performance.Herein,a long chain heterostructure composed of the Co_(9)S_(8) and SnS are first reported,which can generate rich phase interfaces,and small crystal domains.The unique structure can facilitate the properties of reactivity,conductivity and ionic diffusion.In addition,the heterostructure surface is modified by the N-doped carbon(N-DC@(CoSn)S),successfully improving the structural stability.The synergistic effects of Co_(9)S_(8)/SnS heterostructure and coated carbon layer effectively increase the capacity and cycling stability.The N-DC@(CoSn)S anode delivers enhanced high specific capacities of 820.6 mAh·g^(−1) at 1.0 A·g^(–1) after 500 cycles for LIBs and 339.2 mAh·g^(–1)at 0.5 A·g^(–1) after 1000 cycles for SIBs,respectively.This work is expected to provide a material design idea for preparing LIBs/SIBs with high capacity and long cycling life.

关键词： Interface engineering Long chain heterostructure High capacity Cycling stability Li Na-ion batteries

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Random Raman Fiber Laser as a Liquid Refractive Index Sensor

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Photonic Sensors 2024年第1期14卷 13-22页

作者： Bing HAN Yuxi MA Han WU yong zhao College of Information Science and Engineering Northeastern UniversityShenyang 110819China Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology Qinhuangdao 066004China College of Electronics and Information Engineering Sichuan UniversityChengdu 610064China

In this paper,a new concept of forward-pumped random Raman fiber laser(RRFL)-based liquid refractive index sensing is proposed for the first time.For liquid refractive index sensing,the flat fiber end immersed in the liquid can act as the point reflector for generating random fiber lasing and also as the sensing head.Due to the high sensitivity of the output power of the RRFL to the reflectivity provided by the point reflector in the ultralow reflectivity regime,the proposed RRFL is capable of achieving liquid refractive index sensing by measuring the random lasing output power.We theoretically investigate the effects of the operating pump power and fiber length on the refractive index sensitivity for the proposed RRFL.As a proof-of-concept demonstration,we experimentally realize high-sensitivity half-open short-cavity RRFL-based liquid refractive index sensing with the maximum sensitivity and the sensing resolution of-39.88W/RIU and 2.5075×10^(-5) RIU,respectively.We also experimentally verify that the refractive index sensitivity can be enhanced with the shorter fiber length of the RRFL.This work extends the application of the random fiber laser as a new platform for highly-sensitive refractive index sensing in chemical,biomedical,and environmental monitoring applications,etc.

关键词： Fiber optic sensors refractive index measurements fiber lasers Rayleigh scattering stimulated Raman scattering

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Advances in the research and application of neurokinin-1 receptor antagonists

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 91-105页

作者： Xiangyu hong Junjie MA Shanshan ZHENG Guangyu zhao Caiyun FU College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou310018China

Recently,the substance P(SP)/neurokinin-1 receptor(NK-1R)system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019(COVID-19).Besides,studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK-1R system with the progression of multiple carcinoma types and poor clinical prognosis.These findings indicate that the modulation of SP/NK-1R system with NK-1R antagonists can be a potential broad-spectrum antitumor strategy.This review updates the latest potential and applications of NK-1R antagonists in the treatment of human diseases and cancers,as well as the underlying mechanisms.Furthermore,the strategies to improve the bioavailability and efficacy of NK-1R antagonist drugs are summarized,such as solid dispersion systems,nanonization,and nanoencapsulation.As a radiopharmaceutical therapeutic,the NK-1R antagonist aprepitant was originally developed as radioligand receptor to target NK-1R-overexpressing tumors.However,combining NK-1R antagonists with other drugs can produce a synergistic effect,thereby enhancing the therapeutic effect,alleviating the symptoms,and improving patients’quality of life in several diseases and cancers.

关键词： Neurokinin-1 receptor(NK-1R)antagonist Pathophysiological disorder Tumor target Bioavailability Nanoencapsulation Synergistic therapy

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