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Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/β-catenin axis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 867-874页

作者： Xiao-hua XU yi-chao gan Gen-bo XU Ting CHEN hong ZHOU Jin-fen TANG ying GU Fei XU ying-ying XIE Xiao-ying ZHAO Rong-zhen XU Department of Hematology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Cancer Institute the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective:To evaluate the effects of tetrandrine citrate, a novel tetrandrine salt with high water solubility, on the growth of imatinib (IM)-resistant chronic myeloid leukemia (CML) in vitro and in vivo, and reveal action molecular mechanisms. Methods:Cell viability in vitro was measured using methyl thiazolyl tetrazolium (MTT) assay. CML cell growth in vivo was assessed using a xenograft model in nude mice. Bcr-Abl and β-catenin protein levels were determined using Western blotting. Bcr-Abl messenger RNA (mRNA) was measured by reverse transcription polymerase chain reaction (RT-PCR). Flow cytometry (FCM) was used to determine cell cycle status. Results:Tetrandrine citrate inhibited the growth of IM-resistant K562 cells, primary leukemia cells, and primitive CD34 + leukemia cells, and their inhibition concentration that inhibited 50% of target cells (IC 50 ) ranged from 1.20 to 2.97 μg/ml. In contrast, tetrandrine citrate did not affect normal blood cells under the same conditions, and IC 50 values were about 10.12-13.11 μg/ml. Oral administration of tetrandrine citrate caused complete regression of IM-resistant K562 xeno-grafts in nude mice without overt toxicity. Western blot results revealed that treatment of IM-resistant K562 cells with tetrandrine citrate resulted in a significant decrease of both p210 Bcr-Abl and β-catenin proteins, but IM did not affect the Bcr-Abl protein levels. Proteasome inhibitor, MG132, did not prevent tetrandrine-mediated decrease of the p210 Bcr-Abl protein. RT-PCR results showed that tetrandrine treatment caused a decrease of Bcr-Abl mRNA. FCM analysis indicated that tetrandrine induced gap 1 (G 1 ) arrest in CML cells. Conclusions:Tetrandrine citrate is a novel orally active tetrandrine salt with potent anti-tumor activity against IM-resistant K562 cells and CML cells. Tetrandrine citrate-induced growth inhibition of leukemia cells may be involved in the depletion of p210 Bcr-Abl mRNA and β-catenin protein.

关键词： Chronic myeloid leukemia Imatinib-resistance Tetrandrine citrate Bcr-Abl protein β-catenin protein

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YVO_4: Eu^(3+) photoluminescence films with Bi doping

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Rare Metals 2014年第6期33卷 723-726页

作者： Zhen-Xiang Dai Yu-Qin Dong gan-hong Zheng Shi-Bing Qian Qian Ma Guang Li Anhui Key Laboratory of Information Materials and Devices School of Physics and Material Science Anhui University

Y0.95-xEu0.05VO4：x Bi3＋（x = 0, 0.02, 0.04,0.06, 0.08, and 0.10 mol） six photoluminescence films were deposited on glass substrates by sol–gel spin-coating method. Their morphology and optical property were investigated. The micrographs for the six samples have no change with Bi3→doping. The emission spectra result shows that a dominant red emission peak at 620 nm, which is due to the Eu3＋electric dipole transition of5D0→7F2,is observed under excitation wavelengths 254 nm. Furthermore, with the content of Bi3→increasing from 0 to0.08 mol, the emission intensity of samples strengthens and reaches a maximum at x = 0.08 mol, then decreases with the doping content to 0.10 mol.

关键词： Photoluminescence film Bi3+content Emission intensity

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具有避障功能的农机自动作业全覆盖路径规划方法

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农机化研究 2025年第2期47卷 36-43页

作者：罗荣浩干熊杨光友湖北工业大学农机工程研究设计院武汉430068 湖北省农机装备智能化工程技术研究中心武汉430068

针对不同尺寸和类型障碍物条件下的农机车辆自动作业全覆盖路径规划问题,提出了静态全覆盖路径规划方法和路径优化方案。根据矩形田块信息、障碍物信息、农机最小转弯半径和机具宽度,自动选定作业方向、作业行距、地头转弯区域和转弯模... 详细信息

针对不同尺寸和类型障碍物条件下的农机车辆自动作业全覆盖路径规划问题,提出了静态全覆盖路径规划方法和路径优化方案。根据矩形田块信息、障碍物信息、农机最小转弯半径和机具宽度,自动选定作业方向、作业行距、地头转弯区域和转弯模式等参数;根据障碍物形状、高覆盖率高作业路径比的需求,对算法进行优化调整,以达到更好的作业效果。软件仿真测试结果表明:对有小矩形障碍物的田块,改进后的算法覆盖率提升了0.11%,重复率降低了0.71%;对大矩形障碍物的田块,两种分区路径的覆盖率分别为89.24%和98.08%,重复率分别为3.53%和2.84%。研究结果表明:算法提高了田块的利用率,降低了作业成本,能够有效避开大小障碍物,同时满足高覆盖率和低重复率的田间作业要求。

关键词：农机车辆路径规划算法自动作业避障

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Evolution and roles of cytokinin genes in angiosperms 1:Do ancient IPTs play housekeeping while non-ancient IPTs play regulatory roles?

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Horticulture Research 2020年第1期7卷 2462-2476页

作者： Xiaojing Wang Shanshan Lin Decai Liu Lijun gan Richard McAvoy Jing Ding yi Li State Key Laboratory of Crop Genetics and Germplasm Enhancement and the College of Horticulture Nanjing Agricultural UniversityNanjingP.R.China College of Life Sciences Nanjing Agricultural UniversityNanjingP.R.China Department of Plant Science and Landscape Architecture University of ConnecticutStorrsCT 06269USA

Isopentenyltransferase(IPT)genes,including those encoding ATP/ADP-IPTs and tRNA-IPTs,control the rate-limiting steps of the biosynthesis of N6-(Δ2-isopentenyl)adenine(iP)-type and trans-zeatin(tZ)-type cytokinins and cis-zeatin(cZ)-type cytokinins,***,the evolution and roles of these IPTs in angiosperms are not well ***,we report comprehensive analyses of the origins,evolution,expression patterns,and possible roles of ATP/ADP-IPTs and tRNA-IPTs in *** found that Class I and II tRNA-IPTs likely coexisted in the last common ancestor of eukaryotes,while ATP/ADP-IPTs likely originated from a Class II tRNA-IPT before the divergence of ***-IPTs are conservatively retained as 2–3 copies,but ATP/ADP-IPTs exhibit considerable expansion and ***,tRNA-IPTs are constitutively expressed throughout the plant,whereas the expression of ATP/ADP-IPTs is tissue-specific and rapidly downregulated by abiotic ***,previous studies and our present study indicate that ATP/ADP-IPTs and their products,iPs/tZs,may regulate responses to environmental stresses and organ development in *** therefore hypothesize that tRNA-IPTs and the associated cZs play a housekeeping role,whereas ATP/ADP-IPTs and the associated iP/tZ-type cytokinins play regulatory roles in organ development and stress responses in angiosperms,which echoes the conclusions and hypothesis presented in the accompanying study by Wang,*** al Evolution and roles of cytokinin genes in angiosperms 2:Do ancient CKXs play housekeeping roles while non-ancient CKXs play regulatory roles?Hortic Res https://***/10.1038/s41438-020-0246-z.

关键词： IPT Evolution likely

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Favorable anion adsorption/desorption of high rate NiSe_(2) nanosheets/hollow mesoporous carbon for battery-supercapacitor hybrid devices

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Nano Research 2021年第8期14卷 2574-2583页

作者： Xiaojuan Zhao Houzhao Wan Pei Liang Nengze Wang Cong Wang yi gan Xu Chen Qiuyang Tan Xiang Liu Jun Zhang yi Wang Hanbin Wang Hao Wang Hubei Key Laboratory of Ferro&Piezoelectric Materials and Devices School of Microelectronics and Faculty of Physics and Electronic ScienceHubei UniversityWuhan 430062China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Max Planck Institute for Solid State Research Heisenbergstr 170569 StuttgartGermany

High-rate battery-type cathode materials have attracted wide attention for advanced battery-supercapacitor hybrid(BSH)***,a core-shell structure of the hollow mesoporous carbon spheres(HMCS)supported NiSe2 nanosheets(HMCS/NiSe2)is constructed through two-step *** HMCS/NiSe_(2)shows a max specific capacity of 1,153.5 C·g^(-1) at the current density of 1 A·g^(-1),and can remain at 774.5 C·g^(-1) even at 40 A·g^(-1)(the retention rate as high as 67.1%)and then the HMCS/NiSe_(2) electrode can keep 80.5%specific capacity after 5,000 cycles at a current density of 10 A·g^(-1).Moreover,the density functional theory(DFT)calculation confirmed that the introduction HMCS into NiSe_(2) made adsorption/desorption of OH-easier,which can achieve higher rate *** HMCS/NiSe_(2)//6 M KOH//HMCS hybrid device has energy density of 47.15 Wh·kg^(-1) and power density of 801.8 W·kg^(-1).This work provides a feasible electrode material with a high rate and its preparation method for high energy density and power density energy storage devices.

关键词： nickel selenide mesoporous carbon supercapacitor high rate core-shell structure

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Design and simulation of a 2-D array flexible ultrasound transducer system for tissue characterization-A pilot study

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Medicine in Novel Technology and Devices 2022年第1期13卷 59-64页

作者： Zhihua gan Brian Guo Jiqi Cheng yi-Xian Qin Department of Biomedical Engineering Stony Brook UniversityStony BrookNY11794USA Department of Electrical and Computer Engineering Stony Brook UniversityStony BrookNY11794USA

Noninvasive diagnosis of bone density and mechanical properties using non-radiation imaging modality is an emerging area with promising in early prediction of osteopenia and treatment effectiveness in the clinic and functional disuse,i.e.,long-term bedrest and space *** in quantitative ultrasound have shown advantages in measuring both bone density and mechanical strength,non-radiation,imaging capability,and easy to *** challenge that remained is the poor penetration of ultrasound signals passing through trabecular and cortical bones and acoustic energy scattering.A new scanning confocal ultrasound technology is developed in this lab to detect the alteration of bone to provide diagnostic results in bone density and structure properties.A software-controlled flexible ultrasound system with 2-D dual array transducer is developed and proposed for the purpose of noninvasive bone density diagnosis and assessment of bone ***(Tx)transducer elements are divided into sub-blocks to excite the ultrasound signals in sequence to decrease the system complexity while maintaining beam pattern properties by the signal processing procedure at receiving(Rx)*** is also applied to reduce acoustic side lobes and to make the resolution in the ultrasound field of view(FOV)more *** study may provide basic understanding of modulated confocal ultrasound beam forming for tissue characterization,such as trabecular bone structual and strength properties.

关键词： Flexible ultrasound system Noninvasive diagnostic imaging Sub-block triggering Ultrasound imaging resolution Apodization Quantitative ultrasound Trabecular bone property Scanning ultrasound Bone density and strength

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Chiral Synthesis of 13-Acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one

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Chinese Chemical Letters 2001年第3期12卷 205-206页

作者： An Pai LI Yong hong gan Xiao Shui PENG Tong Xing WU Xin Fu PAN Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

An enantioselective synthetic route to (+)-13-acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one 1a and (-)-13-acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one 1b was developed from (S)-(-)-alpha -cyclocitral 8a and... 详细信息

关键词： Synthesis enantioselective podocarpane anisic chiral

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Time-Resolved Measurement of Nonradiative Processes by Using Laser Interferometry

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Chinese Physics Letters 1996年第4期13卷 313-316页

作者： FU Shao-wei WU Zong-sen gan Chang-niing ZHANG Shu-yi ZHANG Zhi CHEN Hui-lan Laboratory of Modern Acoustics and Institute of AcousticsNanjing UniversityNanjing 210093 Laboratory of Coordination Chemistry and Department of ChemistryNanjing UniversityNanjing 210093

Photoacoustic signals generated by nonradiative processes of photo-initiated chemical reactions in solutions have been detected by a laser heterodyne interierometer witli high sensitivity and wide *** technique can accurately carry out the time-resolved measurement of transient processes in nanosecond *** experimental results and theoretical calculations for probing some fast chemicol reactions are described.

关键词： heterodyne radiative transient

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Phase Structures of Microemulsions Determined by the Steady-State Fluorescence Method

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Chinese Chemical Letters 2001年第12期12卷 1109-1112页

作者： Guo Quan SHAO Qiang SHEN hong Zhi MAO gan Zuo LI Wei Can ZHANG Key Lab for Colloid and Interface Chemistry of State Education Ministry Shandong UniversityJinan 250100 Hefei Institute of Economics and Technology Hefei 230052 不详

The steady-state fluorescence method has been tentatively used to determine the phase structures of microemulsion systems consisting of cetyltrimethylammonium bromide (CTAB), n-butanol (n-C4H9OH), octane (n-C8H18), and water. The excimer/monomer intensity ratio (I-e/I-m) of pyrene has demonstrated that the various structures in the microemulsion phase region can be distinguished. The results are consistent with electrical conductivity data already reported.

关键词： phase structure fluorescence microemulsion CTAB pyrene

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Diagnostic features and therapeutic strategies for malignant paraganglioma in a patient:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9834-9844页

作者： Lei gan Xu-Dong Shen Yang Ren hong-Xia Cui Zhi-Xiang Zhuang Department of Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

BACKGROUND Paragangliomas and extra-adrenal pheochromocytomas are uncommon neuroendocrine tumors with ubiquitous *** paraganglioma is a relatively rare *** report the treatment and pathological characteristics of a patient with malignant paraganglioma,and summarize the latest advances in the treatment of malignant paraganglioma based on a literature *** SUMMARY A 45-year-old Chinese woman presented to the hospital due to pain in the waist(right side) and right buttock,and was diagnosed as malignant paraganglioma after the placement of ureteral stent,implantation of ileus catheter,and transvaginal removal of the vaginal *** relief of intestinal obstruction,the patient received intravenous chemotherapy and peritoneal perfusion *** her pelvic mass disease was stable,she developed multiple liver metastases and bone *** to the development of spinal cord compression,she underwent orthopedic surgery,followed by radiotherapy,and molecular targeted therapy with apatinib,but with poor disease *** Clinical management of paraganglioma is challenging for endocrinologists and *** studies are required to develop standardized therapeutic strategies for malignant paragangliomas.

关键词： Malignant paraganglioma Chemotherapy Radiotherapy Targeted therapy Case report

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