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Tissue-resident macrophages exacerbate lung injury after remote sterile damage

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Cellular & Molecular Immunology 2024年第4期21卷 332-348页

作者： Hanhui Zhong Jingjing Ji Jinling Zhuang Ziying Xiong Pengyun Xie Xiaolei Liu Jundi zheng Wangli Tian Xiaoyang hong Jing Tang The Department of Anesthesiology Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdongChina The Department of Critical Care Medicine General Hospital of Southern Theater Command of PLAGuangzhouChina The Department of Respiratory Medicine Guangdong Provincial Hospital of Integrated Chinese and Western MedicineFoshanChina Pediatric Intensive Care Unit Senior Department of Pediatricsthe Seventh Medical Center of PLA General HospitalBeijingChina

Remote organ injury,which is a common secondary complication of sterile tissue damage,is a major cause of poor prognosis and is difficult to ***,we report the critical role of tissue-resident macrophages in lung injury after trauma or stroke through the inflammatory *** found that depleting tissue-resident macrophages rather than disrupting the recruitment of monocyte-derived macrophages attenuated lung injury after trauma or *** findings revealed that the release of circulating alarmins from sites of distant sterile tissue damage triggered an inflammatory response in lung-resident macrophages by binding to receptor for advanced glycation end products(RAGE)on the membrane,which activated epidermal growth factor receptor(EGFR).Mechanistically,ligand-activated RAGE triggered EGFR activation through an interaction,leading to Rab5-mediated RAGE internalization and EGFR phosphorylation,which subsequently recruited and activated P38;this,in turn,promoted RAGE translation and trafficking to the plasma membrane to increase the cellular response to RAGE ligands,consequently exacerbating *** study also showed that the loss of RAGE or EGFR expression by adoptive transfer of macrophages,blocking the function of RAGE with a neutralizing antibody,or pharmacological inhibition of EGFR activation in macrophages could protect against trauma-or stroke-induced remote lung ***,our study revealed that targeting the RAGE-EGFR signaling pathway in tissue-resident macrophages is a potential therapeutic approach for treating secondary complications of sterile damage.

关键词： tissue-resident macrophage RAGE remote sterile damage

Primary pulmonary meningioma and minute pulmonary meningothelial-like nodules: Rare pulmonary nodular lesions requiring more awareness in clinical practice

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World Journal of Clinical Cases 2024年第11期12卷 1857-1862页

作者： Li-Dan Liu Ke-Xin Zhang Hai-Ning Zhang Yi-Wen zheng hong-Tao Xu Department of Pathology The First Hospital and College of Basic Medical Sciences of China Medical UniversityShenyang 110001Liaoning ProvinceChina

In this editorial,we comment on an article by Ruan et al published in a recent issue of the World Journal of Clinical *** meningothelial proliferative lesions,including primary pulmonary meningiomas,minute pulmonary meningothelial-like nodules,and metastatic pulmonary meningiomas are rare pulmonary *** lesions are difficult to differentiate from lung cancers based on clinical and imaging ***,we briefly introduce the clinical,imaging,and pathological characteristics of these lesions and discuss their pathogenesis to strengthen the current understanding of pulmonary meningothelial proliferative lesions in clinical diagnosis and therapy.

关键词： Pulmonary meningothelial proliferation Primary pulmonary meningioma Minute pulmonary meningothelial-like nodule Lung neoplasm Rare pulmonary nodular lesion

Universal transfer of full-class metal electrodes for barrier-free two-dimensional semiconductor contacts

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InfoMat 2024年第1期6卷 96-107页

作者： Mengyu hong Xiankun Zhang Yu Geng Yunan Wang Xiaofu Wei Li Gao Huihui Yu Zhihong Cao zheng Zhang Yue Zhang Academy for Advanced Interdisciplinary Science and Technology School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijingthe People's Republic of China Key Laboratory of Advanced Materials and Devices for Post-Moore Chips Ministry of EducationUniversity of Science and Technology BeijingBeijingthe People's Republic of China

Metal–semiconductor contacts are crucial components in semiconductor *** two-dimensional transition-metal dichalcogenide semiconductors can sustain transistor scaling for next-generation integrated ***,their performance is often degraded by conventional metal deposition,which results in a high barrier due to chemical disorder and Fermi-level pinning(FLP).Although,transferring electrodes can address these issues,they are limited in achieving universal transfer of full-class metals due to strong adhesion between pre-deposited metals and ***,we propose a nanobelt-assisted transfer strategy that can avoid the adhesion limitation and enables the universal transfer of over 20 different types of *** contacts obey the Schottky–Mott rule and exhibit a FLP of S=*** the electron and hole contacts show record-low Schottky barriers of 4.2 and 11.2 meV,*** a demonstration,we construct a doping-free WSe_(2) inverter with these high-performance contacts,which exhibits a static power consumption of only 58 *** strategy provides a universal method of electrode preparation for building high-performance post-Moore electronic devices.

关键词： metal electrode transfer metal–semiconductor contacts Schottky barrier two-dimensional semiconductors

A Minimum Residual Based Gradient Iterative Method for a Class of Matrix Equations

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 17-34页

作者： Qing-qing zheng Department of Mathematics College of ScienceChina University of Petroleum-BeijingBeijing102249China

In this paper, we present a minimum residual based gradient iterative method for solving a class of matrix equations including Sylvester matrix equations and general coupled matrix equations. The iterative method uses a negative gradient as steepest direction and seeks for an optimal step size to minimize the residual norm of next iterate. It is shown that the iterative sequence converges unconditionally to the exact solution for any initial guess and that the norm of the residual matrix and error matrix decrease monotonically. Numerical tests are presented to show the efficiency of the proposed method and confirm the theoretical results.

关键词： Sylvester matrix equation coupled matrix equation minimum residual gradient descent convergence analysis

Variational Analysis Based on Proximal Subdifferential on Smooth Banach Spaces

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Acta Mathematica Sinica,English Series 2024年第2期40卷 595-618页

作者： Xi Yin zheng Department of Mathematics Yunnan UniversityKunming 650091P.R.China

This paper first shows that for any p∈(1,2)there exists a continuously differentiable function f on l^(p)(and L^(p))such that the proximal subdifferential of f is empty everywhere,and hence it is not suitable to develop theory on proximal subdifferential in the classical Banach spaces l^(P)and L^(P) with p∈(1,2).On the other hand,this paper establishes variational analysis based on the proximal subdifferential in the framework of smooth Banach spaces of power type 2,which conclude all Hilbert spaces and all the classical spaces l^(P)and L^(P)with p∈(2,+∞).In particular,in such a smooth space,we provide the proximal subdifferential rules for sum functions,product functions,composite functions and supremum functions,which extend the basic results on the proximal subdifferential established in the framework of Hilbert *** of our main results are new even in the Hilbert space *** applications,we provide KKT-like conditions for nonsmooth optimization problems in terms of proximal subdifferential.

关键词： Smooth Banach space proximal subdifferential proximal normal cone KKT condition

Tuning SMSI to stabilize metallic Pd species:A case study on Pd/TiO_(2) for HCHO oxidation

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Chinese Chemical Letters 2024年第3期35卷 162-166页

作者： Chunying Wang Xiaofeng Liu Jingyi Wang Yaobin Li Shaohua Xie Fudong Liu Changbin Zhang Yuming zheng Wenpo Shan hong He Center for Excellence in Regional Atmospheric Environment Key Laboratory of Urban Pollutant ConversionInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo Urban Environment Observation and Research StationChinese Academy of SciencesNingbo 315800China Department of Civil Environmentaland Construction Engineering(CECE)Catalysis Cluster for Renewable Energy and Chemical Transformations(REACT)Nano Science Technology Center(NSTC)University of Central FloridaOrlandoFL 32816USA State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China

Pretreatment of the carrier for supported catalysts can effectively improve the strong metal-support interaction(SMSI)and increase the dispersion of precious metals,which are critical to many important catalytic *** this work,we tuned SMSI on Pd/TiO_(2)catalysts through inducing surface defects of TiO_(2)by pretreated with different atmospheres(H_(2)/N_(2),N_(2),O_(2)/N_(2))at the high temperature(800℃).Multiple characterization results illustrated that surface defects anchored Pd species and thus enhanced their *** reduction,Ti^(3+)species formed and transferred onto the metallic Pd species and then induced SMSI,which effectively stabilize Pd species in the metallic *** stronger MSI,the more stability of Pd *** a case,Pd/TiO_(2)–800H_(2),with strongest MSI,displayed the best HCHO oxidation performance at low temperature(10℃).

关键词： Pd/TiO_(2) Surface defects SMSI Formaldehyde Stability of Pd species

Performance Limits and Advancements in Single 2D Transition Metal Dichalcogenide Transistor

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Nano-Micro Letters 2024年第12期16卷 134-188页

作者： Jing Chen Ming-Yuan Sun Zhen-Hua Wang zheng Zhang Kai Zhang Shuai Wang Yu Zhang Xiaoming Wu Tian-Ling Ren hong Liu Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100084People’s Republic of China BNRist Tsinghua UniversityBeijing 100084People’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shenzhen Research Institute of Shandong University Shenzhen 518057People’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan 250100People’s Republic of China

Two-dimensional(2D)transition metal dichalcogenides(TMDs)allow for atomic-scale manipulation,challenging the conventional limitations of semiconductor *** capability may overcome the short-channel effect,sparking significant advancements in electronic devices that utilize 2D *** the dimension and performance limits of transistors based on 2D TMDs has gained substantial *** review provides a comprehensive investigation into these limits of the single 2D-TMD *** delves into the impacts of miniaturization,including the reduction of channel length,gate length,source/drain contact length,and dielectric thickness on transistor operation and *** addition,this review provides a detailed analysis of performance parameters such as source/drain contact resistance,subthreshold swing,hysteresis loop,carrier mobility,on/off ratio,and the development of p-type and single logic *** review details the two logical expressions of the single 2D-TMD logic transistor,including current and *** also emphasizes the role of 2D TMD-based transistors as memory devices,focusing on enhancing memory operation speed,endurance,data retention,and extinction ratio,as well as reducing energy consumption in memory devices functioning as artificial *** review demonstrates the two calculating methods for dynamic energy consumption of 2D synaptic *** review not only summarizes the current state of the art in this field but also highlights potential future research directions and *** underscores the anticipated challenges,opportunities,and potential solutions in navigating the dimension and performance boundaries of 2D transistors.

关键词： Two-dimensional transistors Dimension limits Performance limits Memory devices Artificial synapses

基于近红外光谱技术和多变量统计过程控制的五味子提取生产过程监测方法

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中国中药杂志 2017年第20期42卷 3906-3911页

作者：徐敏张磊岳洪水庞洪伟叶正良丁黎中国药科大学药物分析教研室江苏南京210009 天津天士力之骄药业有限公司天津300402 天津市中药注射剂安全性评价企业重点实验室天津300402

将近红外光谱分析技术与多变量数据分析技术相结合,建立注射用益气复脉(冻干)组方药材五味子提取过程的在线监测方法。采用生产上5个正常批次建立了五味子提取过程的多变量统计过程控制(multivariate statistical process control,MSPC... 详细信息

将近红外光谱分析技术与多变量数据分析技术相结合,建立注射用益气复脉(冻干)组方药材五味子提取过程的在线监测方法。采用生产上5个正常批次建立了五味子提取过程的多变量统计过程控制(multivariate statistical process control,MSPC)模型,并利用PC scores,DModX和Hotelling T^23种控制图对2个测试批次进行监测。结果显示,MSPC模型对提取过程具有良好的监测性能。将所建立的MSPC模型应用到实际生产中,能够有效地实现对五味子提取过程的在线监测,并实时反映生产过程中物料属性的变化。该文建立的监测方法为过程分析技术在中药注射剂生产过程质量控制领域的应用提供了参考。

关键词：多变量统计过程控制近红外光谱分析技术五味子提取过程注射用益气复脉(冻干)

Three-Dimensional Sound Source Location Algorithm for Subsea Leakage Using Hydrophone

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China Ocean Engineering 2024年第2期38卷 326-337页

作者： LI Hao-jie CAI Bao-ping YUAN Xiao-bing KONG Xiang-di LIU Yong-hong Javed Akbar KHAN CHU zheng-de YANG Chao TANG An-bang College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China Shenzhen Urban Public Safety Technology Institute Shenzhen 518000China Institute of Hydrocarbon Recovery Universiti Teknologi PETRONASBandar Seri IskandarPerak Darul Ridzuan 32610Malaysia

Leakages from subsea oil and gas equipment cause substantial economic losses and damage to marine ecosystem,so it is essential to locate the source of the ***,due to the complexity and variability of the marine environment,the signals collected by hydrophone contain a variety of noises,which makes it challenging to extract useful signals for *** solve this problem,a hydrophone denoising algorithm is proposed based on variational modal decomposition(VMD)with grey wolf ***,the average envelope entropy is used as the fitness function of the grey wolf optimizer to find the optimal solution for the parameters K andα.Afterward,the VMD algorithm decomposes the original signal parameters to obtain the intrinsic mode functions(IMFs).Subsequently,the number of interrelationships between each IMF and the original signal was calculated,the threshold value was set,and the noise signal was removed to calculate the time difference using the valid signal obtained by ***,the arrival time difference is used to locate the origin of the *** localization accuracy of the method in finding leaks is investigated experimentally by constructing a simulated leak test rig,and the effectiveness and feasibility of the method are verified.

关键词： grey wolf optimizer variational modal decomposition mean envelope entropy correlation coefficient time difference of arrival