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Leaching isomorphism rare earths from phosphorite ore by sulfuric acid and phosphoric acid

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Rare Metals 2017年第10期36卷 840-850页

作者： Hui-Xin Jin Fu-Zhong Wu Xiao-Hao Mao Mei-Long Wang hong-yan xie College of Materials and Metallurgy Guizhou University Guiyang 550025 China Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving Guiyang 550025 China

Most of the phosphorite deposits in the world contain isomorphism rare earths （RE） which are considerably difficult to be leached into solution in the wet phos- phoric acid process. In this work, a systematic study of leaching RE using sulfuric acid, phosphoric acid, mixed acid and two-step leaching of phosphoric acid and sulfuric acid was performed. The aims are to illuminate the main factors that inhibit RE leaching and to provide insights into the further enrichment of RE in the wet phosphoric acid solution. The results indicate that H2SO4 is not an effective acid for leaching isomorphism RE from phosphorite ore. The low RE leaching efficiency attributes to the RE cocrystallized and encapsulated by phosphogypsum （PG） as well as the precipitation of RE by RE sulfates or phosphates. High concentration of H3PO4 can enhance the dissolution and diffusion of RE ions. Hence, the optimized leaching mode of improving RE leaching efficiency is to adequately dissolve phosphorite ores in high concentration of H3PO4 solution and then add H2SO4 to crystallize PG. The effect of corystallization or encapsulation of PG on RE can be decreased due to the crystallizing mode of PG in the bulk solution instead of on the interface of solid reactants. RE leaching efficiency can be high up to 65% by the optimized leaching mode.

关键词： Phosphorite Isomorphism Rare earths Leaching Sulfuric acid Phosphoric acid

Increased expression of CSP and CYP genes in adult silkworm females exposed to avermectins

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Insect Science 2015年第2期22卷 203-219页

作者： Ning Xuan Xia Guo hong-yan xie Qi-Nian Lou Xing-Bo Lu Guo-Xia Liu Jean-Francois Picimbon Biotechnology Research Center Shandong Provincial Key Laboratory for Genetic Improvement Cultivation Ecology and Physiology of Crops Shandong Academy of Agricultural Sciences Jinan Shandong Silkworm Institute Shandong Academy of Agricultural SciencesYantai plant Protection Institute Shandong Academy of Agricultural Sciences Jinan China

We analyzed 20 chemosensory protein （CSP） genes of the silkworm Bombyx mori. We found a high number of retrotransposons inserted in introns. We then analyzed expression of the 20 BrnorCSP genes across tissues using quantitative real-time polymerase chain reaction （PCR）. Relatively low expression levels of BmorCSPs were found in the gut and fat body tissues. We thus tested the effects of endectocyte insecticide abamectin （B 1 a and Blb avermectins） on BmorCSP gene expression. Quantitative real-time PCR experi- ments showed that a single brief exposure to insecticide abamectin increased dramatically CSP expression not only in the antennae but in most tissues, including gut and fat body. Furthermore, our study showed coordinate expression of CSPs and metabolic cytochrome P450 enzymes in a tissue-dependent manner in response to the insecticide. The function of CSPs remains unknown. Based on our results, we suggest a role in detecting xenobiotics that are then detoxified by cytochrome P450 anti-xenobiotic enzymes.

关键词： abamectin Bombyx mori chemosensory protein cytochrome P450 oxidase insecticide moth

Novel frameshift mutation in the AHDC1 gene in a Chinese global developmental delay patient:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7517-7522页

作者： Shuang-Zhu Lin hong-yan xie yan-Lai Qu Wen Gao Wan-Qi Wang Jia-Yi Li Xiao-Chun Feng Chun-Quan Jin Diagnosis and Treatment Center for Children The First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Changchun University of Chinese Medicine Changchun 130000Jilin ProvinceChina

BACKGROUND Xia–Gibbs syndrome(XGS,OMIM:615829),caused by mutations within the ATHook DNA-binding motif-containing protein 1(AHDC1)gene(OMIM:615790),located on the short arm of chromosome 1 within the cytogenetic band 1p36.11,contains five noncoding 5 exons,a single 4.9-kb coding exon,and a noncoding 3 *** SUMMARY In this case report,we diagnosed and treated a 6-mo-old girl with *** primary clinical symptoms included global developmental delay,hypotonia,and mild dysmorphic *** high-throughput whole-exosome sequencing to sequence the patient and her parents,and the results showed a novel frameshift mutation of c.1155dupG(***386Alafs*3)in the AHDC1 *** paternal gene was wild *** This report extends the mutation spectrum of the AHDC1 gene to provide the diagnostic basis for genetic counseling in families with XGS.

关键词： Xia-Gibbs syndrome AT-Hook DNA-binding motif-containing protein 1 Children Global developmental delay Case report

Connexin:a potential novel target for protecting the central nervous system?

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Neural Regeneration Research 2015年第4期10卷 659-666页

作者： hong-yan xie Yu Cui Fang Deng Jia-chun Feng Departmet of Neurology the First Hospital of Jilin University Department of Neurosurgery the First People’s Hospital of Xianyang

Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings re-garding the role of connexins/hemichannels/gap junctions in the physiological and pathological mechanisms underlying central nervous system diseases such as brain ischemia, traumatic brain and spinal cord injury, epilepsy, brain and spinal cord tumor, migraine, neuroautoimmune disease, Alzheimer’s disease, Parkinson’s disease, X-linked Charcot-Marie-Tooth disease, Peli-zaeus-Merzbacher-like disease, spastic paraplegia and maxillofacial dysplasia. Connexins are considered to be a potential novel target for protecting the central nervous system.

关键词： connexin gap junction biosynthetic pathways biodegradation brain central nervous system diseases

Pharmacological interventions for phantom limb pain

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Chinese Medical Journal 2013年第3期126卷 542-549页

作者： FANG Jun LIAN yan-hong xie Kang-jie CAI Shu-nü Department of Anaesthesiology Zhejiang Cancer Hospital Hangzhou Zhejiang 310022 China

Objective To review the mechanisms and current clinical application of pharmacological interventions for phantom limb pain. Data sources Both Chinese and English language literatures were searched using MEDLINE （1982-2011）, Pubmed （1982-2011） and the Index of Chinese Language Literature （1982-2011 ）. Study selection Data from published articles about pharmacological management of phantom limb pain in recent domestic and foreign literature were selected. Data extraction Data were mainly extracted from 96 articles which are listed in the reference section of this review. Results By reviewing the mechanisms and current clinical application of pharmacological interventions for phantom limb pain, including anticonvulsants, antidepressants, local anaesthetics, N-methyI-D-aspartate receptor antagonists, non-steroidal anti-inflammatory drugs, tramadol, opioids, calcitonin, capsaicin, beta-adrenergic blockers, clonidine, muscle relaxants, and emerging drugs, we examined the efficacy and safety of these medications, outlined the limitations and future directions. Conclusions Although there is lack of evidence-based consensus guidelines for the pharmacological management of phantom limb pain, we recommend tricyclic antidepressants, gabapentin, tramadol, opioids, local anaesthetics and N-methyI-D-aspartate receptor antagonists as the rational options for the treatment of phantom limb pain.

关键词： phantom limb pain neuropathic pain pharmacological management

c-Myc promotes tubular cell apoptosis in ischemia-reperfusion-induced renal injury by negatively regulating c-FLIP and enhancing FasL/Fas-mediated apoptosis pathway

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Acta Pharmacologica Sinica 2019年第8期40卷 1058-1066页

作者： Dan Xu Bao Wang Pan-pan Chen yan-zhe Wang Nai-jun Miao Fan Yin Qian Cheng Zhuan-li Zhou hong-yan xie Li Zhou Jun Liu Xiao-xia Wang hong Xue Wei Zhang Li-min Lu Department of Physiology and Pathophysiology School of Basic Medical SciencesShanghai Medical CollegeFudan University Department of Nephrology Shanghai Tong Ren HospitalShanghai Jiao Tong University School of Medicine

c-Myc plays an important role in cell proliferation,differentiation,and cell ***/Fas pathway is a key regulator of cell *** study was aimed to investigate the effects of c-Myc on the FasL/Fas pathway in ischemia-reperfusion(I/R)-induced renal *** were objected to bilateral renal ischemia for 60 min and reperfused for 24 or 48 ***-52 E cells were treated with hypoxia-reoxygenation(H/R)or *** was used to identify the distribution of *** apoptosis was assessed by TUNEL ***-c-Myc and recombinant pcDAN 3.0 were used to overexpress c-Myc and c-FLIP,*** assay and luciferase assay were used to detect the binding of c-Myc to c-FLIP *** I/R rats,c-Myc was increased significantly and mainly located in renal tubular epithelial cells;meanwhile,c-FLIP was decreased,cleaved caspase-8,cleaved caspase-3 and TUNEL-positive staining cells were *** of I/R rats with c-Myc inhibitor 10058-F4 significantly attenuated the decrease in c-FLIP,the increase in cleaved caspase-8,cleaved caspase-3,TUNEL-positive cells,Scr and BUN in I/R *** NRK-52 E cells,hypoxia and reoxygen induced the increase in c-Myc and decrease in *** and luciferase assay results indicated that cMyc binds to the promoter region of c-FLIP *** of c-Myc markedly decreased *** of c-FLIP inhibited the increase in cleaved caspase-8 and caspase-3 induced by *** indicated that c-Myc is increased in kidneys of I/R rats and negatively regulates the expression of c-FLIP,then enhanced FasL-induced cell apoptosis in I/R stress.

关键词： c-Myc c-FLIP Fas/Fas ischemia-reperfusion tubular cell apoptosis

Exploring the characteristics of inquiry and the correlation with TCM syndromes about the patients with cardiovascular disease

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Traditional Medicine Research 2017年第2期2卷 105-114页

作者： Zhao-Xia Xu Yi-Qin Wang Jin Xu Peng Qian Guo-Ping Liu Xue-Ping Li yan-hong xie Laboratory of Synthetic Study on TCM Diagnostic Information Shanghai University of Traditional Chinese MedicineShanghai201203China

Objective:Inquiry occupies an important position in the Traditional Chinese Medicine(TCM)diagnostic *** the characteristics of inquiry symptoms and the correlation with TCM syndromes can determine the important guiding significance to build recognition model and diagnostic criteria of ***:In this study,we collected 3707 valid cases,analyzed the inquiry symptoms of patients with cardiovascular disease,then to explore the distribution of inquiry information and the correlation with TCM syndromes based on the methods,such as frequency analysis,expert score,and correlation ***:We found the symptoms of frequency analysis and expert symptom score all in the top 50,add up to *** to the results by correlation analysis,the correlation coefficient between each symptom and each syndrome are sorted from high to low,the same with the experts score to each inquiry symptom basing on its importance of in diagnosing each ***:Inquiry occupies an important effect in differentiation *** research could provide certain objective basis for establishment of TCM syndromes diagnostic criteria of cardiovascular disease,thus provide some ideas and methods for the research of establishing TCM syndrome identification model,then to provide a reference for the syndrome standardization and objectification.

关键词： Characteristics of inquiry TCM syndrome Cardiovascular disease

Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen Jin He Jingmei hong Jiayu xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

基于共生理论下的子母公司合作关系与绩效表现的实证研究——来自上市公司与跨国公司的经验证据

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预测 2017年第5期36卷 76-80页

作者：朱娜娜赵红岩谢敏东华大学旭日工商管理学院上海200051

本文通过OLS回归分析和案例研究两种方法考察了基于共生理论的子母公司关系。其中为了剔除内生性问题,采用工具变量法和两阶段最小二乘法进行回归,实证结果表明母公司权益比与子公司企业绩效呈正相关关系。此外,通过对德尔福公司的案例... 详细信息

本文通过OLS回归分析和案例研究两种方法考察了基于共生理论的子母公司关系。其中为了剔除内生性问题,采用工具变量法和两阶段最小二乘法进行回归,实证结果表明母公司权益比与子公司企业绩效呈正相关关系。此外,通过对德尔福公司的案例分析,我们还发现母公司的控制有利于子公司,尤其是海外子公司的发展和成长。因此有理由认为,母公司加强对子公司的控制有利于实现子母公司之间的互惠共生。

关键词：共生合作子母公司绩效表现