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Layout design of a mixed-flow production line based on processing energy consumption and buffer configuration

Advances in Manufacturing 2021年第3期9卷 369-387页

作者： Cai-Xia Zhang Shu-Lin Dong hong-yan chu Guo-Zhi Ding Zhi-Feng Liu Shi-Yao Guo Chong-Bin yang Institute of Advanced Manufacturing and Intelligent Technology Beijing University of TechnologyBeijing100124People’s Republic of China Beijing Key Laboratory of Advanced Manufacturing Technology Beijing University of TechnologyBeijing100124People’s Republic of China Beijing Xinghang Electromechanical Equipment Co. Ltd.Beijing100074People’s Republic of China School of Mechanical Engineering and Automation Beihang UniversityBeijing100191People’s Republic of China

Green manufacturing is a growing trend,and an effective layout design method for production lines can reduce resource wastage in *** study focuses on existing problems such as low equipment utilization,long standby time,and low logistics efficiency in a mixed-flow parallel production *** reduce the energy consumption,a novel method considering an independent buffer configuration and idle energy consumption analysis is proposed for this production line’s layout design.A logistics intensity model and a machine tool availability model are established to investigate the influences of independent buffer area configuration on the logistics intensity and machine tool *** solve the coupling problem between machine tools in such production lines,a decoupling strategy for the relationship between machine tool processing rates is *** energy consumption model for the machine tools,based on an optimized configuration of independent buffers,is *** model can effectively reduce the idle energy consumption of the machine tools while designing the workshop ***,considering the problems encountered in workshop production,a comprehensive optimization model for the mixed-flow production line is *** verify the effectiveness of the mathematical model,it is applied to an aviation cabin production *** results indicate that it can effectively solve the layout problem of mixed-flow parallel production lines and reduce the idle energy consumption of machine tools during *** proposed buffer configuration and layout design method can serve as a theoretical and practical reference for the layout design of mixed-flow parallel production lines.

关键词： Layout design Energy consumption Mixed flow production line Independent buffer configuration

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Determination of alcohol compounds using corona discharge ion mobility spectrometry

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Journal of Environmental Sciences 2007年第6期19卷 751-755页

作者： HAN Hai-yan HUANG Guo-dong JIN Shun-ping ZHENG Pei-chao XU Guo-hua LI Jian-quan WANG hong-mei chu yan-nan Laboratory of Environmental Spectroscopy and Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

Ion mobility spectrometry （IMS） is a very fast, highly sensitive, and inexpensive technique, it permits efficient monitoring of volatile organic compounds like alcohols. In this article, positive ion mobility spectra for six alcohol organic compounds have been systematically studied for the first time using a high-resolution IMS apparatus equipped with a discharge ionization source. Utilizing protonated water cluster ions （H2O）nH^＋ as the reactant ions and clean air as the drift gas, alcohol organic compounds, ethanol, 1- propanol, 2-propanol, 1-butanol, 1-pentanol and 2-octanol, all exhibit product ion characteristic peaks in their respective ion mobility spectrometry, that is a result of proton transfer reactions between the alcohols and reaction ions （H2O）nH^＋. The mixture of these alcohols, including two isomers, has been detected, and the results showed that they could be distinguished effectively in the ion mobility spectrum. The reduced mobility values have been determined, which are in very well agreement with the traditional ^63Ni-IMS experimental values. The exponential dilution method was used to calibrate the alcohol concentrations, and a detection limit available for the alcohols is in order of magnitude of a few ng/L.

关键词： alcohols VOCs ion mobility spectrometry proton transfer reaction

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Urgent needs in fostering neglected tropical diseases(NTDs)laboratory capacity in WHO Western Pacific Region:results from the external quality assessment on NTDs diagnosis in 2012-2015

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Infectious Diseases of Poverty 2017年第1期6卷 955-962页

作者： yan Lu Glenda Gonzales Shao-hong Chen Hao Li Yu-chun Cai yan-hong chu Lin Ai Mu-Xin Chen Hai-Ning Chen Jia-Xu Chen National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Center for Tropical Diseases207 Ruijin Er RdShanghai 200025People’s Republic of China Malaria Other Vector borne and Parasitic Diseases(MVP)unitthe World Health Organization Regional Office for the Western PacificP.O.Box 29321000 ManilaPhilippines National Institute of Parasitic Diseases Chinese Center for Diseases Control and Prevention207 Ruijin Er RdShanghai 200025China

Background:Neglected tropical diseases(NTDs)are a heterogeneous group of mainly chronic,debilitating and often stigmatizing diseases that largely affects low-income and politically marginalized populations,causing a large burden of public health,social and economies in the NTDs endemic *** are caused by infections with a range of pathogen,including bacteria,parasites,protozoa and *** accurate diagnosis of NTDs is important for reducing morbidity,preventing mortality and for monitoring of control *** Quality Assessment(EQA),a component of laboratory quality assurance,aims to assess the performance of participating laboratories in detecting parasitic *** aim of this paper is to report the findings and put forward the recommendations on capacity build from the EQA results of participating NTDs laboratories in selected countries in the WHO Western Pacific Region from 2012 to ***:Reference or public health laboratories at national level working on NTDs in 6 countries participated in EQAs organized by the National Institute of Parasitic Diseases(NIPD)of Chinese Center for Disease Control and Prevention(CDC)based in Shanghai,*** representatives of each participating laboratory were invited to NIPD to detect NTDs’parasitic infections using the same prepared samples for serological tests(IHA and ELISA)and helminth eggs’morphological tests(Direct smear and Kato-Katz).All of the results were scored and analyzed by using SPSS statistics 19.0 ***:The percentage of participants who had EQA score≥60 during 2012-2015 for direct smear test were 80.00%(2012),71.43%(2013),100%(2014)and 75.00%(2015),whereas for Kato-Katz test were 80.00%(2012),57.14%(2013),100%(2014)and 37.50%(2015),*** detection rate of helminth eggs varied in different species,with Ascaris lumbricoides being the highest at 94.07%in *** laboratories did very well with ELISA tests as shown by the high scores in all four years e

关键词： Neglected tropical diseases Diagnosis External quality assessment Western Pacific Region

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Low Temperature Catalytic Combustion of Ethanol over Pt/γ-Al_2O_3/Ce_xZr_(1-x)O_2 Honeycomb Catalysts

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Chemical Research in Chinese Universities 2009年第1期25卷 81-85页

作者： WANG Jian-li LIU Zhi-min CAO hong-yan GONG Mao-chu CHEN Yong-dong CHEN Yao-qiang College of Chemistry Siehuan University Chengdu 610064 P. R. China

It has been found that the catalytic activity toward the decomposition of ethanol in a fix bed reactor can be greatly improved by loading Pt on the surface of CexZr1-xO2. In this study, we have investigated the effects of different x of Pt/γ-Al2O3/CexZr1-xO2 on the catalytic activity of catalysts. The prepared catalysts were characterized by BET, XRD, and TPR. The BET surface areas of the catalysts decreased with x decreasing. XRD results reveal that deposited Pt dispersed on the CexZr1-xO2 and γ-Al2O3 matrix. The order of catalytic activities is Pt/γ-Al2O3/ Ce0.5Zr0.5O2〉Pt/γ-Al2O3/Ce0.25Zr0.75O2〉Pt/γ-Al2O3/Ce0.75Zr0.26O2〉Pt/γ-Al2O3/CeO2〉Pt/γ-Al2O3/ZrO2. Among the catalysts, the reduction peak area of Pt/γ-Al2O3/Ce0.5Zr0.5O2 is the largest and the oxygen mobility is noticeably promoted, which is in good harmony with the catalytic activity. Incorporation of ZrO2 into the CeO2 lattice considerably decreases the destruction temperature for ethanol. Based on these observations, the mechanistic role of oxygen mobility in the oxidation reaction has been suggested.

关键词： Ethanol Catalytic combustion Oxygen storage material Monolithic catalyst

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Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： Liang chu Haoyu Shen Hudie Wei hongyu Chen Guoqiang Ma Wensheng yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

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The subthalamic neurons are activated by both orexin-A and orexin-B

The subthalamic neurons are activated by both orexin-A and o...

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中国神经科学学会第十二届全国学术会议

作者： yan Xue Qing Shen hong-yan chu Ying Wang Cui Liu Yun-Hai Liu Lei Chen Department of Physiology Qingdao University

Objective The subthalamic nucleus occupies a critical position in the indirect pathway of the basal ganglia circuit and therefore is involved in motor control under both normal and pathological conditions. Morphological studies reveal that the subthalamic nucleus receives a relative dense orexinergic projection originating from the hypothalamus. Both orexin-1（OX1） and orexin-2（OX2） receptors are expressed in the subthalamic nucleus. However, to date, the functions of orexinergic systems in the subthalamic nucleus are unknown. The present study is to explore whether orexinergic system modulate the activity of the subthalamic nucleus. Methods In vivo multibarrel electrophysiological recordings were used to study the direct electrophysiological effects and receptor mechanisms of subthalamic orexins at single cell level. We also microinjected orexins directly into the subthalamic nucleus to observe the possible influence on motor behaviors. Results Exogenous application of orexin-A significantly increased the spontaneous firing rate in 64.0% subthalamic neurons recorded. OX1 receptors are the major receptors involved in orexin-A-induced excitation. Application of orexin-B increased the firing rate in 81.0% subthalamic neurons recorded, entirely through OX2 receptors. The orexin-B-induced increase in firing rate was negatively correlated with the basal firing rate. Endogenous orexinergic systems are involved in the control of the spontaneous firing activity. Further elevated body swing test revealed that microinjection of orexins and the receptors antagonists into the subthalamic nucleus induced contralateral-biased swing and ipsilateral-biased swing, respectively. Conclusion The present studies suggest that orexinergic systems play important roles in the subthalamic nucleus which may provide further evidence for the involvement of subthalamic orexins in Parkinson’s disease.

关键词： Subthalamic nucleus orexin-A orexin-B single unit recording elevated body swing test

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng chu Quan Shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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Electrocatalytic nitrite reduction to ammonia on isolated bismuth alloyed ruthenium

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Journal of Energy Chemistry 2025年第1期100卷 369-376页

作者： Shiyao Shang Fuzhou Wang Zeyi Sun Chaofan Qiang Ke chu School of Materials Science and Engineering Lanzhou Jiaotong University

Electrochemical reduction of NO2-to NH3（NO2-RR） is recognized as an appealing approach for achieving renewable NH3synthesis and waste ***,we report isolated Bi alloyed Ru （Bi1Ru） as an efficient NO2-RR *** calculations and in situ electrochemical measurements reveal the creation of Bi1-Ru dual sites which can remarkably promote NO2-activation and suppress proton adsorption,while accelerating the NO2-RR protonation energetics to render a high NO2--to-NH3conversion ***,Bi1Ru assembled in a flow cell delivers an NH3yield rate of 1901.4μmol h-1cm-2and an NH3-Faradaic efficiency of 94.3%at an industrial-level current density of 324.3 mA *** study offers new perspectives for designing and constructing p-block single-atom alloys as robust and high-current-density NO2-RR catalysts toward the ammonia electrosynthesis.

关键词： Ammonia

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Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期68卷 152-156页

作者： Lihua Zhang Lingjing Chen Huatian Shi Yue Wei Gui Chen Tai-chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

关键词： photocatalysis noble metal-free CO2 reduction formate cobalt hydride

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