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A novel alternative for pyrogen detection based on a transgenic cell line

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1221-1229页

作者： Qing He Chuan-Fei Yu Gang Wu Kai-Qin Wang Yong-Bo Ni Xiao Guo Zhi-Hao Fu Lan Wang De-Jiang Tan Hua Gao Can Wang Gang chen xu-hong chen Bo chen Jun-Zhi Wang National Institutes for Food and Drug Control BeijingChina School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyangChina Shanghai Institute for Food and Drug Control ShanghaiChina KeyMed Biosciences Inc. ChengduChina

Pyrogen,often as a contaminant,is a key indicator affecting the safety of almost all parenteral drugs(including biologicals,chemicals,traditional Chinese medicines and medical devices).It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted‘reduction,replacement and refinement’principle,which has been highly considered by regulatory agencies from different *** used NF-κB,a central signalling molecule mediating inflammatory responses,as a pyrogenic marker and the monocyte line THP-1 transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence ***,we show that this test can quantitatively and sensitively detect endotoxin(lipopolysaccharide from different strains)and nonendotoxin(lipoteichoic acid,zymosan,peptidoglycan,lectin and glucan),has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals(group A&C meningococcal polysaccharide vaccine;basiliximab;rabies vaccine(Vero cells)for human use,freeze-dried;Japanese encephalitis vaccine(Vero cells),inactivated;insulin aspart injection;human albumin;recombinant human erythropoietin injection(CHO Cell)).The within-laboratory reproducibility of the test in three independent laboratories was 85%,80%and 80%and the interlaboratory reproducibility among laboratories was 83.3%,95.6%and 86.7%.The sensitivity(true positive rate)and specificity(true negative rate)of the test were 89.9%and 90.9%,*** summary,the test provides a novel alternative for pyrogen detection.

关键词： pyrogen rabbit replace

Construction of dual crosslinked network binder via sequential ionic crosslinking for high-performance silicon anodes

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Rare Metals 2023年第7期42卷 2238-2249页

作者： Ji-Na Wu hong-xu chen Chao chen Hai-Dong Li hong-Wen Zhang Bo Wang School of Materials Science and Engineering Changzhou UniversityChangzhou213164China Nanotechnology Research Institute Jiaxing UniversityJiaxing314001China Key Laboratory of Yarn Materials Forming and Composite Processing Technology of Zhejiang Province Jiaxing UniversityJiaxing314001China School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin150080China

Nowadays,silicon has become a promising anode active material for lithium-ion batteries due to its high specific ***,traditional binder materials cannot effectively restrain the volume expansion of silicon during lithiation/*** by the growth process of climbing plants,we sequentially crosslink sodium alginate with calcium ions and hyperbranched polyethyleneimine to construct a dual crosslinked network *** the sequentially crosslinking,sodium alginate preferentially crosslinks with Ca^(2+)to form the"trellis"network,which restricts the free movement of hyperbranched polyethyleneimine and guides it,like"vine",to gradually anchor on the surrounding"trellis"through hydrogen and ionic *** this dual crosslinked network,the ionic ally crosslinked sodium alginate maintains the anode structural integrity;the anchored hyperbranched polyethyleneimine forms strong multidimensional hydrogen bonds with silicon nanoparticles through its amino-rich branch chains;and the network utilizes the bonding reversibility of hydrogen and ionic bonds to repeatedly eliminate the mechanical stress and self-heal the structure damages caused by the volume change of *** from the multifunction of the dual crosslinked network,the silicon anode has achieved an excellent electrochemical performance with a specific capacity of 2403 mAh·g^(-1)at the current density of500 mA·g^(-1)after 100 cycles.

关键词： Sodium alginate Hyperbranched polyethyleneimine(HBPEI) Ionic crosslinking Binder Silicon anode Lithium-ion battery(LIB)

Pressure-induced bimetallic carbon nanotubes from metalorganic frameworks as optimized bifunctional electrocatalysts for water splitting

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Rare Metals 2023年第1期42卷 155-164页

作者： hong-xu chen Hui xu Zhi-Rong Song Yi Liu Hui Cui Jun-Kuo Gao Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province Institute of Optoelectronic Materials and DevicesCollage of Optical and Electronic TechnologyChina Jiliang UniversityHangzhou310018China Institute of Functional Porous Materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou310018China Institute for Composites Science Innovation School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China Argonne National Laboratory Physics DivisionLemontIL60439USA Department of Chemistry and International Institute for Nanotechnology(IIN) Northwestern UniversityEvanstonIL60208USA

Carbon nanotubes(CNTs)have attracted great interest in numerous applications due to their excellent electronic and structural ***,harsh synthesis conditions and high energy consumption limit the further application of ***,we developed a facile and innovative strategy to generate CNTs by physically pressurizing metal-organic frameworks(MOFs)and then *** synthesized bimetallic nitrogen/sulfur double-doped carbon nanotubes are denoted as Fe_(x)Co_(1-x)P(x=0.5,0.6,0.7,0.8,0.9).The introduction of pressure not only revolutionized the morphology of the electrocatalysts,but also enhanced the activity of oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)in alkaline ***_(0.6)Co_(0.4)-P exhibits superior OER and HER performances in 1.0 mol·L^(-1)KOH solution with overpotentials of 364 and 346 mV at 10 mA·cm^(-2),which are 28 and 5 mV lower than unpressurized Fe0.6Co0.4.

关键词： Metal-organic frameworks(MOFs) Carbon nanotubes(CNTs) Bifunctional Pressurizing Oxygen evolution reaction(OER) Hydrogen evolution reaction(HER)

Efficacy of immunosuppression monotherapy after liver transplantation:A meta-analysis

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World Journal of Gastroenterology 2014年第34期20卷 12330-12340页

作者： Xiang Lan Meng-Gang Liu hong-xu chen hong-Ming Liu Wei Zeng Dong Wei Ping chen Department of Hepatobiliary Surgery Daping Hospitalthe Third Military Medical University

AIM: To assess the advantages and disadvantages of immunosuppression monotherapy after transplantation and the impact of monotherapy on hepatitis C virus (HCV) recurrence.

关键词： Liver transplantation Immunosuppression monotherapy Cytomegalovirus Diabetes Meta-analysis

Unsteady aerodynamic noise prediction of contra-rotating open rotor using meshless method

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Chinese Journal of Aeronautics 2024年第8期37卷 144-165页

作者： Zhiliang hong Meng SU Haitao ZHANG Zerui xu Lin DU Lingfeng chen College of Safety Science and Engineering Civil Aviation University of ChinaTianjin 300300China Civil Aviation Administration of China Beijing 100710China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China

The Contra-Rotating Open Rotor(CROR)design confronts significant noise challenges despite being one of the possible options for future green *** efficiently estimate the noise emitted from a CROR,a three-dimensional unsteady prediction model based on the meshless method is *** unsteady wake flow and the aerodynamic load fluctuations on the blade are solved through the viscous vortex particle method,the blade element momentum theory and vortex lattice ***,the acoustic field is obtained through the Farassat’s formulation *** of this method is conducted on a CROR,and a mesh-based method,e.g.,Nonlinear Harmonic(NLH)method,is also employed for *** is found that the presented method is three times faster than NLH method while maintaining a comparable precision.A thorough parametric analysis is also carried out to illustrate the effects of rotational speed,rotor-rotor spacing and rear rotor diameter on the noise *** rotor speed is found to be the most influencing factor,and by optimizing the speed difference between the front and rear rotors,a notable noise reduction can be *** current findings not only contribute to a deeper comprehension of the CROR’s aeroacoustic properties but also offer an effective tool for engineering applications.

关键词： Contra-Rotating Open Rotor(CROR) Aerodynamic noise Blade element momentum theory Viscosity vortex particle method Farassat’s formulation 1A

Scalable Temporal Dimension Preserved Tensor Completion for Missing Traffic Data Imputation With Orthogonal Initialization

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2188-2190页

作者： hong chen Mingwei Lin Jiaqi Liu Zeshui xu School of Mathematics and Statistics Fujian Normal UniversityFuzhou 350117China College of Computer and Cyber Security Fujian Normal UniversityFuzhou 350117China Business School Sichuan UniversityChengdu 610064China IEEE

Dear Editor,This letter puts forward a novel scalable temporal dimension preserved tensor completion model based on orthogonal initialization for missing traffic data(MTD)*** MTD imputation acts directly on accessing ... 详细信息

关键词： Dimension management traffic

Arbuscular mycorrhizae status of host plant affects offspring’s phenotype and transcriptome expression in a low-phosphorus environment

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Journal of Plant Ecology 2024年第2期17卷 173-187页

作者： Shijun Liu Jing xu hong Huang Jianjun Tang Xin chen Key Laboratory of Plant Biotechnology of Liaoning Province School of Life SciencesLiaoning Normal UniversityDalian 116081China College of Life Sciences Zhejiang UniversityHangzhou 310058China The Institute of Environmental Resources and Soil Fertilizers Zhejiang Academy of Agricultural SciencesHangzhou 310021China

Although the effects of arbuscular mycorrhizal fungi(AMF)on host plants have been well documented,whether the effects of AMF on parental generations affect offspring performance is not fully *** conducted a common garden experiment to determine whether AMF status of host plants(Medicago truncatula)affects phenotype and transcriptome expression of their *** from four type parental treatments(low-phosphorus(P)soil without AMF,low-P soil with AMF,high-P soil without AMF and high-P soil with AMF)were grown under low-P(LPS)and normal-P soil(OHS)*** fowering pattern of LP offspring was similar to their parents,such that plants with AMF fowered earlier than those without AMF under OHS condition but were opposite under LPS *** transcriptome differential analysis showed that some differential transcripts(45 for parental plants growing under low-P condition and 3 for parental plants growing under high-P condition)expression patterns between offspring were comparable,and that only affected by parental AMF status regardless of the P environment that offspring was ***(146 for parental plants growing under low-P condition and 2 for parental plants growing under high-P condition),however,were affected both by the parental AMF status and the offspring P *** addition,the number of differential transcripts between offspring whose parental plants grew under high-P condition was far less than under low-P *** results indicate that AMF may not only affect the current generation of host plants but also affect the offspring especially when their parents have experienced a stressful environment.

关键词： arbuscular mycorrhizal fungi low-phosphorus environment fowering pattern transgenerational effects transcriptome differential analysis

A 26.5–29.5-GHz Doherty PA with enhanced linearity and efficiency based on adaptive bias circuit for 5G MIMO arrays

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Science China(Information Sciences) 2024年第7期67卷 341-342页

作者： Long WANG Jixin chen Debin HOU Xiaojie xu Wei hong State Key Laboratory of Millimeter Waves Southeast University Misic Microelectronics Co. Ltd.

Power amplifiers (PAs) play a crucial role in achieving key performance metrics such as efficiency, power, and ***, in the millimeter-wave frequency range, the performance of active devices rapidly deteriorates with increasing frequency. The typical Doherty architecture, through load modulation techniques, can achieve high back-off efficiency [1]. To enhance the linearity of the PA, adaptive bias circuits (ADBs) have been widely adopted [2, 3].

关键词： POWER-AMPLIFIER

Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China

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Journal of Environmental Sciences 2024年第4期138卷 561-571页

作者： Ziyi Lin Xiaolong Fan Gaojie chen Youwei hong Mengren Li Lingling xu Baoye Hu chen Yang Yanting chen Zhiqian Shao Jinsheng chen Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy ofSciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China

To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,*** concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and *** on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping *** to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace *** the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain *** risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future.

关键词： PM_(2.5)-bound trace elements Seasonal variations Source appointment Health risks Traffic-related source