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Saturation Estimation with Complex Electrical Conductivity for Hydrate-Bearing Clayey Sediments:An Experimental Study

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Journal of Ocean University of China 2024年第1期23卷 173-189页

作者： xinG Lanchang ZHANG Shuli ZHANG Huanhuan WU Chenyutong WANG Bin lao Liyun WEI Wei HAN Weifeng WEI Zhoutuo GE xinmin DENG Shaogui College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580China School of Water Energy and EnvironmentCranfield UniversityCranfield MK430ALUnited Kingdom Department of Alternative Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007China School of Geosciences China University of Petroleum(East China)Qingdao 266580China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Clays have considerable influence on the electrical properties of hydrate-bearing *** is desirable to understand the electrical properties of hydrate-bearing clayey sediments and to build hydrate saturation(S_(h))models for reservoir evaluation and *** electrical properties of tetrahydrofuran-hydrate-bearing sediments with montmorillonite are characterized by complex conductivity at frequencies from 0.01 Hz to 1 *** effects of clay and Sh on the complex conductivity were analyzed.A decrease and increase in electrical conductance result from the clay-swelling-induced blockage and ion migration in the electrical double layer(EDL),*** quadrature conductivity increases with the clay content up to 10%because of the increased surface site density of counterions in *** the in-phase conductivity and quadrature conductivity decrease consistently with increasing Sh from 0.50 to *** sets of models for Sh evaluation were *** model based on the Simandoux equation outperforms Archie’s formula,with a root-mean-square error(E_(RMS))of 1.8%and 3.9%,respectively,highlighting the clay effects on the in-phase *** fre-quency effect correlations based on in-phase and quadrature conductivities exhibit inferior performance(E_(RMS)=11.6%and 13.2%,re-spectively)due to the challenge of choosing an appropriate pair of frequencies and intrinsic uncertainties from two *** second-order Cole-Cole formula can be used to fit the complex-conductivity *** pair of inverted Cole-Cole parameters,i.e.,characteristic time and chargeability,is employed to predict S_(h) with an E_(RMS) of 5.05%and 9.05%,respectively.

关键词： gas hydrate complex electrical conductivity hydrate-bearing clayey sediment hydrate saturation Simandoux equation frequency dispersion Cole-Cole formula

Causal relationships between gut microbiota and dementia:A twosample,bidirectional,Mendelian randomization study

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World Journal of Clinical Cases 2024年第16期12卷 2780-2788页

作者： Zhao-Lin Ren Hai-hong Zhou Chu-Pei Chen Hao He Duo-lao Wang Zhou Liu Department of Neurology The Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Department of Clinical Medicine Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpool L693BXUnited Kingdom

BACKGROUND Existing evidence suggests that gut microbiota represent a significant environmental risk factor for various forms of dementia,including Alzheimer's dementia,vascular dementia,and dementia in other diseases classified ***,the exact causal relationships between gut microbiota and the different forms of dementia or their subtypes remain *** To investigate putative causal relationships between gut microbiota and dementia or its subtypes using Mendelian randomization(MR)*** A bidirectional,two-sample,MR analysis was conducted utilizing publicly available gut microbiota-related genome-wide association study(GWAS)summary data from the MiBioGen consortium alongside GWAS summary statistics for dementia and its subtypes from the FinnGen *** variables were selected according to the fundamental tenets of MR and their strengths were evaluated using the *** MR methods were employed,and the robustness of our findings was *** account for multiple comparisons,we applied the Bonferroni method for P-value *** We identified several gut microbiota taxa exhibiting putative causal relationships with dementia or its subtypes,potentially serving as risk or protective factors for the *** addition,reverse MR analysis indicated that the relative abundance of several gut microbiota taxa might be influenced by dementia or its *** exhaustive sensitivity analysis confirmed the absence of heterogeneity and horizontal *** applying correction for multiple testing,we observed that the order Bacillales(odds ratio:0.830,95%confidence interval:0.740-0.932,P=0.00155,Padjust=0.0311)exhibited a strong association with Alzheimer’s disease-related *** The results suggest that gut microbiota is causally associated with *** findings provide novel insights into the pathophysiology of dementia and have important implications for its treatment and prevention.

关键词： Mendelian randomization FinnGen MiBioGen Gut microbiota Dementia Alzheimer’s disease Vascular dementia

Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome

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World Journal of Diabetes 2024年第4期15卷 724-734页

作者： Gu-lao Zhang Yuan Liu Yan-Feng Liu Xian-Tao Huang Yu Tao Zhen-Huan Chen Heng-Li Lai Department of Cardiology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330000Jiangxi ProvinceChina

BACKGROUND Diabetic cardiomyopathy(DCM),which is a complication of diabetes,poses a great threat to public *** studies have confirmed the role of NLRP3(NOD-like receptor protein 3)activation in DCM development through the inflammatory *** is an oral hypoglycemic dipeptidyl peptidase-IV inhibitor used to treat *** has recently been reported to have anti-inflammatory and protective effects on myocardial *** To examine the therapeutic effects of teneligliptin on DCM in diabetic *** Streptozotocin was administered to induce diabetes in mice,followed by treatment with 30 mg/kg *** Marked increases in cardiomyocyte area and cardiac hypertrophy indicator heart weight/tibia length reductions in fractional shortening,ejection fraction,and heart rate;increases in creatine kinase-MB(CK-MB),aspartate transaminase(AST),and lactate dehydrogenase(LDH)levels;and upregulated NADPH oxidase 4 were observed in diabetic mice,all of which were significantly reversed by ***,NLRP3 inflammasome activation and increased release of interleukin-1βin diabetic mice were inhibited by *** mouse cardiomyocytes were treated with high glucose(30 mmol/L)with or without teneligliptin(2.5 or 5μM)for 24 ***3 inflammasome *** in CKMB,AST,and LDH levels in glucose-stimulated cardiomyocytes were markedly inhibited by teneligliptin,and AMP(p-adenosine 5‘-monophosphate)-p-AMPK(activated protein kinase)levels were ***,the beneficial effects of teneligliptin on hyperglycaemia-induced cardiomyocytes were abolished by the AMPK signaling inhibitor compound *** Overall,teneligliptin mitigated DCM by mitigating activation of the NLRP3 inflammasome.

关键词： Diabetic cardiomyopathy Teneligliptin NLRP3 AMPK Interleukin-1β

Net effect of air pollution controls on health risk in the Beijing-Tianjin-Hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin Peter K.K.Louie Alexis K.H.Lau Jimmy C.H.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat Hossain Chengcai Li Xiang Qian lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public Health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTH(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide Health risk Carbon neutrality Mega-events

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非法经营罪中的经营行为研究

现代法学 2024年第5期46卷 49-68页

作者：劳东燕清华大学法学院

针对非法经营罪的泛化适用,有必要严格界定其构成要件,并注重出罪机制的构建。经营行为系非法经营罪实行行为的组成部分,如何对其进行合理界定,是关于该罪法教义学建构必须关注的问题。非法经营罪中经营行为有这些共性特点:涉及经济领... 详细信息

针对非法经营罪的泛化适用,有必要严格界定其构成要件,并注重出罪机制的构建。经营行为系非法经营罪实行行为的组成部分,如何对其进行合理界定,是关于该罪法教义学建构必须关注的问题。非法经营罪中经营行为有这些共性特点:涉及经济领域内的业务活动,指向的是业务内容而非业务方式;有直接或间接相对应的合法业务;行为蕴含的类型性风险具有“扰乱市场秩序”的性质;经营行为本身构成“违反国家规定”。非法经营罪中的经营行为应当体现经营性的面向。所谓的经营性,意指行为蕴含经济性利益,以出售商品或服务的环节为核心内涵,出于营利目的,并具有反复进行的意思。在非法经营罪有无未遂形态的问题上,司法实务界坚持的是否定论立场。否定论的立场缺乏合理性,是对经营行为过于宽泛的解读,是将该罪当作行为犯的结果。经营行为以销售环节为核心的特性,决定了非法经营罪存在未遂形态。

关键词：非法经营罪经营行为出罪机制犯罪未遂扰乱市场秩序

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民办学校公共服务职能论析

教育研究 2024年第2期45卷 134-146页

作者：劳凯声首都师范大学教育学院北京100048

公共服务是社会治理的重要模式,也是解决社会民生问题的实际行动。民办学校的分类管理改革推动了不同类型民办学校法律身份和主体资格向精细化的方向发展,导致其所供给的教育服务出现分化。由于不同民办学校均须遵循公益性的要求,因此,... 详细信息

公共服务是社会治理的重要模式,也是解决社会民生问题的实际行动。民办学校的分类管理改革推动了不同类型民办学校法律身份和主体资格向精细化的方向发展,导致其所供给的教育服务出现分化。由于不同民办学校均须遵循公益性的要求,因此,营利性民办学校供给的私人服务在一定条件下可以表现为具有公共服务性质的市场化公益行为。公益性对不同民办学校的公共服务供给有不同的要求,对非营利性民办学校而言,应禁止学校内部的利益分配;而对营利性民办学校而言,在允许分配利润的同时,应遏制过度逐利行为。“社会企业”反映了营利部门和非营利部门跨界的时代潮流,对理解民办学校公共服务具有重要的现实意义。民办学校应根据自身情况参与公共服务供给,满足社会一般需要的同时,满足特殊需要群体对教育的自主选择要求。

关键词：公共服务民办学校分类管理市场化公益行为

Omega results for coefficients of Rankin-Selberg L-functions over sparse sequences

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纯粹数学与应用数学 2024年第3期40卷 407-416页

作者： CUI Hanfang lao Huixue School of Mathematics and Statistics Shandong Normal UniversityJi′nan 250358China

Ω results involving the coefficients of automorphic L-functions are important research object in analytic number *** f be a primitive holomorphic cusp *** by λf×f(n) the nth Fourier coefficient of Rankin-Selberg L-function L(f×f,s).This paper combines Kühleitner and Nowak′s Omega theorem and the analytic properties of Rankin-Selberg L-functions to study Omega results for coefficients of Rankin-Selberg L-functions over sparse sequences,and establishes the asymptotic formula for Σ_(n≤x)λf×f(n^(m))(m=2,3).

关键词： cusp form Rankin-Selberg L-function Omega theorem

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非法经营罪中支付结算业务的界定

法学 2024年第9期 76-92页

作者：劳东燕清华大学法学院

司法实务中对支付结算型非法经营罪存在泛化适用的倾向,根本原因是由于对“非法从事资金结算业务”做宽泛解读所致。只有作为提供支付结算服务的中介机构,其从事的业务才可能成立非法经营罪中的支付结算业务,这符合支付结算业务作为特... 详细信息

司法实务中对支付结算型非法经营罪存在泛化适用的倾向,根本原因是由于对“非法从事资金结算业务”做宽泛解读所致。只有作为提供支付结算服务的中介机构,其从事的业务才可能成立非法经营罪中的支付结算业务,这符合支付结算业务作为特许业务的要求,并有《商业银行法》等前置性规定作为规范依据。据此,现行司法解释中有关支付结算型非法经营罪的规定存在正当性方面的疑问,以是否借助虚假交易等形式套现来理解支付结算型的非法经营罪,是对该罪构成要件与不法本质的曲解。无论是通过信用卡套现与“养卡”的行为,还是为票据套现提供中介服务的行为,抑或利用单位账户套现或转入私人账户的行为,都难以构成支付结算型非法经营罪;但相关行为可能成立骗取贷款罪或洗钱罪等罪名,在无法成立其他犯罪的情况下,对相应行为应做无罪处理。

关键词：非法经营罪支付结算业务信用卡套现票据套现单位账户套现

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网络暴力刑法治理的基本立场

政法论坛 2024年第3期42卷 39-54页

作者：劳东燕清华大学法学院

私权模式的法律救济机制适配于对传统言语暴力的处理。网络暴力不应定位为个体之间的侵害,而应解读为社会系统性力量对个体施加的权利侵害,这使得网络暴力表现出不同于传统言语暴力的特性。私权模式的法律救济机制已然丧失现实基础,与... 详细信息

私权模式的法律救济机制适配于对传统言语暴力的处理。网络暴力不应定位为个体之间的侵害,而应解读为社会系统性力量对个体施加的权利侵害,这使得网络暴力表现出不同于传统言语暴力的特性。私权模式的法律救济机制已然丧失现实基础,与网络暴力的治理需要之间存在脱节的问题。有必要在以“国家—社会—个人”三元结构为基础的法律体系中来考虑对网络暴力的应对。个人在面临社会性压制时仰赖公权力的保护,故而网络暴力涉及的是国家的积极保护义务。需要采取以公力救济为主导的法律机制,适用以事前规制为中心的风险规制法模式,并适度扩张刑法的介入范围。在刑法领域,立法层面需要考虑出台反网络暴力的领域法,并对侮辱罪、诽谤罪的刑法规定做出修正,司法层面需要采取功能主义立场,并将这种立场贯彻于具体的法教义学问题之中。

关键词：网络暴力网络犯罪积极保护义务平台治理功能主义