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Diagnostic Efficacy and Possible Underlying Mechanisms of Noninvasive Clinical Markers in Hepatocellular Carcinoma

Journal of Clinical and Translational Hepatology 2023年第4期11卷 889-898页

作者： Chao-Xu Fu Jun Li Zheng-Da Chen Yan-Ping Cao hong-Ling Zhang hong-Ting Sui Bao-Cheng Shan Lei Xu Yang Zhou Min Zhou En-Yue Yang hong-xin piao Department of Internal Medicine Yanbian UniversityYanjiJilinChina Meritco Services ShanghaiChina Jilin Cancer Hospital ChangchunJilinChina Xiamen University Medical Center/Xiang’an Hospital affiliated to Xiamen University XiamenFujianChina Department of Critical Care Medicine Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhouFujianChina The First Affiliated Hospital of Qiqihaer Medical University HeilongjiangChina Beidahuang Group Beian Hospital HeiheHeilongjiangChina Office of Clinical Trials Affiliated Hospital of Yanbian UniversityYanjiJilinChina

Background and Aims:In this study,we aimed to evaluate the diagnostic values of alpha-fetoprotein(AFP),soluble AXL(sAXL),des-γ-carboxy prothrombin(DCP),the aspartate aminotransferase-to-platelet ratio index(APRI),and the gamma-glutamyl transpeptidase-to-platelet ratio(GPR)in hepatocellular carcinoma(HCC)and the possible underlying mechanisms of the correlations between ***:We collected serum samples from 190,128,and 75 patients with HCC,cirrhosis,and chronic viral hepatitis,and from 82 healthy *** levels of AFP,sAXL,and DCP were determined,and APRI and GPR values were *** operating characteristic(ROC)curves were used to analyze the diagnostic value of single and combined ***:We detected significant differences between the HCC group and other groups regarding serum AFP,sAXL,DCP,and APRI *** significantly differed between the HCC group and other groups,except for the liver cirrhosis ***,sAXL,DCP,APRI,and GPR had positive correlations with each other,and AFP showed a higher area under the curve(AUC)and Youden index values,while APRI and DCP showed the highest sensitivity and ***,when AFP was combined with sAXL,DCP,APRI,and GRP,the highest AUC(0.911)and a higher net reclassification improvement value were obtained compared with those obtained for the individual ***:AFP,sAXL,DCP,APRI,and GPR are independent risk factors for HCC,and the diagnostic performance of AFP combined with sAXL,DCP,APRI,and GPR for HCC diagnosis was superior to that of the individual biomarkers.

关键词： Hepatocellular carcinoma HCC-specific biomarkers Alpha-fetoprotein Chronic viral hepatitis Cirrhosis

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延边地区慢性丙型肝炎患者血清中自身抗体的检测及其临床意义

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世界华人消化杂志 2005年第24期13卷 2889-2891页

作者：许顺姬韩学吉朴红心延边大学医学院附属医院检验科吉林省延吉市133000 延边大学医学院附属医院感染科吉林省延吉市133000

目的:分析延边地区慢性丙型肝炎患者血清中自身抗体阳性率及其临床意义.方法:选择100名慢性丙型肝病患者(慢性79例,肝硬化21例),检测自身抗体(ALC,ANA,ASA,AMA,RF)阳性率,并比较自身抗体(+)及自身抗体(-)群年龄、性别、肝功能状态.结果... 详细信息

目的:分析延边地区慢性丙型肝炎患者血清中自身抗体阳性率及其临床意义.方法:选择100名慢性丙型肝病患者(慢性79例,肝硬化21例),检测自身抗体(ALC,ANA,ASA,AMA,RF)阳性率,并比较自身抗体(+)及自身抗体(-)群年龄、性别、肝功能状态.结果:慢性丙型肝炎患者血清中自身抗体至少一种阳性的62例.ACL阳性40例最多,其次为ANA阳性29例,RF阳性19例,ASA阳性8例,AMA阳性3例.另外,自身抗体阳性组和阴性组有关因素比较发现,自身抗体阳性组比阴性组年龄较大(58.7岁vs49.7岁)、女性多见(79.2%vs46.2%)、肝功能及肝病状态差.结论:慢性丙型肝炎患者血清中常出现自身抗体,自身抗体出现可影响肝功能状态,加重病情,在临床诊疗中应慎重.

关键词：自身抗体丙型肝炎

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毛囊类器官研究:现状、问题与前景

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中国组织工程研究 2025年第31期29卷 6733-6742页

作者：王钊龚琳朴永君大连医科大学附属第一医院皮肤科辽宁省大连市116000

背景:毛囊体外重建依赖于毛乳头细胞及角质形成细胞3D共培养时的自组装行为,该过程与毛囊胚胎发育极为相似,因此,毛囊类器官可作为毛囊再生相关基础研究良好的体外模型,目前,通过仿生系统培养的全人源毛囊类器官已能成功移植到动物体内... 详细信息

背景:毛囊体外重建依赖于毛乳头细胞及角质形成细胞3D共培养时的自组装行为,该过程与毛囊胚胎发育极为相似,因此,毛囊类器官可作为毛囊再生相关基础研究良好的体外模型,目前,通过仿生系统培养的全人源毛囊类器官已能成功移植到动物体内。毛囊类器官研究使毛囊再生成为可能,但构建方法亦无统一定论,仍面临诸多挑战。目的:综述目前毛囊类器官的研究进展,总结毛囊类器官培养方法及表征,阐述应用前景,为后续研究提供可靠依据,以期促进其在组织工程及脱发治疗的临床转化。方法:应用计算机在中国知网(CNKI)及PubMed数据库中,以“毛囊再生,毛发再生,类器官”为中文检索词,“hair growth,hair loss,hair regeneration,hair follicle,dermal papilla cell,organoid”为英文检索词进行检索,查阅国内外关于毛囊类器官的相关文献,共纳入文献67篇进行后续分析。结果与结论:①不同来源的毛乳头细胞与角质形成细胞可在体外构建毛囊类器官,以获得鼠源、人-鼠嵌合及人源毛囊类器官,并成功用于啮齿动物移植模型;②多种重编程方法如电刺激、添加重组蛋白、解离细胞基因过表达等可用于促进毛囊类器官毛胚形成及毛钉伸长,同时,多种3D打印技术的应用已实现大小可控毛囊类器官的批量生产,极大提高了生产效率;③在解离细胞共培养体系中加入黑素细胞时,或可破译新生毛囊的色素缺失难题,而加入人脐静脉血管内皮细胞时,细胞聚集体内的新生血管可改善营养供给,减少中心部位坏死;④随着工程化类毛囊技术逐渐趋于成熟,患者自体细胞构建的毛囊类器官或可用于严重脱发的个体化医疗。

关键词：脱发毛囊再生毛乳头细胞毛囊类器官上皮-间充质交互作用 3D培养类器官组织工程工程化类器官

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The effect of the density difference between supercritical CO_(2) and supercritical CH_(4) on their adsorption capacities: An experimental study on anthracite in the Qinshui Basin

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Petroleum Science 2022年第4期19卷 1516-1526页

作者： Si-Jie Han Shu-Xun Sang piao-piao Duan Jin-Chao Zhang Wen-xin Xiang Ang Xu Jiangsu Key Laboratory of Coal-based Greenhouse Gas Control and Utilization China University of Mining and TechnologyXuzhouJiangsu221008China Carbon Neutrality Institute China University of Mining and Technology XuzhouJiangsu221008China School of Resources and Geosciences China University of Mining and TechnologyXuzhouJiangsu221116China

Deep unmineable coals are considered as economic and effective geological media for CO_(2) storage and CO_(2) enhanced coalbed methane(CO_(2)-ECBM) recovery is the key technology to realize CO_(2) geological sequestration in coals. Anthracite samples were collected from the Qinshui Basin and subjected to mercury intrusion porosimetry, low-pressure CO_(2) adsorption, and high-pressure CH_(4)/CO_(2) isothermal adsorption experiments. The average number of layers of adsorbed molecules(ANLAM) and the CH_(4)/CO_(2) absolute adsorption amounts and their ratio at experimental temperatures and pressures were calculated. Based on a comparison of the density of supercritical CO_(2) and supercritical CH_(4), it is proposed that the higher adsorption capacity of supercritical CO_(2) over supercritical CH_(4) is the result of their density differences at the same temperature. Lastly, the optimal depth for CO_(2)-ECBM in the Qinshui Basin is recommended. The results show that:(1) the adsorption capacity and the ANLAM of CO_(2) are about twice that of CH_(4) on SH-3 anthracite. The effect of pressure on the CO_(2)/CH_(4) absolute adsorption ratio decreases with the increase of pressure and tends to be consistent.(2) A parameter(the density ratio between gas free and adsorbed phase(DRFA)) is proposed to assess the absolute adsorption amount according to the supercritical CO_(2)/CH_(4) attributes. The DRFA of CO_(2) and CH_(4) both show a highly positive correlation with their absolute adsorption amounts, and therefore, the higher DRFA of CO_(2) is the significant cause of its higher adsorption capacity over CH_(4) under the same temperature and pressure.(3) CO_(2) adsorption on coal shows micropore filling with multilayer adsorption in the macro-mesopore, while methane exhibits monolayer surface coverage.(4) Based on the ideal CO_(2)/CH_(4) competitive adsorption ratio, CO_(2) storage capacity, and permeability variation with depth, it is recommended that the optimal depth for CO_(

关键词： CO_(2)geological storage Competitive adsorption Deep unmineable coal Average number of layers of adsorbed molecules Density ratio between free phase and adsorbed phase Micropore filling

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Boundedness of Solutions of Quasi-periodic p-Laplacian Equations with Jumping Nonlinearity

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Acta Mathematica Sinica,English Series 2023年第1期39卷 176-192页

作者： xin Li ZHANG Ya Qun PENG Da Xiong piao School of Mathematics and Physics Qingdao University of Science and TechnologyQingdao 266061P.R.China School of Mathematics(Zhuhai) Sun Yat-sen UniversityZhuhai 519082P.R.China School of Mathematical Sciences Ocean University of ChinaQingdao 266100P.R.China

In this article,we prove the existence of quasi-periodic solutions and the boundedness of all solutions of the p-Laplacian equation(φ_(p)(x’))’+aφ_(p)(x+)-bφ_(p)(x-)=g(x,t)+f(t),where g(x,t)and f(t)are quasi-periodic in t with Diophantine frequency.A new method is presented to obtain the generating function to construct canonical transformation by solving a quasi-periodic homological equation.

关键词： Quasi-periodic twist mapping invariant curve boundedness p-Laplacian

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Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus

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World Journal of Pediatrics 2024年第5期20卷 525-531页

作者： Yan Li Yu-Rong piao Tong-xin Han Hua-Wei Mao Department of Immunology Ministry of Education Key Laboratory of Major Diseases in ChildrenBeijing Key Laboratory for Genetics of Birth DefectsNational Center for Children’s HealthBeijing Children’s HospitalCapital Medical UniversityNo.56 Nan Li Shi LuBeijing100045China

Splenic infarction(SI)is a rare clinical phenomenon that occurs when the blood supply to the spleen is interrupted,resulting in tissue ischemia and necrosis[1].There are many causes of SI;in adult patients,cardioembolism,hematological malignancy,and infectious disease are the most common[2].Rheumatic diseases,especially systemic lupus erythematosus(SLE)and granulomatosis with polyangitis,can also lead to SI[3];however,only a few cases have been *** are currently no statistically meaningful data on the etiology of SI in *** most patients with SI can recover after conservative treatment,a small number of patients develop complications,such as splenic abscess,splenic rupture,splenic hemorrhage,and hemoperitoneum,and may even undergo splenectomy in severe cases.

关键词： erythematosus lupus treatment

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Autophagy regulation combined with stem cell therapy for treatment of spinal cord injury

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Neural Regeneration Research 2023年第8期18卷 1629-1636页

作者： Yao Shen Yi-piao Wang xin Cheng Xuesong Yang Guang Wang Division of Histology and Embryology International Joint Laboratory for Embryonic Development&Prenatal MedicineMedical CollegeJinan UniversityGuangzhouGuangdong ProvinceChina Key Laboratory for Regenerative Medicine of the Ministry of Education Jinan UniversityGuangzhouGuangdong ProvinceChina

Stem cells are a group of cells with unique self-renewal and differentiation abilities that have great prospects in the repair of spinal cord injury. However, stem cell renewal and differentiation require strict control of protein turnover in the stem cells to achieve cell remodeling. As a highly conserved “gatekeeper” of cell homeostasis, autophagy can regulate cell remodeling by precisely controlling protein turnover in cells. Recently, it has been found that the expression of autophagy markers changes in animal models of spinal cord injury. Therefore, understanding whether autophagy can affect the fate of stem cells and promote the repair of spinal cord injury is of considerable clinical value. This review expounds the importance of autophagy homeostasis control for the repair of spinal cord injury from three aspects—pathophysiology of spinal cord injury, autophagy and stem cell function, and autophagy and stem cell function in spinal cord injury—and proposes the synergistic therapeutic effect of autophagy and stem cells in spinal cord injury.

关键词： autophagy chaperone-mediated autophagy embryonic stem cells induced pluripotent stem cells inflammation mesenchymal stem cells neural stem cells oxidative stress spinal cord injury

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Enzymatic biosynthesis of novel neobavaisoflavone glucosides via Bacillus UDP-glycosyltransferase

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Chinese Journal of Natural Medicines 2017年第4期15卷 281-287页

作者： MA Tao DAI Yi-Qun LI Nan HUO Qiang LI hong-Mei ZHANG Yu-xin piao Zheng-Hao WU Cheng-Zhu School of Pharmacy Bengbu Medical CollegeBengbu 233030China Department of Biochemistry Bengbu Medical CollegeBengbu 233030China Department of Basic Medical Science School of MedicineHangzhou Normal UniversityHangzhou 321004China

The present study was designed to perform structural modifications of of neobavaisoflavone(NBIF), using an in vitro enzymatic glycosylation reaction, in order to improve its water-solubility. Two novel glucosides of NBIF were obtained from an enzymatic glycosylation by UDP-glycosyltransferase. The glycosylated products were elucidated by LC-MS, HR-ESI-MS, and NMR analysis. The HPLC peaks were integrated and the concentrations in sample solutions were calculated. The MTT assay was used to detect the cytotoxic activity of compounds in cancer cell lines. Based on the spectroscopic analyses, the two novel glucosides were identified as neobavaisoflavone-4′-O-β-D-glucopyranoside(1) and neobavaisoflavone-4′, 7-di-O-β-D-glucopyranoside(2). Additionally, the water-solubilities of compounds 1 and 2 were approximately 175.1-and 4 031.9-fold higher than that of the substrate, respectively. Among the test compounds, only NBIF exhibited weak cytotoxicity against four human cancer cell lines, with IC50 values ranging from 63.47 to 72.81 μmol·L^(-1). These results suggest that in vitro enzymatic glycosylation is a powerful approach to structural modification, improving water-solubility.

关键词： Neobavaisoflavone Glycosylation UDP-glycosyltransferase Water-solubility Cytotoxicity

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Radiofrequence ablation of liver cancers

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World Journal of Gastroenterology 2002年第3期8卷 393-399页

作者： Lian-xin Liu hong-Chi Jiang Da-Xun piao,Department of Surgery,the First Clinical College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Department of Surgery the First Clinical College Harbin Medical University No.23 Youzheng Street Nangang District Harbin 150001 Heilongjiang Province China. scott_lxliu@***

Primary and secondary malignant liver cancer are some of most common malignant tumors in the world. Chemotherapy and radiotherapy are not very effective against them. Surgical resection has been considered the only potentially curtive option, but the majority of patients are not candidates for resection because of tumor size, location near major intrahepatic blood vessels and bile ducts, precluding a margin-negative resection, cirrhotic, hepatitis virus infection or multifocial. Radiofrequence ablation (RFA), which is a new evolving effective and minimally invasive technique, can produce coagulative necrosis of malignant tumors. RFA should be used percutaneously, laparascopically, or during the open laparotomy under the guidance of ultrasound, CT scan and MRI. RFA has lots of advantages superior to other local therapies including lower complications, reduced costs and hospital stays, and the possibility of repeated treatment. In general, RFA is a safe, effective treatment for unresectable malignant liver tumors less than 7.0 cm in diameter. We review the principle, mechanism, procedures and experience with RFA for treating malignant liver tumors.

关键词： Carcinoma, Hepatocellular Colorectal Neoplasms Humans Liver Neoplasms Radio Waves Research Support, Non-U.S. Gov't

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Multimodel projections and uncertainties of net ecosystem production in China over the twenty-first century

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Chinese Science Bulletin 2014年第34期59卷 4681-4691页

作者： Tao Wang xin Lin Shushi Peng Nan Cong Shilong piao Laboratory for Glaciology and Environmental Geophysics CNRS/Joseph Fourier-Grenoble University 38402 GrenobleFrance Laboratory for Climate and Environmental Science CEA CNRS UVSQ 91191 Gif-sur-Yvette France State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences College of Water Sciences Beijing Normal University Sino-French Institute for Earth System Science College of Urban and Environmental Sciences Peking University

Ecosystems in China have been absorbing anthropogenic CO2 over the last three decades. Here, we assess future carbon uptake in China using models from phase 5 of Coupled Model Intercomparison Project under four socio-economic scenarios. The average of China's carbon sink from 2006 to 2100 represented by multimodel mean net ecosystem production(NEP) is projected to increase(relative to averaged NEP from 1976 to 2005) in the range of 0.137 and 0.891 Pg C a-1across differentscenarios. Increases in NEP are driven by increases in net primary production exceeding increases in heterotrophic respiration, and future carbon sink is mainly attributed to areas located in eastern China. However, there exists a considerable model spread in the magnitude of carbon sink and model spread tends to be larger when future climate change becomes more intense. The model spread may result from intermodel discrepancy in the magnitude of CO2 fertilization effect on photosynthesis, soil carbon turnover time, presence of carbon-nitrogen cycle and interpretation of land-use changes. For better quantifying future carbon cycle, a research priority toward improving model representation of these processes is recommended.

关键词：中国东部地区生态系统生产量不确定性模式预测二氧化碳使用模型净初级生产力

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