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Analytical Method for the Wave Diffraction of Asymmetrically Arranged Breakwaters

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China Ocean Engineering 2024年第5期38卷 797-808页

作者： ZHOU Pei-xin ZHANG hong-sheng College of Ocean Science and Engineering Shanghai Maritime University Bureau of Transport of Beilun District of Ningbo

The layout forms of several breakwater structures can be generalized as asymmetrical arrangements in actual engineering. However, the problem of wave diffraction around asymmetrically arranged breakwaters has not been adequately investigated. In this study, we propose an analytical method of wave diffraction for regular waves passing through asymmetrically arranged breakwaters, and we use the Nystr?m method to obtain the analytical solution numerically. We compared the results of this method with those of previous analytical solutions and with numerical results to demonstrate the validity of our approach. We also provided diffraction coefficient diagrams of breakwaters with different layout forms. Moreover, we described the analytical expression for the problem of diffraction through long-wave incident breakwaters and presented an analysis of the relationship between the diffraction coefficients and the widths of breakwater gates. The analytical method presented in this study contributes to the limited literature on the theory of wave diffraction through asymmetrically arranged breakwaters.

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Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： hong Weng kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan Gang Wang Fang Yu Jun Luo Meng‑xin Lu Zhong‑Hua Yang Tao Liu xing Huang Hang Zheng xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

Influencing factors of self-management ability among dry eye patients in west China

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1621-1627页

作者： Jie Ren xin Zhang Ji-hong Zeng Yun-Xia Gao Department of Ophthalmology West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To investigate the current situation and influencing factors of self-management ability in dry eye patients in west ***:A total of 265 patients clinically diagnosed with dry eye received a convenience survey questionnaire at West China Hospital of Sichuan *** participants completed the rating scale of health self-management skill for adults(AHSMSRS),Huaxi Emotional-Distress Index(HEI),e-health literacy scale(e-HEALS)and Brief Illness Perception Questionnaire(Brief-IPQ).A generalized linear model was employed to establish a multivariate linear model with demographic data,psychological state,e-HEALS,and illness perception as independent variables and health selfmanagement skill score as the dependent ***:The mean score for health self-management skill was 165.58±*** analysis revealed that advanced age,better illness perception and improved psychological state were associated with better health selfmanagement ability among dry eye ***,the health self-management ability of patients with a disease duration less than 1y was found to be higher compared to those with a disease duration exceeding ***:The health self-management ability of dry eye patients in west China is relatively ***,duration of disease,illness perception and psychological state are the influencing factors on the health selfmanagement ability of dry eye patients.

关键词： dry eye self-management ability influencing factors

Modulating the Electrolyte Inner Solvation Structure via Low Polarity Co-solvent for Low-Temperature Aqueous Zinc-Ion Batteries

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Energy & Environmental Materials 2024年第5期7卷 108-117页

作者： Yongchao kang Feng Zhang Houzhen Li Wangran Wei Huitong Dong Hao Chen Yuanhua Sang hong Liu Shuhua Wang State Key Laboratory of Crystal Materials Shandong University Institute for Advanced Interdisciplinary Research (i AIR) University of Jinan

Aqueous zinc-ion batteries are regarded as the promising candidates for large-scale energy storage systems owing to low cost and high safety;however, their applications are restricted by their poor low-temperature performance. Herein, a low-temperature electrolyte for low-temperature aqueous zinc-ion batteries is designed by introducing low-polarity diglyme into an aqueous solution of Zn（ClO4）2. The diglyme disrupts the hydrogenbonding network of water and lowers the freezing point of the electrolyte to-105℃. The designed electrolyte achieves ionic conductivity up to16.18 mS cm-1at-45℃. The diglyme and ClO4-reconfigure the solvated structure of Zn2+, which is more favorable for the desolvation of Zn2+at low temperatures. In addition, the diglyme effectively suppresses the dendrites,hydrogen evolution reaction, and by-products of the zinc anode, improving the cycle stability of the battery. At-20℃, a Zn‖Zn symmetrical cell is cycled for 5200 h at 1 mA cm-2and 1 mA h cm-2, and a Zn‖polyaniline battery achieves an ultra-long cycle life of 10 000 times. This study sheds light on the future design of electrolytes with high ionic conductivity and easy desolvation at low temperatures for rechargeable batteries.

关键词： aqueous zinc-ion batteries high performance inner solvation structure low polarity co-solvent low-temperature electrolyte

Branch-Chain-Rich Diisopropyl Ether with Steric Hindrance Facilitates Stable Cycling of Lithium Batteries at-20℃

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Nano-Micro Letters 2024年第10期16卷 121-135页

作者： Houzhen Li Yongchao kang Wangran Wei Chuncheng Yan xinrui Ma Hao Chen Yuanhua Sang hong Liu Shuhua Wang State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100People's Republic of China

Li metal batteries(LMBs)offer signifi-cant potential as high energy density alternatives;nev-ertheless,their performance is hindered by the slow desolvation process of electrolytes,particularly at low temperatures(LT),leading to low coulombic efficiency and limited cycle ***,it is essential to opti-mize the solvation structure thereby achieving a rapid desolvation process in LMBs at ***,we introduce branch chain-rich diisopropyl ether(DIPE)into a 2.5 M Li bis(fluorosulfonyl)imide dipropyl ether(DPE)elec-trolyte as a co-solvent for high-performance LMBs at-20℃.The incorporation of DIPE not only enhances the disorder within the electrolyte,but also induces a steric hindrance effect form DIPE’s branch chain,excluding other solvent molecules from Li+solvation *** of these factors contribute to the weak interactions between Li^(+)and solvent molecules,effectively reducing the desolvation energy of the ***,Li(50μm)||LFP(mass loading~10 mg cm^(-2))cells in DPE/DIPE based electrolyte demonstrate stable performance over 650 cycles at-20℃,delivering 87.2 mAh g^(-1),and over 255 cycles at 25℃ with 124.8 mAh g^(-1).DIPE broadens the electrolyte design from molecular structure considera-tions,offering a promising avenue for highly stable LMBs at LT.

关键词： Solvation structure Li metal battery Low temperature Steric hindrance Disorder

Progress and prospects of graphene-based materials in lithium batteries

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Rare Metals 2024年第5期43卷 1886-1905页

作者： Shen Lai Tao Huang Pei Liu hong-Bin Wang Shi-Chun Yang xin-Hua Liu Kai Yang Qian-Ling Zhang Jian-hong Liu Jiang-Tao Hu Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen518060China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Department of Electrical and Electronic Engineering Advanced Technology InstituteUniversity of SurreyGuildfordSurrey GU27XHUK

Reasonable design and applications of graphene-based materials are supposed to be promising ways to tackle many fundamental problems emerging in lithium batteries,including suppression of electrode/electrolyte side reactions,stabilization of electrode architecture,and improvement of conductive ***,extensive fundamental research on this aspect has been performed so ***,when it comes to large-scale industrial applications,the utilization of graphene-based materials progresses at a very slow ***,there presents a severe technological decoupling between academic research and industrial application,and there is an urgent need to link ***,in order to address current issues of graphene-based materials used in lithium batteries,we present their latest advancements with stateof-the-art *** applications of graphenebased materials in practical lithium batteries are highlighted and predicted to bridge the gap between the academic progress and industrial manufacture,thereby paving the way for accelerating the development of graphenebased material as well as lithium battery industry.

关键词： Lithium batteries Graphene-based materials Academic research Industrial application Development direction

Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

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World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An Yu-Xia Hao hong-Xia Li xing-kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

Operando measurement of lattice deformation profiles of synchrotron radiation monochromator

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Nuclear Science and Techniques 2024年第7期35卷 8-19页

作者： Yue Zhang Zhong-Liang Li Shang-Yu Si Lian Xue hong-xin Luo Xiao-Wei Zhang Jun Hu Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai201204China ShanghaiTech University Shanghai201210China University of the Chinese Academy of Sciences Beijing100049China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of ScienceBeijing100049China

This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale thermal lattice deformation on a double-crystal monochromator at different incident *** nanoscale thermal lattice deformation of the monochromator first crystal was obtained by analyzing the intensity of the distorted DuMond *** diagrams of the 333 diffraction index,sensitive to lattice deformation,were obtained directly using a 2D detector and an analyzer crystal orthogonal to the *** increasing incident power and power density,the maximum height of the lattice deformation increased from 3.2 to 18.5 nm,and the deformation coefficient of the maximum height increased from 1.1 to 3.2 nm/*** maximum relative standard deviation was 4.2%,and the maximum standard deviation was 0.1 *** on the measured thermal deformations,the flux saturation phenomenon and critical point for the linear operation of the monochromator were predicted with increasing incident *** study provides a simple solution to the problem of the lower precision of synchrotron radiation monochromator characterizations compared to simulations.

关键词： Synchrotron radiation Monochromator Lattice deformation X-ray dynamic diffraction

Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis

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World Journal of Gastroenterology 2024年第11期30卷 1588-1608页

作者： xing-Nian Zhou Quan Zhang hong Peng Yu-Jie Qin Yu-hong Liu Lu Wang Ming-Liang Cheng xin-Hua Luo hong Li Department of Infectious Diseases The Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Infectious Diseases Guizhou Provincial People's HospitalGuiyang 550001Guizhou ProvinceChina

BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and *** silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and *** To investigate the association between ferroptosis and pyroptosis and the upstream regulatory *** This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce *** D(GSDMD)^(-/-)mice were used as an experimental *** changes in liver tissue were monitored by hematoxylin and eosin ***,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial ***-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain ***1,p53,and GSDMD were assessed by immunofluorescence *** Serum AST and ALT levels were elevated in patients with ***1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver *** the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was *** mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were *** vitro,knockdown of p53 and overexpression of GPX

关键词： Silent information regulator sirtuin 1 Ferroptosis Pyroptosis p53/glutathione peroxidase 4/gasdermin D Acute liver failure