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Brain pathways of pain empathy activated by pained facial expressions: a meta-analysis of fMRI using the activation likelihood estimation method

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Neural Regeneration Research 2019年第1期14卷 172-178页

作者： Ruo-Chu Xiong Xin Fu Li-Zhen wu Cheng-Han Zhang hong-xiang wu Yu Shi Wen wu Clinical Medicine First Clinical Medicine School Southern Medical University Department of Rehabilitation Medicine Zhujiang Hospital Southern Medical University

OBJECTIVE: The objective of this study is to summarize and analyze the brain signal patterns of empathy for pain caused by facial expressions of pain utilizing activation likelihood estimation, a meta-analysis method. DATA SOURCES: Studies concerning the brain mechanism were searched from the Science Citation Index, Science Direct, PubMed, DeepDyve, Cochrane Library, SinoMed, Wanfang, VIP, China National Knowledge Infrastructure, and other databases, such as SpringerLink, AMA, Science Online, Wiley Online, were collected. A time limitation of up to 13 December 2016 was applied to this study. DATA SELECTION: Studies presenting with all of the following criteria were considered for study inclusion: Use of functional magnetic resonance imaging, neutral and pained facial expression stimuli, involvement of adult healthy human participants over 18 years of age, whose empathy ability showed no difference from the healthy adult, a painless basic state, results presented in Talairach or Montreal Neurological Institute coordinates, multiple studies by the same team as long as they used different raw data. OUTCOME MEASURES: Activation likelihood estimation was used to calculate the combined main activated brain regions under the stimulation of pained facial expression. RESULTS: Eight studies were included, containing 178 subjects. Meta-analysis results suggested that the anterior cingulate cortex(BA32), anterior central gyrus(BA44), fusiform gyrus, and insula(BA13) were activated positively as major brain areas under the stimulation of pained facial expression. CONCLUSION: Our study shows that pained facial expression alone, without viewing of painful stimuli, activated brain regions related to pain empathy, further contributing to revealing the brain's mechanisms of pain empathy.

关键词： nerve regeneration facial expression pain empathy functional magnetic resonance imaging GringleALE activation likelihood estimation brain function imaging anterior cingulate cortex anterior central gyrus fusiform gyrus insula neural regeneration

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Bioinspired nanotransducers for neuromodulation

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Nano Research 2024年第2期17卷 618-632页

作者： Fan Yang xiang wu Sa Cai Guosong hong Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA wu Tsai Neurosciences Institute Stanford UniversityStanfordCA 94305USA School of Science Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The field of neuromodulation has experienced significant advancements in the past decade,owing to breakthroughs in disciplines such as materials science,genetics,bioengineering,photonics,and *** convergence of these fields has resulted in the development of nanotransducers,devices that harness the synergies of these diverse *** nanotransducers,essential for neuromodulation,often draw inspiration from energy conversion processes found in nature for their unique *** this review,we will delve into the latest advancements in wireless neuromodulation facilitated by optical,magnetic,and mechanical *** will examine their working principles,properties,advantages,and limitations in comparison to current methods for deep brain neuromodulation,highlighting the impact of natural systems on their design and ***,we will underscore potential future directions,emphasizing how continued progress in materials science,neuroscience,and bioengineering might expand the horizons of what is achievable with nanotransducer-enabled neuromodulation.

关键词： bioinspired synthesis neuromodulation mechanoluminescence focused ultrasound nanotransducers sono-optogenetics

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Dual-ion carrier storage through Mg^(2+) addition for high-energy and long-life zinc-ion hybrid capacitor

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 179-185页

作者： Junjie Zhang xiang wu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

Cation additives can efficiently enhance the total electrochemical capabilities of zinc-ion hybrid capacitors (ZHCs).However their energy storage mechanisms in zinc-based systems are still under ***,we modulate the electrolyte and achieve dual-ion storage by adding magnesium *** we assemble several Zn//activated carbon devices with different electrolyte concentrations and investigate their electrochemical reaction dynamic *** zinc-ion capacitor with Mg^(2+)mixed solution delivers 82 mAh·g^(-1)capacity at 1 A·g^(-1) and maintains 91%of the original capacitance after 10000 *** is superior to the other assembled zinc-ion devices in single-component *** finding demonstrates that the double-ion storage mechanism enables the superior rate performance and long cycle lifetime of ZHCs.

关键词： zinc-ion hybrid capacitor MgSO_(4) electrolyte rate performance storage mechanism

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Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

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Magnetic field imaging with radio-frequency optically pumped magnetometers [Invited]

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Chinese Optics Letters 2024年第6期22卷 38-45页

作者： Xiyu Liu Junlong Han Wei Xiao Teng wu xiang Peng hong Guo School of Electronics Peking UniversityBeijing 100871China

High-sensitivity radio-frequency optically pumped magnetometers (RF-OPMs), working without cryogenic condition, play a critical role in magnetic field imaging(MFI) at low frequencies(e.g., 100 Hz to 1 MHz). We introduce the principle of operation and recent developments of RF-OPMs and focus on reviewing the MFI applications in magnetic induction tomography, ultralow-field magnetic resonance imaging, and magnetic particle imaging. For the applications of RF-OPMs, ranging from industrial monitoring to medical imaging and security screening, the unshielded and portable RF-OPMs(and RF-OPM array)techniques are still under the further development for detecting and scanning over the target object for accomplishing the final three-dimensional imaging, and thus extremely require the abilities of active compensation of the ambient magnetic field and sensor miniaturization in the future.

关键词： magnetic field imaging radio frequency optically pumped magnetometer

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Optical Microsphere Nano-Imaging:Progress and Challenges

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Engineering 2024年第5期36卷 102-123页

作者： Guangxing wu Minghui hong Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

The optical diffraction effect imposes a radical obstacle preventing conventional optical microscopes from achieving an imaging resolution beyond the Abbe diffraction limit and thereby restricting their usage in a multitude of nanoscale *** the past decade,the optical microsphere nanoimaging technique has been demonstrated to be a cost-effective solution for overcoming the diffraction limit and has achieved an imaging resolution of up to about k6k8 in a real-time and label-free manner,making it highly competitive among numerous super-resolution imaging *** this review,we summarize the underlying nano-imaging mechanisms of the microsphere nanoscope and key advancements aimed at imaging performance enhancement:first,to change the working environment or modify the peripheral hardware of a single microsphere nanoscope at the system level;second,to compose the microsphere compound lens;and third,to engineer the geometry or ingredients of *** also analyze challenges yet to be overcome in optical microsphere nano-imaging,followed by an outlook of this technique.

关键词： Microsphere Nano-imaging Virtual imaging Microsphere compound lens Engineered microsphere

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Ab initio Structure Determination of [Co(NH_3)_5Br]Br_2 Using Conventional X-ray Powder Diffraction

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Chinese Chemical Letters 1997年第7期8卷 647-648页

作者： hong xiang wu and Li Dun MA(Center for Analysis and Measuremnt, Fudan University, Shanghai, 200433)(Project supported by the National Natural Science Foundation of China(NSFC) NO. 29573098) Center for Analysis and Measurement Fudan University Shanghai 200433 China

The crystal structure of [Co(NH3)5Br]Br2 has been determined ab initio from the conventional X-ray powder diffraction data. The approximate structure with all 7 indeyendent non-H atoms was solved by direct methods. The final orthorhombic unit-cell parameters after Rietveld refinement are: a=13.6927, b=10.7071, c=6.9400A, V=1017.47A3, F30=93(0.0075,43), M20=49, Z=4. Space group is Pnma. The structure agreement factors are: Rp=0.066,Rwp=0.090, RF=0.041, RB=0.042.

关键词： Br2 Using Conventional X-ray Powder Diffraction Ab initio Structure Determination of NH3

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Microstructure and mechanical properties of a cast TRIP-assisted multiphase stainless steel

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China Foundry 2024年第3期21卷 221-228页

作者： Meng-xin Wang Zi-xiang wu Jing-yu He xiang Chen School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Stainless steels are used in a wide range of complex environments due to their excellent corrosion *** stainless steels can offer an excellent combination of strength,toughness and corrosion resistance due to the coexistence of different *** microstructure and mechanical properties of a novel cast multiphase stainless steel,composed of martensite,ferrite,and austenite,were investigated following appropriate heat treatment processes:solution treatment at 1,050℃ for 0.5 h followed by water quenching to room temperature,and aging treatment at 500℃ for 4 h followed by water quenching to room *** show reversed austenite is formed by diffusion of Ni element during aging process,and the enrichment of Ni atoms directly determines the mechanical stability of *** austenite with a lower Ni content undergoes a martensitic transformation during plastic *** tensile strength of the specimen exceeds 1,100 MPa and the elongation exceeds 24%after solid solution,and further increases to 1,247 MPa and 25%after aging *** enhancement is due to the TRIP effect of austenite and the precipitation of the nanoscale G-phase pinning dislocations in ferrite and martensite.

关键词： multiphase stainless steel mechanical properties TRIP effect reversed austenite G-phase

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Reynolds-number scaling analysis on lift generation of a flapping and passive rotating wing with an inhomogeneous mass distribution

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Chinese Journal of Aeronautics 2024年第2期37卷 259-269页

作者： Suyang QIN Haotian HANG Yang xiang hong LIU J.C.wu center for aerodynamics school of aeronautics and astronauticsshanghai jiao tong universityshanghai 200240china

Insects usually fly by passively rotating wings,which has been applied to the design of flapping-wing Micro-Air Vehicles(MAVs)to reduce mechanical *** this paper,a robotic passive rotating-wing model is designed to investigate wing kinematics and lift generation,which are measured by a high-speed camera and a force transducer,*** addition,flow fields are measured using the Particle Image Velocimetry(PIV).Experimental results demonstrate that passive rotating motion has a coordinative relationship with actively stroking *** the stroke amplitude or frequency increases,the rotating amplitude is *** characterize the active stroking motion,a driving Reynolds number Redrivingis defined,which varies from 68 to 366 in this *** the gravity center of the wing towards trailing ed ge induces the increase of additional torque M,which decreases the wing rotating amplitude and promotes the advance of wing *** find that the timing of wing rotation is gradually delayed and the mean lift coefficient C^(-)_(L)monotonously decreases as *** increasing the additional torque M,C^(-)_(L)is slightly improved and approaches to the lift coefficient of a real fruit fly at driving Re approximately equal to *** instantaneous lifts combined with the vortical structures further demonstrate that the lift generation associated with wing rotation is mainly attributed to the growth of the LeadingEdge Vortex(LEV)and the passive wake capture *** wake capture is influenced by LEV,reversal stroke motion and wing additional torque together,which can only maintain the lift at a high level for a considerable *** high-lift generation mechanisms of flapping and passive rotating flight could shed light on the simplified design of MAVs and the improvement of their aerodynamic performance.

关键词： Flapping flight Unsteady lift Passive rotation Vortex flow Leading-edge vortex

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Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1693-1710页

作者： Xiong Chen Jinfu Qian Shiqi Liang Jianchang Qian wu Luo Yujuan Shi hong Zhu xiang Hu Gaojun wu Xiaokun Li Guang Liang Department of Endocrinology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China Department of Wound Repair the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Department of Cardiology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China School of Pharmaceutical Sciences Hangzhou Medical CollegeHangzhou 311399China

Protein tyrosine kinases (RTKs) modulate a wide range of pathophysiological events in several non-malignant disorders, including diabetic complications. To find new targets driving the development of diabetic cardiomyopathy (DCM), we profiled an RTKs phosphorylation array in diabetic mouse hearts and identified increased phosphorylated fibroblast growth factor receptor 1 (p-FGFR1) levels in cardiomyocytes, indicating that FGFR1 may contribute to the pathogenesis of DCM. Using primary cardiomyocytes and H9C2 cell lines, we discovered that high-concentration glucose (HG) transactivates FGFR1 kinase domain through toll-like receptor 4 (TLR4) and c-Src, independent of FGF ligands. Knocking down the levels of either TLR4 or c-Src prevents HG-activated FGFR1 in cardiomyocytes. RNA-sequencing analysis indicates that the elevated FGFR1 activity induces pro-inflammatory responses via MAPKs–NFκB signaling pathway in HG-challenged cardiomyocytes, which further results in fibrosis and hypertrophy. We then generated cardiomyocyte-specific FGFR1 knockout mice and showed that a lack of FGFR1 in cardiomyocytes prevents diabetes-induced cardiac inflammation and preserves cardiac function in mice. Pharmacological inhibition of FGFR1 by a selective inhibitor, AZD4547, also prevents cardiac inflammation, fibrosis, and dysfunction in both type 1 and type 2 diabetic mice. These studies have identified FGFR1 as a new player in driving DCM and support further testing of FGFR1 inhibitors for possible cardioprotective benefits.

关键词： Diabetic cardiomyopathy Protein tyrosine kinases FGFR1 Cardiomyocytes Inflammatory responses Toll-like receptor4 c-Src NFkB

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