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CLINICAL PATHOLOGICAL FEATURE OF EARLY TONGUE AMYLOIDOSIS

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Chinese Medical Sciences Journal 2006年第2期21卷 104-106页

作者： wei-hong pan Na-ping Li Department of Stomatology Union HospitalHuazhong University of Science ＆ Technology Wuhan 430022 Department of Pathology Tongji Medical CollegeHuazhong University of Science ＆ Technology Wuhan 430022

To investigate the clinical pathological feature and diagnostic criteria of tongue amyloidosis （AL）. During 1992 to 2005, 25 patients pathologically diagnosed as tongue AL in our hospital were reviewed retrospectively, and all of them had no enlarged tongue. Haematoxylin and eosin （HE） and immunohistochemi ning were used to detect the amyloid deposition on the tongue. Results Totally 84% （21/25） patients had symptoms of xemstomia and taste-blindness, 44% （11/25） patients complained of activity limitation of tongue. Macroscopic observation showed mueosa pallescenee, punctuate hemorrhage, red grain particles, and ulcers on the tongue. HE staining indicated amyloid depositions in basement membrane, muscle cell, vessel wall, and nerve fiber, lmmunohistochemieal study demonstrated kappa light-chain deposition in 64% （16/25） eases, and lambda light-chain deposition in 36% （9/25） eases. They presented in vessel wall, nerve fiber, and muscle cells. Conclusion The biopsy is an important means for the diagnosis of early tongue AL, and the wide variety of amyloid fight chain is helpful to differential diagnosis.

关键词： tongue amyloidosis immunohistochemistry clinical

Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist

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Chinese Chemical Letters 2009年第3期20卷 302-305页

作者： Yan Chun Zhang Jin Pei Zhou Xiao Ming Wu wei hong pan Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of novel nitric oxide-donating derivatives （7a-e, 8a-e） were synthesized by coupling furoxan and nitric oxide with irbesartan analogue and their cytotoxicity against BEL7402 cells in vitro were evaluated by MTT method. It was found that 8c exhibits the most cytotoxic activities with ICso value of 12.5 μmol/L. The hybrids of AT1 antagonist and nitric oxide donor appear to have beneficial effects on antitumor.

关键词： AT1 antagonist Nitric oxide-donating Antitumor Synthesis

Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 973-981页

作者： Qing-Yang Feng Zi-Xuan Hu Xi-Ling Song hong-wei pan[[ Department of Ophthalmology the First Affiliated Hospital of Jinan University Guangzhou 510630 Guangdong Province China Department of Public Health and Preventive Medicine Jinan University Guangzhou 510632 Guangdong Province China Institute of Ophthalmology School of Medicine Jinan University Guangzhou 510632 Guangdong Province China

Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of mefalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. We illustrate their possible mechanisms in the pathogenesis of pterygium as well as the related intervention based on them for pterygium therapy.

关键词： pterygium growth factors matrixmetalloproteinases tissue inhibitors of metalloproteinases interleukins tumor suppressor genes proliferation andapoptosis cell adhesion molecules extmcellular matrix proteins

Mechanical Properties, Crystallization and Biodegradation Behavior of the Polylactide/Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/ Poly(butylene adipate-co-terephthalate) Blown Films

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Chinese Journal of Polymer Science 2020年第10期38卷 1072-1081,I0005页

作者： Xiang-Yu Wang hong-wei pan Shi-Ling Jia Zeng-Wen Cao Li-Jing Han Hui-Liang Zhang Li-Song Dong Key Laboratory ofPolymer Ecomaterials Chinese Acadermy of SciencesChangchun Istitute of Applied ChemistryChangchun 130022 China University of Science and Technology of China Hefei 230026 China Zhejiang Zhongke Applied Chemistry Technology Co LtdHangzhou 30000 China

Polactide(PLA),poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P(3HB-CO-4HB)),and poly(butylene adipate co-terephthalate)(PBAT)ternary blends were prepared by extrusion *** biodegradable PLA/P(3HB-co 4HB)/PBAT films were successfully obtained by using blown films *** siffness-toughness balance was achieved for 55/10/35 PLA/P(3HB-co 4HB)/PBAT *** tensile strength reached 33.0 MPa(MD)and 23.5 MPa(TD).the elongation at break exceeded 1309%,and tear strength exceeded 110 kN/*** Young's modulus as low as about 1800 MPa also met packaging *** observations revealed rough and long ligaments,indicating that the tear specimens were broken *** addition of PBAT elastomers was the main reason for the improved toughness of the *** DMA and SEM analysis,it was demonstrated that PLA P(3HB co 4HB),and PBAT were prilly *** increasing P(3HB CO-4HB)content,the melt and cold crstallization of PLA was *** enzymatic degradation experiments indicated that the films had good *** findings gave important implications for designing and manufacturing biodegradation package of high biological carbon content.

关键词： Polylactide Poly(3 hydroxybutyrate co4-hydrxybutyrate) Blown flms Mechanical properties Biodegradability

Studies on Rheological, Thermal, and Mechanical Properties of Polylactide/Methyl Methacrylate-Butadiene-Styrene Copolymer/Poly(propylene carbonate) Polyurethane Ternary Blends

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Chinese Journal of Polymer Science 2019年第12期37卷 1273-1282,I0007页

作者： Ji-Li Zhao hong-wei pan Hui-Li Yang Jun-Jia Bian Hui-Liang Zhang Ge Gao Li-Song Dong College of Chemistry Jilin UniversityChangchun 130012China Department of Science Beihua UniversityJilin 132013China Key Laboratory of Polymer Ecomaterials Chinese Academy of SciencesChangchun Institute of Applied ChemistryChangchun 130022China Zhejiang Zhongke Applied Chemistry Technology Co. Ltd.Hangzhou 310000China

Polylactide(PLA),methyl methacrylate-butadiene-styrene copolymer(MBS),and poly(propylene carbonate)polyurethane(PPCU)were blended and subjected to blown film *** rheological,mechanical,morphological,thermal,and crystalline properties of the PLA/MBS/PPCU ternary blends and the mechanical properties of the resulting films were *** of mechanical test showed that PPCU and MBS could synergistically toughen *** impact strength of 50/10/40 PLA/MBS/PPCU blend(74.7 k J/m^2)was about 7.5 times higher than that of the neat PLA(10.8 k J/m^2),and the elongation at break of 50/10/40 PLA/MBS/PPCU blend(276.5%)was higher by about 45 times that of PLA(6.2%).The tear strength of PLA/MBS/PPCU films was 20 k N/m higher than that of PLA,and the elongation at break(MD/TD)of 50/10/40 PLA/MBS/PPCU films was 271.1%/222.3%,whereas that of PLA was only 2.7%/3.0%.POM observations displayed that the density of spherulite nucleation increased and the size of crystalline particles decreased with the addition of *** increasing PPCU content from 5%to 20%,the density of spherulite nucleation increased and the size of crystalline particles decreased continuously,but the nucleation density of spherulites was slightly lowered with increasing PPCU content from 30%to 40%.The PLA/MBS/PPCU films exhibited excellent mechanical properties,which expanded the application range of these biodegradable films.

关键词： Biodegradable Polylactide Poly(propylene carbonate)polyurethane Methyl methacrylate-butadiene-styrene copolymer Films

Biodegradable Poly(butylene adipate-co-terephthalate)/Poly(glycolic acid) Films: Effect of Poly(glycolic acid) Crystal on Mechanical and Barrier Properties

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Chinese Journal of Polymer Science 2023年第7期41卷 1123-1132页

作者： hong-wei pan Ye Wang Shi-Ling Jia Yan Zhao Jun-Jia Bian Hui-Li Yang Yan-Ping Hao Li-Jing Han Hui-Liang Zhang Key Laboratory of Polymer Ecomaterials Chinese Academy of SciencesChangchun Institute of Applied ChemistryChangchun130022China School of Pharmaceutical Sciences Changchun University of Chinese MedicineChangchun130117China Changchun University of Technology Changchun130012China Shandong Dawn Polymer Co. Ltd.Longkou265700China

Binary biodegradable polymers films, poly(butylene adipate-co-terephthalate)(PBAT) and poly(glycolic acid)(PGA), were prepared through batch melt mixing to obtain Film Ⅰ and Film Ⅱ under two different processing conditions. PGA crystals played a major role in enhancing the mechanical and barrier properties of the films. For Film Ⅰ, there were initial PGA crystals before the film blowing process, the PGA molecular chain further crystallized, forming the oriented crystallization of PGA. Moreover, the Xcand crystalline size in Film Ⅰ were higher than those in Film Ⅱ. Compared with the different processing methods, Film Ⅰ has excellent mechanical and oxygen barrier properties due to the crystallization and orientation. The tensile strength reached 45.0 MPa, and tear strength exceeded 138.2 kN/m, while the elongation at break was as high as 750% for PBAT/PGA 85/15 in Film Ⅰ. The WVTR, WVP coefficients, and OP coefficients of PBAT/PGA films were decreased obviously with increasing the PGA content both in Film Ⅰ and Film Ⅱ. Moreover, the barrier properties of oxygen in Film Ⅰ were better than that in Film Ⅱ. This work reveals a feasible processing technique by introducing of initial crystallization of PGA to blow PBAT/PGA films with excellent mechanical and barrier properties.

关键词： Poly(butylene adipate-co-terephthalate) Poly(glycolic acid)(PGA) Biodegradable polymers Films

Biodegradable Foaming Material of Poly(butylene adipate-co-terephthalate)(PBAT)/Poly(propylene carbonate)(PPC)

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Chinese Journal of Polymer Science 2022年第2期40卷 208-219页

作者： Han-Lin Tian Ze-Peng Wang Shi-Ling Jia hong-wei pan Li-Jing Han Jun-Jia Bian Ying Li Hui-Li Yang Hui-Liang Zhang Changchun University of Technology School of Chemical EngineeringChangchun 130012China Key Laboratory of Polymer Ecomaterials Chinese Academy of SciencesChangchun Institute of Applied ChemistryChangchun 130022China Jilin COFCO Biochemistry Packaging Co. Ltd.Liaoyuan 136300China

A biodegradable blend foaming material of poly(butylene adipate-co-terephthalate)(PBAT)/poly(propylene carbonate)(PPC)was successfully prepared by chemical foaming agent and screw extrusion ***,PBAT was modified by bis(tert-butyl dioxy isopropyl)benzene(BIBP)for chain extension,and then the extended PBAT(E-PBAT)was foamed with PPC using a twin(single)screw *** analyzing the properties of the blends,we found that Young’s modulus increased from 58.8 MPa of E-PBAT to 244.7 MPa of E-PBAT/PPC 50/*** viscosity of the polymer has a critical influence on the formation of *** with neat PBAT(N-PBAT),the viscosity of E-PBAT increased by 3396 Pa·s and E-PBAT/PPC 50/50 increased by 8836 Pa·***,the dynamic mechanical analysis(DMA)results showed that the storage modulus(E’)at room temperature increased from 538 MPa to 1650 *** various phase morphologies(“sea-island”,“quasi-co-continuous”and“cocontinuous”)and crystallinity of the blends affected the spread velocity of gas and further affected the foaming morphology in E-PBAT/PPC ***,through the analysis of phase morphology and foaming mechanism,we concluded that the E-PBAT/PPC 70/30 component has both excellent strength and the best foaming performance.

关键词： Poly(butylene adipate-co-terephthalate) Poly(propylene carbonate) Phase structure Biodegradable foam Extrusion foaming

Design strategies of high-performance lead-free electroceramics for energy storage applications

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Rare Metals 2024年第3期43卷 853-878页

作者： Biao Guo Fei Jin Li Li Zi-Zhao pan Xin-wei Xu hong Wang Department of Materials Science and Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055China School of Microelectronics and State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China

A greater number of compact and reliable electrostatic capacitors are in demand due to the Internet of Things boom and rapidly growing complex and integrated electronic systems,continuously promoting the development of high-energy-density ceramic-based *** significant successes have been achieved in obtaining high energy densities in lead-based ferroelectric ceramics,the utilization of lead-containing ceramies has been restricted due to environmental and health hazards of ***-free ferroelectric ceramics have garnered tremendous attention and are expected to replace lead-based ceramics in the near ***,the energy density of lead-free ceramics is still lagging behind that of lead-containing ***,severely limiting their *** efforts have been made to enhance the energy storage performance of lead-free ceramics using multi-scale design strategies,and exciting progress has been achieved in the past *** review briefly discusses the energy storage mechanism and fundamental characteristics of a dielectric capacitor,summarizes and compares the state-of-the-art design strategies for high-energy-density lead-free ceramics,and highlights several critical issues and requirements for industrial *** prospects and challenges of lead-free ceramics for energy storage applications are also discussed.

关键词： Dielectric materials Lead-free ceramic Environment friendly Energy storage Design strategy

Superior Toughened Biodegradable Poly(L-lactic acid)-based Blends with Enhanced Melt Strength and Excellent Low-temperature Toughness via In situ Reaction Compatibilization

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Chinese Journal of Polymer Science 2023年第3期41卷 373-385,I0007页

作者： Shi-Ling Jia Xiang-Yu Wang Ye Zhang Xiang-Yu Yan hong-wei pan Yan Zhao Li-Jing Han Hui-Liang Zhang Li-Song Dong Hui-Xuan Zhang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Materials Science and Engineering Changchun University of TechnologyChangchun 130012China

The toughened poly(L-lactic acid)/poly(butylene succinate-butylene terephthalate)(PLLA/PBST) blend with enhanced melt strength and excellent low temperature toughness and strength was prepared by melt compounding through in situ compatibilization reaction in presence of multifunctional epoxy compound(ADR).The PLLA/PBST blend was an immiscible system,and the compatibility of the PLLA/PBST blend was improved after adding *** and GPC curves confirmed the formation of the PLLA-g-PBST copolymer,which improved the interfacial bonding of the blend and therefore the PLLA/PBST/ADR blend showed excellent melt strength and mechanical *** the PLLA/PBST/ADR blend with 70/30 PLLA/PBST content,the complex viscosity increased significantly with increasing ADR ***,the tensile strength,elongation at break and impact strength all increased obviously with increasing the ADR *** elongation at break of the blend reached the maximum value of 392.7%,which was 93.2 times that of neat *** the impact strength of the blend reached the maximum value of 74.7 k J/m~2,which was 21.3 times that of neat ***,the PLLA/PBST/ADR blend exhibited excellent lowtemperature toughness and *** –20 ℃,the elongation at break of the PLLA/PBST/ADR blend was as high as 93.2%,and the impact strength reached 18.8 k J/m~***,the tensile strength of the blend at low temperature was also high(64.7 MPa),which was beneficial to the application of PLA in the low temperature *** addition,the PLLA/PBST/ADR blend maintaind good biodegradability,which was of great significance to the wide application of PLLA.

关键词： Poly(L-lactic acid) PBST Compatibilization Super toughness Low-temperature mechanical properties Biodegradability