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World Journal of Clinical Oncology 2025年第2期16卷 130-143页

作者： wei-Wu Chen Yue-hong kong Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Bone is a major site of metastasis in nasopharyngeal carcinoma(NPC).Recently,nuclear factor kappa-beta ligand(RANKL)inhibitors have garnered attention for their ability to inhibit osteoclast formation and bone resorption,as well as their potential to modulate immune functions and thereby enhance the efficacy of programmed cell death protein 1(PD-1)inhibitor *** SUMMARY We present a case of a patient with NPC who developed sternal stalk metastasis and multiple bone metastases with soft tissue invasion following radical chemoradiotherapy and targeted *** to chemotherapy,the patient experienced severe bone marrow suppression and opted out of further chemotherapy ***,the patient received combination therapy,including RANKL inhibitors(denosumab)alongside PD-1,radiotherapy,and granulocyte-macrophage colonystimulating factor(PRaG)therapy(NCT05435768),and achieved 16 months of progression-free survival and more than 35 months of overall survival,without encountering any grade 2 or higher treatment-related adverse *** Denosumab combined with PRaG therapy could be a new therapeutic approach for the second-line treatment in patients with bone metastases.

关键词： Nasopharyngeal carcinoma Bone metastasis Radiotherapy Programmed cell death protein 1 inhibitors Denosumab Case report

Toxic marine diatoms of hong kong:A paleoecological study

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Journal of Environmental Sciences 1997年第1期9卷 1-10页

作者： Mike Dickman Tom Glenwright Ecology and Biodiversity Department,The University of hong kong,hong kong Ecology Department University of Hong Kong Hong Kong Hong Kong

To determine whether toxic diatoms in hong kong's Victoria Harbour have become more common during the last four decades,a gravity core was taken from the anaerobic sediments of Kowloon Bay in the harbour. Analysis of these sediments from a depth of 0-1cm,4-5cm and 9-10cm indicated that 6.4%,2.4% and 1.5% of the diatoms observed at each of these three respective depths belonged to the genus Pseudonitzschia. The abundance of Pseudonitzschia frustules in the surface sediments of Victoria Harbour was significantly higher(phong kong's coastal waters as a re- sult of man's activities.

关键词： paleoecology sediment cores marine diatoms toxic diatoms Pseudonitzschia.

Alkaline leaching mechanism of MSWI bottom ash: the pivotal role of Si(Al) chemical bonding environments

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Science China Technological Sciences 2025年

作者： Ningning SHAO Zekun JIAO weipeng FENG Yu JIN Fanlong kong Zhijun DONG Zuotai ZHANG Institute of Technology for Marine Civil Engineering Shenzhen Institute of Information Technology (SZIIT) Guizhou NASH Ecological Technology Co. LTD School of Environmental Science and Engineering Key Laboratory of Municipal Solid Waste Recycling Technology and Management of Shenzhen City Southern University of Science and Technology (SUSTech)

Municipal solid waste incineration bottom ash(MSWIBA) is a complex assemblage of aluminosilicate materials encompassing diverse solid wastes. Thus, its complexity poses great challenges to their resource utilization. For the sake of the alkali activation use of MSWIBA, this work focused on the characterizations and alkaline leaching experiments of various classified MSWIBA after sorting. Among the different categories of MSWIBA, waste glass(BA-G) and other unidentified slags(BA-O) were identified as potential precursors for alkali activation use. The alkaline leaching experiments proved that alkaline concentration, reaction temperature, reaction time, and raw material classification influenced the leaching process and results. Among these, the Si/Al chemical bonding environments from the material type played a pivotal role. When the materials had Qn(n>2) as the primary bonding structure, steric hindrance by the chain frameworks affected the alkali dissolution process, resulting in gradual disintegration from the outer layers inward. For the materials dominated by Q1frameworks, OH-could penetrate the frameworks, leading to their rapid depolymerization and outward dissolution. Overall, the Si/Al bonding environment played a crucial role in alkaline dissolution, providing theoretical guidance for classifying the alkali-activation utilization of MSWIBA and other aluminosilicate solid wastes.

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Deformity frequencies of benthic marine diatoms associated with contaminated sediments in hong kong

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Journal of Environmental Sciences 1998年第1期10卷 15-26页

作者： Ecology and Biodiversity Department, The University of hong kong, Pokfulam Road, hong kong

The relationship between contaminated sediments and deformity frequencies for benthic diatoms was the subject of this study. There were two basic types of diatom deformities observed in this study of Tolo Harbour diatoms: 1. Diatoms with deformed cell wall morphology and 2. diatoms with deformed ornamentation. Deformed individuals of Fragilaria capucina and Achananthes hauckiana Grun. displayed external cell wall deformities while deformed individuals of Diatoma displayed deformities in valve ornamentation. Abnormal cell morphology was used as an indicator of a degraded ecosystem. There was a significant correlation( P <0.05, r s=0.652) between sediment toxicity as reflected by the microtox test and benthic diatom diversity. Species diversity and species richness levels at the twelve sites were closely correlated with one another and inversely correlated with sediment toxicity as reflected by our microtox results( r s=0.809, P <0.01). The microtox test for acute toxicity was correlated ( P <0.05) with diatom species richness. The deformity frequencies and microtox tests were not significantly correlated. This lack of correlation was expected as in numerous laboratory studies, toxic substances were not necessarily mutagenic. The use of diatom deformity frequencies as a means of assessing the mutagenic/teratogenic impacts of anthropogenic substances on a marine benthic diatom community necessitates the enumeration of a large number of diatoms making this method extremely labor intensive.

关键词： deformity frequencies benthic marine diatoms contaminated sediments.

Transmission capacity maximization for LED array-assisted multiuser VLC systems

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Science China(Information Sciences) 2015年第8期58卷 117-130页

作者： kong Lei SHEN hong XU wei ZHANG Hua ZHAO ChunMing YOU XiaoHu National Mobile Communications Research Laboratory Southeast University

In this paper, we present a light-emitting diode(LED) array-assisted visible light communication(VLC) system. Considering the requirements of illumination, the human eye safety, and the energy saving,we optimize the optical power allocation(PA) to maximize the transmission capacity of the overall ***, we discuss two typical scenarios where the LED array in each room serves multiple users either simultaneously or in a round-robin manner. The problem corresponding to the first case turns out to be nonconvex whose globally optimal solution is hard to obtain. To address this difficult problem, we first adopt the famous gradient projection algorithm to obtain a locally optimal solution, then we employ powerful convex relaxation techniques, and achieve a high-quality solution. While for the round-robin case, we are able to derive an optimal solution in closed form by virtue of Karush-Kuhn-Tucker conditions. Interestingly, the derived closedform solution follows a water-filling pattern with both square root and two-side clipping operations, which differs from the conventional water-filling-like PA in radiofrequency channels. Numerical results depict the performance advantage provided by the proposed PA strategies under various settings.

关键词： light-emitting diodes visible light communication power allocation multiuser transmission convex relaxation

Particulate problems of different occupational environments in hong kong

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Journal of Environmental Sciences 1999年第4期11卷 385-391页

作者： LEUNG Y.C., CHEUNG K.K. (Department of Mechanical Engineering, The University of hong kong, hong kong Special Administrative Region) 香港大学机械工程系香港

This paper studied the air pollution problems that occurred in various working environments in hong kong through questionnaire survey and field measurements. Results of the survey showed that more than half of the respondents, who were affected by different kinds of air pollution, were suffering from either eye and nasal allergies, or throat irritation. Many of them recognized dust particulate to be the most serious air pollutant in their working environments. A portable laser dust monitor was employed to measure the levels of dust particulate that would be inhaled by people of different occupations and subject to different environments. The measurement results revealed that only some occupations were exposed to unacceptably high particulate levels. Generally, the particulate levels of most of the studied working environments, catering premises and entertainment places were much lower than the ambient levels and unlikely to pose any occupational hygiene problems.

关键词： air pollution dust particulate hong kong

PROSPECTS FOR S&T COOPERATION BETWEEN hong kong & THE MAINLAND

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Bulletin of the Chinese Academy of Sciences 1997年第3期11卷 213-214页

作者： Chia-wei Woo(hong kong University of Science and Technology, hong kong,

On July 1, 1997, hong kong returns to her mother country. This is a great day for the Chinese people; indeed, it will be a milestone in Chinese history. In terms of scientific and technological cooperation, it may tur... 详细信息

关键词： THE MAINLAND PROSPECTS FOR S&T COOPERATION BETWEEN hong kong

Development and experience in the monitoring,assessment and control of environmentalpollutants in hong kong

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Journal of Environmental Sciences 1991年第2期3卷 1-10页

作者： Feng Yingsheng(Y.S.Fung)Deparnent of Chemistry,University of hong kong,hong kong

The late start of environmental protection in hong kong was discussed in the light of problems encountered during the development of environmental protection legislation in hong kong for the past 20 years. The collaboration in monitoring and assessment of environmental pollutants between the University of hong kong and various governments were descrbed in parallel with the progress in environmental protection in hong kong. The developments of new analytical techniques for environmental monitoring and analysis is given and their application in environmental control described. The joint projects in assessment and control of environmental pollutants carried out in collaboration with local industries and other organizations within and without the university are given and discussed. The problems and possible solution facing hong kong in development control equipment for small scale industries are discussed and areas of development identified. The development and experience in the monitoring assessment and control of environmental pollutants in hong kong are summarized and areas of difficulties are illustrated.

关键词： monitoring of pollutants assessment of pollutants control of pollutants small scale industries urban pollution.

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调理中焦气机是脓毒症MODS的根本治法

中国中医急症 2018年第3期27卷 475-477,483页

作者：刘委宏孔立刘阳田正云郝浩张飞虎谢娜山东中医药大学山东济南250355 山东中医药大学附属医院山东济南250355

临床上多器官功能障碍综合征(MODS)起病急,发展迅速,病死率极高,是近年医学领域研究的重要课题,中医药研究也有了很大的发展。孔立教授认为脓毒症MODS是五脏气机逆乱的生理病理状态,始于一处,乱于五脏,终致三焦气机逆乱,因此治疗脓毒症... 详细信息

临床上多器官功能障碍综合征(MODS)起病急,发展迅速,病死率极高,是近年医学领域研究的重要课题,中医药研究也有了很大的发展。孔立教授认为脓毒症MODS是五脏气机逆乱的生理病理状态,始于一处,乱于五脏,终致三焦气机逆乱,因此治疗脓毒症的根本治法是调理中焦气机,经方之中调理中焦气机首选半夏泻心汤类方,该类方辛开苦降、调和脾胃阴阳,恢复中焦气机,最终达到恢复五脏正常功能。

关键词：多器官功能障碍综合征气机逆乱中焦气机

Weather and traffic accidents in hong kong

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Journal of Geographical Sciences 1998年第3期8卷 93-98页

作者： Yuk Yee Yan Department of Geography hong kong Baptist University Kowloon Tong, hong kong

The influence of rainfall and thermal stress in accident occurrence for the period 1985 through 1994 in hong kong was investigated. The existence of seasonal variations and weekly cycle was also examined. Daity accident and meteorological data were obtained from the Transport Department and the hong kong Observatory respectively. Utilizing regression analyses and ANOVA, it is discovered that seasonal variation was not important in contributing traffic accidents, and Saturday peak was not ascertained. A non linear relationship between accident occurrence and various rain conditions was found. Accident numbers increased till rain exceeded 50.0 mm. High traffic volume and low speed urban driving in hong kong can be the major cause of traffic accidents on rainy days. The impact of heat stress on accident occurrence was found to be statistically significant.

关键词： traffic accidents rainfall thermal stress clo.