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Crotalaria ferruginea extract attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting MAPK/NF-κB signaling pathways

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Asian Pacific Journal of Tropical Biomedicine 2021年第11期11卷 481-490页

作者： wei Pan Li-Ping Meng Jie Su Zheng-Biao Yang wei-Feng Du Zhi-wei Xu Yun-Xiang Chen Sheng Zhang Feng Xie Cong Xu hong-Zhong Yang wei-hong ge Department of Pharmacology College of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China State Key Laboratory of Safety Evaluation for New Drugs Hangzhou Medical CollegeHangzhou 310013China Department of Surgical Nursing The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China

Objective:To evaluate the anti-inflammatory activity of Crotalaria ferruginea extract(CFE)and its ***:An intratracheal lipopolysaccharide(LPS)instillationinduced acute lung injury(ALI)model was used to study the antiinflammatory activity of CFE in *** LPS-induced shock model was used to analyze the effect of CFE on ***-stimulated RAW264.7 cell model was used to investigate the anti-inflammatory activity of CFE in vitro and the effects on mitogen-activated protein kinase(MAPK)or nuclear factor-κB(NF-κB)signaling ***:CFE administration decreased the number of inflammatory cells,reduced the levels of tumor necrosis factor-α(TNF-α),monocyte chemotactic protein-1(MCP-1),interleukin-6(IL-6),and interferon-γ,and diminished protein content in the bronchoalveolar lavage fluid of *** also reduced lung wet-to-dry weight ratio,myeloperoxidase,and lung tissue pathological *** preadministration improved the survival rate of mice challenged with a lethal dose of *** reduced LPS-activated RAW264.7 cells to produce nitric oxide,TNF-α,MCP-1,and ***,CFE inhibited nuclear translocation and phosphorylation of NF-κB P65,extracellular signal-regulated kinase,c-Jun N-terminal kinases,and P38 ***:CFE exhibits potent anti-inflammatory activity in LPS-induced ALI mice,LPS-shock mice,and RAW264.7 cells,and its mechanism may be associated with the inhibition of NF-κB and MAPK signaling *** ferruginea may be a useful therapeutic drug for the treatment of ALI and other respiratory inflammations.

关键词： Crotalaria ferruginea Acute lung injury Cytokine Lipopolysaccharide Nuclear factor-κB Mitogen-activated protein kinase

Intensive vs non-intensive statin pretreatment before percutaneous coronary intervention in Chinese patients:A meta-analysis of randomized controlled trials

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World Journal of Clinical Cases 2022年第5期10卷 1557-1571页

作者： Xian Yang Xi Lan Xin-Lin Zhang Zhong-Lin Han Si-Min Yan Wen-Xiao Wang Biao Xu wei-hong ge Department of Pharmacy Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Pharmacy Nanjing Medical Center for Clinical PharmacyNanjing 210000Jiangsu ProvinceChina Department of Cardiology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Pharmacy The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND The results of intensive statin pretreatment before percutaneous coronary intervention(PCI)is inconsistent between Chinese and Western populations,and there are no corresponding meta-analyses involving hard clinical endpoints in the available published *** To evaluate the efficacy and safety of high-dose statin loading before PCI in Chinese patients through a *** Relevant studies were identified by searching the electronic databases of PubMed,Embase and Cochrane’s Library to December *** outcomes included an assessment of major adverse cardiovascular event(MACE),non-fatal myocardial infarction(MI),cardiac death,target vessel revascularization(TVR),myalgia/myasthenia and abnormal alanine aminotransferase(ALT)in all enrolled *** effect model and fixed effect model were applied to combine the data,which were further analyzed byχ2 test and I2 *** main outcomes were then analyzed through the use of relative risks(RR)and its 95%confidence interval(95%CI).RESULTS Eleven studies involving 3123 individuals were *** with patients receiving placebo or no statin treatment before surgery,intensive statin treatment was associated with a clear reduction of risk of MACE(RR=0.44,95%CI:0.31-0.61,Pgery,no advantage to intensive statin treatment was seen(RR=1.04,95%CI:0.82-1.31,P=0.74).In addition,no significant difference was observed between intensive statin therapy and non-intensive statin therapy on the incidence of TVR(RR=0.43,95%CI:0.18-1.02,P=0.06),myalgia/myasthenia(RR=1.35,95%CI:0.30-5.95,P=0.69)and abnormal alanine aminotransferase(RR=1.47,95%CI:0.54-4.02,P=0.45)except non-fatal MI(RR=0.54,95%CI:0.33-0.88,P=0.01).CONCLUSION Compared with placebo or no statin pretreatment,intensive statin before PCI displayed reduced incidence of ***,there was no significant benefit between high and moderate-intensity sta

关键词： Intensive Non-intensive Statin Percutaneous coronary intervention Chinese Meta-analysis

Existence of Positive Solutions for Boundary Value Problems on the Semi-infinite Interval

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Chinese Quarterly Journal of Mathematics 2005年第4期20卷 380-384页

作者： NI Xiao-hong ge wei-gao Department of Mathematics Huzhou Teacher＇s College Huzhou 313000 China

In this paper, the authors study the existence of positive solution of the following BVP {1/p（t）（P（t）x′）′＋f（t,x（t）,p（t）x′（t））=0,o〈t〈＋∞ αx（0）-βlimt→0p（t）x′（t）=0,γ limt→＋∞x（t）＋δlimt→＋∞p（t）x′（t）=0 on the semi-infinite interval. By considering characterization of the nonlinearity, they obtain some new existence results.

关键词： Sturm-Liouville boundary value problem positive solution fixed point

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天津市大学生形态发育现状调查与分析

天津体育学院学报 2000年第2期15卷 39-41页

作者：安红葛惟倬黄波天津外国语学院体育部天津300204

对天津市 19～ 2 2岁城市汉族大学生的坐高、身高、体重、胸围、肩宽、骨盆宽 6项身体形态指标进行现场抽样测试 ,对身体形态现状、性别特征、年龄特征和形态发育 6项派生指标进行综合分析研究。研究表明 ,天津市大学生形态发育具有显... 详细信息

对天津市 19～ 2 2岁城市汉族大学生的坐高、身高、体重、胸围、肩宽、骨盆宽 6项身体形态指标进行现场抽样测试 ,对身体形态现状、性别特征、年龄特征和形态发育 6项派生指标进行综合分析研究。研究表明 ,天津市大学生形态发育具有显著的性别差异 ;其形态发育基本稳定 ,各年龄组之间无显著性差异。

关键词：天津市大学生形态发育现状调查

固体催化剂下生物油模型化合物的催化加氢研究

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可再生能源 2010年第1期28卷 52-55,62页

作者：魏宏鸽仲兆平李睿靳立维东南大学能源与环境学院江苏南京210096

采用生物油模型化合物可以简化因生物油成分复杂而给加氢研究带来的困难。配制合理的生物油模型化合物,采用2种固体催化剂CoMo/TiO2和NiMo/TiO2,研究了加氢温度(100～300℃)、氢气压力(0.5～2.5MPa)、反应时间(1～4 h)和催化剂类型对不... 详细信息

采用生物油模型化合物可以简化因生物油成分复杂而给加氢研究带来的困难。配制合理的生物油模型化合物,采用2种固体催化剂CoMo/TiO2和NiMo/TiO2,研究了加氢温度(100～300℃)、氢气压力(0.5～2.5MPa)、反应时间(1～4 h)和催化剂类型对不同组分模型化合物加氢过程的影响,得出试验中模型化合物的最佳加氢工况:反应温度为250℃,冷氢气压力为1.5 MPa,反应时间为2 h。NiMo/TiO2的催化活性略高于CoMo/TiO2。

关键词：生物油模型化合物催化加氢 NiMo/TiO2 CoMo/TiO2

燃煤电厂CO_2捕集压缩系统与蒸汽循环的整合分析

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华东电力 2010年第9期38卷 1448-1452页

作者：梁海文魏宏鸽孟凡垟东南大学能源与环境学院南京210096 华电电力科学研究院杭州330010

以质量分数为30%的一乙醇胺(MEA)为吸收液,借助流程模拟软件将醇胺法CO2捕集压缩系统与燃煤电厂蒸汽循环进行了整合分析。以典型600MW超临界机组为研究对象进行了仿真计算,评估了脱碳系统对机组经济性的影响,并对贫液中CO2负荷率、CO2... 详细信息

以质量分数为30%的一乙醇胺(MEA)为吸收液,借助流程模拟软件将醇胺法CO2捕集压缩系统与燃煤电厂蒸汽循环进行了整合分析。以典型600MW超临界机组为研究对象进行了仿真计算,评估了脱碳系统对机组经济性的影响,并对贫液中CO2负荷率、CO2捕获率、再生塔压力、抽汽位置等重要过程参数进行了优化,给出了优化的参数。仿真结果显示,在THA工况、CO2捕获率为90%时,分别采用0.97MPa和0.29MPa的低压蒸汽抽汽提供再生热时,机组发电效率分别下降了12.17%、11.19%,捕集压缩CO2能耗为423.86kWh/t、389.68kWh/t。

关键词：燃煤电厂 CO2捕集蒸汽循环整合流程模拟

DecMamba:Mamba Utilizing Series Decomposition for Multivariate Time Series Forecasting

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Computers, Materials & Continua 2025年第1期82卷 1049-1068页

作者： Jianxin Feng Jianhao Zhang ge Cao Zhiguo Liu Yuanming Ding Communication and Network Key Laboratory Dalian UniversityDalian116622China

Multivariate time series forecasting iswidely used in traffic planning,weather forecasting,and energy *** decomposition algorithms can help models better understand the underlying patterns of the original series to improve the forecasting accuracy of multivariate time ***,the decomposition kernel of previous decomposition-based models is fixed,and these models have not considered the differences in frequency fluctuations between *** problems make it difficult to analyze the intricate temporal variations of real-world time *** this paper,we propose a series decomposition-based Mamba model,DecMamba,to obtain the intricate temporal dependencies and the dependencies among different variables of multivariate time series.A variable-level adaptive kernel combination search module is designed to interact with information on different trends and periods between *** backbone structures are proposed to emphasize the differences in frequency fluctuations of seasonal and trend *** with superior performance is used instead of a Transformer in backbone structures to capture the dependencies among different variables.A new embedding block is designed to capture the temporal features better,especially for the high-frequency seasonal component whose semantic information is difficult to acquire.A gating mechanism is introduced to the decoder in the seasonal backbone to improve the prediction accuracy.A comparison with ten state-of-the-art models on seven real-world datasets demonstrates that DecMamba can better model the temporal dependencies and the dependencies among different variables,guaranteeing better prediction performance for multivariate time series.

关键词： Data prediction time series Mamba series decomposition