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Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress

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Neural Regeneration Research 2019年第10期14卷 1734-1742页

作者： Yun-Kai Xie Xin Zhou hong-tao yuan Jie Qiu Dan-Qing Xin Xi-Li Chu Da-Chuan Wang Zhen Wang Department of Physiology School of Basic Medical SciencesShandong UniversityJinanShandong ProvinceChina Department of Spinal Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandong ProvinceChina

Previous studies have shown that resveratrol,a bioactive substance found in many plants,can reduce early brain injury after subarachnoid hemorrhage,but how it acts is still *** study explored the mechanism using the experimental subarachnoid hemorrhage rat model established by injecting autologous blood into the cerebellomedullary *** models were treated with an intraperitoneal injection of 60 mg/kg resveratrol 2,6,24 and 46 hours after *** 48 hours after injury,their neurological function was assessed using a modified Garcia *** edema was measured by the wet-dry *** apoptosis in the prefrontal cortex was detected by terminal deoxyribonucleotidyl transferase-mediated biotin-16-dUTP nick-end labeling *** of reactive oxygen species and malondialdehyde in the prefrontal cortex were determined by ***,glucose-regulated protein 78,nuclear factor-erythroid2-related factor 2 and heme oxygenase-1 mRNA expression levels in the prefrontal cortex were measured by reverse transcription polymerase chain *** necrosis factor-alpha content in the prefrontal cortex was detected by enzyme linked immunosorbent *** staining was used to detect the number of positive cells of nuclear factor-erythroid 2-related factor 2,heme oxygenase 1,glucose-regulated protein 78,CHOP and glial fibrillary acidic *** blot assay was utilized to analyze the expression levels of nuclear factor-erythroid 2-related factor 2,heme oxygenase 1,glucose-regulated protein 78 and CHOP protein expression levels in the prefrontal *** results showed that resveratrol treatment markedly alleviated neurological deficits and brain edema in experimental subarachnoid hemorrhage rats,and reduced neuronal apoptosis in the prefrontal *** reduced the levels of reactive oxygen species and malondialdehyde,and increased the expression of nuclear factor-erythroid 2-related factor 2,heme oxygenase-1 mRNA

关键词： nerve regeneration resveratrol oxidative stress endoplasmic reticulum stress neuroinflammation subarachnoid hemorrhage nuclear factor-erythroid 2-related factor 2 heme oxygenase-1 glucose-regulated protein 78 neural regeneration

Sono-photocatalytic amination of quinoxalin-2(1H)-ones with aliphatic amines

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Chinese Chemical Letters 2024年第10期35卷 269-272页

作者： Wen-tao Ouyang Jun Jiang Yan-Fang Jiang Ting Li yuan-yuan Liu hong-tao Ji Li-Juan Ou Wei-Min He School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China School of Materials Science and Engineering Hunan Institute of TechnologyHengyang 421002China National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass Nanjing Forestry UniversityNanjing 210037China

The first example of sono-photocatalytic bond formation was *** both visible light and ultrasound wave as the energy,various 3-aminoquinoxalin-2(1H)-ones were efficiently obtained with good functional group tolerance in the absence of any additive or external *** with the conventional photocatalysis,sono-photocatalysis not only dramatically improved the reaction rates and yields,but also reduced energy consumption.

关键词： Sono-photocatalysis External photocatalyst-free Quinoxalin-2(1H)-ones Amination Aliphatic amines

Dynamic plugging regulating strategy of pipeline robot based on reinforcement learning

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Petroleum Science 2024年第1期21卷 597-608页

作者： Xing-yuan Miao hong Zhao College of Mechanical and Transportation Engineering China University of PetroleumBeijing102249China

Pipeline isolation plugging robot (PIPR) is an important tool in pipeline maintenance operation. During the plugging process, the violent vibration will occur by the flow field, which can cause serious damage to the pipeline and PIPR. In this paper, we propose a dynamic regulating strategy to reduce the plugging-induced vibration by regulating the spoiler angle and plugging velocity. Firstly, the dynamic plugging simulation and experiment are performed to study the flow field changes during dynamic plugging. And the pressure difference is proposed to evaluate the degree of flow field vibration. Secondly, the mathematical models of pressure difference with plugging states and spoiler angles are established based on the extreme learning machine (ELM) optimized by improved sparrow search algorithm (ISSA). Finally, a modified Q-learning algorithm based on simulated annealing is applied to determine the optimal strategy for the spoiler angle and plugging velocity in real time. The results show that the proposed method can reduce the plugging-induced vibration by 19.9% and 32.7% on average, compared with single-regulating methods. This study can effectively ensure the stability of the plugging process.

关键词： Pipeline isolation plugging robot Plugging-induced vibration Dynamic regulating strategy Extreme learning machine Improved sparrow search algorithm Modified Q-learning algorithm

Motor cortical circuit adaptations in parkinsonism

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Neural Regeneration Research 2024年第10期19卷 2107-2108页

作者： hong-yuan Chu Department of Neurodegenerative Science Van Andel Research InstituteGrand RapidsMIUSA Aligning Science Across Parkinson’s(ASAP)Collaborative Research Network

Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of parki... 详细信息

关键词： parkin impairment rigidity

Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage

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Neural Regeneration Research 2020年第10期15卷 1920-1930页

作者： Ye Xiong Dan-Qing Xin Quan Hu Ling-Xiao Wang Jie Qiu hong-tao yuan Xi-Li Chu De-Xiang Liu Gang Li Zhen Wang Department of Physiology School of Basic Medical SciencesShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong University and Brain Science Research InstituteShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Taian Central HospitalTaianShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesShandong UniversityJinanShandong ProvinceChina

Hydrogen sulfide,which can be generated in the central nervous system from the sulfhydryl-containing amino acid,L-cysteine,by cystathionine-β-synthase,may exert protective effects in experimental subarachnoid hemorrhage;however,the mechanism underlying this effect is *** study explored the mechanism using a subarachnoid hemorrhage rat model induced by an endovascular perforation *** were treated with an intraperitoneal injection of 100 mM L-cysteine(30μL)30 minutes after subarachnoid *** 48 hours after subarachnoid hemorrhage,hematoxylin-eosin staining was used to detect changes in prefrontal cortex cells.L-cysteine significantly reduced cell *** function was assessed using a modified Garcia *** water content was measured by the wet-dry method.L-cysteine significantly reduced neurological deficits and cerebral edema after subarachnoid *** was used to detect the number of activated *** transcription-polymerase chain reaction(RT-PCR)was used to detect the levels of interleukin 1β and CD86 mRNA in the prefrontal cortex.L-cysteine inhibited microglial activation in the prefrontal cortex and reduced the mRNA levels of interleukin 1βand ***-PCR and western blot analysis of the complement system showed that L-cysteine reduced expression of the complement factors,C1q,C3αand its receptor C3aR1,and the deposition of C1q in the prefrontal *** staining was applied to detect changes in reactive oxygen species,and immunohistochemistry was used to detect the number of NRF2-and HO-1-positive cells.L-cysteine reduced the level of reactive oxygen species in the prefrontal cortex and the number of NRF2-and HO-1-positive *** blot assays and immunohistochemistry were used to detect the protein levels of CHOP and GRP78 in the prefrontal cortex and the number of CHOP-and GRP78-positive cells.L-cysteine reduced CHOP and GRP78 levels and the number of CHOP-and GRP78-

关键词： aminooxyacetic acid central nervous system complement deposition cystathionine-β-synthase early brain injury endoplasmic reticulum stress hydrogen sulfide neuroinflammation oxidative stress subarachnoid hemorrhage

The Investigation of Data Voting Algorithm for Train Air-Braking System Based on Multi-Classification SVM and ANFIS

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Chinese Journal of Electronics 2024年第1期33卷 274-281页

作者： Juhan WANG Ying GAO yuan CAO tao TANG School of Electronics and Information Engineering Beijing Jiaotong University Graduate Department China Academy of Railway Science National Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong University

The pressure data of the train air braking system is of great significance to accurately evaluate its operation state. In order to overcome the influence of sensor fault on the pressure data of train air braking system, it is necessary to design a set of sensor fault-tolerant voting mechanism to ensure that in the case of a pressure sensor fault, the system can accurately identify and locate the position of the faulty sensor, and estimate the fault data according to other normal data. A fault-tolerant mechanism based on multi-classification support vector machine(SVM) and adaptive network-based fuzzy inference system(ANFIS) is introduced. Multi-classification SVM is used to identify and locate the system fault state, and ANFIS is used to estimate the real data of the fault sensor. After estimation, the system will compare the real data of the fault sensor with the ANFIS estimated data. If it is similar,the system will recognize that there is a false alarm and record it. Then the paper tests the whole mechanism based on the real data. The test shows that the system can identify the fault samples and reduce the occurrence of false alarms.

关键词： Support vector machines Fault diagnosis Pressure sensors Fuzzy logic Fault tolerance Adaptive systems Fault tolerant systems

The Uptake and Distribution Evidence of Nano-and Microplastics in vivo after a Single High Dose of Oral Exposure

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Biomedical and Environmental Sciences 2024年第1期37卷 31-41页

作者： hong tao SUN Wei DENG yuan LYU Jian Da JIN Cui hong BAI Ying Long NA Jun ZHANG Rui GAO yuan PAN Guo Wei YANG Zuo Sen YAN Ling Jun Research Center for Universal Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Pain Management Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Maternal and Child Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Institute of Preventive Medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina

Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in *** Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after *** was performed to corroborate these *** In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(P<0.05).In the 3μm group,the FI only increased in the lung at 2 h(P<0.05).In the 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(P<0.05).The presence of nano-/microplastics in tissues was further verified by *** peak time of nanoplastic absorption in blood was *** Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.

关键词： Microplastics Nanoplastics IVIS Spectrum small-animal imaging system Tissue distribution Blood

yuan Huiqin: Master of Peking Opera

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China News Release 2024年第3期 23-25页

作者： tao hong 不详

Peking Opera,a traditional Chinese art form originating in Beijing with a history spanning some 200 years,holds a unique position due to its early association with the imperial *** its significance,the United Nations Educational,Scientific and Cultural Organization approved the inclusion of Peking Opera on its Representative List of the Intangible Cultural Heritage of Humanity on November 16,2010.

关键词： Opera holds Peking

Wettability and corrosion behavior between alkaline slag from sodium smelting of vanadium-titanium magnetite and refractory substrates

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Journal of Iron and Steel Research International 2024年第6期31卷 1399-1410页

作者： Fei Zhao Zhi-wei Bian hong-xin Zhao De-sheng Chen Zhang-fu yuan Yu-lan Zhen Li-na Wang tao Qi Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China National Engineering Research Center of Green Recycling for Strategic Metal Resources Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Hebei Zhongke Tongchuang Vanadium&Titanium Technology Co. Ltd.Hengshui 053000HeheiChina

The sodium smelting of vanadium-titanium magnetite can achieve the comprehensive utilization of Fe,V,and ***,the generation of alkaline slag during this process may cause damage to refractory *** wettability and corrosion behavior of alkaline slag on three types of refractory(MgO-C,SiC,and high alumina refractory)substrates were investigated at temperatures up to 1200℃.The effects of duration on the wettability of molten slag on SiC substrates were also *** showed that the high alumina refractory exhibited better wettability with the molten slag than the others,and thus,it is easier to be *** results of scanning electron microscopy coupled with energy dispersive spectroscopy showed that MgO-C and high alumina refractory substrates were severely *** was a visible and regular interfacial reaction layer between the slag and SiC refractory substrate,which was produced by the redox reaction between the metal oxides in the slag and the SiC refractory *** the increase in holding time,the interface layer expands and silico-ferrite phases are generated at the *** redox reaction between Fe_(2)O_(3) and SiC substrate is the main reason for the *** comparing the differences in wettability and corrosion behavior between the alkaline slag from sodium smelting of vanadium-titanium magnetite and MgO-C,SiC and high alumina refractories,it is concluded that SiC refractory has good corrosion resistance to the *** oxides in the slag accelerate the oxidation rate of SiC refractory.

关键词： Wettability Corrosion Alkaline slag-Contact angle Vanadium-titanium magnetite Refractory