检索结果-南通市图书馆

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1073-1078页

作者： Chu-Yuan Lou Yong Wang Jia-Yuan Xing Teng Ma Lei tao Xiao-tang Wang Run-Sheng Wang Neuroophthalmic Center Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004Shaanxi ProvinceChina

AIM:To investigate the short-term efficacy and safety of inebilizumab for neuromyelitis optica spectrum disorders(NMOSD).METHODS:A total of 33 patients with NMOSD treated with inebilizumab(Group INB,n=15)or rituximab(Group RTX,n=18)in addition to high-dose glucocorticoids were *** groups underwent hormone shock therapy during the acute ***,Group INB received inebilizumab injections during the remission phase,while Group RTX received rituximab injections.A comparison of aquaporins 4(AQP4)titer values,peripheral blood B lymphocyte counts,and visual function recovery was conducted before and 8wk after ***,adverse reactions and patient tolerability were analyzed after using inebilizumab treatment ***:Following inebilizumab treatment,there was a significantly improvement in the visual acuity of NMOSD patients(P0.05).Furthermore,inebilizumab exhibited higher safety levels than that of rituximab ***:The combination of inebilizumab and high-dose glucocorticoids proves to be *** comparison to rituximab injections,inebilizumab displays better tolerance and ***,it demonstrates a partial effect in preventing optic nerve ***,it stands as an effective method to reduce the disability rates and improve the daily living ability of patients with NMOSD.

关键词： neuromyelitis optica spectrum disorders inebilizumab rituximab glucocorticoids

Fully endoscopic far-lateral supracerebellar infratentorial approach for trigeminal neuralgia: illustrative case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华神经外科杂志(英文) 2024年第2期10卷 1-5页

作者： Yao hong Yang Wenlei tang Hao Cheng Yijun Lin Shaojian Wu Zhe Bao Department of Neurosurgery Center of Pituitary Tumor Ruijin Hospital Shanghai Jiao Tong University School of Medicine# Ruijin Er Road Shanghai China

Background Trigeminal neuralgia (TN) is a common cause of craniofacial pain. The retrosigmoid approach is usually used to treat TN, but no cases of endoscopic far-lateral supracerebellar infratentorial approach (EF-SCITA) were used to undergo operation for *** presentation Two patients were presented with severe facial pain and preliminary diagnosis was TN. Preoperative magnetic resonance imaging revealed that a superior cerebellar artery (SCA) compressed the trigeminal nerve in case 1, and a tumor located in the petrous apex extending into the Meckel’s cave compressed the trigeminal nerve in case 2. Operations were achieved through the EF-SCITA. The pain was totally relieved with no postsurgical complications in both *** We present the first two case reports of EF-SCITA to relieve classical and secondary TN successfully. The EF-SCITA can be a promising approach for treating TN.

关键词： Approach Endoscopic surgery Trigeminal neuralgia

LSM6 promotes cell proliferation and migration regulated by HMGB1 in laryngeal squamous cell carcinoma

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Engineered Regeneration 2024年第2期5卷 247-254页

作者： Dengbin Ma Jiayi Li Hui Li Yao tang Xia Gao hong Chen Xiaoyun Qian Xiaohui Shen Department of Otolaryngology Head and Neck Surgery Research Institute of OtolaryngologyNanjing Drum Tower HospitalJiangsu Provincial Key Medical DisciplineAffiliated Hospital of medical SchoolNanjing UniversityNanjing210008China Department of Otorhinolaryngology Minda Hospital of Hubei Minzu UniversityEnshi445000China Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University 321 Zhongshan RoadNanjing210008China

Elevated levels of high mobility group protein B1(HMGB1)play a significant role in the pathogenesis of many diseases,but is particularly important for the formation of malignant ***,the function of HMGB1 and the underlying mechanism of laryngeal squamous cell carcinoma(LSCC)remain incompletely understood,causing *** we found immunohistochemistry from 97 LSCC tissues showed HMGB1 was upreg-ulated,which was associated with poor ***1 knockdown could significantly inhibit wound closure and colony *** full-genome gene expression microarray was performed to investigate the *** knockdown of HMGB1 by siRNA,among the expressed differential genes,10 genes were ran-domly selected for ***,shRNA lentivirus targeting these genes were constructed to explore their role in LSCC by cell proliferation ***6 downregulation was dramatically promoted by HMGB1 knockdown,resulting in higher expression in LSCC ***,downregulation of LSM6 could significantly suppress cell proliferation,migration and colony *** study indicated that HMGB1 promoted LSCC cell malig-nant phenotypes through regulation of *** anticipate that HMGB1-LSM6 could be a putative therapeutic target for LSCC.

关键词： HMGB1 LSM6 Laryngeal squamous cell carcinoma Cell proliferation Migration

Basic Survey Scheduling for the Wide Field Survey Telescope(WFST)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第1期24卷 59-69页

作者： Yan-Peng Chen Ji-An Jiang Wen-tao Luo Xian-Zhong Zheng Min Fang Chao Yang Yuan-Yu hong Zong-Fei Lü Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Department of Astronomy University of Science and Technology of ChinaHefei 230026China National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230026China

Aiming at improving the survey efficiency of the Wide Field Survey Telescope, we have developed a basic scheduling strategy that takes into account the telescope characteristics, observing conditions, and weather conditions at the Lenghu site. The sky area is divided into rectangular regions, referred to as “tiles,” with a size of2°. 577 × 2°. 634 slightly smaller than the focal area of the mosaic CCDs. These tiles are continuously filled in annulars parallel to the equator. The brightness of the sky background, which varies with the moon phase and distance from the moon, plays a significant role in determining the accessible survey fields. Approximately 50connected tiles are grouped into one block for observation. To optimize the survey schedule, we perform simulations by taking into account the length of exposures, data readout, telescope slewing, and all relevant observing conditions. We utilize the Greedy Algorithm for scheduling optimization. Additionally, we propose a dedicated dithering pattern to cover the gaps between CCDs and the four corners of the mosaic CCD array, which are located outside of the 3° field of view. This dithering pattern helps to achieve relatively uniform exposure maps for the final survey outputs.

关键词： telescopes surveys Moon

Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第4期45卷 833-844页

作者： Ying Liu Lin Yang hong-Yong Xiang Ming Niu Jia-Cheng Deng Xue-Yuan Li Wen-Jie Hao hong-Sheng Ou-Yang Tong-Yu Liu Xiao-Chun tang Da-Xin Pang hong-Ming Yuan State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Animal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin 130062China Chifeng Best Genetics Technology Co. Ltd.ChifengNei Mongol 024000China Chongqing Jitang Biotechnology Research Institute Co. Ltd.Chongqing 400015China

Porcine reproductive and respiratory syndrome(PRRS)is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus(PRRSV),resulting in substantial economic losses in the swine *** the CD163 SRCR5 domain,either through deletion or substitution,can eff1ectively confer resistance to PRRSV infection in ***,large fragment modifications in pigs inevitably raise concerns about potential adverse effects on growth *** the impact of genetic modifications on normal physiological functions is a promising direction for developing PRRSV-resistant *** the current study,we identified a specific functional amino acid in CD163 that influences PRRSV *** infection experiments conducted on Marc145 and PK-15CD163 cells illustrated that the mE535G or corresponding pE529G mutations markedly inhibited highly pathogenic PRRSV(HP-PRRSV)proliferation by preventing viral binding and ***,individual viral challenge tests revealed that pigs with the E529G mutation had viral loads two orders of magnitude lower than wild-type(WT)pigs,confirming effective resistance to *** of the physiological indicators and scavenger function of CD163 verified no significant differences between the WT and E529G *** findings suggest that E529G pigs can be used for breeding PRRSV-resistant pigs,providing novel insights into controlling future PRRSV outbreaks.

关键词： PRRSV CD163 Point mutation E529G Pigs

Building and sharing medical cohorts for research

在线全文

学校读者我要写书评

暂无评论

The Innovation 2024年第3期5卷 23-24页

作者： Guo-Bo Chen Siyang Liu Lei Zhang tao Huang Xiaohua tang Yixue Li Changqing Zeng Department of Genetic and Genomic Medicine Zhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315000China School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518017China China National GeneBank Shenzhen 518116China Shanghai Institute of Nutrition and Health Chinese Academy of SciencesShanghai 200031China Wenzhou Central Hospital Dingli Clinical Medical School of Wenzhou Medical UniversityWenzhou 325000China Guangzhou Laboratory Guangzhou 510320China Henan Academy of Sciences Zhengzhou 450046China

Cohort studies are costly and time *** require not only laboratory equipment and assays but also collaboration from participants and health *** to cost constraints,they are often confined to a specific ***,they play a crucial role in providing fundamental insights for medical advancements,shedding light on the origins of diseases,and acting in socioeconomic influence in policy making.

关键词： consuming constraints insight

Thickness dependence of superconductivity in layered GeP_(5)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第3期43卷 1323-1328页

作者： Lin Wu Ke-Meng Yang Wei Gan Rui-Chun Xiao Ya-Jie Dai Xi tang hong Lin Hui Han Hui Li Information Materials and Intelligent Sensing Laboratory of Anhui Province Institute of Physical Science and Information TechnologyAnhui UniversityHefei230601China

Understanding the relationship between dimensionality and superconductivity has attracted substantial research *** this work,we report the effective modulation of superconductivity in GeP_(5)through *** superconducting phase transition temperature improves by~10%as the thickness of GeP_(5)decreases from bulk to~96 nm,behaving as a unique negative relationship between the superconducting phase transition temperatureand thickness.

关键词： superconductivity dimensionality

A repertoire of intronic lariat RNAs reveals tissue-specific regulation and target mimicry potential in plants

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第6期67卷 1280-1291页

作者： Yong Zhang Xiaotuo Zhang Qi tang Lei Li Ting Jiang Yixiao Fang hong Zhang Jixian Zhai Guodong Ren Binglian Zheng State Key Laboratory of Genetic Engineering Institute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China Department of Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China

Lariat RNA is concomitantly produced by excised intron during RNA splicing,which is usually debranched by DBR1,an RNA debranching ***,increasing evidence showed that some lariat RNA could escape *** is known about how and why these lariat RNAs could be *** comparing the atlas of lariat RNAs between the non-dividing cell(mature pollen)and three actively dividing tissues(young shoot apex,young seeds,and young roots),we identified hundreds to thousands of lariat RNA naturally retained in each tissue,and the incidence of lariat RNA retention is much less in shoot apex while much more in *** lariat RNAs derived from the same intron or different lariat RNAs from the same pre-m RNA could be retained in one tissue while degraded in the other *** deciphering lariat RNA sequences,we identified an AG-rich(RAAAAVAAAR)motif and a UC-rich(UCUCUYUCUC)motif for pollen-specific and the other three tissues-retained lariat RNAs,*** of the pollen-specific AG-rich motif indeed enhanced lariat RNA retention in ***,hundreds of lariat RNAs harbored mi RNA binding sites,and dual-luciferase reporter assay showed that these natural lariat RNAs had the potential to protect expression of mi RNA target ***,our results uncover that selective retention of lariat RNA is an actively regulatory process,and provide new insights into understanding how lariat RNA metabolism may impact mi RNA activity.

关键词： intron turnover lariat RNA miRNA RNA splicing DBR1

An economic way to achieve all-weather CO2 reduction

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第3期11卷 46-47页

作者： Junwang tang Department of Chemical Engineering University College London

Utilising solar power to convert carbon dioxide（CO2） into hydrocarbon fuels presents an eco-friendly method to address dependence on fossil fuels and contribute to a net-zero CO2emission goal[1,2].

关键词：

UAV-assisted data collection for wireless sensor networks with dynamic working modes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第3期10卷 805-812页

作者： Jie Chen Jianhua tang Shien-Ming Wu School of Intelligent Engineering South China University of TechnologyGuangzhou511442China

Wireless Sensor Network(WSN)is a cornerstone of Internet of Things(IoT)and has rich application *** this work,we consider a heterogeneous WSN whose sensor nodes have a diversity in their Residual Energy(RE).In this work,to protect the sensor nodes with low RE,we investigate dynamic working modes for sensor nodes which are determined by their RE and an introduced energy ***,we employ an Unmanned Aerial Vehicle(UAV)to collect the stored data from the heterogeneous *** aim to jointly optimize the cluster head selection,energy threshold and sensor nodes’working mode to minimize the weighted sum of energy con-sumption from the WSN and UAV,subject to the data collection rate *** this end,we propose an efficient search method to search for an optimal energy threshold,and develop a penalty-based successive convex approximation algorithm to select the cluster *** we present a low-complexity iterative approach to solve the joint optimization problem and discuss the implementation *** results justify that our proposed approach is able to reduce the energy consumption of the sensor nodes with low RE significantly and also saves energy for the whole WSN.

关键词： Unmanned aerial vehicle Wireless sensor networks Cluster heads Dynamic working modes