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Mechanisms Underlying the Antifatigue Effects of the Mycelium Extract of Cordyceps(Paecilomyces hepiali, CBG-CS-2) in Mice in the Forced Swimming Test

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Food and Nutrition Sciences 2015年第2期6卷 287-298页

作者： Soo-Wan Chae Fusako Mitsunaga Su-Jin Jung Ki-Chan Ha hong-sig sin Seung-Hwan Jang Shin Nakamura Department of Pharmacology Chonbuk National University Medical School Jeonju-si Republic of Korea Clinical Trial Center for Functional Foods (CTCF2) Chonbuk National University Hospital Jeonju-si Republic of Korea Intelligence and Technology Lab Inc. Kaizu Japan NPO Primate Agora Inuyama Japan Healthcare Claims & Management Inc. Jeonju-si Republic of Korea Chebigen Inc. Jeonju-si Republic of Korea

Cordyceps (CS) is used as an alternative medicine and functional food. We examined in vivo mechanisms underlying the antifatigue effects of the cultured mycelium extract of CS (CS extract) in forced swimming mice, a fatigue model that is induced by muscle exercise. Animals orally administered with CS extract significantly extended the loaded forced-swimming time, indicating its antifatigue effects. CS extract modulated the increased levels of blood IL-6 that was induced by forced swimming. CS extract protected the forced swimming-induced increase in NKp46 expression of splenic NK cells, suggesting regulation of fatigue-elicited hyper-reactivity by activated NK cells. By DNA microarray analysis of the quadriceps femoris muscle, it was uncovered that CS extract prevented the forced swimming-mediated upregulation of the expression of 5 genes associating with muscular inflammation (Ccl6, Ccl8, and Wfdc17) and muscle regeneration (Sfrp4 and Nfil3), whereas it regulated the downregulation in the expression of Svs5 participating in actin binding. CS extract exhibits the antifatigue effects through preventing IL-6 accumulation in blood, regulating NK cell activation in the spleen, and alleviating altered expression of genes related to inflammation, regeneration, and actin binding in the local muscle. Thus, CS extract is an effective functional food for preventing fatigue.

关键词： DNA Microarray IL-6 NK Cell Activation Muscle Inflammation

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Nutrigenomic Study on Immunomodulatory Function of CordycepsMycelium Extract (Paecilomyces hepiali) in Mitomycin C–Treated Mice

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Food and Nutrition Sciences 2014年第22期5卷 2217-2224页

作者： Soo-Wan Chae Fusako Mitsunaga Su-Jin Jung Ki-Chan Ha hong-sig sin Seung-Hwan Jang Shin Nakamura Department of Pharmacology Chonbuk National University Medical School Jeonju Republic of Korea Clinical Trial Center for Functional Foods (CTCF2) Chonbuk National University Hospital Jeonju Republic of Korea Intelligence and Technology Lab Inc. Kaizu Japan NPO Primate Agora Inuyama Japan Healthcare Claims & Management Inc. Jeonju Republic of Korea Chebigen Inc. Jeonju Republic of Korea

Cordyceps (CS) is a Chinese herb that produces various effects including immune modulation, and now CS culture product is interested in the use as a functional food. We prepared CS mycelium culture extract (Paecilomyces hepiali, CBG-CS-2), CS extract, for functional foods. This study aimed to deduce the molecular mechanism of immunomodulatory effect of CS extract in Peyer’s patches (PPs), a main gut immune site, in mice that treated with mitomycin C (MMC), an immunosuppressing antibiotics. Nutrigenomics give us invaluable molecular information about both of foods and nutrition to improve or maintain good health. Here we performed nutrigenomics using DNA microarray to investigate the effect of CS extract on gene expression altered in PPs of the immunosuppressed mice. Interestingly, CS extract protected from the MMC-mediated downregulation of 22 genes, which are associated with IgA production and other immune response in PPs. These suggested that CS extract alleviated the downregulated expression of immune related genes in the gut immune site in an immunosuppressed state. Thus CS extract appears to be practical functional food for immunodepression and/or its related hypofunction.

关键词： DNA Microarray Functional Food Gene Expression Immunosuppression

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Extremely low-frequency magnetic field exposure level for Koreans by occupational code

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Emerging Contaminants 2018年第1期4卷 40-46页

作者： Joon sig Jung Mailan Arachchige Don Rajitha Kawshalya In Keun Shim Jung Min Ryu Myung Hee Kwon Duck Shin Park Seung Cheol hong National Indoor Environment&Noise Research Division National Institute of Environmental Research42 Hwankyeong-RoSeo-KuIncheonSouth Korea Dept.of Emergency and Disaster Management Inje University197 Inje-roGimhae-siGyungnamSouth Korea Transportation Environment Research Team Korea Railroad Research Institute176 Cheoldobagmulgwan-RoUiwang-siGyeonggi-doSouth Korea Dept.of Occupational Health&Safety Engineering Inje University197 Inje-roGimhae-siGyungnamSouth Korea

This study attempted to identify the level of exposure of 350 subjects to the extremely low-frequency magnetic field(ELF-MF).The occupational group showed significantly high levels of ELF-MF in every exposure indicator during work and transportation(p<0.05).About 11%and 6%of the members of the occupational group were exposed to over 2mG and 4 mG,respectively,of ELF-MF during"all"*** 24-h ELF-MF exposure levels of the subjects in both groups were *** the occupational group,for every activity,the percentile for less than 2mG corresponded to 100%of C-4(agriculture),95%of C-1(professional),97%of C-2(engineer,office/sales),81%of C-3(services),85%of C-5(technician,labor management),and 50%of C-6(electrician).In the non-occupational group,the percentile for less than 2mG corresponded to 92%of students,83%of homemakers,81%of the elderly,and 88%of the *** percentile for over 4mG was 5%for students,homemakers,and the elderly and 13%of the *** and the unemployed had the highest ELF-MF levels in both groups,*** were exposed to ELF-MF mostly at work,while the unemployed subjects were most affected by the activities classified under sleep and transportation.

关键词： ELF-MF EMF Exposure assessment Occupational code Occupational exposure

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Design of an all-day electrical power generator based on thermoradiative devices

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Science China(Technological Sciences) 2021年第10期64卷 2166-2173页

作者： ZHANG Xin YANG GuoFeng YAN MengQi ANG Lay Kee ANG Yee sin CHEN JinCan School of Science Jiangnan UniversityWuxi 214122China Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Physics Xiamen UniversityXiamen 361005China

Energy harvesting from sun and outer space using thermoradiative devices(TRDs),despite being promising renewable energy sources,is limited only to daytime and nighttime period,*** a system with 24-hour continuous electric power generation remains an open question thus ***,a TRD-based power generator that harvests solar energy via concentrated solar irradiation during daytime and via thermal infrared emission towards the outer space at nighttime is proposed,thus achieving the much sought-after 24-hour electrical power ***,a rigorous thermodynamical model is developed to investigate the all-day performance characteristics,parametric optimum design,and the role of various energy loss *** calculated results predict that the daytime TRD-based system yields a peak efficiency of 12.6%under 10 suns,thus sig-nificantly outperforming the state-of-art record-setting solar thermoelectric *** work reveals the potential of TRD towards 24-hour electricity generation and future renewable energy technology.

关键词： sustainable energy HgCdTe solar energy thermoradiative optimum design

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Highly divergent sympatric lineages of Leptotila verreauxi(Aves:Columbidae)suggest a secondary contact area in the Isthmus of Tehuantepec,Mexico

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Avian Research 2024年第1期15卷 12-21页

作者： Orlando J.Espinosa-Chávez Adolfo G.Navarro-sigüenza Hernando Rodríguez-Correa Luis A.Sánchez-González Museo de Zoología“Alfonso L.Herrera” Depto.de Biología EvolutivaFacultad de CienciasUniversidad Nacional Autonoma de MexicoApdo.Postal 70-399CP 04510Ciudad de MexicoMexico Posgrado en Ciencias Biologicas Unidad de PosgradoEdificio D1◦PisoCircuito de PosgradosCiudad UniversitariaUniversidad Nacional Autonoma de MexicoCoyoacanCP 04510CDMXMexico Escuela Nacional de Estudios Superiores Unidad Morelia Universidad Nacional Autonoma de Mexico.Antigua Carretera a Patzcuaro No.8701 Col.Ex Hacienda de San Jose de la HuertaC.P.58190MoreliaMichoacanMexico

Due to a complex geological and biotic history,the Isthmus of Tehuantepec(IT),has been long recognized as a driver for the evolutionary divergence of numerous lowland and highland *** distributed in the lowlands of the American continent,the White-Tipped Dove(Leptotila verreauxi)is a polytypic species with 13 recognized *** of these have been recorded in Mexico,and the distribution of three abuts at the IT,suggesting a contact *** estimate phylogenetic patterns,divergence times and genetic differentiation,we examined two mt DNA(ND2 and COI)and one n DNA(β-fibint 7)*** also used correlative ecological niche models(ENM)to assess whether ecological differences across the IT may have acted as a biogeographical *** estimated paleodistributions during the Middle Holocene,Last Glacial Maximum and Last Interglacial,to evaluate the influence of climate changes on the distribution and demographic *** results showed genetically distinct lineages that diverged approximately 2.5 million years *** and ecological factors may have played a dual role in promoting differentiation,but also in the formation of a secondary contact zone in the southern *** ecological niche comparisons indicated that the ecological niche of sympatric lineages at the IT are not identical,suggesting niches divergence;in addition,environmental niche models across the region indicated no abrupt biogeographic barriers,but the presence of regions with low *** results suggest that genetic differentiation originated by a vicariant event probably related to environmental factors,favored the evolution of different ecological ***,the absence of a biogeographic barrier but the presence of less suitable areas in the contact regions,suggest that secondary contact zones may be also maintained by climatic factors for the eastern group,but also by biotic interactions for the western group.

关键词： Biogeographical boundary Humid and dry forests Isthmus of Tehuantepec Phylogeography Secondary contact

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Isoform Selective PI3K-beta Inhibitors

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Chinese Journal of Chemistry 2013年第3期31卷 299-303页

作者： hong Lin Regenerative Medicine Discovery Performance Unit GlaxoSmithKline 1250 South Collegeville Road Collegeville PA 19426-0989 U.S.A.

Although PI3K/AKT has undoubtedly been one of the most important pathways that impact tumorigenesis and proliferation, PI3K-beta has not been considered as a stand-alone target for potential cancer treatment until the re-cent discovery of the key role that PI3K-beta plays in phosphatase and TENsin homolog （PTEN）-deficient tumors. Medicinal chemistry efforts from the pharmaceutical industry and academia in the past few years have led to sig-nificant advancements in understanding beta isoform selectivity and in the development of a clinical drug candidate.

关键词： phosphatidylinositol 3-kinase PI3K-beta PTEN-deficient selectivity structure-activity relationship

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sig公司开发出低成本大型塑料瓶生产设备 006

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中国食品安全报

作者：资料来源：sig Blowtec

本报讯：sig Blowtec公司应用高新技术开发出低成本的大型塑料瓶生产设备。大型饮水机，在公共场所、办公室、车间甚至家庭中早已成为普遍的设施。预计到2004年，市场需求量将增加数倍。看准了这个机遇，sig Blowtec公司开发出能生产容...

本报讯：sig Blowtec公司应用高新技术开发出低成本的大型塑料瓶生产设备。大型饮水机，在公共场所、办公室、车间甚至家庭中早已成为普遍的设施。预计到2004年，市场需求量将增加数倍。看准了这个机遇，sig Blowtec公司开发出能生产容积2升的聚碳酸酯（P

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T-2 toxin-induced apoptosis involving Fas,p53,Bcl-xL,Bcl-2,Bax and caspase-3 signaling pathways in human chondrocytes

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 455-463页

作者： Jing-hong CHEN Jun-ling CAO Yong-lie CHU Zhi-lun WANG Zhan-tian YANG hong-lin WANG Ministry of Education Key Laboratory of Environment and Genes related to Diseases Institute of Endemic Diseases School of Medicine Xi ＇an Jiaotong University Xi ＇an 710061 China

Objective:To investigate the effects of T-2 toxin on expressions of Fas,p53,Bcl-xL,Bcl-2,Bax and caspase-3 on human ***:Human chondrocytes were treated with T-2 toxin(1～20 ng/ml)for 5 ***,p53 and other apoptosis-related proteins such as Bax,Bcl-2,Bcl-xL,caspase-3 were determined by Western blot analysis and their mRNA expressions were determined by reverse transcriptase-polymerase chain reaction(RT-PCR).Results:Increases in Fas,p53 and the pro-apoptotic factor Bax protein and mRNA expressions and a decrease of the anti-apoptotic factor Bcl-xL were observed in a dose-dependent manner after exposures to 1～20 ng/ml T-2 toxin,while the expression of the anti-apoptotic factor Bcl-2 was ***,T-2 toxin could also up-regulate the expressions of both pro-caspase-3 and caspase-3 in a dose-dependent ***:These data suggest a possible underlying molecular mechanism for T-2 toxin to induce the apoptosis sig- naling pathway in human chondrocytes by regulation of apoptosis-related proteins.

关键词： Apoptosis Apoptosis-related proteins Chondrocyte T-2 toxin

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Modeling Patch Characteristics of Farmland Loss for Site Assessment in Urban Fringe of Beijing, China

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Chinese Geographical Science 2013年第3期23卷 365-377页

作者： LIU Xiaona ZHANG Weiwei LI hong SUN Danfeng College of Resources and Environmental Sciences China Agricultural University Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Institute of System Comprehensive Development Beijing Academy of Agriculture and Forest Science

Farmland protection and delimitation in the urban fringe considers not only natural factors but also the spatial characters and site factors. Taking Daxing District, Beijing in China as a case study, this paper used landscape ecology and power-law methods to ana- lyze and evaluate farmland loss during the period of 2004~2007 based on the interpretation results of SPOT5 remote sensing images in 2004 and 2007. At the patch level, we selected four landscape indices, namely patch size, shape index, the nearest neighbor distance between farmland and construction land （including residential land and other construction land）, and cropping type, to evaluate the risk of farmland loss and establish a farmland site analysis indicator system. The results showed that patch size and shape index have a sig- nificant positive correlation with farmland loss, whereas the distance to construction land has a clear negative correlation with farmland loss. As regards cropping type, fallow farmland is much easier for non-agriculUlral use than cultivated farmland. The relative transition ratio among vegetable land, fallow farmland and cultivated farmland is 1 ： 5.6 ： 1. The patch size of lost farmland follows a power-law distribution, indicating that not only small parcels but also large parcels can be lost. Patch size less than 4 ha or more than 15 ha is in high loss risk, between 4 ha and 10 ha in medium loss risk, and larger than 10 ha and less than 15 ha in low risk. Farmland with a more regular shape has a higher likelihood of loss. Patch shape index less than 2.0 is in high loss risk, between 2.0 and 3.0 in medium loss risk, and larger than 3.0 in low risk. Construction land has a varying impact on farmland loss, the residential land effeeted distance is 1000 m, and that of the other construction land is 2000 m. This analysis showed the relationships between site factors and farmland loss, and the analysis framework can provide support and reference for farmland protection and delimi

关键词： farmland loss loss risk site analysis logistic regression analysis power-law distribution

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Oxidation behaviour of electron beam physical vapour deposition β-NiAlHf coatings at 1100℃ in dry and humid atmospheres

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Rare Metals 2016年第7期35卷 513-519页

作者： Kai Yan hong-Bo Guo Hui Peng Sheng-Kai Gong School of Materials Science and Engineering Beihang University Beijing Key Laboratory for Advanced Functional Material and Thin Film Technology Beihang University

NiA1 intermetallic compounds attract increas- ing attention for high-temperature applications due to their combination of excellent properties, especially as metallic protective coatings on superalloys or as bond coats in thermal barrier coatings （TBCs）. Oxidation behaviour of the β-NiA1Hf coatings prepared by electron beam physical vapour deposition （EB-PVD） was investigated at 1100 ℃ for short time and 100h in 20% 02＋Ar and 15 % H20 ＋ Ar, respectively. The results of mass changes re- veal that the addition of minor reactive element Hf sig- nificantly improves the cyclic oxidation resistance of the 13- NiA1 coatings in both dry and humid atmospheres. During the initial oxidation stage, water vapour retards the phase transformation from 0-A1203 to a-A1203. Moreover, com- pared with the case in dry atmosphere, water vapour sig- nificantly reduces the surface roughness of the oxide scales formed on EB-PVD β-NiA1Hf coatings after 100 h cyclic oxidation, which corresponds with the difference of surface morphologies of the oxide scales.

关键词： β-NiA1Hf coatings Water vapour Oxidation Phase transformation Roughness

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