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IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53

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Genes & Diseases 2024年第1期11卷 495-508页

作者： Baoyu He Jing Liang Qianqian Qin Yuqin Zhang shuo shi Jinghe Cao Zhixin Zhang Qingli Bie Rou Zhao Li Wei Baogui Zhang Bin Zhang Department of Laboratory Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine JinanShandong 250355China Department of Reproductive Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Department of Gastrointestinal Surgery Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Institute of Forensic Medicine and Laboratory Medicine Jining Medical UniversityJiningShandong 272067China

Cancer stem cells(CSCs)are considered tumor-initiating cells and the main drivers of disease *** these rare cancer cells,however,remains challenging with respect to therapeutic ***,we report the up-regulation of IL-13RA2 expression in colorectal cancer(CRC)tissues and spheroid *** expression of IL-13RA2 was positively correlated with canonical stemness markers in *** further demonstrated that the level of IL-13 was up-regulated in the serum of CRC ***,recombinant IL-13(rIL13)stimulation promoted the sphere formation,proliferation,and migration of CRC cells in vitro and enhanced tumorigenesis in *** phenotype could be reversed by knocking down ***,IL-13 activated autophagy by inducing LC3I/LC3II transformation in CRC-CSCs,which was crucial for the biological functions of *** further demonstrated that IL-13RA2 acted as a modular link of the E3 ligase UBE3C and the substrate p53 protein,enhancing the interaction of UBE3C and p53,thereby inducing the K48-linked ubiquitination of *** conclusion,the IL-13/IL-13RA2 signaling cascade promotes CRC-CSC self-renewal and tumorigenesis by inducing p53 ubiquitination,adding an important layer to the connection between IL-13 and p53,which can be translated into novel targeted therapies.

关键词： Autophagy Colorectal cancer stem cells IL-13/IL-13RA2 signaling p53

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Identifying the origin of porous evolution of microsized bismuth in potassium-ion batteries

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Science China Chemistry 2024年第7期67卷 2234-2239页

作者： Shenxu Chu Kaixiang Lei Qian Yang Jiaxin Li Yuqing Zhao Mengjia Gu Lin Li Xing Hu Yu Zhang Zhuo Chen shuo shi Shulei Chou shijian Zheng Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China Institute for Carbon Neutralization Technology College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Microsized bismuth(Bi)with in-situ constructed three-dimensional(3D)porous network has been considered as a promising anode for high-performance potassium-ion batteries(PIBs).However,the mechanism of the in-situ porous evolution of microsized Bi during the charge/discharge process is still ***,various electrolytes are employed to disclose the origin of porous evolution of microsized Bi in *** and theoretically,the 3D porous network originates from the uniform interfacial charge distribution on the Bi surface in the linear ether-based *** addition,the universality of the interfacial charge distribution mechanism was verified by microsized Sn and *** in-situ constructed 3D porous network of Bi enables a superior potassium storage performance in a wide temperature range from-40 to 40℃.More importantly,the K_(0.9)Mn_(0.7)Ni_(0.3)O_(2)||Bi full cell delivers excellent cycling stability(a high capacity retention of 88.44%even after 2,000 cycles)and good temperature *** work gives a distinct clarification of the origin of the porous evolution of microsized Bi during cycling,which is critical for developing high-performance PIBs.

关键词： potassium-ion batteries microsized Bi porous evolution linear ether-based electrolyte interfacial charge distribution

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Differential distribution of fibrovascular proliferative membranes in 25-gauge vitrectomy for proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1462-1468页

作者： Nan Lu shi-Lin Yang shuo Guo Dong-Ni Yang Li Liu Chun-Hui Fan Ying Guo Jian Liu Wei Zhao Department of Ophthalmology the First Hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina School of Control Engineering Northeastern University at QinhuangdaoQinhuangdao 066004Hebei ProvinceChina

AIM:To analyze the distribution of fibrovascular proliferative membranes(FVPMs)in proliferative diabetic retinopathy(PDR)patients that treated with pars plana vitrectomy(PPV),and to evaluate the outcomes ***:This was a retrospective and cross-sectional *** 25-gauge(25-G)PPV cases operated for PDR from May 2018 to April *** to the FVPMs images outlined after operations,subjects were assigned into three groups:arcade type group,juxtapapillary type group,and central type *** patients were followed up for over one *** characteristics,operation-related variables,postoperative parameters and complications were ***:Among 103 eyes recruited,the FVPMs distribution of nasotemporal and inferiosuperioral was significantly different(both P<0.01),with 95(92.23%)FVPMs located in the nasal quadrants,and 74(71.84%)in the *** eyes with a central FVPM required the longest operation time,with silicon oil used in most patients,generally combined with tractional retinal detachment(RD)and rhegmatogenous RD,the worst postoperative bestcorrected visual acuity(BCVA)and the highest rates of recurrent RD(all P<0.05).FVPM type,age of onset diabetes mellitus,preoperative BCVA,and combined with tractional RD and rhegmatogenous RD were significantly associated with BCVA improvement(all P<0.05).Compared with the central type group,the arcade type group had higher rates of BCVA ***:FVPMs are more commonly found in the nasal and inferior mid-peripheral retina in addition to the area of arcade *** 25-G PPV for treating PDR eyes with central FVPM have relatively worse prognosis.

关键词： proliferative diabetic retinopathy fibrovascular proliferative membrane 25-gauge pars plana vitrectomy

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Clinical practice guideline for acupuncture and moxibustion:Allergic rhinitis

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Journal of Integrative Medicine 2024年第3期22卷 245-257页

作者： shi-hao Du Sheng Chen Shan-ze Wang Guan-qun Wang shuo Du Wei Guo Xiao-long Xie Bi-hui Peng Chao Yang Ji-ping Zhao Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Traditional Chinese Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for ***,these CPGs mentioned acupuncture without making recommendations for clinical implementation and therapeutic protocols,therefore limiting the applicability of acupuncture therapies for ***,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies have initiated a project to develop the CPG for the use of acupuncture and moxibustion to treat *** CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline *** the development of the CPG,the guideline development group(GDG)played an important *** clinical questions,recommendations and therapeutic protocols were all formulated by the GDG using the modified Delphi *** CPG contains recommendations for 15 clinical questions about the use of acupuncture and moxibustion *** include one strong recommendation for the intervention based on high-quality evidence,three conditional recommendations for either the intervention or standard care,and 11 conditional recommendations for the intervention based on very low quality of *** CPG also provides one filiform needle acupuncture protocol and five moxibustion protocols extracted based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Clinical practice guideline Allergic rhinitis Acupuncture Moxibustion GRADE

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Clinical practice guideline for acupuncture and moxibustion: Female urinary incontinence

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Journal of Integrative Medicine 2024年第3期22卷 258-269页

作者： Chao Yang Shan-ze Wang Sheng Chen shuo Du Guan-qun Wang Wei Guo Xiao-long Xie Bi-hui Peng shi-hao Du Ji-ping Zhao Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong provincial hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Urinary incontinence (UI) is a common problem *** has a major impact on physical and social activities and interpersonal *** is common in women,but is under-reported and *** affects the quality of life of female patients *** and moxibustion have been proposed as potentially effective interventions for female ***,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies initiated a project to develop a clinical practice guideline (CPG) for the use of acupuncture and moxibustion to treat female *** CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation (GRADE) methodology,referring to the principles of the World Health Organization Handbook for Guideline *** the development of the CPG,the guideline development group (GDG) played an important *** clinical questions,recommendations and therapeutic protocols were all formulated by GDG using the modified Delphi *** CPG contains ten recommendations about the use of acupuncture and moxibustion interventions for ten clinical questions,which include nine conditional recommendations for the intervention and one conditional recommendation for either the intervention or the *** CPG also provides one protocol for conventional filiform needle therapy,two therapy protocols for deep needling stimulation on lumbosacral acupoints,and four moxibustion therapy protocols,based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Acupuncture Clinical practice guideline Female urinary incontinence Moxibustion GRADE

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三星堆新发现对认识中华远古文明的启示

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思想战线 2024年第5期50卷 84-94页

作者：石硕四川大学历史文化学院

三星堆新发现，在中国早期文明认识领域掀起轩然大波。面对诸多的未知，怎样看待三星堆新发现?它对认识中华远古文明带来什么启示?这颇值得深思。三星堆新发现拓展了我们认识中国早期文明的视野，但也带来严峻挑战。对于认识中华远古文... 详细信息

三星堆新发现，在中国早期文明认识领域掀起轩然大波。面对诸多的未知，怎样看待三星堆新发现?它对认识中华远古文明带来什么启示?这颇值得深思。三星堆新发现拓展了我们认识中国早期文明的视野，但也带来严峻挑战。对于认识中华远古文明，它至少带来三个重要启示：一，在中华远古文明领域，我们尚有太多未知，为此我们须保持审慎、谦逊和敬意。二，中华文明在源头上并非整齐划一，而存在较大区域差异和多样性，这种差异和多样性以及多姿多彩，恰恰构成中华文明体系的博大精深，也赋予其强大生命力和顽强韧性。三，巫术礼仪是中华文明的源头，如何破译远古先民巫术礼仪背后的神性思维逻辑，可能是我们理解中华远古文明的一把钥匙。

关键词：三星堆《山海经》《华阳国志》古蜀国中华远古文明

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如何做中国民族史研究?——马长寿、周伟洲治民族史的启示

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中央民族大学学报(哲学社会科学版) 2024年第1期51卷 134-141页

作者：石硕四川大学历史文化学院

如何做中国民族史研究?前辈学者筚路蓝缕，为我们树立了典范。马长寿先生在中国民族研究中，最突出的特点是用社会学、人类学的视野、理论与方法，通过扎实深入的田野工作，切入中国民族研究，取得卓越成就；其弟子周伟洲，则以史学功... 详细信息

如何做中国民族史研究?前辈学者筚路蓝缕，为我们树立了典范。马长寿先生在中国民族研究中，最突出的特点是用社会学、人类学的视野、理论与方法，通过扎实深入的田野工作，切入中国民族研究，取得卓越成就；其弟子周伟洲，则以史学功力见长，在西北和北方民族史领域取得不俗成就。他们治民族史的经历和特点，为我们提供了做民族史研究的三个重要启示：1,要有人类学、民族学的视野、理论和方法；2,要通过田野考察打通历史与现实，建立对民族的实感，这是认识民族的基础；3,要有扎实的史学功底和宏阔的历史视野。

关键词：马长寿周伟洲中国民族史人类学视野

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半月形文化带:理解中国民族及历史脉络的一把钥匙——童恩正“半月形文化带”的学术意义与价值

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清华大学学报（哲学社会科学版） 2024年第2期39卷 68-82,234,235页

作者：石硕四川大学历史文化学院成都610064

“半月形文化传播带”是童恩正依据考古材料,提出的一条从中国东北到西南的地理文化带。长期以来,对半月形文化带的意义与价值,学界虽有所涉及,但总体上缺乏将其置于中国历史及民族活动框架中,系统考察其与历史上民族活动的内在关联性... 详细信息

“半月形文化传播带”是童恩正依据考古材料,提出的一条从中国东北到西南的地理文化带。长期以来,对半月形文化带的意义与价值,学界虽有所涉及,但总体上缺乏将其置于中国历史及民族活动框架中,系统考察其与历史上民族活动的内在关联性。事实上,半月形文化带不但被历史时期民族活动所充分印证,且在中华民族形成的历史进程中起了关键性连接作用。半月形文化带不仅为我们认识中国文明起源开辟了新视野,同时北方游牧民族在该地带上的承袭性和文化融合以及所呈现的对农耕区域的包裹性,均构成了中国历史的重要特点。半月形文化带有助于我们摆脱把长城作为农、牧线性分割的认知和多从单一民族视角认识北方民族与华夏农耕民族关系的窠臼,更多看到北方民族在中国历史中的交融连接及文化整体性,从而为我们深入认识理解历史上游牧民族同农耕民族之间的互动整合以及中华民族历史脉络提供了一个新的整体性视野和思路。半月形文化带蕴含着中国历史、考古、民族、地理、语言、生态和人类学的丰富内涵,堪称理解中国民族和历史脉络的一把钥匙。

关键词：半月形文化带童恩正北方游牧民族农牧结合带

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Genetically modified pigs:Emerging animal models for hereditary hearing loss

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Zoological Research 2024年第2期45卷 284-291页

作者： Xiao Wang Tian-Xia Liu Ying Zhang Liang-Wei Xu shuo-Long Yuan A-Long Cui Wei-Wei Guo Yan-Fang Wang shi-Ming Yang Jian-Guo Zhao State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Department of Otolaryngology-Head and Neck Surgery Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230022China State Key Laboratory of Animal Biotech Breeding Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Hereditary hearing loss(HHL),a genetic disorder that impairs auditory function,significantly affects quality of life and incurs substantial economic losses for *** investigate the underlying causes of HHL and evaluate therapeutic outcomes,appropriate animal models are *** have been extensively used as valuable large animal models in biomedical *** this review,we highlight the advantages of pig models in terms of ear anatomy,inner ear morphology,and electrophysiological characteristics,as well as recent advancements in the development of distinct genetically modified porcine models of hearing ***,we discuss the prospects,challenges,and recommendations regarding the use pig models in HHL ***,this review provides insights and perspectives for future studies on HHL using porcine models.

关键词： Pigs Animal models Hereditary hearing loss Genetic modification Inner ear

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Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection:How to achieve a better outcome

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1833-1848页

作者： Fan Mu Liang-shuo Hu Kun Xu Zhen Zhao Bai-Cai Yang Yi-Meng Wang Kun Guo Jian-Hua shi Yi Lv Bo Wang Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Anaesthesiology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Gynaecology Wenzhou Medical University Affiliated Jiaxing Women and Children HospitalJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Although the benefits of antiviral therapy for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)have been proven,researchers have not con-firmed the differences in patient outcomes between patients who received preoperative antiviral therapy for a period of time(at least 24 wk)and patients who received remedial antiviral therapy just before radical resection for HBV-related *** To investigate the efficacy of perioperative remedial antiviral therapy in patients with HBV-related *** A retrospective study of patients who underwent radical resection for HBV-related HCC at the First Affiliated Hospital of Xi’an Jiaotong University from January 2016 to June 2019 was *** the history of antiviral therapy,patients were assigned to remedial antiviral therapy and preoperative antiviral therapy *** Kaplan–Meier analysis revealed significant differences in overall survival(P<0.0001)and disease-free survival(P=0.035)between the two *** analysis demonstrated that a history of preoperative antiviral treatment was independently related to improved survival(hazard ratio=0.27;95%confidence interval:0.08-0.88;P=0.030).CONCLUSION In patients with HBV-related HCC,it is ideal to receive preoperative long-term antiviral therapy,which helps patients tolerate more extensive hepatectomy;however,remedial antiviral therapy,which reduces preoperative HBV-DNA levels to less than 4 Log10 copies DNA/mL,can also result in improved outcomes.

关键词： Hepatectomy Hepatitis B virus Antiviral therapy Hepatocellular carcinoma Hepatitis B virus-DNA

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