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A case of huge primary liposarcoma in the liver

World Journal of Gastroenterology 2006年第7期12卷 1157-1159页

作者： Liang-Mou Kuo hong-shiue chou Kun-Ming Chan Ming-Chin Yu Wei-Chen Lee Department of General Surgery Chang-Gung Memorial Hospital and Medical School of Chang-Gung University Taoyuan Taiwan China

Primary liver liposarcoma is a rare disease. Because of its rarity, the knowledge of the clinical course, management, and prognosis of primary liver liposarcoma are all limited for clinicians. A 61-year-old female patient who suffered from a huge primary liposarcoma in the central portion of the liver had the clinical presentations of fever, nausea, vomiting, jaundice, and body weight loss. The huge tumor was resected successfully. However, the tumor recurred repeatedly and she had repeated hepatectomies to remove the tumor. The tumor became aggravating after repeated surgeries. Eventually, the patient had cervical spinal metastasis of liposarcoma and she survived for 26 months after liver liposarcoma was diagnosed. Although the tumor may become aggravating after repeated surgeries, repeated hepatectomies are still the best policy to achieve a long-term survival for the patients.

关键词： Liver liposarcoma Hepatectomy

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Outcomes associated with the intention of loco-regional therapy prior to living donor liver transplantation for hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2020年第1期12卷 17-27页

作者： Tsung-Han Wu Yu-Chao Wang Chih-Hsien Cheng Chen-Fang Lee Ting-Jung Wu hong-shiue chou Kun-Ming Chan Wei-Chen Lee Department of General Surgery and Chang Gung Transplantation Institute Chang Gung Memorial Hospital at LinkouChang Gung University College of MedicineTaoyuan 33305Taiwan Department of Organs Transplantation Institute Chang Gung University College of MedicineTaoyun 33305Taiwan

BACKGROUND Loco-regional therapy for hepatocellular carcinoma(HCC) during the period awaiting liver transplantation(LT) appears to be a logical approach to reduce the risk of tumor progression and dropout in the *** donor LT(LDLT)offers a flexible timing for transplantation providing timeframe for well preparation of *** To investigate outcomes in relation to the intention of pre-transplantation locoregional therapy in LDLT for HCC *** A total of 308 consecutive patients undergoing LDLTs for HCC between August2004 and December 2018 were retrospectively *** were grouped according to the intention of loco-regional therapy prior to LT,and outcomes of patients were analyzed and compared between *** Overall,38 patients(12.3%) were detected with HCC recurrence during the follow-up period after *** who were radiologically beyond the University of California at San Francisco criteria and received loco-regional therapy as down-staging therapy had significant inferior outcomes to other groups for both recurrence-free survival(RFS,P < 0.0005) and overall survival(P= 0.046).Moreover,patients with defined profound tumor necrosis(TN) by locoregional therapy had a superior RFS(5-year of 93.8%) as compared with others(P= 0.010).CONCLUSION LDLT features a flexible timely transplantation for patient with ***,the loco-regional therapy prior to LDLT does not seem to provide benefit unless a certain effect in terms of profound TN is noted.

关键词： Hepatocellular carcinoma Loco-regional therapy Living donor liver transplantation Outcomes Tumor necrosis Liver transplantation

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Modified preoperative score to predict disease-free survival for hepatocellular carcinoma patients with surgical resections

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World Journal of Hepatology 2022年第9期14卷 1778-1789页

作者： Yin Lai Jin-Chiao Lee Hao-Chien Hung Yu-Chao Wang Chih-Hsien Cheng Tsung-Han Wu Chen-Fang Lee Ting-Jung Wu hong-shiue chou Kun-Ming Chan Chen-Yao Kao Wei-Chen Lee Department of General Surgery Chang-Gung Memorial HospitalChang-Gung University College of MedicineTaoyuan 333Taiwan Department of Special Education National University of TainanTainan 700Taiwan

BACKGROUND No prognostic models specific to hepatocellular carcinoma patients receiving surgical resection have been considered strong and convincing enough for survival prediction thus far,and there are no models including only preoperative *** derived a nomogram to predict disease-free survival in a previous *** To simplify our score and compare research outcomes among other scoring *** We retrospectively reviewed data from 1106 patients with hepatocellular carcinoma who underwent liver resection at the Linkou Chang Gung Memorial Hospital between April 2003 and December *** analyses were conducted to identify the significant survival ***,Harrell’s C-index,and Akaike information criterion were compared between our score,AJCC 8^(th)edition,Tokyo score,and Taipei Integrated Scoring System(TTV-CTPAFP model).RESULTS Among the 1106 patients,731(66.1%)had tumor recurrence at a median followup of 83.9 *** risk factors were identified:platelet count,albumin level,indocyanine green retention rate,multiplicity,and radiologic total tumor *** were divided into three risk groups,and the 5-year survival rates were 61.7%,39%,and 25.7%,*** C-index was 0.617,which was higher than the Tokyo score(0.613)and the Taipei Integrated Scoring System(0.562)and equal to the value of the AJCC 8th edition(0.617).CONCLUSION The modified score provides an easier method to predict *** treatment can be planned preoperatively by dividing patients into risk groups.

关键词： Hepatocellular carcinoma Preoperative Prediction Tumor recurrence

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