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Prevalence of Chronic Kidney Disease and Associated Factors among HIV Patients in the Era of HAART in Ivory Coast: A Cross Sectional, Analytical Study

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Open Journal of Nephrology 2023年第1期13卷 20-30页

作者： Wognin Manzan Anastasie Gonan Yannick Kpan Kehi Jonathan Koffi Reine Abdul Khatibat tia.Weu Mélanie Bourhaima Ouattara Internal Medicine Teaching Hospital of Bouaké Alassane Ouattara University Bouaké Ivory Coast

Background: Chronic kidney disease (CKD) may be common among HIV patients living in sub-saharan Africa due to the confluence of CKD risk factors and genetic predisposition. Preventive strategy through early detection and treatment has been advocated for CKD in Africa where majority of patients present late and cannot afford the cost of renal replacement therapy which is not widely available. The purpose of this study was to identify the prevalence and factors associated with CKD among HIV infected adults receiving HAART in a teaching hospital in Ivory Coast. Methods: This is a cross-sectional study of HIV patients on Highly Active Anti Retroviral Therapy followed at the HIV clinic of the medical out-patient department of the University teaching hospital of Bouaké from January to December 2021. CKD was defined as a serum creatinine-based estimated glomerular filtration rate ≤ 60 ml/min/1.73 m2. The collected data was analyzed by using Epi Info 2002 software. Results: Four hundred and two HIV-infected adults 18 years and over were recruited during the study period. We noticed 123 (30.6%) males. The mean age was 40 years. CKD was observed in 42 (10.44) patients infected-HIV. Eighty eight point three percent of patients had CD4 more than 500 cells. Low eGFR correlated with age more than 60 years old, worker in public sector, unemployed, no formal education and HIV type 2. Conclusion: Our study identified a prevalence of CKD of 10.44% by CKD EPI equations among HIV patients on HAART that attended the teaching hospital of Bouaké in Ivory Coast. Early screening and follow up of renal functions is important to minimize the risk of developing end stage kidney disease.

关键词： HIV CKD Prevalence Africa

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主流与非主流金融对家庭创业的影响——基于CHFS项目28143户家庭的调查数据

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重庆大学学报（社会科学版） 2018年第2期24卷 24-35页

作者：田霖金雪军郑州大学商学院河南郑州450001 浙江大学经济学院浙江杭州310027

针对新形势、新金融背景下创业、创新的新矛盾、新问题,从金融包容理念出发,探讨主流与非主流金融对家庭创业的影响。二值响应模型揭示了农业及工商业是否为创业的诱导要素及其边际作用,多值响应模型则剖析各类诱因对不同创业动机的作... 详细信息

针对新形势、新金融背景下创业、创新的新矛盾、新问题,从金融包容理念出发,探讨主流与非主流金融对家庭创业的影响。二值响应模型揭示了农业及工商业是否为创业的诱导要素及其边际作用,多值响应模型则剖析各类诱因对不同创业动机的作用强度和贡献大小。实证分析表明,"没有其他工作选择""求富""企业家精神内驱""追求自由、自在"及其他动因的创业对各类解释变量的响应不同,关键自变量、家庭特征变量与区域特征变量均表现出不一样的回归系数及相对风险比率。研究显示,主流金融对家庭创业具有主导作用和显著贡献;在新金融态势下,互联网金融的崛起使非主流金融在创业中的贡献初步显现,要致力于实现主流与非主流金融对称性互惠共生的良好生态;需要针对不同区域、不同行业、不同创业动机、不同风险偏好的潜在创业者,采取不同的激励机制与支持方案,同时尽量完善各项配套措施。

关键词：主流金融非主流金融金融包容家庭创业

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测土配方施肥辅助决策平台的研究与应用

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计算机应用研究 2008年第9期25卷 2748-2750,2774页

作者：陈天恩赵春江陈立平陈红国家农业信息化工程技术研究中心北京100097 农业部农业信息技术重点开放实验室北京100097

为了解决目前我国测土配方施肥软件难以推广的问题,采用面向构件技术设计了测土配方施肥辅助决策技术体系,并着重对其构件体系进行阐述;对测土配方施肥的作业流程进行了业务单元的划分,并将划分结果映射为相应的业务构件;在此基础上,给... 详细信息

为了解决目前我国测土配方施肥软件难以推广的问题,采用面向构件技术设计了测土配方施肥辅助决策技术体系,并着重对其构件体系进行阐述;对测土配方施肥的作业流程进行了业务单元的划分,并将划分结果映射为相应的业务构件;在此基础上,给出了按需搭建构件化测土配方施肥辅助决策系统的方法;最后,结合实例分析了构件化测土配方施肥辅助决策系统在大范围推广应用、节约开发成本、缩短开发周期、实现软件重用等方面具有的优势。

关键词：构件化测土配方施肥空间分析施肥推荐软件架构

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tia.合金在(α_2+γ)两相区的热成形能力及组织演变(英文)

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稀有金属材料与工程 2013年第7期42卷 1356-1361页

作者：邓志海李金山张铁邦胡锐钟宏常辉西北工业大学凝固技术国家重点实验室陕西西安710072

为了利用现有的高温合金锻造设备实现tia.合金的包套锻造，对Ti-43A1-4Nb-1Mo-0．1B合金在（a2＋y）两相区的热成形能力进行了研究。结果表明，当温度下降到（a2＋y）两相区时，合金的热成形能力明显下降，只能在1050℃以上温度以0．001... 详细信息

为了利用现有的高温合金锻造设备实现tia.合金的包套锻造，对Ti-43A1-4Nb-1Mo-0．1B合金在（a2＋y）两相区的热成形能力进行了研究。结果表明，当温度下降到（a2＋y）两相区时，合金的热成形能力明显下降，只能在1050℃以上温度以0．001s。的应变速率进行变形；当温度低于1050℃时，试样发生开裂；当温度升高或应变速率降低时，组织中形成更多的动态再结晶晶粒，裂纹消失。然而，当试样采用厚度为1．5mm的不锈钢进行包套后，合金的热成形能力大大改善，可以在1050～1150℃以0．1S。的应变速率进行均匀变形，该变形条件更加有利于充分利用当前的工业锻造设备。同未包套试样相比，在相同变形条件下，包套试样中的动态再结晶晶粒较少。

关键词：热成形能力组织演变 β 凝固tia.合金包套锻造

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Factors Associated with Echocardiographic Abnormalities in Patients with Chronic Kidney Disease in a Tertia.y Hospital in Ivory Coast

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Open Journal of Nephrology 2022年第1期12卷 36-47页

作者： Weu M. tia.Abdoulaye Togo Manzan A. Wognin Reine M. Koffi Jonathan Kpan Bourhaima Ouattara Dame A. Gnionsahe Department of Internal Medicine University Teaching Hospital (CHU) of Bouaké Bouaké C&ocirc te d'Ivoire Nephrology-Hemodialysis Department University Teaching Hospital (CHU) of Yopougon Abidjan C&ocirc te d'Ivoire

Background: Cardiovascular risk factors (CVRF) are very frequent in pa-tients with chronic kidney disease (CKD) and impose a new environment to which the heart must adapt. Cardiac ultrasound is a non-invasive and easy-to-perform examination that allows quantitative and qualitative assessment of the anatomy and function of the heart. The objectives of this study were to describe abnormalities observed on trans-thoracic Doppler-echocar-diography and to investigate the factors associated with them. Materials and Method: This was a monocentric retrospective cross-sectional study conducted in CKD patients hospitalized in a hospital center in Côte d'Ivoire from January 2017 to December 2018. Results: One hundred and four cases were collected with a mean age of 48.87 ± 14.47 years and a sex ratio of 1.7. Patients with end-stage-renal-disease (ESRD) represented 83.7% with 55.8% of cases of chronic glomerulonephritis. Cardiovascular risk factors were 100% anemia, 84.6% inflammatory profile, 77.9% hypertension, 76.9% hypocalcemia and in 67.3% oedema. Cardiac abnormalities were observed in 78.8% of patients. Left ventricular hypertrophy (LVH), accounting for 20.2% of cases, was associated with male gender (OR 0.127 CI 0.025 - 0.643;p = 0.013) and hypertensive nephropathy (OR 0.189 CI 0.056 - 0.637;p = 0.007). History of hypertension (OR 0.297 CI 0.084 - 1.050;p = 0.060) and diabetes (OR 5.315 CI 1.260 - 22.419;p = 0.023), hypertensive nephropathy (OR 0.174 CI 0.052 - 0.585;p = 0.005) and hypocalcemia (OR 6.094 CI 1.723 - 21.559;p = 0.005) are incriminated in the development of left ventricular dilatation (LVD) which accounted for 38.5% of cases. Conclusion: Left ventricular hypertrophy and dilatation are the main echocardiographic abnormalities observed in our population.

关键词： Chronic Renal Failure Left Ventricular Hypertrophy Ivory Coast

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Winery by‑products as a feed source with functional properties:dose–response effect of grape pomace,grape seed meal,and grape seed extract on rumen microbial community and their fermentation activity in RUSITEC

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2439-2453页

作者： Ratchaneewan Khiaosa‑ard Mubarik Mahmood Elsayed Mickdam Catia.Pacifico Julia Meixner Laura‑Sophie Traintinger Institute of Animal Nutrition and Functional Plant Compounds Department for Farm Animals and Veterinary Public HealthUniversity of Veterinary Medicine ViennaVeterinaerplatz 11210 ViennaAustria. Animal Nutrition Section Department of Animal SciencesSub Campus JhangUniversity of Veterinary and Animal Sciences12 Km Chiniot RoadJhang 35200LahorePakistan. Nutrition and Clinical Nutrition Department Faculty of Veterinary MedicineSouth Valley UniversityQena 83523Egypt. Present address:Biome Diagnostics GmbH ViennaAustria.

Background Grape and winery by-products have nutritional values for cattle and also contain functional compounds like phenols,which not only bind to protein but can also directly affect microbiota and their function in the *** characterized the nutritional and functional effects of grape seed meal and grape pomace as well as an effective dosage of grape phenols on ruminal microbiota and fermentation characteristics using a rumen simulation *** Six diets(each n=8)were compared including a control diet(CON,no by-product),a positive control diet(EXT,CON+3.7%grape seed extract on a dry matter(DM)basis),two diets with grape seed meal at 5%(GS-low)and 10%(GS-high),and two diets with grape pomace:at 10%(GP-low)and 20%(GP-high),on a DM *** inclusion of the by-product supplied total phenols at 3.4%,0.7%,1.4%,1.3%,and 2.7%of diet DM for EXT,GS-low,GS-high,GP-low,and GP-high,*** were tested in four experimental *** treatments decreased ammonia concentrations and the disappearances of DM and OM(P<0.05)compared to *** and GP-high lowered butyrate and odd-and branch-chain short-chain fatty acids while increased acetate compared to CON(P<0.05).Treatments did not affect methane *** decreased the abundance of many bacterial genera including those belonging to the core ***-high and EXT consistently decreased Olsenella and Anaerotipes while increased Ruminobacter *** The data suggest that the inclusion of winery by-products or grape seed extract could be an option for reducing excessive ammonia *** to grape phenols at a high dosage in an extract form can alter the rumen microbial ***,however,does not necessarily alter the effect of grape phenols on the microbial community function compared to feeding high levels of winery *** suggests the dominant role of dosage over the form or source of the grape phenols in affecting ruminal microbial *** conclusion,

关键词： Functional feed Grape pomace Grape seed Protein degradation Rumen microbiota

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Safety, Tolerability and Anti-Diarrhoeal Activity of “Diarra”, a Preparation of Medicinal Plants Used in Ivorian Traditional Medicine

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Pharmacology & Pharmacy 2023年第10期14卷 428-440页

作者： Kouakou Etienne Effo Yacouba Adebo Adehouni Gbongué Eric tia.Amenan Geneviève Irié-N’Guessan N’Doua Gisèle Kouakou Siransy Department of Pharmacology Clinical and Therapeutic Pharmacy Faculty of Pharmaceutical and Biological Sciences University of Félix Houphou&#235t-Boigny Abidjan C&#244te d’Ivoire

Background: “Diarra”, a traditional herbal remedy made from five (5) medicinal plants, might be endowed with anti-diarrhoeal properties according to its owner. However, scientific evidence of its safety, tolerability and activity has not been established. Objective: This study aimed to assess the safety, tolerability and anti-diarrhoeal activity of “Diarra” in experimental rats. Materials and Methods: Safety was assessed by acute (OECD 423) and sub-acute (OECD 407) toxicity studies at doses of 5, 10 and 20 mg/kg. Clinical tolerability was assessed for 28 days. On day 29, a blood sample was taken to evaluate biological tolerability. The anti-diarrhoeal activity was investigated in a castor oil-induced diarrhoea model. Rats were given the remedy at doses of 5, 10 and 20 mg/kg and then castor oil 1 hour later. They were observed for 4 hours and diarrhoeal stools were collected. The Percentage of diarrhoeal inhibition was calculated. Results: A single dose of “Diarra” at a dose of 2000 mg/kg did not induce any lethality, behavioural or weight change in rats for 14 days. When administered once daily for 28 days, “Diarra” did not cause lethality or significant behavioural disorders or significant weight loss in rats. No biological disorders were observed. The treatment of rats with “Diarra” at doses of 5 mg/kg, 10 mg/kg and 20 mg/kg in a single administration inhibited the occurrence of diarrhoeal stools. The respective percentages of inhibition were 60%, 50% and 62%, similar to those of loperamide at a dose of 2 mg/kg (68%). Conclusion: “Diarra” has an anti-diarrheal activity in rats. It is also safe to use this remedy as such.

关键词： Safety Tolerability Antidiarrheal Diarra Traditional Medicine

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Influence of SLE phenotype at onset on prognosis

Influence of SLE phenotype at onset on prognosis

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The 8th International Congress on SLE

作者： Maura Couto Cátia.Duarte Cláudia Vaz Pedro Abreu Luíns Inês Armando Malcata Rheumatology Department of the Coimbra University Hospital Coimbra Portugal Rheumatology Department of the Coimbra University Hospital Coimbra Portugal Rheumatology Department of the Coimbra University Hospital Coimbra Portugal Rheumatology Department of the Coimbra University Hospital Coimbra Portugal Rheumatology Department of the Coimbra University Hospital Coimbra Portugal Rheumatology Department of the Coimbra University Hospital Coimbra Portugal

＜正＞Purpose:Evaluate the prognostic value of disease phenotype at onset in Systemic Lupus Erythematous（SLE）patients. Methods:All patients fulfilling the 1982 ACR Classification Criteria for SLE and followed in the...

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Neural cell injury microenvironment induces neural differentia.ion of human umbilical cord mesenchymal stem cells

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Neural Regeneration Research 2012年第34期7卷 2689-2697页

作者： Jin Zhou Guoping tia.Jinge Wang Xiaoguang Luo Siyang Zhang Jianping Li Li Li Bing Xu FengZhu Xia Wang Chunhong Jia Weijin Zhao Danyang Zhao Aihua Xu Department of Neurology First People's Hospital of Shenyang Shenyang 110041 Liaoning Province China First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China College of Basic Medical Sciences China Medical University Shenyang 110001 Liaoning Province China Liaoning Provincial Blood Center Shenyang 110044 Liaoning Province China

This study aimed to investigate the neural differentia.ion of human umbilical cord mesenchymal stem cells （hUCMSCs） under the induction of injured neural cells. After in vitro isolation and culture, passage 5 hUCMSCs were used for experimentation, hUCMSCs were co-cultured with normal or AI31.4o-injured PC12 cells, PC12 cell supernatant or PC12 cell lysate in a Transwell co-culture system. Western blot analysis and flow cytometry results showed that choline acetyltransferase and microtubule-associated protein 2, a specific marker for neural cells, were expressed in hUCMSCs under various culture conditions, and highest expression was observed in the hUCMSCs co-cultured with injured PC12 cells. Choline acetyltransferase and microtubule-associated protein 2 were not expressed in hUCMSCs cultured alone （no treatment）. Cell Counting Kit-8 assay results showed that hUCMSCs under co-culture conditions promoted the proliferation of injured PC12 cells. These findings suggest that the microenvironment during neural tissue injury can effectively induce neural cell differentia.ion of hUCMSCs. These differentia.ed hUCMSCs likely accelerate the repair of injured neural ceils.

关键词： stem ceil umbilical cord mesenchymal stem cell co-culture induction differentia.ion neural cell microtubule-associated protein 2 injured cell Transwell neural regeneration regeneration

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外露式钢柱脚低层钢框架结构动力性能分析

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建筑钢结构进展 2018年第5期20卷 39-46页

作者：包恩和王天成李琦桂林理工大学土木与建筑工程学院广西桂林541004

针对外露式钢柱脚低层钢框架动力响应机理不明的情况,在提出外露式钢柱脚滞回曲线模型的基础上,以首层剪重比、钢柱脚强度系数及框架形状等为主要研究参量,建立16个3层规则钢框架模型,采用弹塑性方法进行了研究,结果如下:当首层剪重比值... 详细信息

针对外露式钢柱脚低层钢框架动力响应机理不明的情况,在提出外露式钢柱脚滞回曲线模型的基础上,以首层剪重比、钢柱脚强度系数及框架形状等为主要研究参量,建立16个3层规则钢框架模型,采用弹塑性方法进行了研究,结果如下:当首层剪重比值从0.30提高为0.35时,对低层钢框架结构首层变形及塑性能量集中等有较好的缓和效果,钢柱脚强度系数越小越明显;外露式钢柱脚耗能效果不显著,但外露式钢柱脚在塑性滑移过程中能够把地震输入能量转移到其它构件;外露式钢柱脚动力响应滞回曲线的形状、屈服弯矩与定义的外露式钢柱脚滞回曲线模型相吻合;首层剪重比值提高了0.05可以减小外露式钢柱脚变形。

关键词：低层钢框架结构外露式钢柱脚滑移型滞回曲线模型首层剪重比钢柱脚强度系数

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