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Marker Ki-67 is a potential biomarker for the diagnosis and prognosis of prostate cancer based on two cohorts

World Journal of Clinical Cases 2024年第1期12卷 32-41页

作者： Zhen Song Qi Zhou Jiang-Lei Zhang Jun ouyang Zhi-Yu Zhang Department of Urology Taixing People’s HospitalTaizhou 225400Jiangsu ProvinceChina Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Reproductive Medicine Center The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Prostate cancer(PCa)is a widespread malignancy,predominantly affecting elderly males,and current methods for diagnosis and treatment of this disease continue to fall *** marker Ki-67(MKI67)has been previously demonstrated to correlate with the proliferation and metastasis of various cancer cells,including those of ***,verifying the association between MKI67 and the diagnosis and prognosis of PCa,using bioinformatics databases and clinical data analysis,carries significant clinical *** To explore the diagnostic and prognostic efficacy of antigens identified by MKI67 expression in *** For cohort 1,the efficacy of MKI67 diagnosis was evaluated using data from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)*** cohort 2,the diagnostic and prognostic power of MKI67 expression was further validated using data from 271 patients with clinical *** In cohort 1,MKI67 expression was correlated with prostate-specific antigen(PSA),Gleason Score,T stage,and N *** receiver operating characteristic(ROC)curve showed a strong diagnostic ability,and the Kaplan-Meier method demonstrated that MKI67 expression was negatively associated with the progression-free interval(PFI).The time-ROC curve displayed a weak prognostic capability for MKI67 expression in *** cohort 2,MKI67 expression was significantly related to the Gleason Score,T stage,and N stage;however,it was negatively associated with the *** time-ROC curve revealed the stronger prognostic capability of MKI67 in patients with *** COX regression analysis was performed to select risk factors,including PSA level,N stage,and MKI67 expression.A nomogram was established to predict the 3-year *** MKI67 expression was positively associated with the Gleason Score,T stage,and N stage and showed a strong diagnostic and prognostic ability in PCa.

关键词： Marker Ki-67 Prostate cancer Biomarker Diagnosis Prognosis

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A Situational Awareness Method for Initial Insulation Fault of Distribution Network Based on Multi-Feature Index Comprehensive Evaluation

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Energy Engineering 2024年第8期121卷 2191-2211页

作者： Hao Bai Beiyuan Liu hongwen Liu Jupeng Zeng Jian ouyang Yipeng Liu Electric Power Research Institute China Southern Power GridGuangzhou510663China State Key Laboratory of Disaster Prevention and Reduction for Power Grid Changsha University of Science and TechnologyChangsha410114China Electric Power Research Institute of Yunnan Power Grid Co. Ltd.Kunming650032China Qujing Power Supply Bureau of Yunnan Power Grid Co. Ltd.Qujing655099China

Most ground faults in distribution network are caused by insulation deterioration of power *** is difficult to find the insulation deterioration of the distribution network in time,and the development trend of the initial insulation fault is unknown,which brings difficulties to the distribution *** order to solve the above problems,a situational awareness method of the initial insulation fault of the distribution network based on a multi-feature index comprehensive evaluation is ***,the insulation situation evaluation index is selected by analyzing the insulation fault mechanism of the distribution network,and the relational database of the distribution network is designed based on the data and numerical characteristics of the existing distribution management ***,considering all kinds of fault factors of the distribution network and the influence of the power supply region,the evaluation method of the initial insulation fault situation of the distribution network is proposed,and the development situation of the distribution network insulation fault is classified according to the evaluation ***,principal component analysis was used to reduce the dimension of the training samples and test samples of the distribution network data,and the support vector machine(SVM)was *** optimal parameter combination of the SVM model was found by the grid search method,and a multi-class SVM model based on 1-v-1 method was ***,the trained multi-class SVM was used to predict 6 kinds of situation level prediction *** results of simulation examples show that the average prediction accuracy of 6 situation levels is above 95%,and the perception accuracy of 4 situation levels is above 96%.In addition,the insulation maintenance decision scheme under different situation levels is able to be given when no fault occurs or the insulation fault is in the early stage,which can meet the needs of power distribution an

关键词： Distribution grid insulation degradation initial insulation fault multi-feature indices multi-class SVM situational level situational awareness

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GDI and GSI: China’s New Propositions for Global Governance

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China Economist 2024年第5期19卷 107-116页

作者： ouyang Xiangying Institute of World Economy and Politics Chinese Academy of Social Sciences(IWEP-CASS)BeijingChina

In the post-pandemic era,the global economic and security landscapes are fraught with complexities and *** them,four risk flashpoints merit attention:Certain countries are raising interest rates to subdue inflation,despite their already high levels of debt;the bulk commodities market is experiencing volatility,leading to global turbulence and change;trade protectionism is at the forefront of major-power rivalry in political and economic spheres;and regional security crises are compounding international *** those flashpoints are contradictions that obstruct world peace and progress,including development imbalances,governance gaps,and structural tensions in global *** the face of uncertainties,it is crucial for China to seize strategic opportunities and transform crises into favorable *** has launched the Global Development Initiative(GDI)and the Global Security Initiative(GSI)to contribute to global prosperity and *** two initiatives demonstrate China’s commitment to addressing global deficits in peace,development,security,and governance.

关键词： Global Development Initiative(GDI) Global Security Initiative(GSI) China’s approach to global governance Ukraine crisis China-Russia relationship

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An Efficient and Provably Secure SM2 Key-Insulated Signature Scheme for Industrial Internet of Things

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工程与科学中的计算机建模(英文) 2024年第1期138卷 903-915页

作者： Senshan ouyang Xiang Liu Lei Liu Shangchao Wang Baichuan Shao Yang Zhao School of Mechanical Engineering Northwestern Polytechnical UniversityXi’anChina Department of Process and Information Technology Chengdu Aircraft Industrial(Group)Co.Ltd.ChengduChina School of Information and Software Engineering The Network and Data Security Key Laboratory of Sichuan ProvinceUniversity of Electronic Science and Technology of ChinaChengduChina

With the continuous expansion of the Industrial Internet of Things(IIoT),more andmore organisations are placing large amounts of data in the cloud to reduce ***,the channel between cloud servers and smart equipment is not trustworthy,so the issue of data authenticity needs to be *** SM2 digital signature algorithm can provide an authentication mechanism for data to solve such ***,it still suffers from the problem of key *** order to address this concern,this study first introduces a key-insulated scheme,SM2-KI-SIGN,based on the SM2 *** scheme boasts strong key insulation and secure *** scheme uses the elliptic curve algorithm,which is not only more efficient but also more suitable for IIoT-cloud ***,the security proof of SM2-KI-SIGN is given under the Elliptic Curve Discrete Logarithm(ECDL)assumption in the random oracle.

关键词： Key-insulated SM2 algorithm digital signature Industrial Internet of Things(IIoT) provable security

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Large-Scale CRISPR Screen of LDLR Pathogenic Variants

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Research 2024年第2期2023卷 213-225页

作者： Mengjing Li Lerong Ma Yiwu Chen Jianing Li Yanbing Wang Wenni You hongming Yuan Xiaochun Tang hongsheng ouyang Daxin Pang Key Lab for Zoonoses Research Ministry of EducationAnimal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin Province 130062China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300071China Chongqing ResearchInstitute Jilin UniversityChongqing 401123China Chongqing Jitang Biotechnology Research Institute Co.Ltd. ChongqingChina

Familial hypercholesterolemia(FH)is a frequently occurring genetic disorder that is linked to early-onset cardiovascular *** left untreated,patients with this condition can develop severe cardiovascular ***,many patients remain undiagnosed,and even when diagnosed,the treatment is often not *** mutations in the LDLR gene are the primary cause of FH,predicting whether novel variants are pathogenic is not a straightforward *** the functionality of LDLR variants is crucial in uncovering the genetic basis of *** study utilized CRISPR/Cas9 cytosine base editors in pooled screens to establish a novel approach for functionally assessing tens of thousands of LDLR variants on a large scale.A total of more than 100 single guide RNAs(sgRNAs)targeting LDLR pathogenic mutations were successfully screened with relatively high *** of these,5 sgRNAs were further subjected to functional verification studies,including 1 in the promoter,1 in the antisense RNA,1 in the exon,and 2 in the *** for the variant caused by the sgRNA located at intron 16,the functionalities of the other LDLR variants were all *** high similarity of LDLR intron sequences may lead to some false ***,these results confirm the reliability of the large-scale screening strategy for functional analysis of LDLR variants,and the screened candidate pathogenic mutations could be used as an auxiliary means of clinical gene detection to prevent FH-induced heart disease.

关键词： LDLR Screen straight

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Travel Notes onGuizhou Province

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Qiu Shi 2024年第2期16卷 70-80页

作者： ouyang Qiansen The presidium of the China Writers Association The Guizhou Federation of Literary The Guizhou Writers Association

Guizhou Province in southwest China is not supported by any *** to the Guizhou Department of Land and Resources,the province has over 1.2 million mountain *** visits to the countless valleys and mountains that comprise this province in the years of the fight against poverty make up the most precious and unforgettable journey of my life.

关键词： Guizhou Notes forget

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Data as a Factor of Production Promoting the Deep Integration of the Digital Economy and the Real Economy:Theoretical Logic and Analysis Framework

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2024年第2期19卷 129-153页

作者： ouyang Rihui China Center for Internet Economy Research Central University of Finance and EconomicsBeijing 100081China

Data is the primary factor of production in the digital economy,playing a role in promoting the deep integration of the digital economy and the real economy and smoothing the national economic *** entering the circulation system of the real economy,data is rapidly integrated into production,circulation,consumption,distribution,and other *** optimizes resource allocation,unblocks circulation channels,promotes accurate matching of supply and demand,stimulates emerging demand,and forms a virtuous circle of digital technology application,traditional physical enterprise transformation,and technological *** development is an important feature of the digital *** promotes the integration of factors of production,products,enterprises,industries,and markets,which fosters a circular system with deep integration of the digital economy and the real *** promote the deep integration of the digital economy and the real economy,the government and business entities should take measures to improve the circular efficiency of the digital economy and the real *** measures include attaching importance to the role of data-driven development,improving data capacity,data development,and utilization in enterprises,exploring diverse circulation models of enterprise data,and creating typical application scenarios and industrial data spaces.

关键词： data data as a factor of production(data factor) digital economy real economy integrated development

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Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions

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Genes & Diseases 2024年第2期11卷 874-889页

作者： Yancheng Lai Xiaole Lu Yankai Liao Pei ouyang Hai Wang Xian Zhang Guanglong Huang Songtao Qi Yaomin Li Department of Neurosurgery Institute of Brain DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Laboratory for Precision Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Glioblastoma(GBM)is the most common intrinsic and aggressive primary brain tumor in adults,with a median survival of approximately 15 *** heterogeneity is considered responsible for the treatment resistance and unfavorable ***-mesenchymal transition(PMT)represents GBM malignant progression and recurrence,which might be a breakthrough to understand GBM heterogeneity and overcome treatment *** is a complicated process influenced by crosstalk between GBM and tumor microenvironment,depending on intricate ligand-receptor *** this review,we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-receptor interactions inducing *** also discuss the current therapies targeting the PMT-related autocrine and paracrine ***,this review offers a comprehensive understanding of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

关键词： Autocrine Glioblastoma Ligand-receptor interaction Microenvironment Paracrine Proneural-mesenchymal transition

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A lunar time scale from the perspective of the Moon’s dynamic evolution

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Science China Earth Sciences 2024年第1期67卷 234-251页

作者： Dijun GUO Jianzhong LIU James WHEAD Fuqin ZHANG Zongcheng LING Shengbo CHEN Jianping CHEN Xiaozhong DING Jinzhu JI Ziyuan ouyang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Center for Lunar and Planetary Sciences Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Department of Earth Environmental and Planetary SciencesBrown UniversityProvidence RI 02912USA Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China College of Geoexploration Science and Technology Jilin UniversityChangchun 130026China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China School of Resources and Environmental Engineering Inner Mongolia University of TechnologyHohhot 010051China Center for Excellence in Comparative Planetology Chinese Academy of SciencesHefei 230026China

A geologic time scale is a chronological system that separates the geological strata of a planetary body into different units in temporal sequence and shows its progressive *** time scale of the Moon was established a half-century ago during the telescopic-early Apollo exploration era,using data with limited spatial coverage and *** past decades have seen a wide array of studies,which have significantly extended our understanding of global lunar geologic *** on a comprehensive review of lunar evolution with respect to the dynamical changes,we propose two major updates to the current lunar time scale paradigm to include the evolution of both endogenic and exogenic dynamic forces now known to have influenced early lunar ***,based on the temporal interplay of exogenic and endogenic processes in altering the Moon,we defined three Eon/Eonothem-level units to represent three dynamical evolutionary ***,the pre-Nectarian System is redefined and divided as the magma ocean-era Magma-oceanian System and the following Aitkenian System beginning with the South Pole-Aitken *** ejecta of this basin,Das Formation,was deposited on the primordial lunar crust as the oldest stratum produced from exogenic *** updated lunar time scale,facilitated by the post-Apollo exploration and research advances,provides an integrated framework to depict the evolution of the Moon and has important implications for the geologic study of other terrestrial planets.

关键词： The Moon Geologic time scale Evolution history Endogenic process Exogenic process

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Vocational Identity and Agency of Chinese College Students: Effects of Filial Piety and Implications in Career Education

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教育技术与创新 2024年第2期6卷 18-32页

作者： Baixiao ouyang School of Education City University of MacaoChina

Balancing family obligations and personal aspirations is crucial for college students in making life *** critical review examined empirical studies on the effects of filial piety on college students’vocational identity and *** to identity capital theory,college students need a sense of agency to construct identity consciously and adapt to *** piety may profoundly influence this process as the core value and internalized social structure for the role of being an adult child in a Chinese ***,no studies have been conducted from the identity capital *** review found that filial piety had direct effects on college students'vocational identity and also indirect effects by shaping specific agency *** impact of filial piety on the agency was more likely to occur through providing normative guidance about adult roles,influencing how college students view family as a supportive resource,and perpetuating parenting *** on these findings,this article suggested further examining the mediating role of agency between filial piety and identity development,as well as the effects of filial piety on the psychological foundation of agency *** review suggested enhancing the agency of college students and encouraging reflections on filial piety in career education.

关键词： filial piety agency vocational identity college students career education

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