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Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides

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Chinese Chemical Letters 2024年第5期35卷 386-391页

作者： Dan ouyang Huan Huang Yanting He Jiajing Chen Jiali Lin Zhuling Chen Zongwei Cai Zian Lin Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350108China School of Pharmacy Bengbu Medical UniversityBengbu 233000China Partner State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina

Saccharides are a sort of ubiquitous and vital molecules within the whole ***,the application of saccharides analysis with matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)is restricted by their low ionization efficiency and the instability of the sialic acid *** strategy based on nonreductive amination provides a good solution,however,this is often time consuming and may result in sample loss due to removal of excessive derivatization ***,hydralazine(HZN)was utilized as a reactive matrix for labeling reducing saccharides directly on MALDI target which eliminated tedious sample preparation and avoided sample *** optimization,effective and reproducible on-MALDI-target derivatization of neutral and acidic saccharides was achieved in both positive and negative *** with 2,5-dihydroxybenzoic acid(DHB)and 9-aminoacridine(9-AA),HZN improved the detection sensitivity of reducing saccharides and provided more abundant fragment ions in MS/MS ***,26 kinds of neutral glycans and 5 kinds of sialic glycans were identified from ovalbumin(OVA)and bovine fetuin,*** with the statistical models,this strategy could be used to distinguish and predict samples of 6 brands of beer,and discriminate 2 kinds of beer fermentation *** addition,HZN was applied for quantitative analysis of glucose in urine samples,and the obtained urine glucose concentrations of diabetic patients were consistent with the clinical test results,showing the potential of qualitative and quantitative analysis of reducing saccharides in complex samples.

关键词： Hydralazine Reactive matrix On-MALDI-target derivatization Saccharides

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荧光定量聚合酶链反应检测支气管肺泡灌洗液中结核分枝杆菌脱氧核糖核酸诊断肺结核的价值

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中国实用医药 2018年第10期13卷 16-18页

作者：吴淑红荣福欧阳雁弟南方医科大学顺德医院 528300

目的探讨荧光定量聚合酶链反应(PCR)检测支气管肺泡灌洗液(BALF)结核分枝杆菌脱氧核糖核酸(TbDNA)诊断肺结核的临床价值。方法选取51例肺结核患者作为肺结核组,另选60例非肺结核患者作为对照组。所有患者均完善BALF TbDNA检测及毛刷涂... 详细信息

目的探讨荧光定量聚合酶链反应(PCR)检测支气管肺泡灌洗液(BALF)结核分枝杆菌脱氧核糖核酸(TbDNA)诊断肺结核的临床价值。方法选取51例肺结核患者作为肺结核组,另选60例非肺结核患者作为对照组。所有患者均完善BALF TbDNA检测及毛刷涂片抗酸染色镜检、痰涂片抗酸染色镜检。以评价BALF中TbDNA检测对诊断肺结核的敏感性、特异性、阳性预测值(PPV)、阴性预测值(NPV)。结果荧光定量PCR检测BALF中的TbDNA,其阳性对肺结核诊断的敏感性、特异性、PPV、NPV分别为74.51%、96.67%、95.00%、81.69%,肺结核组毛刷涂片抗酸染色镜检的敏感性为13.73%,痰涂片抗酸染色镜检敏感性为15.69%。对照组中,荧光定量PCR检测BALF中的TbDNA的特异性为96.67%,毛刷涂片抗酸染色镜检及痰涂片抗酸染色镜检的特异性均为100.00%。肺结核组荧光定量PCR检测BALF中的TbDNA与痰涂片抗酸染色镜检及毛刷涂片抗酸染色镜检敏感性比较差异有统计学意义(P0.05)。结论荧光定量PCR检测BALF中的TbDNA有良好的特异性和敏感性,有望辅助传统的检查来早期诊断肺结核。

关键词：荧光定量聚合酶链反应支气管肺泡灌洗液结核分枝杆菌脱氧核糖核酸肺结核

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Metabolic disorders in prediabetes:From mechanisms to therapeutic management

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World Journal of Diabetes 2024年第3期15卷 361-377页

作者： Wen-Xin Ping Shan Hu Jing-Qian Su Song-Ying ouyang Biomedical Research Center of South China College of Life SciencesFujian Normal UniversityFuzhou 350117Fujian ProvinceChina

Diabetes,one of the world's top ten diseases,is known for its high mortality and complication rates and low cure *** precedes the onset of diabetes,during which effective treatment can reduce diabetes *** risk factors include high-calorie and high-fat diets,sedentary lifestyles,and *** may include considerable damage to vital organs,including the retina,liver,and *** for treating prediabetes include a healthy lifestyle diet and pharmacological ***,while these options are effective in the short term,they may fail due to the difficulty of long-term *** may also be used to treat *** review examines prediabetic treatments,particularly metformin,glucagon-like peptide-1 receptor agonists,sodium glucose cotransporter 2 inhibitors,vitamin D,and herbal *** the remarkable impact of prediabetes on the progression of diabetes mellitus,it is crucial to intervene promptly and effectively to regulate ***,the current body of research on prediabetes is limited,and there is considerable confusion surrounding clinically relevant *** paper aims to provide a comprehensive summary of the pathogenesis of prediabetes mellitus and its associated therapeutic *** ultimate goal is to facilitate the clinical utilization of medications and achieve efficient and timely control of diabetes mellitus.

关键词： Prediabetes Glucagon-like peptide agonists Sodium–glucose cotransporter 2 inhibitors Vitamin D Chinese herbal medicines

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Simultaneously achieving high energy density and responsivity in submicron BaTiO_(3) film capacitors integrated on Si

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Journal of Advanced Ceramics 2024年第2期13卷 198-206页

作者： Jun ouyang Yinxiu Xue Chuanqi Song Meiling Yuan Kun Wang Yuyao Zhao hongbo Cheng Hanfei Zhu Chao Liu Institute of Advanced Energy Materials and Chemistry School of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Key Laboratory of Key Film Materials&Application for Equipment School of Material Sciences and EngineeringXiangtan UniversityXiangtan 411105China School of Materials Science and Engineering Shandong UniversityJinan 250061China Academic Affairs Office Civil Aviation University of ChinaTianjin 300300China China Tobacco Shandong Industrial Co. Ltd.Jinan 250014China

In the research field of energy storage dielectrics,the“responsivity”parameter,defined as the recyclable/recoverable energy density per unit electric field,has become critically important for a comprehensive evaluation of the energy storage capability of a *** this work,high recyclable energy density and responsivity,i.e.,W_(rec)=161.1 J·cm^(-3) and ξ=373.8 J·(kV·m^(2))^(-1),have been simultaneously achieved in a prototype perovskite dielectric,BaTiO_(3),which is integrated on Si at 500℃ in the form of a submicron thick *** ferroelectric film features a multi-scale polar structure consisting of ferroelectric grains with different orientations and inner-grain ferroelastic domains.A LaNiO_(3) buffer layer is used to induce a{001}textured,columnar nanograin microstructure,while an elevated deposition temperature promotes lateral growth of the nanograins(in-plane diameter increases from~10-20 nm at lower temperatures to~30 nm).These preferably oriented and periodically regulated nanograins have resulted in a small remnant polarization and a delayed polarization saturation in the film’s P-E behavior,leading to a high recyclable energy ***,an improved polarizability/dielectric constant of the BaTiO_(3) film has produced a much larger maximum polarization than those deposited at lower temperatures at the same electric field,leading to a record-breaking responsivity for this simple perovskite.

关键词： energy storage energy density responsivity BaTiO_(3) dielectric capacitor Si

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A high-sensitive and self-selective humanoid mechanoreceptor for spatiotemporal tactile stimuli cognition

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Nano Research 2024年第5期17卷 4400-4409页

作者： Shuxin Bi Xuan Zhao Fangfang Gao Xiaochen Xun Bin Zhao Liangxu Xu Tian ouyang Qingliang Liao Yue Zhang Academy for Advanced Interdisciplinary Science and Technology Beijing Advanced Innovation Center for Materials Genome EngineeringUniversity of Science and Technology(Beijing)Beijing 100083China Key Laboratory of Advanced Materials and Devices for Post-Moore Chips Ministry of EducationBeijing Key Laboratory for Advanced Energy Materials and TechnologiesSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

The cognition of spatiotemporal tactile stimuli,including fine spatial stimuli and static/dynamic temporal stimuli,is paramount for intelligent robots to feel their surroundings and complete manipulation ***,current tactile sensors have restrictions on simultaneously demonstrating high sensitivity and performing selective responses to static/dynamic stimuli,making it a challenge to effectively cognize spatiotemporal tactile ***,we report a high-sensitive and self-selective humanoid mechanoreceptor(HMR)that can precisely respond to spatiotemporal tactile *** HMR with PDMS/chitosan@CNTs(PDMS:polydimethylsiloxane;CNT:carbon nanotube)graded microstructures and polyurethane hierarchical porous spacer exhibits high sensitivity of 3790.8 kPa^(-1).The HMR demonstrates self-selective responses to static and dynamic stimuli with mono signal through the hybrid of piezoresistive and triboelectric ***,it can respond to spatiotemporal tactile stimuli and generate distinguishable and multi-type characteristic *** the assistance of the convolutional neural network,multiple target objects can be easily identified with a high accuracy of 99.1%.This work shows great potential in object precise identification and dexterous manipulation,which is the basis of intelligent robots and natural human-machine interactions.

关键词： mechanoreceptors self-selective high-sensitive spatiotemporal tactile stimuli cognition sensors

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Achieving Ultra-Broad Microwave Absorption Bandwidth Around Millimeter-Wave Atmospheric Window Through an Intentional Manipulation on Multi-Magnetic Resonance Behavior

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Nano-Micro Letters 2024年第9期16卷 291-307页

作者： Chuyang Liu Lu Xu Xueyu Xiang Yujing Zhang Li Zhou Bo ouyang Fan Wu Dong‑Hyun Kim Guangbin Ji School of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016JiangsuPeople’s Republic of China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuPeople’s Republic of China School of Physics Nanjing University of Science and TechnologyNanjing 210094JiangsuPeople’s Republic of China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuPeople’s Republic of China School of Physics Chungbuk National UniversityCheongju 28644South Korea Department of Chemistry School of ScienceTianjin UniversityTianjin 300072People’s Republic of China

The utilization of electromagnetic waves is rapidly advancing into the millimeter-wave frequency range,posing increasingly severe challenges in terms of electromagnetic pollution prevention and radar ***,existing millimeter-wave absorbers are still inadequate in addressing these issues due to their monotonous magnetic resonance *** this work,rare-earth La^(3+)and non-magnetic Zr^(4+)ions are simultaneously incorporated into M-type barium ferrite(BaM)to intentionally manipulate the multi-magnetic resonance *** leveraging the contrary impact of La^(3+)and Zr^(4+)ions on magnetocrystalline anisotropy field,the restrictive relationship between intensity and frequency of the multi-magnetic resonance is successfully *** magnetic resonance peak-differentiating and imitating results confirm that significant multi-magnetic resonance phenomenon emerges around 35 GHz due to the reinforced exchange coupling effect between Fe^(3+)and Fe^(2+)***,Mosbauer spectra analysis,first-principle calculations,and least square fitting collectively identify that additional La^(3+)doping leads to a profound rearrangement of Zr^(4+)occupation and thus makes the portion of polarization/conduction loss increase *** a consequence,the La^(3+)-Zr^(4+)co-doped BaM achieves an ultra-broad bandwidth of 12.5+GHz covering from 27.5 to 40+GHz,which holds remarkable potential for millimeter-wave absorbers around the atmospheric window of 35 GHz.

关键词： Microwave absorption Ultra-broad bandwidth M-type barium ferrite Magnetocrystalline anisotropy field Multimagnetic resonance

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Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment

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Nano Research 2024年第5期17卷 4359-4370页

作者： ouyang Yue Xuechuan Wang Mengdi Hou Siwei Sun Manhui Zheng Xiaoliang Zou Zhongxue Bai Chunlin Liu Xinhua Liu College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXi’an 710021China College of Pharmacy Shaanxi University of Chinese MedicineXi’an 710021China Institute of Basic and Translational Medicine Xi’an Medical UniversityXi’an 710021China School of Mechanical Engineering Chengdu UniversityChengdu 610000China

Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical *** continuous treatment,healing induction,and real-time visualization of wound status and complications,including wound re-tearing,inflammation,and morphology,are key focal points for comprehensive ***,an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive(DLGel)by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer *** subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue,providing a basis for reliable wound *** achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion,excellent hemostatic performance,outstanding antimicrobial properties,and self-repair ***,a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound *** strategy translates biological information into visual graphics,providing real-time early warning and assessment of postoperative wound-abnormality/-morphology,such as laceration,inflammation,and ***,DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure,wound healing,and real-time postoperative wound-status warning and assessment within the unobservable and undetectable“black box”regions in a context of non-clinical comprehensive therapy.

关键词： electroactive bio-adhesive quadruple energy dissipation comprehensive wound therapy postoperative wound-status warning and assessment

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Optimization of Product Distribution for MIP Units Using Data Mining

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 146-157页

作者： Wang Qing Zhang Xiaoguo Mei Junwei Gao Zhibo Yang Kuizhi Yang Dawei ouyang Fusheng International Joint Research Center of Green Energy Chemical Engineering East China University of Science and TechnologyShanghai 200237China SINOPEC Changling Petrochemical Co. LtdYueyang 414012China

Based on data from a petrochemical company’s MIP unit over the past three years,19 input variables and 2 output variables were selected for modeling using the maximum information coefficient and Pearson correlation coefficient among 155 variables,which included properties of feedstock oil and spent catalyst,operational variables,and material *** distillation range variables were reduced using factor analysis,and the feedstock oils were clustered into three types using the K-means++*** feedstock oil type was then used as an input variable for *** XGBoost model and a back propagation(BP)neural network model with a structure of 20-15-15-2 were developed to predict the combined yield of gasoline and propylene,as well as the coke *** the test set,the BP neural network model demonstrated better fitting and generalization abilities with a mean absolute percentage error and determination coefficient of 1.48%and 0.738,respectively,compared to the XGBoost *** was therefore chosen for further optimization *** genetic algorithm was utilized to optimize operational variables in order to increase the combined yield of gasoline and propylene while controlling the growth of coke *** commercial test results in the MIP unit showed an average increase of 1.39 percentage points for the combined yield of gasoline and propylene and an average decrease of 0.11 percentage points for coke *** results indicate that the model effectively improves the combined yield of gasoline and propylene while controlling the increase in coke yield.

关键词： MIP process K-Means++ BP neural network model XGBoost algorithm genetic algorithm

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Conversion of Lignin into Porous Carbons for High-Performance Supercapacitors via Spray Drying and KOH Activation: Structure-Properties Relationship and Reaction Mechanism

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Journal of Renewable Materials 2024年第7期12卷 1207-1218页

作者： Shihao Feng Qin ouyang Jing Huang Xilin Zhang Zhongjun Ma Kun Liang Qing Huang Zhejiang Key Laboratory of Data-Driven High-Safety Energy Materials and Applications Ningbo Key Laboratory of Special Energy Materials and ChemistryNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China Engineering Laboratory of Advanced Energy Materials Qianwan Institute of CNITECHNingbo315336China School of Physics Henan Normal UniversityXinxiang453007China School of Environment Henan Normal UniversityXinxiang453007China

Lignin-derived porous carbons have emerged as promising electrode materials for ***,the challenge remains in designing and controlling their structure to achieve ideal electrochemical performance due to the complex molecular structure of lignin and its intricate chemical reactions during the activation *** this study,three porous carbons were synthesized from lignin by spray drying and chemical activation with vary-ing KOH *** speciﬁc surface area and structural order of the prepared porous carbon continued to increase with the increase of the KOH ***-mass spectrometry(TG-MS)was employed to track the molecular fragments generated during the pyrolysis of KOH-activated lignin,and the mechanism of the thermochemical conversion was *** the thermochemical conversion of lignin,KOH facili-tated the removal of H2 and CO,leading to the formation of not only more micropores and mesopores,but also more ordered carbon *** pore structure exhibited a greater impact than the carbon structure on the electrochemical performance of porous *** optimized porous carbon exhibited a capacitance of 256 F g-1 at a current density of 0.2 A g-1,making it an ideal electrode material for high-performance supercapacitors.

关键词： Lignin porous carbon KOH activation mechanism supercapacitor

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Unveiling optical anisotropy in disrupted symmetry WSe_(2)/SiP heterostructures

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Nano Research 2024年第9期17卷 8585-8591页

作者： Biqi Hu Xing Xie Xinyu ouyang Junying Chen Shaofei Li Jun He Zongwen Liu Jian-Tao Wang Yanping Liu Institute of Quantum Physics School of PhysicsCentral South University932 South Lushan RoadChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South University932 South Lushan RoadChangsha 410083China School of Chemical and Biomolecular Engineering The University of SydneyNSW 2006Australia The University of Sydney Nano Institute The University of SydneyNSW 2006Australia Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Shenzhen Research Institute of Central South University Shenzhen 518000China

Two-dimensional(2D)transition metal dichalcogenides(TMDs)have garnered considerable attention for their promising applications in sensors and optoelectronic devices,owing to their exceptional optical,electronic,and optoelectronic ***,the inherent high symmetry of TMD lattices imposes limitations on their functional ***,we present a strategy to disrupt the C_(3)rotational symmetry of monolayer WSe_(2)by fabricating a heterostructure incorporating WSe_(2)and SiP *** comprehensive experimental investigations and first-principle calculations,we elucidate that in the WSe_(2)/SiP heterostructure,excitons-both neutral and charged-emanating from WSe_(2)exhibit pronounced anisotropy,which remains robust against temperature ***,we observe an anisotropic ratio reaching up to 1.5,indicating a substantial degree of ***,we demonstrate the tunability of exciton anisotropy through the application of a magnetic field,resulting in a significant reduction in the anisotropic ratio with increasing field strength,from 1.57 to ***,the change in heterojunction anisotropy ratio reaches 24.8%as the magnetic field *** findings elucidate that the perturbation of the C_(3)rotational symmetry of the WSe_(2)monolayer arises from a non-uniform charge density distribution within the layer,exhibiting mirror *** results underscore the potential of heterostructure engineering in tailoring the properties of isotropic materials and provide a promising avenue for advancing the application of anisotropic devices across various fields.

关键词： symmetry breaking heterostructure engineering anisotropy optical spectroscopy

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