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Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy

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Neural Regeneration Research 2024年第3期19卷 598-605页

作者： Yaowei Lv Xiangyun Yao Xiao Li Yuanming ouyang Cunyi Fan Yun Qian Department of Orthopedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration ShanghaiChina Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine ShanghaiChina College of Fisheries and Life Science Shanghai Ocean UniversityShanghaiChina

Diabetic peripheral neuropathy is a common complication of diabetes *** the pathophysiological metabolic mechanism impels the generation of ideal ***,existing limited treatments for diabetic peripheral neuropathy expose the urgent need for cell metabolism *** the lack of comprehensive understanding of energy metabolism changes and related signaling pathways in diabetic peripheral neuropathy,it is essential to explore energy changes and metabolic changes in diabetic peripheral neuropathy to develop suitable treatment *** review summarizes the pathophysiological mechanism of diabetic peripheral neuropathy from the perspective of cellular metabolism and the specific interventions for different metabolic pathways to develop effective treatment *** metabolic mechanisms(e.g.,polyol,hexosamine,protein kinase C pathway)are associated with diabetic peripheral neuropathy,and researchers are looking for more effective treatments through these pathways.

关键词： cell metabolism diabetic peripheral neuropathy peripheral nerve injury protein kinase C pathway reactive oxygen species.

Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1787-1800页

作者： Yupeng Wang Lina Wang Tao Li Min ouyang Hejian Xiong Dongfang Zhou Department of Ultrasonic Diagnosis Zhujiang HospitalKey Laboratory of Mental Health of the Ministry of EducationNMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Testing and Analysis Center Hebei Normal UniversityShijiazhuang 050024China Department of Mechanical Engineering The University of Texas at DallasRichardsonTX 75080USA

Radiotherapy(RT)is one of the most feasible and routinely used therapeutic modalities for treating malignant *** particular,immune responses triggered by RT,known as radio-immunotherapy,can partially inhibit the growth of distantly spreading tumors and recurrent ***-ever,the safety and efficacy of radio-immunotherapy is impeded by the radio-resistance and poor immu-nogenicity of ***,we report oxaliplatin(IV)-iron bimetallic nanoparticles(OXA/Fe NPs)as cascade sensitizing amplifiers for low-dose and robust *** OXA/Fe NPs exhibit tumor-specific accumulation and activation of OXA(I)and Fe^(2+)in response to the reductive and acidic microenvironment within tumor *** cascade reactions of the released metallic drugs can sensitize RT by inducing DNA damage,increasing ROS and O_(2) levels,and amplifying the immunogenic cell death(ICD)effect after RT to facilitate potent immune *** a result,OXA/Fe NPs-based low-dose RT triggered a robust immune response and inhibited the distant and metastatic tumors effectively by a strong abscopal ***,a long-term immunological memory effect to protect mice from tumor rechal-lenging is ***,the bimetallic NPs-based cascade sensitizing amplifier system offers an effi-cient radio-immunotherapy regimen that addresses the key challenges.

关键词： Bimetallic nanoparticles Radio-immunotherapy Cascade sensitizing amplifier,Oxaliplatin Fenton-typeHaber-Weiss reaction Radiosensitization Immunogenic cell death Radio-resistance

A harmonic-wave bio-thermal method for continuous monitoring skin thermal conductivity and capillary perfusion rate

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Nano Research 2024年第5期17卷 4420-4427页

作者： Yuxin ouyang Jie Lin Jiajing Pei Rui Sui Di Liu Yanhui Feng Lin Qiu School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Analysis and Testing Beijing Academy of Science and TechnologyBeijing 100089China

The revelation of thermal energy exchange mechanism of human body is challenging yet worthwhile,because it can clearly explain the changes in human symptoms and health ***,the heat transfer of the skin is significant because the skin is the foremost organ for the energy exchange between the human body and the *** order to diagnose the physiological conditions of human skin without causing any damage,it is necessary to use a non-invasive measurement technique by means of a conformal flexible *** harmonic method can minimize the thermal-induced injury to the skin due to its low heat generating properties.A novel type of computational theory assessing skin thermal conductivity,blood perfusion rate of capillaries in the dermis,and superficial subcutaneous tissues was formed by combining the multi-medium thermal diffusion model and the bio-thermal model(Pennes equation).The skins of the hand back of six healthy subjects were *** was found that the results revealed no consistent changes in thermal conductivity were observed across genders and *** measured blood perfusion rates were within the range of human capillary *** was found that female subjects had a higher perfusion rate range(0.0058-0.0061 s^(-1))than male subjects(0.0032-0.0049 s^(-1)),which is consistent with invasive medical studies about the gender difference in blood flow rates and stimulated effects in relaxation situations.

关键词： thermal conductivity blood perfusion rate harmonic method Pennes equation

A laser-engraved wearable gait recognition sensor system for exoskeleton robots

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Microsystems & Nanoengineering 2024年第2期10卷 269-277页

作者： Maowen Sun Songya Cui Zezheng Wang Huayu Luo Huayong Yang Xiaoping ouyang Kaichen Xu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou310027China School of Information and Electrical Engineering Hangzhou City UniversityHangzhou310015China

As a reinforcement technology that improves load-bearing ability and prevents injuries,assisted exoskeleton robots have extensive applications in freight transport and health *** perception of gait information by such robots is vital for their *** information is the basis for motion planning in assistive and collaborative ***,a wearable gait recognition sensor system for exoskeleton robots is *** sensor arrays based on laser-induced graphene are developed with flexibility and *** sensor units are integrated into an insole to detect real-time pressure at key plantar *** addition,the circuit hardware and the algorithm are designed to reinforce the sensor system with the capability of gait *** experimental results show that the accuracy of gait recognition by the proposed system is 99.85%,and the effectiveness of the system is further verified through testing on an exoskeleton robot.

关键词： hardware robot skeleton

Influence of Recycled Concrete Fine Powder on Durability of Cement Mortar

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Fluid Dynamics & Materials Processing 2024年第1期20卷 45-58页

作者： Yadong Bian Xuan Qiu Jihui Zhao Zhong Li Jiana ouyang School of Architectural and Civil Engineering Zhongyuan University of TechnologyZhengzhou450007China School of Civil Engineering Sun Yat-Sen University&Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai519082China

In this paper,the durability of cement mortar prepared with a recycled-concrete fine powder(RFP)was examined;including the analysis of a variety of aspects,such as the carbonization,sulfate attack and chloride ion erosion *** results indicate that the influence of RFP on these three aspects is *** carbonization depth after 30 days and the chloride diffusion coefficient of mortar containing 10%RFP decreased by 13.3%and 28.19%.With a further increase in the RFP content,interconnected pores formed between the RFP particles,leading to an acceleration of the penetration rate of CO_(2)and Cl^(−).When the RFP content was less than 50%,the corrosion resistance coefficient of the compressive strength of the mortar was 0.84-1.05 after 90 days of sulfate *** the expansion and cracking of the mortar was effectively alleviated due to decrease of the gypsum *** electron microscope(SEM)analysis has confirmed that 10%RFP contributes to the formation of a dense microstructure in the cement mortar.

关键词： Recycled concrete fine powder cement mortar carbonization sulfate chloride ion durability

Geological Context of the SLIM Landing Site

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Journal of Earth Science 2024年第2期35卷 708-711页

作者： Yichen Wang Zhiyong Xiao Pei Ma Hanxing ouyang Wei Cao Planetary Environmental and Astrobiological Research Laboratory School of Atmospheric SciencesSun Yat-sen UniversityZhuhai 519000China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Hefei 230026China Planetary Science Institute School of Earth SciencesChina University of GeoscienceWuhan 430074China

INTRODUCTION Japan’s first successful lunar landing mission,Smart Lander for Investigating Moon(SLIM),was landed on the Moon on January 19th,*** made a precise landing within 100 m of the targeted landing zone(central coordinates 13.316°S,25.251°E),which is located around the Shioli crater(D=270 m,central coordinates as 13.33°S,25.23°E)in the southwestern ejecta of the Theophilus crater(D=98.6 km,central coordinates as 11.45°S,26.28°E).

关键词： southwestern coordinates SLIM

Cocrystals of carbamazepine:Structure,mechanical properties,fluorescence properties,solubility,and dissolution rate

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Particuology 2024年第7期90卷 20-30页

作者： Jinbo ouyang Lishan Liu Yin Li Mingyang Chen Limin Zhou Zhirong Liu Li Xu Hamza Shehzad School of Chemistry and Materials Science East China University of TechnologyNanchang 330013China School of Physics and Materials Science Nanchang UniversityNanchang 330013China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

Carbamazepine(CBZ)is an anticonvulsant with very low water solubility,presenting as a white crystalline powder with poor mechanical properties and is hard to *** enhance CBZ's physicochemical properties,such as water solubility and mechanical properties,we selected six cocrystal coformers(CCFs):nicotinamide(NIC),benzamide(BZM),salicylic acid(SCA),fumaric acid(FMA),trimesic acid(TMA),and hesperetin(HPE).Six CBZ cocrystals were successfully prepared using the solution *** transform infrared spectroscopy(FT-IR),powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),and single crystal X-ray diffraction(SCXRD)were used to characterize the crystal structures and gain comprehensive insights into the six *** mechanical,fluorescence,and solubility properties of the six cocrystals were *** results reveal that most of the prepared cocrystals exhibit improved water solubility and mechanical properties when compared to *** them,the dissolution rate of cocrystals excluded from CBZ-HPE has increased by an average of 3 or 4 times compared to CBZ,while CBZ-HPE exhibits superior mechanical ***,all six cocrystals possess better fluorescence performance than *** thoroughly evaluated the mechanical properties of the cocrystals through both experimental and theoretical *** work provides a new direction for studying drug cocrystals to improve the physicochemical properties of drugs.

关键词： Carbamazepine Cocrystal Mechanical properties Fluorescence performance Dissolution rate

An in-situ self-etching enabled high-power electrode for aqueous zinc-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 399-408,I0009页

作者： Shuang Hou Dingtao Ma Yanyi Wang Kefeng ouyang Sicheng Shen hongwei Mi Lingzhi Zhao Peixin Zhang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060GuangdongChina Guangdong Provincial Engineering Technology Research Center for Low Carbon and Advanced Energy Materials School of Semiconductor Science and TechnologySouth China Normal UniversityFoshan 528225GuangdongChina SCNU Qingyuan Institute of Science and Technology Innovation Co. Ltd.Qingyuan 511517GuangdongChina

Sluggish storage kinetics is considered as the main bottleneck of cathode materials for fast-charging aqueous zinc-ion batteries(AZIBs).In this report,we propose a novel in-situ self-etching strategy to unlock the Palm tree-like vanadium oxide/carbon nanofiber membrane(P-VO/C)as a robust freestanding *** investigations including the finite element simulation,in-situ X-ray diffraction,and in-situ electrochemical impedance spectroscopy disclosed it an electrochemically induced phase transformation mechanism from VO to layered Zn_(x)V_(2)O_5·nH_(2)O,as well as superior storage kinetics with ultrahigh pseudocapacitive *** demonstrated,such electrode can remain a specific capacity of 285 mA h g^(-1)after 100 cycles at 1 A g^(-1),144.4 mA h g^(-1)after 1500 cycles at 30 A g^(-1),and even 97 mA h g^(-1)after 3000 cycles at 60 A g^(-1),***,an impressive power density of 78.9 kW kg^(-1)at the super-high current density of 100 A g^(-1)also can be *** design concept of in-situ self-etching free-standing electrode can provide a brand-new insight into extending the pseudocapacitive storage limit,so as to promote the development of high-power energy storage devices including but not limited to AZIBs.

关键词： In-situ self-etching Free-standing electrode Pseudocapacitive storage High-power Zinc-ion batteries

Ultrathin organic solvent nanofiltration membrane with polydopamine-HKUST-1 interlayer for organic solvent separation

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Journal of Environmental Sciences 2024年第7期141卷 182-193页

作者： Haike Li Xindong Li Guozai ouyang Lijinhong Huang Lang Li Wenhao Li Wanfu Huang Duokun Li Ganzhou Key Laboratory of Basin Pollution Simulation and Control Jiangxi University of Science and TechnologyGanzhou 341000China Innovation Center for Water Quality Security Technology at Ganjiang River Basin Jiangxi University of Science and TechnologyGanzhou 341000China School of Architecture and Design Jiangxi University of Science and TechnologyGanzhou 341000China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityWA 6845Australia School of Materials Science and Engineering Tiangong UniversityTianjin 300387China

Polydopamine(PDA)and metal-organic skeleton HKUST-1 were co-deposited on the base membrane of hexamethylenediamine(HDA)-crosslinked polyetherimide(PEI)ultrafiltration membrane as the interlayer,and high-throughput organic solvent nanofiltration membrane(OSN)was prepared by interfacial polymerization and solvent activation *** polyamide(PA)layer surface roughness from 28.4 nm in PA/PEI to 78.3 nm in PA/PDA-HKUST-10.6/PEI membrane,reduced the thickness of the separation layer from 79 to 14 nm,and significantly improved the hydrophilic,thermal and mechanical *** flux of the PA/PDA-HKUST-10.6/PEI membrane in a 0.1 g/L Congo Red(CR)ethanol solution at 0.6 MPa test pressure reached 21.8 L/(m^(2)·hr)and the rejection of CR was 92.8%.Solvent adsorption test,N,N-dimethylformamide(DMF)immersion experiment,and long-term operation test in ethanol showed that the membranes had high solvent *** solvent flux test demonstrated that,under the test pressure of 0.6 MPa,the flux of different solvents ranked as follows:methanol(56.9 L/(m^(2)·hr))>DMF(39.6 L/(m^(2)·hr))>ethanol(31.2 L/(m^(2)·hr))>IPA(4.5 L/(m^(2)·hr))>N-hexane(1.9 L/(m^(2)·hr)).The ability of the membranes to retain dyes in IPA/water dyes solution was also *** flux of the membrane was 30.4 L/(m^(2)·hr)and the rejection of CR was 91.6%when the IPA concentration reached 50%.This OSN membrane-making strategy is economical,environment-friendly and efficient,and has a great application prospect in organic solvent separation systems.

关键词： Interfacial polymerization Organic solvent nanofiltration Interlayer Metal-organic frameworks Polydopamine