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Clinical efficacy of Baijin pills in the treatment of generalized tonicclonic seizure epilepsy with cognitive impairment

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World Journal of Psychiatry 2024年第6期14卷 938-944页

作者： Jing-Bo Li Jing Jiang Lian Xue Shuai Zhao hong-quan liu Department of Neurology The Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Neurology Jiangsu Province Academy of Traditional Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND The generalized tonic-clonic seizure(GTCS)is the most usual variety of epileptic *** is mainly characterized by strong body muscle rigidity,loss of consciousness,a disorder of plant neurofunction,and significant damage to cognitive *** effect of antiepileptic drugs on cognition should also be *** present,there is no effective treatment for patients with epilepsy,but traditional Chinese medicine has shown a significant effect on chronic disease with fewer harmful side effects and should,therefore,be considered for the therapy means of epilepsy with cognitive *** To investigate the clinical efficacy of Baijin pills for treating GTCS patients with cognitive *** This prospective study enrolled patients diagnosed with GTCS between January 2020 and December 2023 and separate them into two groups(experimental and control)using random number table *** control group was treated with sodium valproate,and the experimental group was Baijin pills and sodium valproate for three *** frequency and duration of each seizure,the Montreal Cognitive Assessment Scale(MoCA),and the Quality of Life Rating Scale(QOLIE-31)were recorded before and after *** There were 85 patients included(42 in the control group and 43 in the experimental group).After treatment,the seizure frequency in the experimental group was significantly reduced(P<0.05),and seizure duration was shortened(P<0.01).The total MoCA score in the experimental group significantly increased compared to before treatment(P<0.01),and the sub-item scores,except naming and abstract generalization ability,significantly increased(P<0.05),whereas the total MoCA score in the control group significantly decreased after treatment(P<0.05).The QOLIE-31 score of the experimental group increased significantly after treatment compared to before treatment(P<0.01).CONCLUSION Baijin pills have a good clinical effect on epilepsy with cognitive dysfunction.

关键词： Epilepsy Generalized tonic-clonic seizure Cognitive impairment Traditional Chinese medicine Baijin pills

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A simple Pb-doping to achieve bonding evolution, VSn and resonant level shifting for regulating thermoelectric transport behavior of SnTe

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Journal of Materials Science & Technology 2023年第20期151卷 66-72页

作者： Xu-Ye Xin Jun Ma hong-quan liu Yi-Jie Gu Yan-Fang Wang hong-Zhi Cui College of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China School of Mechanical-electronic and Vehicle Engineering Weifang UniversityWeifang 261061China School of Materials Science and Engineering China University of Petroleum HuadongQingdao 266580China

The intensification of energy crises and environmental pollution inspire researchers’attention to environment-friendly SnTe thermoelectric *** this work,we achieved a lower lattice thermal conductivity and optimized the power factor via the synergistic optimization of bonding characteristic,VSn,and resonant level for the SnTe system,***-introduction produces weak bonding strength,mass fluctuation,and stress distortion,which result in lower thermal *** lowest lattice thermal conductivity achieves 0.66 W m^(–1) K^(–1) at 773 *** introduced VSn relieves loss of electrical conductivity caused by Pb-introduction,and it also makes the bigger g(E)and up-shift of resonance *** VSn,enhanced g(E),and resonant level make electrical conductivity and Seebeck coefficient enhance ***,the further optimization of thermal and electronic transport performance contributes to a higher ZT value of∼0.86 at 773 K in the Sn_(0.685)Pb_(0.285)In_(0.015)Te_(0.7)Se_(0.3) *** strategy of bonding characteristic,VSn,and resonant level synergistic engineering will be widely applicable to various TE systems for achieving better thermoelectric performance.

关键词： SnTe-based material Low thermal conductivity Projected crystal orbital hamiltonian populations VSn Resonant level

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Harmonic State Space Based Impedance Modeling and Virtual Impedance Based Stability Enhancement Control for LCC-HVDC Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 287-298页

作者： Yifeng liu Xiaoping Zhou quan Chen Hanhang Yin Lerong hong Hao Tian Ying Chen Siyuan Li the College of Electrical and Information Engineering Hunan UniversityChangsha 410082China the Zhejiang Magtron Intelligent Technology Limited Cooperation Jiaxing 314000China the State Grid Qianjiang Electric Power Company Qianjiang 433100China

Line commutated converter based high-voltage direct-current(LCC-HVDC)transmissions are prone to harmonic oscillation under weak *** modeling is an effective method for assessing interaction ***,this paper proposes an improved calculation method for the DC voltage and AC currents of commutation stations to address the complex linearization of the commutation process and constructs an overall harmonic state-space(HSS)model of an *** on the HSS model,the closed-loop AC impedances on the LCC-HVDC sending and receiving ends are then derived and *** impedance characteristics of the LCC-HVDC are then analyzed to provide a physical explanation for the harmonic oscillation of the *** effects of the grid strength and control parameters on system stability are also *** improve the impedance characteristics and operating stability of the LCC-HVDC system,a virtual impedance based stability enhancement control is proposed,and a parameter design method is considered to ensure satisfactory phase margins at both the sending and receiving ***,simulation results are presented to verify the validity of the impedance model and virtual impedance based stability enhancement control.

关键词： Line commutated converter based high-voltage direct-current(LCC-HVDC)transmission harmonic state space stability analysis harmonic oscillation virtual impedance

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Bilayer separator enabling dendrite-free zinc anode with ultralong lifespan >5000 h

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Green Energy & Environment 2024年第4期9卷 771-776页

作者： Lu Wang Feifei Wang Zhe Ding Yingxin liu Ziyi Zhang Chunpeng Yang Kian Ping Loh quan-hong Yang Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Department of Chemistry National University of Singapore117543Singapore Institute of Process Engineering Chinese Academy of SciencesBeijing100190China

Aqueous zinc(Zn)batteries with Zn metal anodes are promising clean energy storage devices with intrinsic safety and low ***,Zn dendrite growth severely restricts the use of Zn *** effectively suppress Zn dendrite growth,we propose a bilayer separator consisting of commercial butter paper and glassfiber *** dense cellulose-based butter paper(BP)with low zincophilicity and high mechanical properties prevents the pore-filling behavior of deposited Zn and related separator piercing,effectively suppressing the Zn dendrite *** a result,the bilayer separators endow the ZnjjZn symmetrical batteries with a superlong cycling life of Zn anodes(over 5000 h)at 0.5 mA cm^(-2) and the full batteries enhanced capacity retention,demonstrating the advancement of the bilayer separator to afford excellent cyclability of aqueous metal batteries.

关键词： Zn battery Bilayer separator Butter paper Zn metal anode Zn dendrite

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Development of a micro gas turbine combustor with T-type vaporizers

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航空动力学报 2007年第7期22卷 1118-1126页

作者： XU quan-hong liu Jun XU Jian LIN Yu-zhen liu Gao-en National Key Laboratory on Aero-Engines School of Jet PropulsionBeijing 13niversity of Aeronautics and Astronautics Beijing 100083 China

The study includes the experimental investigation of the evaporation performance of T-type vaporizer,mainly studied the relationship of the inlet air temperature and vaporizer wall temperature with the evaporation ***,it studied the LBO(lean blow out) and combustion efficiency of the micro aero-engine combustor with T-type vaporizer on the normal pressure test *** inlet air condition is environmental pressure and *** gas analysis method is used to study the combustion efficiency,and the inlet air temperature is 300 K,400 K and 500 *** could be concluded that the evaporation performance is improved with the increasing of the inlet air temperature and vaporizer wall temperature;the average LBO is 0.003;the combustion efficiency rises with the inlet air temperature,and it remain constant when the fuel/air ratio changed in the range from 0.008 to *** vaporization ratio is the key factor to determine the combustion performance.

关键词：离心式喷气发动机燃烧室喷雾器索特平均直径燃气涡轮

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The breaking of spin symmetry in the single-particle resonances in deformed nuclei

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Nuclear Science and Techniques 2024年第3期35卷 237-245页

作者： Zhen-Yu Zheng Shou-Wan Chen quan liu School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China

The exploration of spin symmetry (SS) in nuclear physics has been instrumental in identifying atomic nucleus *** this study,we solve the Dirac equation from the relativistic mean field (RMF) in complex momentum *** investigated SS and its breaking in single-particle resonant states within deformed nuclei,with a focus on the illustrative *** was the initial discovery of a resonant spin doublet in a deformed nucleus,with the expectation of the SS approaching the continuum *** increasing single-particle energy,the splitting of the resonant spin doublets widened *** escalating splitting implies diminishing adherence to the SS,indicating a departure from the expected behavior as the energy levels *** also analyzed the width of the resonant states,showing that lower orbital angular momentum resonances possess shorter decay times and that SS is preserved within broad resonant doublets,as opposed to narrow resonant *** the radial density of the upper components for the bound-state and resonant-state doublets,it becomes evident that while SS is well-preserved in the bound states,it deteriorates in the resonant *** impact of nuclear deformation (β_(2)) on SS was examined,demonstrating that an increase in β_(2) resulted in higher energy and width splitting in the resonant spin doublets,which is attributed to increased component ***,the sensitivity of spin doublets to various potential parameters such as surface diffuseness (a),radius (R),and depth (Σ0) is discussed,emphasizing the role of these parameters in *** study provides valuable insights into the behavior of spin doublets in deformed nuclei and their interplay with the nuclear structure,thereby advancing our understanding of SS in the resonance state.

关键词： Spin symmetry Resonant states Deformed nuclei Complex-momentum representation

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Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis

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World Journal of Gastroenterology 2024年第11期30卷 1588-1608页

作者： Xing-Nian Zhou quan Zhang hong Peng Yu-Jie Qin Yu-hong liu Lu Wang Ming-Liang Cheng Xin-Hua Luo hong Li Department of Infectious Diseases The Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Infectious Diseases Guizhou Provincial People's HospitalGuiyang 550001Guizhou ProvinceChina

BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and *** silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and *** To investigate the association between ferroptosis and pyroptosis and the upstream regulatory *** This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce *** D(GSDMD)^(-/-)mice were used as an experimental *** changes in liver tissue were monitored by hematoxylin and eosin ***,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial ***-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain ***1,p53,and GSDMD were assessed by immunofluorescence *** Serum AST and ALT levels were elevated in patients with ***1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver *** the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was *** mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were *** vitro,knockdown of p53 and overexpression of GPX

关键词： Silent information regulator sirtuin 1 Ferroptosis Pyroptosis p53/glutathione peroxidase 4/gasdermin D Acute liver failure

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Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

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Chinese Chemical Letters 2024年第4期35卷 414-419页

作者： Peide Zhu Yangjia liu Yaoyao Tang Siqi Zhu Xinyang liu Lei Yin quan liu Zhiqiang Yu quan Xu Dixian Luo Juncheng Wang State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523058China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052China Institute of Stomatology First Medical CenterChinese PLA General HospitalBeijing 100853China

Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped ***/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.

关键词： Bi-doped CQDs Lipo/Bi-doped CQDs pH sensitivity In vitro/in vivo imaging Diagnosis and treatment integration

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The BTB/TAZ domain-containing protein CmBT1-mediated CmANR1 ubiquitination negatively regulates root development in chrysanthemum

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Journal of Integrative Plant Biology 2024年第2期66卷 285-299页

作者： Lian-Da Du Zhang-Ji Guan Yan-hong liu Hui-Dong Zhu quan Sun Da-Gang Hu Cui-Hui Sun Shandong Collaborative Innovation Center of Fruit&Vegetable Quality and Efficient Production College of Horticulture Science and EngineeringShandong Agricultural UniversityTaian 271018China

Roots are fundamental for plants to adapt to variable environmental *** development of a robust root system is orchestrated by numerous genetic determinants and,among them,the MADS-box gene ANR1 has garnered substantial *** research has demonstrated that,in chrysanthemum,CmANR1positively regulates root system ***,the upstream regulators involved in the CmANR1-mediated regulation of root development remain *** this study,we successfully identified bric-a-brac,tramtrack and broad(BTB)and transcription adapter putative zinc finger(TAZ)domain protein CmBT1 as the interacting partner of CmANR1 through a yeasttwo-hybrid(Y2H)screening ***,we validated this physical interaction through bimolecular fluorescence complementation and pull-down *** assays revealed that CmBT1 exerted a negative influence on root development in *** both in vitro and in vivo assays,it was evident that CmBT1mediated the ubiquitination of CmANR1 through the ubiquitin/26S proteasome *** ubiquitination subsequently led to the degradation of the CmANR1 protein and a reduction in the transcription of CmANR1-targeted gene CmPIN2,which was crucial for root development in *** analysis suggested that CmBT1 modulated root development,at least in part,by regulating the level of CmANR1 ***,these findings shed new light on the regulatory role of CmBT1 in degrading CmANR1 through ubiquitination,thereby repressing the expression of its targeted gene and inhibiting root development in chrysanthemum.

关键词： chrysanthemum MADS-box transcription factor root development

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Impact of volcanism on the formation and hydrocarbon generation of organic-rich shale in the Jiyang Depression, Bohai Bay Basin, China

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Petroleum Science 2024年第3期21卷 1539-1551页

作者： Jia-hong Gao Xin-Ping Liang Zhi-Jun Jin quan-You liu Chang-Rong Li Xiao-Wei Huang Ju-Ye Shi Peng Li State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Efficient Development Institute of EnergyPeking University Petroleum Exploration and Production Research Institute SINOPECBeijing100871 China School of Energy Resources China University of Geosciences Beijing100083 China

Globally,most organic-rich shales are deposited with volcanic ash *** ash,a source for many sedimentary basins,can affect the sedimentary water environment,alter the primary productivity,and preserve the organic matter(OM)through physical,chemical,and biological *** an increasing number of breakthroughs in shale oil exploration in the Bohai Bay Basin in recent years,less attention has been paid to the crucial role of volcanic impact especially its influence on the OM enrichment and hydrocarbon ***,we studied the petrology,mineralogy,and geochemical characteristics of the organic-rich shale in the upper submember of the fourth member(Es_(4)^(1))and the lower submember of the third member(Es_(3)^(3))of the Shahejie Formation,aiming to better understand the volcanic impact on organic-rich shale *** results show that total organic carbon is higher in the upper shale intervals rich in volcanic ash with enriched light rare earth elements and moderate Eu *** indicates that volcanism promoted OM formation before or after the *** positive correlation between Eu/Eu*and Post-Archean Australian Shale indicates hydrothermal activity before the volcanic *** plane graph of the hydrocarbon-generating intensity(S1+S2)suggests that the heat released by volcanism promoted hydrocarbon ***,the nutrients carried by volcanic ash promoted biological blooms during Es_(4)^(1 )and Es_(3)^(3) deposition,yielding a high primary *** blooms consume large amounts of oxygen and form anoxic environments conducive to the burial and preservation of ***,this study helps to further understand the organic-inorganic interactions caused by typical geological events and provides a guide for the next step of shale oil exploration and development in other lacustrine basins in China.

关键词： Volcanic ash Hydrocarbon generation Organic-rich shale Shahejie Formation Jiyang Depression

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