检索结果-南通市图书馆

New Staging Model for Radiation-based Hepatocellular Carcinoma Treatment:A National Multicenter Study

Journal of Clinical and Translational Hepatology 2023年第2期11卷 341-349页

作者： Ting-Shi Su Shi-Xiong Liang Li-qing Li Qiu-Hua Liu Xue-Zhang Duan Jing Sun Hai Zeng Hai-Sheng Zhu Jian-Xu Li Xiao-Fei Zhu hong-qing zhuang Ping Liang Yong Huang Department of Radiation Oncology Guangxi Medical University Cancer HospitalNanningGuangxiChina Department of Radiation Oncology Ruikang HospitalNanningGuangxiChina Radiation Oncology Department The Fifth Medical Center of PLA General HospitalBeijingChina Department of Oncology First Affiliated Hospital of Yangtze UniversityJingzhouHubeiChina Department of Oncology Sixth Affiliated Hospital of Guangxi Medical UniversityFirst People’s Hospital of YulinYulinGuangxiChina Department of Radiation Oncology Changhai Hospital Affiliated to Navy Medical UniversityShanghaiChina Department of Radiation Oncology Peking University Third HospitalBeijingChina Department of Radiation Oncology Nanning First People’s HospitalNanningGuangxiChina

Background and Aims:The study aimed to create a new staging model for radiotherapy-based treatment for prognostic hepatocellular carcinoma(HCC)***:The training cohort comprised 658 patients receiving stereotactic body radiotherapy and external validation cohort comprised 533 patients receiving three-dimensional conformal radiotherapy and intensity-modulated *** established a modified staging system as follows:stage I,solitary nodule without macrovascular invasion,or 2–3 nodules no more than 3.0 cm apart,and performance status(PS)0–2(Ia:ALBI-1 grade;Ib:ALBI-2 or 3 grade);stage II:2–3 nodules with any one nodule more than 3.0-cm apart,or≥4 nodules,and performance status 0–2(IIa:ALBI-1 grade;IIb:ALBI-2 grade);stage III:macrovascular invasion,regional lymph node metastasis or distant metastasis,and performance status 0–2(IIIa:ALBI-1 grade;IIIb:ALBI-2 grade);stage IV:performance status 3–4,or performance status 0–2 with ALBI-3 *** analyzed longterm overall survival based on different ***:The staging model showed an excellent ability to discriminate patients according to four stages and seven substages with notably different curves in the training and validation *** median survival decreased from stages I to IV with 63.0 months in stage I(not reached in Ia,and 53.0 months in Ib),24.0 months in stage II(28.0 months in IIa,and 22.0 months in IIb),11.0 months in stage III(18.0 months in IIIa,and 9.0 months in IIIb),and less than 9.0 months in stage IV in the training ***:The modified staging model may provide an alternative for clinical radiation oncologists.

关键词： Hepatocellular carcinoma Radiotherapy Stereotactic body radiotherapy Staging system Overall survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prognostic and Predictive Factors of Early Breast Cancer

引用

Clinical oncology and cancer researeh 2010年第4期7卷 246-252页

作者： Zhong-jie CHEN Mei-ying YAN hong-qing zhuang Jian-lei HAO Rui-ying LI Zhi-yong YUAN Ping WANG Department of Radiotherapy Tianjin Medical University Cancer Institute & Hospital Key Laboratory of Breast Cancer Prevention and Therapy Tianjin Medical University Ministry of Education Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China. No.5 Psychiatric Department Jining psychiatric hospital Jining 272151 Shandong Province China.

OBJECTIVE To identify risk factors for relapse and death in patients with T1 to T2 breast cancer with 0-3 positive axillary lymph *** The case files of 540 breast cancer patients with T1-T2 tumors with 0-3 positive nodes were reviewed retrospectively. Ten-year locoregional recurrence （LRR）, distant recurrence （DR）, disease-free survival （DFS） and overall survival （OS） of the patients were analyzed. Univariate statistical analysis and Cox proportional hazards models were carried out with SPSS so ware *** The median follow-up of all the patients was 7.2 years. On multivariate analysis, 〉 20% positive axillary nodes was the only variable that influenced LRR adversely （hazard ratio[HR], 12.816; 95% confidence interval, 4.657-35.266, P 〈 0.001）; 〉 20% positive axillary nodes and ductal carcinoma were variables that influenced DR adversely （HR, 11.088, 95% confidence interval, 3.807-32.297, P 〈 0.001; HR, 0.390, 95% confidence interval, 0.179-0.851, P = 0.018）; 1-3 positive axillary nodes and 〉 20% positive axillary nodes were the only variables that had negative e. ect on 10-year OS （HR, 2.110, 95% confi dence interval, 1.364-3.264, P = 0.001; HR, 10.244, 95% confidence interval, 3.497-30.011, P 〈 0.001） and they were also adverse prognostic variables on 10-year DFS （HR, 1.634, 95% confidence interval, 1.171-2.279, P = 0.004; HR, 7.339, 95% confi dence interval,2.906-18.530, P 〈 0.001）.CONCLUSION Axillary lymph nodal status is the only risk factor with a signifi cant impact on 10-year LRR, DR, OS and *** with T1-T2 breast cancer with 0-3 positive lymph nodes have the LRR and DR of over 10 years, and the OS and DFS of less than 10 years, compared to patients with negative lymph *** in primary tumors is a signifi cant prognostic factor for the 10-year DR.

关键词： breast neoplasms recurrence death prognosis lymph nodes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大跨三桁铁路斜拉桥桁间高差控制技术

引用

世界桥梁 2014年第2期42卷 22-25页

作者：洪清庄中铁大桥局安庆长江大桥指挥部安徽安庆246008

钢桁梁斜拉桥钢桁梁采用3片主桁结构,在自重作用下中桁承担荷载较大,施工中容易出现桁间高差(中桁比边桁低),造成钢桁梁连接杆件拼装困难。以宁安铁路安庆长江大桥为背景,通过加强测量观测,控制连接杆件螺栓施拧、桥面板焊接工艺及进度... 详细信息

钢桁梁斜拉桥钢桁梁采用3片主桁结构,在自重作用下中桁承担荷载较大,施工中容易出现桁间高差(中桁比边桁低),造成钢桁梁连接杆件拼装困难。以宁安铁路安庆长江大桥为背景,通过加强测量观测,控制连接杆件螺栓施拧、桥面板焊接工艺及进度,调整主桁杆件架设顺序等具体措施,有效保证了钢桁梁的架设进度及合龙精度。

关键词：斜拉桥钢桁梁架设散拼法高差施工控制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

大跨度连续梁上跨铁路营业线施工安全防护技术

引用

世界桥梁 2015年第6期43卷 20-24页

作者：洪清庄中铁大桥局渝黔铁路项目部重庆江津402283

重庆渝黔铁路新白沙沱长江特大桥引桥78号~81号墩为一联（68＋128＋68）m连续梁,上跨珞璜电厂专用线电气化铁路。为保证复杂条件下上跨铁路营业线的施工安全,对先搭设防护棚架防护后进行挂篮施工和全封闭挂篮施工2种方案进行了比选,最... 详细信息

重庆渝黔铁路新白沙沱长江特大桥引桥78号~81号墩为一联（68＋128＋68）m连续梁,上跨珞璜电厂专用线电气化铁路。为保证复杂条件下上跨铁路营业线的施工安全,对先搭设防护棚架防护后进行挂篮施工和全封闭挂篮施工2种方案进行了比选,最终选用全封闭挂篮工艺施工。对全封闭挂篮结构进行设计计算,挂篮自身封闭系统防护包括挂篮下方防护平台、周边防护网、挂篮上顶横梁防护网、梁面防护等;营业线防护包括施工驻站防护、机械防护和信号防护等安全防护。工程实践表明,该挂篮施工结构安全可靠,所采取的防护技术保证了梁体下方铁路营业线运行安全通畅。

关键词：跨线桥连续梁挂篮防护安全施工技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Polyaniline as Hole-Acceptor and Energy-Acceptor on the Photoluminescence of CdSe

引用

Chemical Research in Chinese Universities 2007年第2期23卷 131-134页

作者： zhuang hong LIU Jing-bo ZENG qing-hui KONG Xiang-gui Colledge of Light Industry and Economics ＆ Management Jilin University Changchun 130062 P. R. China Key Laboratory of Excited State Process Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130033 P. R. China

The results of interaction between CdSe quantum dots and polyaniline were reported. Polyaniline effectively decreases the emission of CdSe quantum dots, and the CdSe luminescence lifetime is decreased by the addition of polyaniline. The mechanism of the emission observed in CdSe is assumed to result from the energy transfer and from the combination of surface-trapped electrons and holes energy is transferred from CdSe to polyaniline, and polyaniline occupies the hole sites.

关键词： CdSe Polyaniline Hole-acceptor Energy-acceptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanical properties and constitutive behaviors of as-cast 7050 aluminum alloy from room temperature to above the solidus temperature

引用

International Journal of Minerals,Metallurgy and Materials 2016年第8期23卷 949-958页

作者： qing-ling Bai hong-xiang Li Qiang Du Ji-shan Zhang Lin-zhong zhuang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China SINTEF Materials and Chemistry TrondheimNorway

The mechanical properties and constitutive behaviors of as-cast AA7050 in both the solid and semi-solid states were determined using the on-cooling and in situ solidification approaches, respectively. The results show that the strength in the solid state tends to increase with decreasing temperature. The strain rate plays an important role in the stress–strain behaviors at higher temperatures, whereas the influence becomes less pronounced and irregular when the temperature is less than 250°C. The experimental data were fitted to the extended Ludwik equation, which is suitable to describe the mechanical behavior of the materials in the as-cast state. In the semi-solid state, both the strength and ductility of the alloy are high near the solidus temperature and decrease drastically with decreasing solid fraction. As the solid fraction is less than 0.97, the maximum strength only slightly decreases, whereas the post-peak ductility begins to increase. The experimental data were fitted to the modified creep law, which is used to describe the mechanical behavior of semi-solid materials, to determine the equivalent parameter fGBWL, i.e., the fraction of grain boundaries covered by liquid phase.

关键词： aluminum alloys mechanical properties constitutive relations fitting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Construction of a dual fluorescence whole-cell biosensor to detect N-acyl homoserine lactones

引用

Journal of Environmental Sciences 2014年第2期26卷 415-422页

作者： Xuemei Deng Guoqiang zhuang Anzhou Ma qing Yu Xuliang zhuang Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Detection of N-acyl homoserine lactones （AHLs） is useful for understanding quorum sensing （QS） behaviors, including biofilm formation, virulence and metabolism. For detecting AHLs and indicating the host cells in situ, we constructed the plasmid pUCGMA2T1-4 to make a dual fluorescent whole- cell biosensor based on the AhlI/R AHL system of Pseudomonas syringae pv. syringae B728a. The plasmid contains three components： constitutively expressed enptll：：gfP for indicating host cells, Pahll：：mcherry that produces red fluorescence in response to AHL, and the ahIR gene that encodes an AHL regulatory protein. Meanwhile, two copies of T1-4 （four tandem copies of a transcriptional terminator） were added into the plasmid to reduce background. The results showed that when the plasmid was placed into Escherichia coli, the dual fluorescence whole-cell biosensor was able to respond with red fluorescence within 6 hr to 5 × 10^-8-1 × 10^-5 mol/L of 3OC6-HSL. Bright green fluorescence indicated the host cells. Furthermore, when the plasmid was transferred to wild- type Pseudomonas PhTA125 （an AHL-producing bacterium）, it also showed both green and red fluorescence. This result demonstrates that this plasmid can be used to construct whole-cell indicators that can indicate the AHL response and spatial behaviors of microbes in a mi tal niche

关键词： whole-cell biosensor quorum sensing dual fluorescence gfp mcherry indicator

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immigrant Pantoea agglomerans embedded within indigenous microbial aggregates: A novel spatial distribution of epiphytic bacteria

引用

Journal of Environmental Sciences 2014年第2期26卷 398-403页

作者： qing Yu Anzhou Ma Mengmeng Cui Xuliang zhuang Guoqiang zhuang Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Immigrant bacteria located on leaf surfaces are important to the health of plants as well as to people who consume fresh fruits and vegetables. However, the spatial distribution and organization of these immigrant bacteria on leaf surfaces are still poorly understood. To examine the spatial organization of these strains, two bacterial strains on tobacco leaves：（1） an indigenous strain, Pseudomonas stutzeri Nov. Y2011 labeled with green fluorescent protein, and （2） an immigrant strain Pantoea agglomerans labeled with cyan fluorescent protein isolated from pear, were studied. Under moist conditions, P. agglomerans cells quickly disappeared from direct observation by laser- scanning confocal microscopy, although elution results indicated that large amounts of live cells were still present on the leaves. Following exposure to desiccation stress, particles of cyan fluorescent protein-labeled P. agglomerans were visible within cracked aggregates of P. stutzeri Nov. Y2011. Detailed observation of sectioned aggregates showed that colonies of immigrant P. agglomerans were embedded within aggregates of P. stutzeri Nov. Y2011. Furthermore, carbon-resource partitioning studies suggested that these two species could coexist without significant nutritional competition. This is the first observation of an immigrant bacterium embedding within aggregates of indigenous bacteria on leaves to evade harsh conditions in the phyllosphere.

关键词： phyllosphere spatial organization epiphytes survival manner

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantitative Study of Iron Metabolism-related Genes Expression in Rat

引用

Biomedical and Environmental Sciences 2013年第10期26卷 808-819页

作者： LI Yan Qin BAI Bin ZHENG Quan qing YAN hong zhuang Gui Hua Department of Public Health College of MedicineXi’an Jiaotong University Department of Orthopedics The First Affiliated Hospital of the College of MedicineXi’an Jiaotong University

Objective To investigate the multiple iron metabolism-related genes expression, its regulation by iron and the expression correlation among the genes in rat tissues. Methods Two groups （n=30） of Sprague-Dawley female weanling rats were fed with a control diet and an iron deficient diet respectively for 4 weeks. All rats were then sacrificed, and blood and tissue samples were collected. The routine blood examination was performed with a veterinary automatic blood cell analyzer. Elemental iron levels in liver, spleen and serum were determined by atomic absorption spectrophotometry. The mRNA expression of genes was detected by real-time fluorescence quantitative PCR. Results After 4 weeks, the hemoglobin （Hb） level and red blood cell （RBC） count were significantly lower in the iron deficient group compared with those in the control group. The iron levels in liver, spleen and serum in the iron deficient group were significantly lower than those in the control group. In reference to small intestine, the relative expression of each iron-related gene varied in the different tissues. Under the iron deficiency, the expression of these genes changed in a tissue-specific manner. The expression of most of the genes significantly correlated in intestine, spleen and lung, but few correlated in liver, heart and kidney. Conclusion Findings from our study provides new regulation by iron and correlation among the mRNA divalent metal transporter 1, ferritin, iron regulation protein, hepcidin, ferroportin 1 and hephaestin in intesti understandings about the relative expression, expressions of transferrin receptors 1 and 2, proteins 1 and 2, hereditary hemochromatosis ne, liver, spleen, kidney, heart, and lung of rat.

关键词： Iron Tfr Dmtl Hepcidin Ferroportin 1 Hephaestin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detection,isolation,and identification of cadmium-resistant bacteria based on PCR-DGGE

引用

Journal of Environmental Sciences 2007年第9期19卷 1114-1119页

作者： HU qing DOU Min-na QI hong-yan XIE Xiang-ming zhuang Guo-qiang YANG Min Department of Environmental Biotechnology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. Biology Science and Technology College Beijing Forestry University Beijing 100083 China

This study focused on the screening of cadmium-resistant bacterial strains from Pb-Zn tailing. We investigated the diversity of microbial community inhabiting Dong-san-cha Pb-Zn tailing in Beijing, China, by polymerase chain reaction-denaturing gradient gel electrophoresis （DGGE） of 16S rRNA gene of bacterial strain, and found two dominant strains in the DGGE profile. Using special culture media, we isolated two strong cadmium-resistant bacterial strains. On the basis of morphological, physiological, and biochemical characteristics, BIOLOG, and 16S rDNA sequencing, the two strains were identified as Bacillus cereus and Enterobacter cloacae. Minimal inhibitory concentrations （MICs） of heavy metals for the bacteria were determined. E. cloacae showed higher MIC values for heavy metals and a larger range of antibiotic resistance than B. cereus.

关键词： Bacillus cereus Enterobacter cloacae PCR-DGGE cadmium resistance antibiotic resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：