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The role of crm-1 in ionizing radiation-induced nervous system dysfunction in Caenorhabditis elegans

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Neural Regeneration Research 2023年第6期18卷 1386-1392页

作者： Hui-Qiang Long Jin Gao Shu-qing He Jian-Fang Han Yu tu Na Chen Suzhou Medical College of Soochow University SuzhouJiangsu ProvinceChina State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhouJiangsu ProvinceChina Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions SuzhouJiangsu ProvinceChina

Ionizing radiation can cause changes in nervous system ***,the underlying mechanism remains *** this study,Coenorhabditis elegans(***)was irradiated with 75 Gy of ^(60)Co whole-body γ *** indicators(head thrashes,touch avoidance,and foraging),and the development of dopaminergic neurons related to behavioral function,were evaluated to assess the effects of ionizing radiation on nervous system function in *** behaviors were impaired after whole-body irradiation and degeneration of dopamine neurons was *** suggests that 75 Gy of γ radiation is sufficient to induce nervous system *** genes nhr-76 and crm-1,which are reported to be related to nervous system function in human and mouse,were screened by transcriptome sequencing and bioinformatics analysis after irradiation or sham *** expression levels of these two genes were increased after ***,RNAi technology was used to inhibit the expression of crm-1,a gene whose homologs are associated with motor neuron development in other *** of crm-1 expression effectively alleviated the deleterious effects of ionizing radiation on head thrashes and touch *** was also found that the expression level of crm-1 was regulated by the nuclear receptor gene *** results of this study suggest that knocking down the expression level of nhr-76 can reduce the expression level of crm-1,while down-regulating the expression level of crm-1 can alleviate behavioral disorders induced by ionizing ***,inhibition of crm-1 may be of interest as a potential therapeutic target for ionizing radiation-induced neurological dysfunction.

关键词： behavior Caenorhabditis elegans degeneration disorder dysfunction nerve injury nervous system neurodevelopment neuron radiation

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基于保守超混沌系统的虹膜特征提取算法

通信技术 2024年第2期57卷 132-138页

作者：赵中军杜久龙邓雷升涂清中国电子科技集团公司第三十研究所四川成都610041

虹膜特征与其他生物特征相比具有独特优势,因其可以为加密算法生成足够长的密钥。虹膜特征提取是虹膜识别过程中的关键问题。针对密钥安全性和计算效率两大问题,提出了一种新颖的基于保守超混沌系统的虹膜特征提取方法,并结合局部二进... 详细信息

虹膜特征与其他生物特征相比具有独特优势,因其可以为加密算法生成足够长的密钥。虹膜特征提取是虹膜识别过程中的关键问题。针对密钥安全性和计算效率两大问题,提出了一种新颖的基于保守超混沌系统的虹膜特征提取方法,并结合局部二进制模式(Local Binary Pattern,LBP)和高斯函数差分(Difference of Gaussian,DOG)技术。首先,选择五维保守超混沌系统,验证其保守性和超混沌性质;其次,根据375位虹膜特征码和上述系统,产生特征矩阵,并对该矩阵进行图像增强处理;最后,通过提取DOG极值点和LBP特征,并根据提出的特征融合规则生成128位密钥。实验表明,生成的密钥可以通过美国国家标准与技术研究院(National Institute of Standards and Technology,NIST)随机性测试,且对虹膜特征码极其敏感。

关键词：超混沌系统保守系统虹膜特征提取局部二进制模式LBP

Synthesis and Crystal Structure of Ethyl (2-Amino-4-(2-chlorophenyl)-4H-benzo-[h]-chromene-2-yl) Formate

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Chinese Journal of Structural Chemistry 2004年第3期23卷 278-281页

作者： Wang XIangshan Shi Daqing tu Shujiang Yao Changsheng Department of Chemistry Xuzhou Normal UniversityXuzhou 221116China Key Laboratory of Biotechnology on Medical Plant XuzhouJiangsu 221116China

The title compound ethyl (2-amino-4-(2-chlorophenyl)-4H-benzo-[h]-chromene-2-yl) formate (C22H18ClNO3, Mr = 379.82) was synthesized and characterized by X-ray single-crystal diffraction analysis. The crystal belongs to monoclinic, space group C2/c with a = 25.168(4), b = 9.584(1), c = 16.503(3) ? b = 111.14(1), Z = 8, V = 3713(1) 3, Dc = 1.359 g/cm3, m(MoKa) = 0.228 mm-1, F(000) = 1584, R = 0.0565 and wR = 0.1320 for 1749 observed reflections (I > 2s(I)). X-ray analysis reveals that the C(1), C(2), C(3), C(4), C(5) and O(1) atoms form a six-membered ring which adopts a boat conformation. In this ring, the bond distances of C(1)C(2) and C(4)C(5) are 1.356(4) and 1.357(4) ? respectively, indicating they are C=C double bonds. In addition, there exist intra- and intermolecular hydrogen bonds in the crystal structure.

关键词： crystal structure, 4H-benzo-[h]-chromene, synthesis

The spatiotemporal evolution of EGFR C797S mutation in EGFR-mutant non-small cell lung cancer:opportunities for third-generation EGFR inhibitors re-challenge

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Science Bulletin 2019年第8期64卷 499-503页

作者： Yi-Chen Zhang qing Zhou Zhi-hong Chen Ming-Feng Zhang Jin-Ji Yang Hai-Yan tu Xu-Chao Zhang Chong-Rui Xu hong-hong Yan Xiao-Xiao Peng Xiao-Yan Bai Shao-Kun Chuai Jun-Yi Ye Yi-Long Wu The Second School of Clinical Medicine Southern Medical University Guangdong Lung Cancer Institute Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences Burning Rock Biotech

Third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have demonstrated impressive activity in EGFR T790M-positive non-small cell lung cancer (NSCLC) progressed from prior EGFR-TKI... 详细信息

关键词： cis The spatiotemporal evolution of EGFR C797S mutation in EGFR-mutant non-small cell lung cancer:opportunities for third-generation EGFR inhibitors re-challenge

Antifungal Secondary Metabolites Isolated from Mangrove Rhizosphere Soil-Derived Penicillium Fungi

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Journal of Ocean University of China 2020年第3期19卷 717-721页

作者： SHEN Nanxing LIANG Zhaoyang LIU qing tu Chuandeng DONG Kunming WANG Changyun CHEN Min Marine Science&Technology Institute College of Environmental Science&EngineeringYangzhou UniversityYangzhou 225127China Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Fungi isolated from mangrove rhizosphere soil of the South China Sea were investigated for the production of potential antifungal metabolites. With 28 fungal isolates, the strains Penicillium javanicum HK1-23 and P. janthinellum HK1-6 showed significant antifungal activities. A bioassay-guided investigation of the two fungal strains led to the isolation of two secondary metabolites, brefeldin A and penicillic acid, with high yields of 143 and 423 mg L^-1, respectively. Penicillic acid showed potent antifungal activities toward Rhizoctonia solani and R. cerealis, with 67.5% and 76% growth inhibition, respectively, at 50 μg mL^-1. Brefeldin A showed strong activity toward R. cerealis, with 56.4% growth inhibition at 50 μg mL^-1. The research highlights the importance of exploring microbes from mangrove rhizosphere soil for the identification of bioactive metabolites for future fungicide development.

关键词： mangrove rhizosphere soil-derived fungus Penicillium brefeldin A penicillic acid antifungal

Precision measurement of the Newtonian gravitational constant

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National Science Review 2020年第12期7卷 1803-1817页

作者： Chao Xue Jian-Ping Liu qing Li Jun-Fei Wu Shan-qing Yang Qi Liu Cheng-Gang Shao Liang-Cheng tu Zhong-Kun Hu Jun Luo Tian Qin Research Center for Gravitational Physics & School of Physics and Astronomy Sun Yat-sen University(Zhuhai Campus) MOE Key Laboratory of Fundamental Physical Quantities Measurement & Hubei Key Laboratory of Gravitation and Quantum Physics PGMF and School of PhysicsHuazhong University of Science and Technology

The Newtonian gravitational constant G,which is one of the most important fundamental physical constants in nature,plays a significant role in the fields of theoretical physics,geophysics,astrophysics and *** G was the first physical constant to be introduced in the history of science,it is considered to be one of the most difficult to measure accurately so *** the past two decades,eleven precision measurements of the gravitational constant have been performed,and the latest recommended value for G published by the Committee on Data for Science and Technology(CODATA) is(6.674 08 ±0.000 31) × 10m~3 kgswith a relative uncertainty of 47 parts per *** uncertainty is the smallest compared with previous CODATA recommended values of G;however,it remains a relatively large uncertainty among other fundamental physical *** this paper we briefly review the history of the G measurement,and introduce eleven values of G adopted in CODATA 2014 after 2000 and our latest two values published in 2018 using two independent methods.

关键词： precision measurement Newtonian gravitational constant CODATA

Soil Aggregate Stability and Aggregate-Associated Carbon Under Different Tillage Systems in the North China Plain

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Journal of Integrative Agriculture 2013年第11期12卷 2114-2123页

作者： DU Zhang-liu REN tu-sheng HU Chun-sheng ZHANG qing-zhong Humberto Blanco-Canqui Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences College of Resources and Environmental Sciences China Agricultural University Center for Agricultural Resources Research Institute of Genetics and Development BiologyChinese Academy of Sciences Agricultural Research Center-Hays Kansas State University

The inlfuences of tillage systems on soil carbon （C） stocks have been studied extensively, but the distribution of soil C within aggregate fractions is not well understood. The objective of this study was to determine the inlfuences of various tillage systems on soil aggregation and aggregate-associated C under wheat （Triticum aestivum L.） and corn （Zea mays L.） double cropping systems in the North China Plain. The experiment was established in 2001, including four treatments：moldboard plow （MP） with residue （MP＋R） and without residue （MP-R）, rotary tillage with residue （RT）, and no-till with residue （NT）. In 2007 soil samples were collected from the 0-5, 5-10, and 10-20 cm depths, and were separated into four aggregate-size classes （〉2 000, 250-2 000, 53-250, and〈53 μm） by wet-sieving method. Aggregate-associated C was determined, and the relationships between total soil C concentration and aggregation-size fractions were examined. The results showed that NT and RT treatments signiifcantly increased the proportion of macroaggregate fractions （〉2 000 and 250-2 000 μm） compared with the MP-R and MP＋R treatments. Averaged across all depths, mean weight diameters of aggregates （MWD） in NT and RT were 47 and 20% higher than that in MP＋R. The concentration of bulk soil organic C was positively correlated with MWD （r=0.98; P=0.024） and macroaggregate fraction （r=0.96; P=0.036） in the 0-5 cm depth. In the 0-20 cm depth, comparing with MP＋R, total C occluded in the〉2 000 μm fraction was increased by 9 and 6%under NT and RT, respectively. We conclude that adoption of conservation tillage system, especially no-till, can increase soil macro-aggregation and total C accumulation in macroaggregates, which may improve soil C sequestration in the intensive agricultural region of the North China Plain.

关键词： tillage systems aggregate stability aggregate-associated C

Effect of final electromagnetic stirring on solidification microstructure of GCr15 bearing steel in simulated continuous casting

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Journal of Iron and Steel Research International 2020年第2期27卷 141-147页

作者： Dan-qing Jiang Rui Wang Qiong Zhang Zhen-qiang Zhang Ting-sheng tu Jiang Wang Zhong-ming Ren School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The effect of final electromagnetic stirring on the solidification structure,element segregation,and carbides of GCrl5 bearing steel was *** experiment of continuous casting of the steel was carried out by using a continuous casting physical simulation apparatus with the final electromagnetic *** liquid core profile was revealed by the pour-out method during the solidification *** ingots were produced under different electromagnetic stirring parameters for *** results show that,at the final stage of solidification,intense electromagnetic stirring exacerbates the central carbon segregation,resulting in more serious precipitation of the primary *** is also found that the carbides in the segregation area are dominantly M3C type,together with a small amount of M7C3-type and M3C2-type *** this physical simulation model,the optimal stirring parameters to obtain a fine and homogeneous structure are the liquid pool width of 15 mm,current intensity of 150 A,and stirring frequency of 5 Hz.

关键词： GCrl5 bearing steel Solidification structure Continuous casting Final electromagnetic stirring Segregation Carbide

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浅埋煤层综采面护巷煤柱尺寸和布置方案优化

采矿与安全工程学报 2011年第4期28卷 505-510页

作者：屠世浩白庆升屠洪盛中国矿业大学矿业工程学院煤炭资源与安全开采国家重点实验室江苏徐州221116

根据浅埋薄基岩煤层顶板几乎沿采空区边缘垂直断裂,地表下沉速度快,采空区迅速压实等特点,运用理论分析、数值模拟和现场实测等研究方法,结合鄂尔多斯乌兰集团温家梁煤矿3-2煤层实际,得出了沿空掘巷合理护巷煤柱宽度为5m;滞后回采工作面... 详细信息

根据浅埋薄基岩煤层顶板几乎沿采空区边缘垂直断裂,地表下沉速度快,采空区迅速压实等特点,运用理论分析、数值模拟和现场实测等研究方法,结合鄂尔多斯乌兰集团温家梁煤矿3-2煤层实际,得出了沿空掘巷合理护巷煤柱宽度为5m;滞后回采工作面50m左右,采空区基本处于稳定状态.在此基础上提出了在保证工作面顺序接替条件下的煤柱护巷与沿空掘巷相结合的回采巷道布置方案.现场应用表明:沿空掘进巷道和实体煤巷道在回采期间能保持较好的稳定性,使该矿工作面煤炭采出率提高了13%.

关键词：采空区覆岩稳定性巷道布置煤柱设计巷道变形机理