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通讯和计算机（中英文版） 2009年第9期6卷 28-34页

作者： LIU hong LIU fu-min School of lnformation Science and Engineering Shandong Normal University Jinan 250014 China

Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： Ying-Shuo Wang Yun-Lian Zhou Guan-Nan Bai Shu-Xian Li Dan Xu Li-Na Chen Xing Chen Xiao-Yan Dong hong-min fu Zhou fu Chuang-Li Hao Jian-Guo hong En-Mei Liu Han-min Liu Xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang Man Tian Yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-Lin Zhang De-Yu Zhao Shun-Ying Zhao Guo-hong Zhu Ying-Xue Zou Quan Lu Yuan-Yuan Zhang Zhi-min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

function Projective Synchronization for Two Gyroscopes under Specific Constraints

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Chinese Physics Letters 2013年第7期30卷 38-42页

作者： min fu-hong School of Electrical and Automation Engineering Nanjing Normal UniversityNanjing 210042

The function projective synchronization between two coupled gyroscope systems is investigated under the sinusoidal *** the theory of discontinuous dynamical systems,the necessary and sufficient conditions of such synchronization are given,and the parameter map is *** simulations for the function synchronization of two coupled gyroscopes are illustrated to verify the effectiveness of this method.

关键词： method. function projective

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Plasmon-induced local electric field improved hydrogen evolution reaction on Ag/Mo_(2)C nanosheets

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Nano Research 2025年第1期18卷 270-277页

作者： HuangJingWei Li Xin Zi Jun Wu Xinli Wang Li Zhu Qiyou Wang Jianfu Han Junwei fu hongmei Li Kai Huang Yu Chen min Liu School of Physics State Key Laboratory of Powder MetallurgyHunan Joint International Research Center for Carbon Dioxide Resource UtilizationCentral South UniversityChangsha 410083China School of Metallurgy and Environment Central South UniversityChangsha 410083China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Nano-Institute Munich Faculty of PhysicsLudwig-Maxilimians-Universität MünchenMünchen 80539Germany Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

Electrocatalytic water splitting offers a promising way for hydrogen production with near-zero ***,such as molybdenum carbides(Mo_(2)C),are promising materials for hydrogen evolution reaction(HER)but still suffer from poor intrinsic water activation ***,we developed a plasmon-induced local electric field(PILEF)strategy to solve this ***(Ag)nanoparticles decorated Mo_(2)C nanosheets(Ag/Mo_(2)C)were successfully prepared by electrostatic *** visible light excited the PILEF on Ag/Mo_(2)C remarkably reducing the activation energy by 92.7 kJ·mol^(-1)from 147.3 kJ·mol^(-1)of Mo_(2)C to 54.6 kJ·mol^(-1).As a result,the plasmonic Ag/Mo_(2)C significantly enhances~2.3-fold of the current density from 2.8 mA·cm^(-2)of Mo_(2)C to 6.5 mA·cm^(-2)at-3 V *** and reduces the overpotential by 104 mV from 403 mV of dark state to 299 mV of light state at the current density of 10 mA·cm^(-2),achieving better performance than reported *** research demonstrates that PILEF enhances HER activities,offering a potential strategy for boosting the intrinsic activities of catalysts.

关键词： sliver particles plasmon effect field effect hydrogen evolution reaction(HER) electrocatalysis

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粉色果实花楸母本起源的分子证据

林业科学研究 2016年第6期29卷 834-838页

作者：汤薇于雪丹张川红叶学敏付其迪郑勇奇中国林业科学研究院林业研究所国家林业局林木培育重点实验室北京100091

[目的]探讨河北驼梁山自然风景区内形态介于花楸树和北京花楸之间的粉色果实花楸的起源。[方法]本研究调查了花楸树、北京花楸和粉色果实花楸的海拔分布格局及生长状况,并通过叶绿体DNA序列分析3个类群的系统发育关系。[结果]北京花楸... 详细信息

[目的]探讨河北驼梁山自然风景区内形态介于花楸树和北京花楸之间的粉色果实花楸的起源。[方法]本研究调查了花楸树、北京花楸和粉色果实花楸的海拔分布格局及生长状况,并通过叶绿体DNA序列分析3个类群的系统发育关系。[结果]北京花楸主要分布在海拔1 300 2 000 m,花楸树分布于1 500 2 200 m,粉果花楸出现在两者重叠分布区内;粉果花楸叶绿体单倍型有70%与北京花楸相同,10%与花楸树相同,其余20%为其特有。[结论]表明:粉色果实花楸是花楸树和北京花楸之间的天然杂交种,是多起源的类群,在自然分类系统中应作为独立的种来处理;花楸树和北京花楸均可作为母本。

关键词：花楸叶绿体非编码区序列单倍型母本起源

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Outcomes of 957 preterm neonatal fundus examinations in a Guangzhou NICU through 2008 to 2011

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 469-472页

作者： Rui-hong Ju, min fu Department of Ophthalmology Zhujiang Hospital Southern Medical University Guangzhou 510280 Guangdong Province China Department of Cardiothoracic Surgery Zhujiang Hospital Southern Medical University Guangzhou 510280 Guangdong Province China

AIM: To take fundus examination in the preterm neonates to observe the common diseases and report the outcomes in a neonatal intensive care unit (NICU) in Guangzhou between May 2008 and May 2011. METHODS: fundus examinations were performed with Retcam II in 957 prematures. RESULTS: There were 957 prematures in this study, including 666 males and 291 females, 2 triple births, 152 twins and 803 singletons. During the three years, 86 infants with any stage retinopathy of prematurity (ROP) (9.0%), 123 infants with retinal hemorrhage (12.9%), 10 infants with neonatal fundual jaundice (1.0%) and 3 babies with congenital choroidal coloboma (0.3%) were found. CONCLUSION: Early detection and prompt treatment of ocular disorders in neonates is important to avoid lifelong visual impairment. Examination of the eyes should be performed in the newborn period and at all well-child visits.

关键词： fundus examination premature retinopathy of prematurity retinal hemorrhage choroidal coloboma early detection

超短齿硬齿面双圆弧齿轮轮齿应力的三维光弹性分析

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太原工学院学报 1983年第2期 41-56页

作者：朱景梓师明善张宏民王富兴

本文利用通常的三维光弹性实验技术和原理,对超短齿双圆弧齿轮进行了齿廓的应力分析。在实验中,专门设计了啮合位置可调的“摸拟啮合冻结试验装置”,使得模型齿轮在加载冻结过程中更真实妥贴的达到理想啮合受载,从而保证了实验结果的精... 详细信息

本文利用通常的三维光弹性实验技术和原理,对超短齿双圆弧齿轮进行了齿廓的应力分析。在实验中,专门设计了啮合位置可调的“摸拟啮合冻结试验装置”,使得模型齿轮在加载冻结过程中更真实妥贴的达到理想啮合受载,从而保证了实验结果的精确性。从对齿高参数不同的几种齿形进行探讨与实验表明,各种齿形上的应力分布规律大致相同,但齿根部位的最大应力值与位置则与所采用的齿形有关,且主要取决于齿高。本文就超短齿(h=1.4M_n)进行了三维应力分析得到了沿齿廓的应力分布,从而为它应用于低速重载齿轮传动的最佳齿形设计提供了可靠的实验依据。

关键词：轮齿加载双圆弧齿轮齿轮模型齿廓齿形设计三维光弹性

8周运动预适应增强脂肪干细胞治疗心肌梗死大鼠的效果

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中国组织工程研究 2025年第7期29卷 1363-1370页

作者：娄国张敏付常喜江苏经贸职业技术学院江苏省南京市211168 南京旅游职业学院江苏省南京市211100 徐州工程学院体育学院江苏省徐州市221008

背景:干细胞移植是心肌梗死的崭新疗法,然而梗死区域极其恶劣的微环境造成干细胞存活率低下并导致远期疗效甚微。运动预适应是一种通过运动诱导机体产生内源性保护效应的方式,可作为心脏康复预防与治疗的新策略。目的:评估运动预适应是... 详细信息

背景:干细胞移植是心肌梗死的崭新疗法,然而梗死区域极其恶劣的微环境造成干细胞存活率低下并导致远期疗效甚微。运动预适应是一种通过运动诱导机体产生内源性保护效应的方式,可作为心脏康复预防与治疗的新策略。目的:评估运动预适应是否能够增强大鼠心肌梗死后脂肪干细胞移植的心脏保护效应,探讨血管生成在其中的作用机制。方法:6周龄雄性SD大鼠随机分为对照组、造模组、干细胞组以及干细胞运动组。利用冠状动脉闭塞术制作急性心肌梗死模型,对照组同期行假手术;干细胞运动组于造模前进行8周有氧运动,造模后30 min进行脂肪干细胞移植;干细胞组仅进行脂肪干细胞移植。干细胞移植后1 d和7 d,利用免疫印迹法测定心肌总Akt(t-Akt)、磷酸化Akt(p-Akt)、血管内皮生长因子(VEGF)、总内皮型一氧化氮合酶(t-eNOS)和磷酸化内皮型一氧化氮合酶(p-eNOS)蛋白表达量,计算p-Akt/t-Akt和p-eNOS/t-eNOS比值;4周后利用彩色多普勒超声诊断系统检测心脏结构与功能以及心肌血流量,TTC染色法检测心肌梗死面积,Masson染色法检测心肌间质胶原沉积,免疫荧光染色法测定心肌毛细血管密度,TUNEL染色法评估心肌细胞凋亡。结果与结论:(1)干细胞移植后4周:与对照组比较,造模组左心室缩短分数、左心室射血分数、心肌毛细血管密度和心肌血流量下降(P0.05);与造模组比较,干细胞组上述指标均无显著性变化(P>0.05),干细胞运动组磷酸化p-Akt蛋白表达量以及p-Akt/t-Akt比值上调(P0.05),干细胞运动组p-Akt、VEGF、p-eNOS蛋白表达量以及p-Akt/t-Akt、p-eNOS/t-eNOS比值升高(P<0.05)。结果表明:运动预适应可增强脂肪干细胞对心肌梗死大鼠心脏重塑的治疗效果,其机制与促进心肌血管生成并增加血流灌注有关。

关键词：干细胞脂肪干细胞运动预适应心肌梗死血管生成心脏重塑血流灌注

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1980-2020年汾河流域耕地显性转型时空分异及其驱动力

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水土保持研究 2025年第1期32卷 257-265+284页

作者：姜民武志平付建新太原师范学院地理科学学院太原师范学院城镇与区域发展研究所太原师范学院汾河流域地表过程与资源生态安全山西省重点实验室太原师范学院碳中和研究院

[目的]刻画耕地利用转型变化特征，揭示耕地转型发展规律，为汾河流域耕地资源保护和乡村转型发展提供理论支撑和参考依据。[方法]基于1980年、1990年、2000年、2010年、2020年土地利用遥感影像数据，利用耕地转型速度、转移矩阵和地理... 详细信息

[目的]刻画耕地利用转型变化特征，揭示耕地转型发展规律，为汾河流域耕地资源保护和乡村转型发展提供理论支撑和参考依据。[方法]基于1980年、1990年、2000年、2010年、2020年土地利用遥感影像数据，利用耕地转型速度、转移矩阵和地理探测器方法，分析了汾河流域耕地利用转型的时空分异特征，并探测了其驱动因子。[结果]（1） 1980—2020年，流域内耕地面积减少10.59万hm2,其中，耕地转为建设用地的面积最大，草地是转入耕地最多的地类，占转入总面积的59.37%。（2） 1980—2020年，汾河流域耕地利用转型速度呈波动下降趋势，其中中游耕地减少最明显，人地矛盾突出。（3）自然因子对耕地转型影响程度明显强于社会经济因子，其中气温q值最大，达0.72。自然因子之间的交互作用对耕地转型的解释力更强。[结论]汾河流域耕地利用转型受自然和社会经济因素共同影响，先后经历了缓和平稳、转型加剧、矛盾尖锐和收敛平衡不同阶段，空间集聚性特征显著，将指导该流域耕地资源合理、有序利用。

关键词：耕地转型空间转型地理探测汾河流域

Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy

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National Science Review 2015年第1期2卷 71-84页

作者： hong-min Meng Ting fu Xiao-Bing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyCollaborative Innovation Center for Molecular Engineering for TheranosticsHunan University

Nucleic acid aptamers, which are generated by a novel technique called SELEX(systematic evolution of ligands by exponential enrichment), have recently atracted signiicant atention in the ield of early detection and treatment of cancer based on their numerous merits, such as high ainity, high speciicity,small size, litle immunogenicity, stable structures, and ease of chemical modiication. furthermore,aptamers can gain more lexibility as cancer cell targeting tools when conjugated to nanomaterials,including metallic nanoparticles, carbon nanomaterials, DNA nanodevices, and polymeric *** discuss the progress achieved in cancer diagnosis and therapy through the conjugation of cell-SELEX-based aptamers with diferent nanomaterials.

关键词： aptamer cell-SELEX nanomaterial cancer cells cancer diagnosis and therapy