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Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes

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Genes & Diseases 2023年第3期10卷 877-890页

作者： min Chen Jie-Ying Zhu Wang-Jing mu Liang Guo School of Kinesiology Shanghai University of SportShanghai 200438China Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Cysteine dioxygenase type 1 (CDO1), belonging to the mammalian non-heme Fe(II) dioxygenases family, is a key enzyme for cysteine catabolism. Its activity and expression is regulated through multiple mechanisms. CDO1 is involved in a spectrum of physiological processes including lipid metabolism, adipogenesis, osteoblastic differentiation, redox homeostasis, fertility, bile acid metabolism, sulfide metabolism, and organismal growth and development. Many of these processes are regulated directly or indirectly by CDO1-mediated metabolism of cysteine. In pathophysiological processes, the degree of CDO1 promoter methylation is closely related to the progression and malignancy of tumors, and overexpression of CDO1 will promote ferroptosis of cancer cells. Moreover, CDO1 may ameliorate metabolic disorders through the taurine-mediated improvement of lipid metabolism and insulin sensitivity and improve neurodegenerative diseases by regulating cysteine level. Therefore, elucidation of the mechanisms underlying the role of CDO1 would provide a clearer view of the therapeutic potential and possible risks of targeting this important enzyme.

关键词： Anti-tumor Antioxidation Cysteine Promoter methylation Taurine

超声辅助双水相提取无花果总黄酮的工艺优化及其理化性质分析

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粮食与油脂 2024年第7期37卷 76-82页

作者：秦晶晶李牧珅魏洪权侯静雯魏婧新乡医学院三全学院药学院河南新乡453200

采用响应面法优化超声辅助双水相法提取无花果总黄酮的工艺,并对其稳定性和体外抗氧化性进行研究。结果表明:提取无花果总黄酮的最佳双水相体系为质量分数25.2%聚乙二醇1000-质量分数为28.3%硫酸铵;最佳提取工艺为超声温度45℃、超声功... 详细信息

采用响应面法优化超声辅助双水相法提取无花果总黄酮的工艺,并对其稳定性和体外抗氧化性进行研究。结果表明:提取无花果总黄酮的最佳双水相体系为质量分数25.2%聚乙二醇1000-质量分数为28.3%硫酸铵;最佳提取工艺为超声温度45℃、超声功率70 W、料液比1∶32(g/mL)、提取时间30 min,在此条件下无花果总黄酮得率为0.83%±0.01%。无花果总黄酮在温度<70℃、pH 6~8、还原剂质量分数<0.024%作用下稳定性好,其在储存和生产中应避免接触金属离子Fe^(3+)、Ba^(2+)、Ca^(2+),食品添加剂(葡萄糖和蔗糖)对其稳定性基本无影响。在一定质量浓度范围内,无花果总黄酮对DPPH自由基、ABTS自由基、羟基自由基、超氧阴离子自由基的最高清除率分别达到97.81%、96.74%、73.54%、59.45%。

关键词：无花果果实总黄酮双水相提取稳定性抗氧化性

东江河源段表层水体及鱼类肠道中的微塑料污染特征

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水生态学杂志 2024年第5期45卷 159-169页

作者：李敏倩董文亮郭翊宸公晗严慕婷华南农业大学海洋学院广东广州510642

统计并分析东江河源段表层水体及鱼类肠道中的微塑料污染现状,可丰富内陆水域尤其是珠江流域的微塑料数据,为进一步研究淡水水体的微塑料污染特征提供数据支撑。2019年6月采集东江河源段的表层水体及䱗(Hemicculter Leuciclus)、黄颡鱼(P... 详细信息

统计并分析东江河源段表层水体及鱼类肠道中的微塑料污染现状,可丰富内陆水域尤其是珠江流域的微塑料数据,为进一步研究淡水水体的微塑料污染特征提供数据支撑。2019年6月采集东江河源段的表层水体及䱗(Hemicculter Leuciclus)、黄颡鱼(Pelteobagrus fulvidraco)、黄鳍刺鰕虎鱼(Acanthogobius flaviman)、鲤(Cyprinus carpio)、鲮(Cirrhinus molitorella)和子陵吻鰕虎鱼(Rhinogobius giurinus)的肠道作为试验材料,在体视显微镜下对表层水和鱼类肠道滤膜进行观察和记录,分析其微塑料污染特征。结果显示,6种鱼类的肠道中都发现了微塑料,丰度为57.3~2910.3个/kg;水体中微塑料丰度为366.67~1200个/m^(3)。表层水中65.93%微塑料为蓝色,以纤维为主,尺寸<2 mm的微塑料占比达88.95%;鱼体中尺寸<0.5 mm的微塑料占比41.41%,超过84.73%为透明和蓝色,主要以纤维和碎片为主。使用傅立叶变换红外光谱仪对微塑料样品进行成分鉴定,表层水中微塑料主要成分是聚苯乙烯,占比37.5%;6种鱼类肠道内的微塑料成分以聚酰胺为主,占比22.39%。东江河源段表层水体的微塑料污染水平较低,水质较好;不同鱼类中的微塑料污染水平存在差异,污染水平总体偏高,可能与食性和栖息水层相关。

关键词：微塑料表层水鱼类肠道污染特征东江河源段

Polycyclic aromatic hydrocarbon:environmental sources,associations with altered lung function and potential mechanisms

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Chinese Medical Journal 2020年第13期133卷 1603-1605页

作者： Li-min Cao Ge mu Wei-hong Chen Department of Occupational&Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Polycyclic aromatic hydrocarbon(PAH)molecules are a large group of organic compounds with two or more fused benzene rings arranged in various confgurations."To date,hundreds of PAHs have been *** are widespread environmental contaminants formed as a result of incomplete combustion of carbonaceous materials in both natural and anthropogenic *** to the natural sources,such as volcanic eruptions and wild fires,anthropogenic sources,such as industrial processes,cigarette smoke,vehicular exhaust,residential heating fuels and charcoal-grilled and flame-broiled food,make a larger contribution to the generation of atmospheric PAHs.'Through inhalation,ingestion and dermal contract,PAHs from all sources can easily be absorbed in the body and further metabolized and excreted in *** urinary monohydroxylated PAH(OH-PAH)has been widely considered as a biomarker to represent individual PAH exposure levels in many studies.

关键词： process. aromatic incomplete

甲氰菊酯在土壤中的降解及对蚯蚓的毒性效应研究

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土壤学报 2024年第3期61卷 794-801页

作者：杨馥荣冉露露杨沐刘畅陈敏蔡依芸杨灿灿何林张平西南大学植物保护学院重庆400715

拟除虫菊酯作为全球第三大杀虫剂品种,在农业生产中广泛使用,同时也带来了一系列不利的环境影响。然而,目前有关拟除虫菊酯在土壤环境中的残留行为和风险评估报道较少。以典型拟除虫菊酯类杀虫剂甲氰菊酯(FEN)为研究对象,重点探究其在... 详细信息

拟除虫菊酯作为全球第三大杀虫剂品种,在农业生产中广泛使用,同时也带来了一系列不利的环境影响。然而,目前有关拟除虫菊酯在土壤环境中的残留行为和风险评估报道较少。以典型拟除虫菊酯类杀虫剂甲氰菊酯(FEN)为研究对象,重点探究其在不同性质土壤中的降解行为以及对典型土壤生物蚯蚓的毒性效应。结果表明,甲氰菊酯在碱性土壤中的降解速度快于酸性土壤,同时在非灭菌土壤中的降解速度为灭菌土壤的4倍。因此,土壤酸碱度和微生物是影响FEN在土壤中降解快慢的主要因素。此外,在降解过程中检测到甲氰菊酯主要代谢物3-苯氧基苯甲酸(3-PBA)的生成。蚯蚓富集结果表明,FEN在蚯蚓体内的含量先升高后降低,最大生物富集因子为0.3。亚急性毒性结果表明,高剂量(5 mg·kg^(–1))甲氰菊酯暴露14 d后,蚯蚓体内蛋白质含量显著降低(P<0.05),细胞色素P450(CYP450)、羧酸酯酶(CarE)、谷胱甘肽-S-转移酶(GST)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性和丙二醛(MDA)含量均显著增加(P<0.05),同时存在剂量效应,证实土壤中残留的FEN对蚯蚓具有毒性效应。本文对甲氰菊酯在土壤环境中的降解行为研究以及生态毒性风险评估具有重要的指导意义。

关键词：甲氰菊酯 3-苯氧基苯甲酸降解生物蓄积性亚急性毒性

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儿童重症监护病房后随访服务的研究进展

护理学杂志 2024年第9期39卷 121-124页

作者：郑泽瑞王林娟周敏魏峰马允昌牟馨深圳市儿童医院儿童重症医学科广东深圳518000

综述国内外儿童重症监护病房后随访服务的现状,包括概念、实施要素、开展情况及实施障碍,为后期进一步构建、实践儿童重症监护病房后随访服务提供参考。

关键词：危重症儿童 PICU 随访服务延续护理重症监护后综合征住院安全护士主导综述文献

国产轮状病毒疫苗接种安全性的真实世界Meta分析

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中华微生物学和免疫学杂志 2024年第5期44卷 431-440页

作者：苏峰时云志徐敏黎慕陈军霍怡菲陈毅锋赵杰苏锦锋中国生物技术股份有限公司人用疫苗事业部北京100024

目的评价国产口服轮状病毒减毒活疫苗(简称轮状病毒疫苗)的安全性。方法检索中国知网(CNKI)、中文期刊服务平台、万方数据库、PubMed、Medline和Embase,筛选2020年1月1日—2023年7月31日发表的关于中国疑似预防接种异常反应(adverse eve... 详细信息

目的评价国产口服轮状病毒减毒活疫苗(简称轮状病毒疫苗)的安全性。方法检索中国知网(CNKI)、中文期刊服务平台、万方数据库、PubMed、Medline和Embase,筛选2020年1月1日—2023年7月31日发表的关于中国疑似预防接种异常反应(adverse event following immunization,AEFI)的研究,从中抽取有关国产轮状病毒疫苗AEFI监测数据。采用R语言对轮状病毒疫苗接种后的安全性进行Meta分析,并对不同区域和不同时间段的AEFI报告发生率进行亚组分析。结果共纳入36篇文献,涉及样本2533.2万剂。国产轮状病毒疫苗AEFI发生率为19/10万剂(95%CI:15/10万剂~24/10万剂);北方和南方地区AEFI发生率分别为26/10万剂(95%CI:17/10万剂~39/10万剂)和16/10万剂(95%CI:11/10万剂~23/10万剂);2017年前为24/10万剂[95%CI:12/10万剂~45/10万剂],2017年后为27/10万剂[95%CI:18/10万剂~39/10万剂]。结论国产轮状病毒疫苗AEFI发生率在预期范围内,真实世界应用中安全性良好。

关键词：口服轮状病毒减毒活疫苗疑似接种异常反应真实世界研究 Meta分析

A Novel Ratiometric Fluorescent Probe for Highly Sensitive and Selective Detection of β-Galactosidase in Living Cells

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Chinese Journal of Chemistry 2019年第4期37卷 330-336页

作者： min Chen Lixuan mu Xingxing Cao Guangwei She Wensheng Shi Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

β-Galactosidase,a glycoside hydrolase enzyme,has been proved to be an important biomarker of cell senescence and primary ovarian *** detection of β-galactosidase has attracted wide ***,one ratiometric fluorescent probe has been successfully synthesized for detecting the β-galactosidase in living *** as-prepared probe exhibits two emission peaks at 490 nm and 530 nm,respectively,and the ratio of fluorescence intensities from the two emission peaks could be utilized to monitor the β-*** present ratiometric fluorescent probe is,therefore,very promising for effective,sensitive,and selective detection of the β-galactosidase in living cells.

关键词： has be

Alga-lysing bioreactor and dominant bacteria strain

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Journal of Environmental Sciences 2007年第5期19卷 546-552页

作者： PEI Hai-yan HU Wen-rong mu Rui-min LI Xiao-cai College of Environmental Science and Engineering Ocean University of China Qingdao 266003 China Shandong Provincial Engineering Centre on Environmental Science and Technology Jinan 250061 China School of Environmental Science and Engineering Shandong University Jinan 250061 China

Alga-lysing bacteria have been paid much attention to in recent years. In this study, the alga-lysing strain P05 which was isolated from an immobilizing biosystem was immobilized by coke and elastic filler, forming two biological reactors. The removal efficiencies of algae, NH4^＋-N and organic matter using the two reactors were studied. The results showed that strain P05 was an ideal algal-lysing bacteria strain because it was easy to be immobilized by coke and elastic filler which are of cheap, low biodegradability and the simple immobilization procedure. After 7 d filming, the biological film could be formed and the reactors were used to treat the eutrophic water. These two reactors were of stability and high effect with low cost and easy operation. The optimal hydraulic retention time （HRT） of each reactor was 4 h. The algae removal rates were 80.38% and 82.1% （in term of Chl-α） of coke reactor and filler reactor, respectively. And that of NH4^＋-N were 52.3% and 52.7%. The removal rates of CODMn were 39.03% and 39.64%. The strain P05 was identified as Bacillus sp. by PCR amplification of the 16S rRNA gene, BLAST analysis, and comparison with sequences in the GenBank nucleotide database.

关键词： alga-lysing algae removal immobilization 16S rRNA Bacillus sp.