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Development of Multi-Agent-Based Indoor 3D Reconstruction

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Computers, Materials and Continua 2024年第1期81卷 161-181页

作者： Cheng H.C. hong F.z. Hussain B. Wang Y. Yue C.P. Optical Wireless Lab Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology Hong Kong

Large-scale indoor 3D reconstruction with multiple robots faces challenges in core enabling technologies. This work contributes to a framework addressing localization, coordination, and vision processing for multi-agent reconstruction. A system architecture fusing visible light positioning, multi-agent path finding via reinforcement learning, and 360° camera techniques for 3D reconstruction is proposed. Our visible light positioning algorithm leverages existing lighting for centimeter-level localization without additional infrastructure. Meanwhile, a decentralized reinforcement learning approach is developed to solve the multi-agent path finding problem, with communications among agents optimized. Our 3D reconstruction pipeline utilizes equirectangular projection from 360° cameras to facilitate depth-independent reconstruction from posed monocular images using neural networks. Experimental validation demonstrates centimeter-level indoor navigation and 3D scene reconstruction capabilities of our framework. The challenges and limitations stemming from the above enabling technologies are discussed at the end of each corresponding section. In summary, this research advances fundamental techniques for multi-robot indoor 3D modeling, contributing to automated, data-driven applications through coordinated robot navigation, perception, and modeling. © 2024 The Authors. Published by Tech Science Press.

关键词： 3D reconstruction multi-agent path finding Multi-agent system multi-robot human collaboration reinforcement learning visible light communication visible light positioning

PRag 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-hong Kong mei-Ling Xu Jun-Jun zhang guang-Qiang Chen zhi-Hui hong hong zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong zhao Chen-Yang zhang Rong-zheng Chen Peng-Fei Xing Li-Yuan zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKgROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRag 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRag 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRag 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRag 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

Research on perturbation of neutron fluence rate in a closed thermal neutron field due to medium materials

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-11页

作者： Yang, Jun-Kai Wang, Ping-Quan Hu, zhi-Meng Li, Fan zeng, Jun-mei Xiao, Lin guo, hong-Yu zhang, Jian gorini, giuseppe zhang, Hui Chu, Chungming Paul Nanjing Univ Coll Engn & Appl Sci Nanjing 210093 Peoples R China Natl Inst Metrol Beijing 100029 Peoples R China Nanjing Univ Aeronaut & Astronaut Dept Nucl Sci & Technol Nanjing 210093 Peoples R China Univ Milano Bicocca Dept Phys I-20126 Milan Italy

The neutron radiation field has vital applications in areas such as biomedicine, geology, radiation safety, and many others for neutron detection and neutron metrology. Correcting neutron fluence rate perturbation accurately is an important yet challenging problem. This study proposes a correction method that analyzes three physical processes. This method, which transforms the detection process from point detection to area detection, is based on a novel physical model and has been validated through theoretical analyses, experiments, and simulations. According to the average differences between the calculated and experimental results, the new method (1.67%) demonstrated better accuracy than the traditional simulation (2.17%). In a closed thermal neutron radiation field, the detector or strong neutron absorption material significantly perturbs the neutron fluence rate, whereas its impact on the energy spectrum shape and neutron directionality is relatively minor. Furthermore, based on the calculation results of the perturbation rate formula for medium materials with different compositions and sizes, the larger the volume and capture cross section of the medium, the higher the perturbation rate generated in the closed radiation field.

关键词： Perturbation rate Area detection Three-dimensional neutron energy spectrum Closed radiation field INFINITE-PLANE ABSORBERS FLUX PERTURBATIONS SPECTRUM

Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma

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World Journal of gastroenterology 2024年第19期30卷 2575-2602页

作者： Tian Peng Fang Sun Jia-Chun Yang mei-hong Cai Man-Xiu Huai Jia-Xing Pan Fei-Yu zhang Lei-Ming Xu Department of gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200092China

BACKgROUND Lactate,previously considered a metabolic byproduct,is pivotal in cancer progression and maintaining the immunosuppressive tumor *** investigations confirmed that lactate is a primary regulator,introducing recently described post-translational modifications of histone and non-histone proteins,termed lysine *** adenocarcinomas are characterized by increased glycolysis and lactate ***,our understanding of lactylation-related genes in pancreatic adenocarcinomas remains *** To construct a novel lactylation-related gene signature to predict the survival of patients with pancreatic *** RNA-seq and clinical data of pancreatic adenocarcinoma(PDAC)were obtained from the gTEx(genotype-Tissue Expression)and TCgA(The Cancer genome Atlas)databases via Xena Explorer,and gSE62452 datasets from *** on lactylation-related genes were obtained from publicly available *** expressed genes(DEgs)were acquired by using R package“DESeq2”in *** COX regression analysis,LASSO Cox and multivariate Cox regressions were produced to construct the lactylation-related prognostic *** analyses,including functional enrichment,ESTIMATE,and CIBERSORT,were performed to analyze immune status and treatment responses in patients with pancreatic *** and normal human cell lines were subjected to western blot analysis under lactic acid intervention;two PDAC cell lines with the most pronounced lactylation were ***,RT-PCR was employed to assess the expression of LRgs genes;SLC16A1,which showed the highest expression,was selected for further ***16A1-mediated lactylation was analyzed by immunofluorescence,lactate production analysis,colony formation,transwell,and wound healing assays to investigate its role in promoting the proliferation and migration of PDAC *** vivo validation was performed using an established tumor *** In this stud

关键词： Pancreatic adenocarcinoma Lactylation Prognosis Immunotherapy Tumor microenvironment

Biderivations of Hom-Lie Algebras and Superalgebras

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2337-2358页

作者： La mei YUAN Jia Xin LI School of Mathematics Harbin Institute of Technology

On Hom-Lie algebras and superalgebras, we introduce the notions of biderivations and linear commuting maps, and compute them for some typical Hom-Lie algebras and superalgebras,including the q-deformed W(2, 2) algebra... 详细信息

关键词： 17A30 17A60 17B05 17B60 17B70 biderivations Hom-Lie algebras linear commuting maps q-deformed W(2 2) algebra q-deformed Witt algebra q-deformed Witt superalgebra

On Variational Principles of Metric Mean Dimension on Subsets in Feldman–Katok Metric

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2519-2536页

作者： Kun mei gAO Rui Feng zHANg School of Mathematics Hefei University of Technology

In this paper, we studied the metric mean dimension in Feldman–Katok(FK for short)metric. We introduced the notions of FK-Bowen metric mean dimension and FK-Packing metric mean dimension on subsets. And we establishe... 详细信息

关键词： 37A35 37B99 Feldman–Katok metric Metric mean dimension variational principle

榫卯联结:民族互嵌式社区建设的传统文化根基

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思想战线 2024年第3期50卷 53-61页

作者：红梅中央民族大学期刊社北京100081

民族互嵌式社区建设是当前基层民族工作的重要组成部分。本文通过对历史上自发形成的北京市古北口河西村、西城区牛街社区和云南郑家庄进行调研和观察,认为民族互嵌式社区的自发形成受中华传统文化的影响,从社会结构和心理认同上与中华... 详细信息

民族互嵌式社区建设是当前基层民族工作的重要组成部分。本文通过对历史上自发形成的北京市古北口河西村、西城区牛街社区和云南郑家庄进行调研和观察,认为民族互嵌式社区的自发形成受中华传统文化的影响,从社会结构和心理认同上与中华传统文化中榫卯结构的文化精髓有异曲同工的相似表达。“道法自然与天人合一”“和谐共存与互补共生”“中和思想与以柔克刚”“和而不同与守正创新”的理念成为各民族互嵌生活的认知和遵循。榫卯联结的传统文化思想,其核心在于各元素既独立存在,又相互支撑,形成稳定与和谐的整体。这一思想理念在河西村、牛街和郑家庄千百年的存续中得到了较为鲜明的体现,可以从经济生产互嵌、生活环境互嵌、乡村管理互嵌、文化交融互嵌、心理相依互嵌五个维度来梳理和实证。在新时代,民族互嵌式社区高质量发展的文化路径主要从文化内容维度、文化传播维度和文化创新维度展开,包括榫卯联结在内的中华优秀传统文化思想是建设和谐共生、充满活力的民族互嵌式社区的文化根基。

关键词：榫卯联结传统文化思想民族互嵌式社区和谐共生文化融合

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Efficacy and Safety of ganyushu granule in Treatment of Premenstrual Syndrome with gan(Liver)Depression and Qi Stagnation Syndrome:A Randomized,Double-Blind,Multicenter,Phase-ⅡClinical Trial

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Chinese Journal of Integrative Medicine 2024年第9期30卷 771-779页

作者： TENg Xiu-xiang XU Lian-wei LIN Jie zHANg Jin-feng zHANg Qin SUN Yun YANg De-feng LI hong-mei zHAO Pei LIU Jun Department of gynecology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100700China Department of gynecology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Department of gynecology The First Hospital of Hunan University of Chinese MedicineChangsha410021China Department of gynecology Shanxi Traditional Chinese Medicine HospitalTaiyuan030024China Department of gynecology Hangzhou Hospital of Traditional Chinese MedicineHangzhou310005China Department of gynecology Wenzhou Hospital Affiliated to Zhejiang University of Traditional Chinese MedicineWenzhouZhejiang Province325000China Department of gynecology Luoyang First People’s HospitalLuoyangHenan Province471000China Department of gynecology The Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHarbin150001China

Objective:To confirm the efficacy and safety of ganyushu granule(gYSg)in treating premenstrual syndrome(PMS)in patients with gan(Liver)depression and qi stagnation syndrome(gDQSS)and determine its effective ***:From June 2018 to March 2021,a total of 240 PMS women with gDQSS were included and randomly divided into 3 groups in a 1:1:1 ratio using central block randomization:high-dose gYSg group(n=78,gYSg 2 packs/time),low-dose gYSg group(n=82.gYSg and its simulant 1 pack/time),and placebo group(n=80,gYSg simulant 2 packs/time).Treatment with gYSg or placebo was given thrice daily and for up to 3 menstrual *** outcomes were PMS diary(PMSD)score and premenstrual tension syndrome self-rating scale(PMTS).Secondary outcomes were Chinese medicine(CM)syndrome ***,PMTS,and efficacy of CM were evaluated with menstrual cycles during the treatment *** indicators were analyzed after each menstrual *** analyses were performed using an intention-to-treat method,and clinical safety was ***:Of the 216 patients included in the effectiveness analysis,70,75,and 71 patients were in the high-,low-dose gYSg,and placebo groups,*** the 2nd treatment cycle,the change in PMSD scores in the high-and low-dose groups was lower than that in the placebo group(Pgh-dose gYSg group after the 1st treatment cycle was lower than that in the placebo group(Pgroup was lower than that in the placebo group(P2nd treatment cycle,the high-dose gYSg group had the best CM syndrome efficacy(PgYSg was safe and well-tolerated at both doses for treating PMS patients with ***-dose gYSg might be the optimal dose for a phaseⅢtrial.

关键词： premenstrual syndrome Chinese medicine ganyushu granule randomized controlled trial

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Omadacycline in the treatment of scrub typhus:Three case reports

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World Journal of Clinical Cases 2024年第25期12卷 5832-5838页

作者： Xue-mei Lang Yun Qiu Ya-Juan Jia hong Sun Su-Min gao hong-mei zhao Department of Emergency Medicine The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai’an 223000Jiangsu ProvinceChina

BACKgROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(***).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical ***,omadacycline application in the treatment of scrub typhus remains *** SUMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and *** samples were collected before omadacycline was administered,and *** infection was confirmed through targeted next-generation sequencing(tNgS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug *** tNgS is an effective method for diagnosing scrub *** can be considered an alternative option for antiinfective therapy in patients with *** infections.

关键词： Omadacycline Scrub typhus Orientia tsutsugamushi Targeted nextgeneration sequencing Eschar Case report