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Predictors of Adverse Pregnancy Outcomes Following Traumatic Injuries

Current Medical Science 2024年第3期44卷 642-647页

作者： Wan-rong LU Ping wu Gong SONG mei-qi GU Zhe XU Li HE National Clinical Research Center for Gynecology and Obstetrics Cancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Traumatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective After traumatic injury in pregnant women,providing timely and appropriate management for high-risk patients is crucial for both pregnant women and *** study aimed to identify risk factors that predict adverse pregnancy outcomes after traumatic *** A retrospective cohort study including 317 pregnant patients who experienced trauma was *** collected data included general demographics,injury mechanisms and adverse pregnancy *** were divided into two subgroups based on the absence or presence of trauma-related adverse pregnancy *** and multivariate logistic regressions were conducted to estimate the associations between clinical variables and adverse pregnancy *** A total of 41(12.93%)patients experienced adverse pregnancy outcomes within the first 24 h *** study revealed that age>35 years(OR=14.995,95%CI:5.024–44.755,P<0.001),third trimester trauma(OR=3.878,95%CI:1.343–11.204,P=0.012),abdominal pain(OR=3.032,95%CI:1.221–7.527,P=0.017),vaginal bleeding(OR=3.226,95%CI:1.093–9.523,P=0.034),positive scan in focused assessment with sonography for trauma(FAST)positive(OR=8.496,95%CI:2.825–25.555,P<0.001),9≤injury severity score(ISS)<16(OR=3.039,95%CI:1.046–8.835,P=0.041)and ISS≥16(OR=5.553,95%CI:1.387–22.225,P=0.015)increased the probability of posttraumatic adverse pregnancy *** age,gestational age at delivery,vaginal bleeding and positive FAST results were risk factors for abnormal *** Advanced maternal age,third trimester,and positive FAST results should alert multidisciplinary trauma teams to closely monitor patients to prevent adverse pregnancy outcomes.

关键词： adverse pregnancy outcomes predictive factors abnormal delivery trauma

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Cervical cancer with transferrin receptor has a poor prognosis and is associated with immune infiltration, according to a comprehensive bioinformatics study

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Cancer Advances 2024年第6期7卷 1-9页

作者： Dong-mei Han Cai-hong wu Bin Ling Hao Jin Center For Precision Cancer Medicine and Translation Research Tianjin Cancer Hospital Airport HospitalTianjin 300181China Tianjin Medical University Cancer Institute&Hospital Tianjin 300060China

Background:The molecular mechanism underlying the involvement of the Transferrin receptor(TFRC)in cervical cancer remains poorly *** study aims to elucidate the role of TFRC in cervical cancer by analyzing data from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)***:TFRC protein expression was obtained from Human Protein Altas(HPA).All datas were collected from TCGA and *** this study,we analyzed the expression of TFRC in cervical cancer and its clinical *** Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene set enrichment analyses(GSEA),investigated the related molecular pathways of *** relationship between TFRC and immune infiltration was then *** prognosis of different immune cell subsets was then analyzed after dividing cervical cancer patients into high and low expression of TFRC ***:TFRC is highly expressed in various tumor tissues compared to control normal tissues,including cervical *** increased expression of TFRC was associated with higher Tumor(T)and Node(N)stage,as well as a higher clinical ***–meier(KM)survival analysis investigated that higher TFRC expression patients have a poor overall survival(OS),disease specific survival(DSS)and progress free interval(PFI).Both KEGG and GSEA enriched signaling pathway by high TFRC and low TFRC *** was a significant negative linear correlation between TFRC expression and immune *** affects the prognosis of cervical cancer patients through immune ***:Cervical cancer patients with TFRC expression may have a worse prognosis.

关键词： cervical cancer prognosis immune infiltration transferrin receptor

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Climate chamber investigation of the effect of indoor thermal histories on thermal adaptation in different seasons

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Energy and Built Environment 2024年第3期5卷 455-463页

作者： Yuxin wu Angchen Jiang hong Liu Baizhan Li Risto Kosonen School of Civil Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhouZhejiang 310018China Joint International Research Laboratory of Green Buildings and Built Environments(Ministry of Education) Chongqing UniversityChongqing 400045China National Centre for International Research of Low-carbon and Green Buildings(Ministry of Science and Technology) Chongqing UniversityChongqing 400045China Department of Mechanical Engineering Aalto UniversityEspoo 02150Finland College of Urban Construction Nanjing Tech UniversityNanjing 210009China

The indoor thermal history of residents in the hot summer and cold winter climate zone in China have undergone a significant change in recent years,which also changes their seasonal thermal adaptations and this has formed feed-back effects to the increasing usage of air conditioning units in this *** study the seasonal variations of thermal adaptation,the thermal comfort experiments were conducted on two groups of *** groups included 20 participants who had indoor history mainly with natural ventilation(NV group)and air-conditioning(AC group),*** results demonstrated that the thermal sensation vote(TSV)in warm environments did not differ between AC and NV subjects in ***,the TSV of AC subjects were much lower than that of NV subjects in the same standard effective temperature and skin temperature in a cold environment in ***,the participants who spent most of their time in AC space in winter showed a low level of thermal adaptation with a narrower acceptable skin temperature range of 32.6-33.5℃.Thus,this study presents the basic information regarding the seasonal effects on human thermal adaptation due to different long-term indoor thermal histories.

关键词： Skin temperature Thermal experience Thermal comfort Cold acclimation Hot summer and cold winter

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Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreaticβ-cell Dysfunction

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Current Medical Science 2024年第2期44卷 346-354页

作者： Kai-yuan WANG Shi-mei wu Zheng-jian YAO Yun-xia ZHU Xiao HAN Key Laboratory of Human Functional Genomics of Jiangsu Province Department of Biochemistry and Molecular BiologyNanjing Medical UniversityNanjing 211166China

Objective:While the reduction of transient receptor potential channel subfamily M member 5(TRPM5)has been reported in islet cells from type 2 diabetic(T2D)mouse models,its role in lipotoxicity-induced pancreaticβ-cell dysfunction remains *** study aims to study its ***:Pancreas slices were prepared from mice subjected to a high-fat-diet(HFD)at different time points,and TRPM5 expression in the pancreaticβcells was examined using immunofluorescence ***-stimulated insulin secretion(GSIS)defects caused by lipotoxicity were mimicked by saturated fatty acid palmitate(Palm).Primary mouse islets and mouse insulinoma MIN6 cells were treated with Palm,and the TRPM5 expression was detected using qRT-PCR and Western ***-induced GSIS defects were measured following siRNA-based Trpm5 *** detrimental effects of Palm on primary mouse islets were also assessed after overexpressing Trpm5 via an adenovirus-derived Trpm5(Ad-Trpm5).Results:HFD feeding decreased the mRNA levels and protein expression of TRPM5 in mouse pancreatic *** reduced TRPM5 protein expression in a time-and dose-dependent manner in MIN6 *** also inhibited TRPM5 expression in primary mouse *** of Trpm5 inhibited insulin secretion upon high glucose stimulation but had little effect on insulin *** of Trpm5 reversed Palm-induced GSIS defects and the production of functional maturation molecules unique toβ***:Our findings suggest that lipotoxicity inhibits TRPM5 expression in pancreaticβcells both in vivo and in vitro and,in turn,drivesβ-cell dysfunction.

关键词： type 2 diabetes β-cell dysfunction lipotoxicity TRPM5

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Subgroups of peripheral immune effector cells in cervical cancer patients are more sensitive to radiation therapy than chemotherapy

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Cancer Advances 2024年第3期7卷 1-7页

作者： Ning Zhao Dong-mei Han Cai-hong wu Hao Jin National Clinical Research Center for Cancer Tianjin Cancer Hospital Airport HospitalTianjin 300308China Center for Precision Cancer Medicine&Translational Research Tianjin Cancer Hospital Airport HospitalTianjin 300308China Oncology Department Tianjin Cancer Hospital Airport HospitalTianjin 300308China.

Background:CD8 positive T lymphocytes and natural killer(NK)cells in the peripheral blood of cervical cancer patients exhibit varying sensitivities to radiotherapy and ***:A total of 50 healthy peoples and 60 cervical cancer patients were *** patients with cervical cancer were separated into two groups:radiation and chemotherapy,and blood sample were collected before and after *** on the proportion of CD8 positive T lymphocytes and NK cells were gathered for analytical ***:Compared to healthy individuals,patients with cervical cancer exhibit a reduced proportion of CD8 positive T cells within their peripheral *** for patients with cervical cancer,radiation therapy has been found to be more effective than chemotherapy in increasing the proportion of CD8 positive T lymphocytes and NK ***:These results suggest that radiation therapy increases the levels of CD8 positive T lymphocytes and NK cells within the peripheral blood of patients with cervical *** study hypothesis that the changes in the percentage of CD8 positive T lymphocytes may serve as a potential indicator for predicting treatment efficacy.

关键词： CD8 positive T lymphocytes flow cytometry natural killer cells radiotherapy uterine cervical neoplasms

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Rubber-based agroforestry systems modify the soil fungal composition and function in Southwest China

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Soil Ecology Letters 2024年第3期6卷 97-107页

作者： Zhenyu hong Xinai Li Debao Li Jianping wu Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Institute of BiodiversitySchool of Ecology and Environmental ScienceYunnan UniversityKunming 650500China Laboratory of Soil Ecology and Health in Universities of Yunnan Province Yunnan UniversityKunming 650500China Dali University Dali 671003China

Rubber-based agroforestry systems have been recognized as a practical and sustainable solution to promote the development of agriculture and the ***,interactions between fungal communities and these systems are still not sufficiently *** this study,we compared the abundance,diversity,and community composition of soil fungi in four treatments,including rubber monoculture and three rubber-based agroforestry treatments involving intercropping with Camellia sinensis,Coffea liberica,and Theobroma *** results revealed that the community composition exhibited significant variation between the four different treatments,while the overall soilα-diversity was relatively stable across all *** pH and soil organic carbon were significantly related to the structure of the fungal *** particular,the complexity of the functional fungal network increased in response to agroforestry treatments,promoting beneficial fungi and suppressing certain plant *** results suggest that rubber-based agroforestry systems can promote the health of soil microbial community composition,and therefore provide an effective approach to enhancing soil quality.

关键词： agroforestry system with intercropping rubber monoculture fungal community fungal function tropical forest

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Boosting zinc anode durability through synergistic inner Helmholtz plane and interfacial electric field regulation

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Science Bulletin 2024年第13期69卷 2025-2029页

作者： Hao Tan Chao Meng Tong Sun Xing-Long wu hong Liu Jian-Jun Wang State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China MOE Key Laboratory for UV Light-Emitting Materials and Technology Department of PhysicsNortheast Normal UniversityChangchun 130024China Jinan Institute of Quantum Technology Jinan BranchHefei National LaboratoryJinan 250101China Shenzhen Research Institute Shandong UniversityShenzhen 518057China

As the need for energy storage devices escalates,aqueous zincion batteries(ZIBs)have risen as a promising alternative to the widely used Li-ion batteries,offering intrinsic safety,environmental compatibility,and cost advantages,positioning them as attractive energy storage systems for the future[1,2].However,challenges such as dendrite growth on Zn anodes,stemming from uneven electric fields on the surface and active water side reactions,compromise cycling stability and lifespan,posing significant hurdles for the practical application of ZIBs[3,4].To mitigate these issues,strategies like electrolyte optimization,artificial solid electrolyte interphase(SEI)layers,and current collector modifications have been proposed[5,6].Nevertheless,most long-cycle experiments are conducted at low current densities and deposition capacities,with high current density and capacity operations typically lasting less than 1000 h[7].

关键词： electrolyte durability offering

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PDGFRB mutation causes intracranial aneurysm

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Journal of Genetics and Genomics 2024年第9期51卷 978-981页

作者： Junyu Liu Chunling Wang Enyu Huang Luming Wang Chengchao wu Weixi Jiang mei wu Xiuru Zhang Junxia Yan Yeqi Wang Jingjing Zhang Department of Neurosurgery XiangYa HospitalCentral South UniversityChangshaHunan 410008China Department of Pharmacology Kyoto University Graduate School of MedicineKyoto 606-8501Japan Key Laboratory for Biorheological Science and Technology of Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044China Affiliated Hospital of Guangdong Medical University&Zhanjiang Key Laboratory of Zebrafish Model for Development and Disease Guangdong Medical UniversityZhanjiangGuangdong 524001China Department of Epidemiology and Health Statistics XiangYa School of Public HealthCentral South UniversityChangshaHunan 410006China Hunan Provincial Key Laboratory of Clinical Epidemiology XiangYa School of Public HealthCentral South UniversityChangshaHunan 410006China

Intracranial aneurysm(IA)is characterized by defects in the middle muscular layer and pathological dilatation of cerebral *** rupture of IA,resulting in aneurysmal subarachnoid hemorrhage,poses a substantial public health problem,especially in developed countries,due to its high mortality,morbidity,and socioeconomic burden(Bakker and Ruigrok,2021).Understanding the risk factors for IA is critical for disease *** numerous studies(Yan et al.,2015;Santiago-Sim et al.,2016;Barak et al.,2021;Liu et al.,2021)have highlighted familial aggregation of IA and identified candidate genes such as ADAMTS15,THSD1,ANK3,and PPIL4,the mechanisms underlying IA formation and rupture remain unclear.

关键词： al. aneurysm rupture

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High-stable and High-capacity Sn/SnO_(2)@C as Anode of Lithium-ion Batteries

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Journal of wuhan University of Technology(Materials Science) 2024年第4期39卷 805-813页

作者：徐天星 wu Jie 李亚娟肖宏 College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science Central South UniversityChangsha 410083China Hunan Times New Energy Technology Co. LtdLuxi 416100China

We synthesized size-controllable nanoparticles with homogeneous distribution of carbon and Sn/SnO_(2)by a solvothermal *** effects of different carbon content and hydrothermal time on the composition,morphology and electrochemical properties of the materials were *** with bulk materials,nanoparticles materials not only have high specific surface area,but also can provide abundant reaction sites,thus enhancing the electrochemical activity of electrode *** importantly,the optimized microspheres Sn/8C-24 delivers a superior electrochemical performance,achieving a specific discharge capacity of 700.4 mAh·g^(-1)after 150 cycles at 0.5 A·g^(-1),and the Coulomb efficiency reaches 98.65%,which is promising for anode of LIBs.

关键词： Sn anode nanoparticles hydrothermal method

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Privacy-Preserving Multi-Keyword Fuzzy Adjacency Search Strategy for Encrypted Graph in Cloud Environment

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Computers, Materials & Continua 2024年第3期78卷 3177-3194页

作者： Bin wu Xianyi Chen Jinzhou Huang Caicai Zhang Jing Wang Jing Yu Zhiqiang Zhao Zhuolin mei School of Computer and Big Data Science Jiujiang UniversityJiujiang332005China Jiujiang Key Laboratory of Network and Information Security Jiujiang332005China School of Computer and Software Nanjing University of Information Science&TechnologyNanjing210044China School of Computer Engineering Hubei University of Arts and ScienceXiangyang441053China School of Modern Information Technology Zhejiang Institute of Mechanical and Electrical EngineeringHangzhou310053China Information Center Jiangxi Changjiang Chemical Co.Ltd.Jiujiang332005China School of Mathematics and Computer Science Ningxia Normal UniversityGuyuan756099China

In a cloud environment,outsourced graph data is widely used in companies,enterprises,medical institutions,and so *** owners and users can save costs and improve efficiency by storing large amounts of graph data on cloud *** on cloud platforms usually have some subjective or objective attacks,which make the outsourced graph data in an insecure *** issue of privacy data protection has become an important obstacle to data sharing and *** to query outsourcing graph data safely and effectively has become the focus of *** query is a basic and frequently used operation in graph,and it will effectively promote the query range and query ability if multi-keyword fuzzy search can be supported at the same *** work proposes to protect the privacy information of outsourcing graph data by encryption,mainly studies the problem of multi-keyword fuzzy adjacency query,and puts forward a *** our scheme,we use the Bloom filter and encryption mechanism to build a secure index and query token,and adjacency queries are implemented through indexes and query tokens on the cloud *** proposed scheme is proved by formal analysis,and the performance and effectiveness of the scheme are illustrated by experimental *** research results of this work will provide solid theoretical and technical support for the further popularization and application of encrypted graph data processing technology.

关键词： Privacy-preserving adjacency query multi-keyword fuzzy search encrypted graph

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