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Advances in coatings on biodegradable magnesium alloys

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Journal of Magnesium and Alloys 2020年第1期8卷 42-65页

作者： Zheng-Zheng Yin Wei-Chen Qi Rong-Chang Zeng Xiao-Bo Chen Chang-Dong Gu Shao-Kang guan Yu-Feng Zheng Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China Department of Orthopaedics and Traumatology Li KaShing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Engineering RMIT UniversityCarltonVIC 3053Australia School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsZhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China State Key Laboratory for Turbulence and Complex Systems and Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China

The clinic applications of bioabsorbable magnesium(Mg)and its alloys have been significantly restricted owing to their poor corrosion *** elemental alloying,surface modification and functionality is a major approach to increasing corrosion resistance for magnesium *** article reviews the cutting-edge advances and progress of biodegradable surface coatings upon Mg alloys over the last decades,aims to build up a knowledge framework of surface modification on biodegradable Mg alloys.A considerable number of conversion,deposition,mechanical and functional coatings and their preparation methods are *** emphasis has been placed on the composition of chemical conversion and deposited coatings to overcome the disadvantages of adhesion,corrosion resistance and biocompatibility of a single coating for biomedical *** issues have been addressed on the integration of the structural and functional factors of the composite coatings.

关键词： Magnesium alloy Biomaterial Corrosion resistance Coating Biodegradability

Effect of rare earth and Mn elements on the corrosion behavior of extruded AZ61 system in 3.5 wt%NaCl solution and salt spray test

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Journal of Magnesium and Alloys 2013年第3期1卷 249-255页

作者： Shijie Zhu Zhidan Liu RuiXiao Qu LiGuo Wang Qingkui Li Shaokang guan School of Materials Science and Engineering Zhengzhou University100 Science RoadZhengzhou 450001China

In this study,multiple addition of rare earth(RE)and manganese(Mn)to AZ61 was conducted aiming to find out the influence to corrosion ***61 containing different amounts of RE and Mn was investigated by electrochemical measurement in condition of 3.5 wt%NaCl solution at 25°*** measurement was conducted in 5 wt%salt spray at 35°C and 3.5 wt%NaCl solution at 25°*** were characterized by SEM,EDS,OM and *** result shows that with RE addition Al8Mn5 in AZ61 changed into *** quantity ofβphase is reduced *** multiple addition of RE and Mn improved the corrosion resistance of *** the ratio of Mn and RE is 0.3,alloy has the best property of corrosion *** addition,the composite addition removed the impurity elements in AZ61 especially Fe.

关键词： AZ61 Rare earth Multiple addition Corrosion resistance Electrochemical properties

Effects of samarium content on microstructure and mechanical properties of Mg–0.5Zn–0.5Zr alloy

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Journal of Materials Science & Technology 2019年第7期35卷 1368-1377页

作者： Kai guan Fanzhi Meng Pengfei Qin Qiang Yang Dongdong Zhang Baishun Li Wei Sun Shuhui Lv Yuanding Huang Norbert Hort Jian Meng State Key Laboratory of Rare Earth Resource Utilization. Changchun Institute of Applied Chemistry Chinese Academy of Science Changchun 130022 University of Science & Technology of China Hefei 230026China School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China Key Laboratory of Superlight Material and Surface Technology Ministry of EducationCollege of Material Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China MagIC-Magnesium Innovation Centre Helmholtz-Zentrum GeesthachtMax-Planck Strasse 121502CeesthachtGermany

Effects of samarium (Sm) content (0, 2.0, 3.5, 5.0, 6.5 wt%) on microstructure and mechanical proper-ties of Mg-0.5Zn-0.5 Zr alloy under as-cast and as-extruded states were thoroughly investigated. Results indicate that grains of the as-cast alloys are gradually refined as Sm content increases. The dominant intermetallic ph^se changes from Mg3Sm to Mg4iSm5 till Sm content exceeds 5.0 wt%. The dynami-cally precipitated intermetallic phase during hot-extrusion in dll Sm-containing alloys is Mg3Sm. The intermetallic particles induced by Sm addition could act as heterogeneous nucleation sites for dynamic recrystallization during hot extrusion. They promoted dynamic recrystallization via the particle stim-ulated nucleation mechanism, and resulted in weakening the basal texture in the as-extruded alloys. Sm addition can significantly enhance the strength of the as-extruded Mg-0.5Zn-0.5Zr alloy at room temperature, with the optimal dosage of 3.5 wt%. The optimal yield strength (YS) and ultimate tensile strength (UTS) are 368 MPa and 383 MPa, which were enhanced by approximately 23.1% and 20.8% com-pared with the Sm-free alloy, respectively. Based on microstructural analysis, the dominant strengthening mechanisms are revealed to be grain boundary strengthening and dispersion strengthening.

关键词： Magnesium alloys Samarium Transmission electron microscopy (TEM) Microstructure Mechanical properties

Optimal timing of staged percutaneous coronary intervention in ST-segment elevation myocardial infarction patients with multivessel disease

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Journal of Geriatric Cardiology 2018年第5期15卷 356-362页

作者： Xue-Dong ZHAO guan-Qi ZHAO Xiao WANG Shu-Tian SHI Wen ZHENG Rui-Feng GUO Shao-Ping NIE Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China

Background Studies have shown that staged percutaneous coronary intervention （PCI） for non-culprit lesions is beneficial for prog- nosis of ST-segment elevation myocardial infarction （STEMI） patients with multivessel disease. However, the optimal timing of staged re- vascularization is still controversial. This study aimed to find the optimal timing of staged revascularization. Methods A total of 428 STEMI patients with multivessel disease who underwent primary PCI and staged PCI were included. According to the time interval between primary and staged PCI, patients were divided into three groups （〈 1 week, 1- weeks, and 2-12 weeks after primary PCI）. The primary endpoint was major adverse cardiovascular events （MACE）, a composite of all-cause death, non-fatal re-infarction, repeat revascularization, and stroke. Cox regression model was used to assess the association between staged PCI timing and risk of MACE. Results During the follow-up, 119 participants had MACEs. There was statistical difference in MACE incidence among the three groups （〈 1 week： 23.0%; 1-2 weeks： 33.0%; 2-12 weeks： 40.0%; P = 0.001）. In the multivariable adjustment model, the timing interval of staged PCI ≤ 1 week and l-2 weeks were both significantly associated with a lower risk of MACE [hazard ratio （HR）： 0.40, 95% confidence intervals （CI）： 0.24-4）.65; HR： 0.54, 95% CI： 0.3 lq3.93, respectively], mainly attributed to a lower risk of repeat revascularization （HR： 0.41, 95% CI： 0.24-0.70; HR： 0.36, 95% CI： 0.18-0.7）, compared with a strategy of 2-12 weeks later of primary PCI. Conclusions The optimal timing of staged PCI for non-culprit vessels should be within two weeks after primary PCI for STEMI patients.

关键词： Myocardial infarction Multivessel disease Non-culprit lesion Percutaneous coronary intervention Timing

A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis

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Acta Pharmaceutica Sinica B 2021年第3期11卷 708-726页

作者： Tailin He Jialin Shang Chenglong Gao Xin guan Yingyi Chen Liwen Zhu luyong Zhang Cunjin Zhang Jian Zhang Tao Pang State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug ScreeningJiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesChina Pharmaceutical UniversityNanjing 210009China Medicinal Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Neurology of Drum Tower Hospital Medical School and the State Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjing 210008China

Ischemic stroke is the second leading cause of death worldwide with limited medications and neuroinflammation was recognized as a critical player in the progression of stroke,but how to control the overactive neuroinflammation is still a long-standing ***,we designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and primary mouse microglia,which were abolished by silencing ***-seq screening identified the forkhead box C1 (Foxc1) is a key gene evoked by MDL-811stimulation and is required for the anti-inflammatory effects of *** found MDL-811-activated SIRT6 directly interacted with enhancer of zeste homolog 2 (EZH2) and promoted deacetylation of EZH2 which could bind to the promoter of Foxc1 and upregulate its expression to modulate ***,our data demonstrated that MDL-811 not only ameliorated sickness behaviors in neuroinflammatory mice induced by LPS,but also markedly reduced the brain injury in ischemic stroke mice in addition to promoting long-term functional ***,MDL-811 also exhibited strong anti-inflammatory effects in human monocytes isolated from ischemic stroke patients,underlying an interesting translational *** together,MDL-811 could be an alternative therapeutic candidate for ischemic stroke and other brain disorders associated with neuroinflammation.

关键词： SIRT6 activator Neuroinflammation Ischemic stroke Deacetylation Microglia Macrophage FOXC1 EZH2

Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice

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Chinese Journal of Natural Medicines 2020年第3期18卷 186-195页

作者： LIU Xin-Yu CHEN guan-Nan DU Guo-Ming PAN Yue SONG Wu-Qi JIANG Ting-Wang LIU Hai-Liang Department of Microbiology Wu Lien-Teh InstituteHarbin Medical UniversityHarbin 150081China Department of Key Laboratory The Second People’s Hospital of ChangshuThe Affiliated Changshu Hospital of Xuzhou Medical UniversityChangshu 215500China

Alcoholic liver disease(ALD) has become one of the leading causes of death in the world. Berbamine(BM), a natural product mainly derived from Berberis vulgaris L, possesses multiple bioactivities as a traditional medicine. However, the protective effect of BM on ALD remains unknown. In this study, we investigated the effect of BM on ethanol-induced hepatic injury in mice and its underlying mechanism. It was shown that BM at 0.3125-40 μmol·L^-1 had no effect on macrophages and hepatocytes proliferation. BM at 5-20 μmol·L^-1 significantly inhibited lipopolysaccharide(LPS) or acetate-induced IL-1β and IL-6 m RNA expression in RAW264.7 cells. Moreover, BM treatment significantly inhibited LPS-induced p65 and STAT3 phosphorylation in RAW264.7 cells. Hepatic histopathology analysis showed that inflammatory cells infiltration and lipid accumulation were suppressed by 25 and 50 mg·kg^-1 BM administration in ethanol-induced hepatic injury mouse model. Meanwhile, BM treatment significantly inhibited serum ALT and AST levels in ethanol-fed mice. Oil red O staining results showed that BM administration ameliorated hepatic lipid accumulation in ethanolfed mice. Preventions of ethanol-induced hepatic injury by BM were reflected by markedly decreased serum and hepatic triglyceride(TG) and total cholesterol(TC) contents. Real-time PCR results showed that BM treatment significantly inhibited pro-inflammatory cytokines m RNA expression in ethanol-fed mouse liver. Remarkably, the mechanism of action of BM was related to the reduction of ethanol-induced NF-κB and STAT3 phosphorylation levels in liver. In addition, BM treatment significantly inhibited ERK phosphorylation but not JNK and p38 of MAPK pathway. Taken together, our results demonstrate a beneficial effect of BM on ethanol-induced liver injury via a mechanism associated with inactivation of NF-κB, STAT3 and ERK pathway, which gives insight into the further evaluation of the therapeutic potential of BM for ALD.

关键词： Berbamine Ethanol Hepatic injury NF-κB Inflammation

Restored intestinal integrity,nutrients transporters,energy metabolism,antioxidative capacity and decreased harmful microbiota were associated with IUGR piglet's catch-up growth before weanling

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Journal of Animal Science and Biotechnology 2023年第1期14卷 390-408页

作者： Chang Cui Caichi Wu Jun Wang Ziwei Ma Xiaoyu Zheng Pengwei Zhu Nuan Wang Yuhua Zhu Wutai guan Fang Chen guangdong Provincial Key Laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China. Shenzhen Kingsino Technology CO. LTDShenzhen 518107China. Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China. Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518116China. College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China. guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China.

Background:Intrauterine growth restriction(IUGR)is a major inducer of higher morbidity and mortality in the pig industry and catch-up growth(CUG)before weanling could significantly restore this negative *** there was limited knowledge about the underlying mechanism of CUG ***:Eighty litters of newborn piglets were divided into normal birth weight(NBW)and IUGR groups according to birth *** 26 d,those piglets with IUGR but over average body weight of eighty litters of weaned piglets were considered as CUG,and the piglets with IUGR still below average body weight were considered as *** study was conducted to systemically compare the intestinal difference among NBW,CUG and NCUG weaned piglets considering the crucial role of the intestine for piglet ***:The results indicated that the m RNA expression of nutrients(amino acids,glucose,and fatty acids)transporters,and mitochondrial electron transport chain(ETC)I were upregulated in CUG piglets'gut with improved morphology compared with those NCUG,as well as the ratio of P-AMPK/AMPK protein expression which is the indicator of energy ***,CUG piglet's gut showed higher antioxidative capacity with increased SOD and GSHPx activity,decreased MDA levels,as well as higher m RNA expressions of Nrf2,Keap1,SOD,and ***,inflammatory parameters including TNF-α,IL-1β,IL-6,and IL-12 factors,and the activation of MAPK and NF-κB signaling pathways were significantly elevated in the NCUG intestine,while the protein expression of ZO-1,Occludin and Claudin-1 was *** alpha diversity of fecal microbiota was higher in CUG piglets in contrast with NCUG piglets,and the increased beneficial bacteria and decreased pathogenic bacteria was also observed in CUG ***:CUG piglet's intestine showed comprehensive restoration including higher nutrients transport,energy metabolism,antioxidant capacity,and intestinal physical barrier,while lower oxidative str

关键词： Antioxidative capacity Catch-up growth Gut Intrauterine growth retardation Piglets

Fermi level tuning in Sn_(1-x)Pb_(x)Te/Pb heterostructure via changing interface roughness

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 118-125页

作者： Tengteng Liu Zhaoxia Yi Bangjin Xie Weiyan Zheng Dandan guan Shiyong Wang Hao Zheng Canhua Liu Hao Yang Yaoyi Li Jinfeng Jia Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) Tsung-Dao Lee InstituteSchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Research Center for Quantum Sciences Shanghai 201315China Hefei National Laboratory Hefei 230088China

Superconducting SnTe-type topological crystalline insulators(TCIs)are predicted to host multiple Majorana zero modes(MZMs)which can coexist in a single *** level(FL)close to the Dirac points of topological surface states is helpful for detecting ***,the TCI SnTe is a heavily p-type semiconductor which is very difficult to modify to n-type via doping or *** this work,we fabricate the atomically flat Sn_(1-x)Pb_(x)Te/Pb heterostructure by molecular beam epitaxy,and make the p-type Sn_(1-x)Pb_(x)Te become n-type through changing the interface *** scanning tunnelling microscope,we find the Dirac points of Sn_(1-x)Pb_(x)Te/Pb heterostructure are always above the FL due to the Fermi level pinning(FLP)induced by topological surface states at atomically flat *** increasing the interface roughness,the FLP effect is suppressed and then the Dirac points of p-type Sn_(1-x)Pb_(x)Te can be tuned very close to or even below the *** work provides a new method for tuning the FL of SnTe-type TCI which has potential application in novel topological superconductor device.

关键词： topological crystalline insulator superconductor heterostructure Fermi level pinning interface roughness

Tidal water exchanges can shape the phytoplankton community structure and reduce the risk of harmful cyanobacterial blooms in a semi-closed lake

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Journal of Oceanology and Limnology 2022年第5期40卷 1868-1880页

作者： Wenxu ZHENG Renhui LI Wenli QIN Binbin CHEN Min WANG Wanchun guan Xiaoling ZHANG Qiao YANG Min ZHAO Zengling MA Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection Wenzhou UniversityWenzhou 325035China National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution Wenzhou UniversityWenzhou 325035China Department of Marine Biotechnology School of Laboratory Medicine and Life ScienceWenzhou Medical UniversityWenzhou 325035China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China School of Petrochemical Engineering and Environment Zhejiang Ocean UniversityZhoushan 316022China

For estuaries,inland lakes play a vital role in the ecological balance under the impact of tide *** effect of tides-induced water exchange on phytoplankton community in a semi-closed lake was studied and compared with that of an adjacent closed lake in the Oujiang River mouth in Zhejiang,East China Sea,from June 29,2020 to June 14,*** show that the dominant species,abundance,dominance,and diversity of the phytoplankton species between the two lakes were significantly *** the closed lake,cyanobacteria were the dominant species during the study *** the semi-closed lake,the diversification of the dominant species was greater,and some species of diatoms and green algae became *** average phytoplankton abundance in the closed lake was 6 times of that in the semi-closed *** average dominance of cyanobacteria in the closed lake was 0.96,and those in the semi-closed lake and the Oujiang River were 0.51 and 0.22,*** blooms occurred throughout the study time in the closed lake but not in the semi-closed ***,the species diversity richness of the phytoplankton in the semi-closed lake was higher than that of the closed one,and the phytoplankton community between the closed lake and semi-closed lake could be divided into distinctly different groups based on non-metic multidimensional scaling analysis(NMDS)and analysis of similarities(ANOSIM)*** salinity of the water was significantly greater and the transparency significantly smaller in the semi-closed lake than those in the closed ***,water exchange driven by local tidal movement increased salinity and decreased transparency of water,which consequently shaped the community structures of different phytoplankton and reduced the risk of a cyanobacterial bloom outbreak in the semi-closed lake.

关键词： estuary harmful cyanobacterial blooms phytoplankton community water exchange tidal movement environmental parameters