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Prognostic effect analysis of molecular subtype on young breast cancer patients

Chinese Journal of Cancer Research 2015年第4期27卷 428-436页

作者： hong-liang chen Ang Ding Fu-Wen Wang Department of Breast Surgery Obstetrics and Gynecology Hospital of Fudan University

Objective： To make a prognostic effect analysis of molecular subtype on young breast cancer ***： Totally 187 cases of young breast cancer patients less than 40 years old treated in Obstetrics and Gynecology Hospital of Fudan University between June 2005 and June 2011 were included in our study. We described their clinical-pathological characteristics, disease-free survival（DFS） rate, and overall survival（OS） rate after a median follow-up period of 61 months. The factors associated with prognosis were also evaluated by univariate and multivariate ***： All patients were premenopausal, with an average age of 35.36±3.88 years old. The mean tumor size was 2.43±1.53 cm. Eighty-one cases had lymph node metastasis（43.3%）, 126 cases had lymphovascular invasion（67.4%）, and 125 cases had histological grade III（66.8%） disease. Twenty-seven cases（14.4%） were Luminal A subtype, 99 cases（52.9%） were Luminal B subtype, 29 cases（15.5%） were human epidermal growth factor receptor 2（HER-2） overexpression subtype, while 32 cases（17.1%） were triple negative breast cancer（TNBC） subtype according to 2013 St Gallen expert consensus. One hundred and thirty-five cases underwent mastectomy whereas 52 cases had breast-conserving surgery. One hundred and seventy-eight cases underwent adjuvant or neoadjuvant chemotherapy. Recurrence or metastasis occurred in 29 cases, 13 of which died. The 5-year DFS and OS rates were 84% and 92%. Multivariate analysis showed that nodal status（P=0.041） and molecular subtype（P=0.037） were both independent prognostic factors of DFS, while nodal status（P=0.037） and TNBC subtype（P=0.048） were both independent prognostic factors of OS. Conclusions： Molecular subtype is an independent prognostic factor of young breast cancer patients. TNBC has a high risk of relapse and death.

关键词： Molecular subtype young breast cancer prognosis

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Self-Organized Public-Key Management for Mobile Ad Hoc Networks Based on a Bidirectional Trust Model

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 188-192页

作者： FU Cai hong Fan LI Rui-xian hong liang chen Jing College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 Hubei China

In traditional networks , the authentication is performed by certificate authoritys（CA）,which can＇t be built in distributed mobile Ad Hoc Networks however. In this pa per, we propose a fully self-organized public key management based on bidirectional trust model without any centralized authority that allows users to generate their public-private key pairs, to issue certificates, and the trust relation spreads rationally according to the truly human relations. In contrast with the traditional self-organized public-key management, the average certificates paths get more short, the authentication passing rate gets more high and the most important is that the bidirectional trust based model satisfys the trust re quirement of hosts better.

关键词： Ad Hoc networks self-organize bidirectional trust public key management.

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AN UNUSUAL BILATERAL VAGAL PARAGANGLIOMAS: ONE CASE STUDY

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Chinese Medical Sciences Journal 2006年第3期21卷 197-200页

作者： Hai-hong chen liang Chai Wei Pan Department of Otorhinolaryngology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003

VAGAL paraganglioma （VP） is an uncommon neoplasm originating from neural crest paraganglion cells located along the vagus nerve, repre-senting less than 5 % of all paragangliomas of the head and neck Despite improve... 详细信息

关键词： bilateral vagal paragangliomas treatment

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Nontraumatic convexal subarachnoid hemorrhage:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6205-6210页

作者： hong-liang chen Bin Li Chao chen Xiao-Xuan Fan Wen-Bin Ma Department of Neurology Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Clinical Medicine Binzhou Medical UniversityBinzhou 256600Shandong ProvinceChina

BACKGROUND Nontraumatic convexal subarachnoid hemorrhage(c SAH)is a rare type of atypical subarachnoid *** mainly presents as a focal and transient neurological deficit with similar manifestations as transient ischemic *** SUMMARY We report a case of a 64-year-old man who visited the hospital with paroxysmal left-sided numbness and weakness is presented in this *** tomography examination indicated a high-density image of the right frontalparietal *** subtraction angiography showed severe stenosis at the right anterior cerebral artery A2-A3 junction(stenosis rate approximately 70%).CONCLUSION The findings of this case indicate that anterior cerebral artery stenosis may lead to the occurrence of c SAH.

关键词： Nontraumatic convexal subarachnoid hemorrhage Subarachnoid hemorrhage Transient ischemic attack Artery atherosclerosis stenosis Case report

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Spectroscopic Studies on the Interaction of Asiatic Acid with Bovine Serum Albumin

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Chinese Journal of Chemistry 2011年第3期29卷 549-554页

作者： Yao, Di Ni, Shouhai Wen, Maogui Bian, Hedong Yu, Qing liang, hong chen, Zhenfeng Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) Ministry of Education of China Guilin Guangxi 541004 China

Fluorescence spectroscopy, Fourier transform infrared （FT-IR） spectroscopy, circular dichroism （CD） and FT-Raman spectroscopy were employed to analyze the binding of the asiatic acid （AA） to bovine serum albumin （BSA） under simulative physiological conditions. Fluorescence data revealed that the fluorescence quenching of BSA by AA was the result of the formation of BSA-AA complex. The fluorescence quenching mechanism of BSA by AA was a static quenching procedure. According to the Van＇t Hoff equation, the thermodynamic parameters enthalpy change （△H0） and entropy change （△S0） for the reaction were evaluated to be --12.55 kJ·mol^-1 and 67.08 kJomol 1, respectively, indicating that hydrophobic and electrostatic interactions played a major role in stabilizing the complex. The influence of AA on the conformation of BSA has also been analyzed on the basis of FT-IR, CD and FT-Raman spectra.

关键词： bovine serum albumin asiatic acid secondary structure fluorescence spectroscopy fourier transforminfrared (FT-IR) circular dichroism raman spectroscopy

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Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer

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World Journal of Gastroenterology 2013年第43期19卷 7788-7794页

作者： Zhen-Jun Li Xiao-Jiang Ying hong-liang chen Ping-Jiang Ye Zhi-liang chen Gang Li Hua-Feng Jiang Jiang Liu Shu-Zhen Zhou Department of Colorectal Surgery Shaoxing People’s Hospital Shaoxing Hospital of Zhejiang University

AIM:To investigate the expression of insulin-like growth factor-1(IGF-1)/insulin-like growth factor-1 receptor(IGF-1R)in colorectal cancer(CRC)tissues and to analyze their correlation with lymphangiogenesis and lymphatic ***:Immunohistochemistry was used to evaluate IGF-1 and IGF-1R expression and lymphatic vessel density(LVD)in 40 CRC *** correlation between IGF-1/IGF-1R and LVD was *** of IGF-1 on migration and invasion of CRC cells were examined using transwell chamber assays.A LoVo cell xenograft model was established to further detect the role of IGF-1 in CRC lymphangiogenesis in vivo. RESULTS:Elevated IGF-1 and IGF-1R expression in CRC tissues was correlated with lymph node metastasis(r=0.715 and 0.569,respectively,P<0.05)and tumor TNM stage(r=0.731 and 0.609,P<0.05).A higher LVD was also found in CRC tissues and was correlated with lymphatic metastasis(r=0.405,P<0.05).A positive correlation was found between LVD and IGF-1R expression(r=0.437,P<0.05).Transwell assays revealed that IGF-1 increased the migration and invasion of CRC *** vivo mouse studies showed that IGF-1 also increased LVD in LoVo cell ***:IGF-1/IGF-1R signaling induces tumorassociated lymphangiogenesis and contributes to lymphatic metastasis of CRC.

关键词： Colorectal cancer Insulin-like growth factor-1 Insulin-like growth factor-1 receptor Lymphangiogenesis Lymphatic metastasis

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Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： liang Chu Haoyu Shen Hudie Wei hongyu chen Guoqiang Ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

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From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun Shen Xin Zhang Lingcong Chao liang chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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基于生产数据挖掘的吹灰需求度置信规则库研究

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热力发电 2017年第6期46卷 113-118页

作者：钱虹宋亮陈琪琪陈纲上海电力学院自动化工程学院上海200090 华能上海石洞口第一电厂上海200942

为对锅炉积灰结渣受热面吹灰优化,以锅炉燃烧特性和吸热特性为理论依据对生产数据进行挖掘处理,建立吹灰需求度置信规则库。运用数理统计、贝叶斯理论,结合现场运行专家经验,完成吹灰策略集和征兆集的提取、规则的表示和规则变量的设定... 详细信息

为对锅炉积灰结渣受热面吹灰优化,以锅炉燃烧特性和吸热特性为理论依据对生产数据进行挖掘处理,建立吹灰需求度置信规则库。运用数理统计、贝叶斯理论,结合现场运行专家经验,完成吹灰策略集和征兆集的提取、规则的表示和规则变量的设定,并对规则库进行测试。结果表明,本吹灰需求度置信规则库对领域专家吹灰经验的知识描述符合电厂实际吹灰需求,达到了吹灰优化的目的。

关键词：锅炉积灰结渣吹灰优化置信规则库数据挖掘贝叶斯理论生产数据

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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng Mingbo Nie hong chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

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