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The ALMA-QUARKS Survey.Ⅰ.Survey Description and Data Reduction

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Research in Astronomy and Astrophysics 2024年第2期24卷 104-124页

作者：刘训川 Tie liu Lei Zhu Guido Garay hong-li liu Paul Goldsmith Neal Evans Kee-Tae Kim Sheng-Yuan liu Fengwei Xu Xing Lu Anandmayee Tej Xiaofeng Mai Leonardo Bronfman Shanghuo li Diego Mardones Amelia Stutz Ken'ichi Tatematsu Ke Wang Qizhou Zhang Sheng-li Qin Jianwen Zhou Qiuyi Luo Siju Zhang Yu Cheng Jinhua He Qilao Gu Ziyang li Zhenying Zhang Suinan Zhang Anindya Saha Lokesh Dewangan Patricio Sanhueza Zhiqiang Shen Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile School of Physics and Astronomy Yunnan UniversityKunming 650091China Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Department of Astronomy The University of Texas at AustinTX 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia Max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Departamento de Astronomía Universidad de ConcepciónCasilla 160-CConcepciónChile Nobeyama Radio Observatory National Astronomical Observatory of JapanNational Institutes of Natural Sciences462-2 NobeyamaMinamimakiMinamisakuNagano 384-1305Japan Center for Astrophysics∣Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA Max-Planck-Institut für Radioastronomie Auf dem Hügel 69D-53125 BonnGermany School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of Japan 2-21-1 OsawaMitakaTokyo181-8588Japan Yunnan Observatories Chinese Academy of SciencesKunming 650216China Physical Research Laboratory NavrangpuraAhmedabad-380009India Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan University of Science and Technology Korea(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic o

This paper presents an overview of the QUARKS survey,which stands for Querying Underlying mechanisms of massive star formation with ALMA-Resolved gas Kinematics and Structures."The QUARKS survey is observing139 massive clumps covered by 156 pointings at Atacama Large Millimeter/submillimeter Array(ALMA)Band 6(λ~1.3 mm).In conjunction with data obtained from the ALMA-ATOMS survey at Band 3(λ~3 mm),QUARKS aims to carry out an unbiased statistical investigation of massive star formation process within protoclusters down to a scale of 1000 au.This overview paper describes the observations and data reduction of the QUARKS survey,and gives a first look at an exemplar source,the mini-starburst Sgr B2(M).The wide-b and width(7.5 GHz)and high-angular-resolution(~0."3)observations of the QUARKS survey allow for the resolution of much more compact cores than those could be done by the ATOMS survey,and to detect previously unrevealed fainter filamentary structures.The spectral windows cover transitions of species including CO,SO,N_(2)D^(+),SiO,H_(30)α,H_(2)CO,CH_(3)CN,and many other complex organic molecules,tracing gas components with different temperatures and spatial extents.QUARKS aims to deepen our understanding of several scientific topics of massive star formation,such as the mass transport within protoclusters by(hub-)filamentary structures,the existence of massive starless cores,the physical and chemical properties of dense cores within protoclusters,and the feedback from already formed high-mass young protostars.

关键词： stars formation-stars kinematics and dynamics-ISM clouds-ISM molecules

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Microstructural evolution and fracture mechanism of a new AlZn-Mg-Cu-Zr alloy processed by equal-channel angular pressing

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Rare Metals 2022年第10期41卷 3546-3551页

作者： hong-li liu Ping li Ke-Min Xue Chen-Hao Qian Rui Hua School of Materials Science and Engineering Hefei University of TechnologyHefei230009China

Equal-channel angular pressing(ECAP) is considered to be one of the most effective processing procedures to produce ultrafine-grained(UFG) materials.A new AI-ZnMg-Cu-Zr alloy was subjected to ECAP experiment in Route B_(C)(i.e.,rotated 90° in the same sense between each pass).The effect of ECAP on the microstructural evolution and fracture mechanism of the alloy was analyzed by optical microscope(OM),X-ray diffraction(XRD),tensile test(at room temperature),and scanning electron microscope(SEM).The results show that the main strengthening phase of the alloy is MgZn_(2),whose content increases apparently after ECAP,the dislocation density increases by one order of magnitude,the hardness value of the 1 pass ECAPed sample increases by 53 %,the ultimate tensile strength(UTS)increases by 29 %,and the true strain increases by 15.4 %.But the further increase in the strength with the passes increasing would cost a slight drop in the true strain.The morphology of the tensile dimples is converted from elongated one to equiaxed one with a uniform distribution of size and depth after pressing.

关键词： Al-Zn-Mg-Cu-Zr alloy Equal-channel angular pressing Microstructural evolution Crystallite size Mechanical properties Fracture mechanism

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Fusobacterium nucleatum and colorectal cancer:A review

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World Journal of Gastrointestinal Oncology 2018年第3期10卷 71-81页

作者： Fu-Mei Shang hong-li liu Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

Fusobacterium nucleatum (F.nucleatum) is a Gramnegative obligate anaerobe bacterium in the oral cavity and plays a role in several oral diseases, including periodontitis and gingivitis. Recently, several studies have reported that the level of F.nucleatum is significantly elevated in human colorectal adenomas and carcinomas compared to that in adjacent normal tissue. Several researchers have also demonstrated that F.nucleatum is obviously associated with colorectal cancer and promotes the development of colorectal neoplasms. In this review, we have summarized the recent reports on F.nucleatum and its role in colorectal cancer and have highlighted the methods of detecting F.nucleatum in colorectal cancer, the underlying mechanisms of pathogenesis, immunity status, and colorectal cancer prevention strategies that target F.nucleatum.

关键词： Fusobacterium nucleatum Carcinoma Colon and rectal carcinoma Host immunity Gut microbiome

Safety evaluation of human umbilical cord-mesenchymal stem cells in type 2 diabetes mellitus treatment:A phase 2 clinical trial

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World Journal of Clinical Cases 2023年第21期11卷 5083-5096页

作者： Xiao-Fen lian Dong-Hui Lu hong-li liu Yan-Jing liu Yang Yang Yuan lin Feng Xie Cai-Hao Huang hong-Mei Wu Ai-Mei Long Chen-Jun Hui Yu Shi Yun Chen Yun-Feng Gao Fan Zhang Department of Endocrinology Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Department of Endocrinology Huizhou Central People’s HospitalHuizhou 516000Guangdong ProvinceChina Department of Endocrinology Longgang District Central Hospital of ShenzhenShenzhen 518000Guangdong ProvinceChina

BACKGROUND Progressive pancreaticβcell dysfunction is a fundamental aspect of the pathology underlying type 2 diabetes mellitus(T2DM).Recently,mesenchymal stem cell(MSC)transplantation has emerged as a new therapeutic method due to its ability to promote the regeneration of pancreaticβcells.However,current studies have focused on its efficacy,and there are few clinical studies on its safety.AIM To evaluate the safety of human umbilical cord(hUC)-MSC infusion in T2DM treatment.METHODS An open-label and randomized phase 2 clinical trial was designed to evaluate the safety of hUC-MSC transplantation in T2DM in a Class A hospital.Ten patients in the placebo group received acellular saline intravenously once per week for 3 wk.Twenty-four patients in the hUC-MSC group received hUC-MSCs(1×106 cells/kg)intravenously once per week for 3 wk.Diabetic clinical symptoms and signs,laboratory findings,and imaging findings were evaluated weekly for the 1st mo and then at weeks 12 and 24 post-treatment.RESULTS No serious adverse events were observed during the 24-wk follow-up.Four patients(16.7%)in the hUC-MSC group experienced transient fever,which occurred within 24 h after the second or third infusion;this did not occur in any patients in the placebo group.One patient from the hUC-MSC group experienced hypoglycemic attacks within 1 mo after transplantation.Significantly lower lymphocyte levels(weeks 2 and 3)and thrombin coagulation time(week 2)were observed in the hUC-MSC group compared to those in the placebo group(all Plin levels(weeks 1,2,3,and 4),fibrinogen levels(weeks 2 and 3),D-dimer levels(weeks 1,2,3,4,12,and 24),and neutrophil-to-lymphocyte ratios(weeks 2 and 3)were observed in the hUC-MSC group compared to those in the placebo group(all Pliver damage or other side effects were observ

关键词： Type 2 diabetes mellitus Cell transplantation Human umbilical cord-mesenchymal stem cells Safety Lymphocytes Immunity

The Main Colors of the Forbidden City

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Journal of Sociology Study 2023年第4期13卷 206-213页

作者： Long Qin hong-li liu Capital Normal University BeijingChina

The main colors of the Forbidden City are Red and Yellow,which can represent rich cultural deposits.According to the Chinese traditional culture,the Red of the Forbidden City has always been regarded as a positive color of celebration,conveying dignity and happiness.The Yellow color is usually considered as a promising color,and represents a bumper harvest.Based on the principle of the Five Elements,Fire is red,which means breeding and encouragement,and shows prosperity and a solid foundation for the country.Yellow represents Winged Dragon,belonging to the Center of the Earth,and symbolizes the divine right of emperors.Therefore,the color of the Forbidden City(see Figure 1)is of great significance to the development of history and the revival of culture.We still need to work determinedly for the protection of the cultural heritages,so that more people can have the opportunity to understand the brilliance of Chinese civilization.

关键词： Forbidden City colors traditional culture red yellow five elements Chinese civilization

HSP70 inhibitor combined with cisplatin suppresses the cervical cancer proliferation in vitro and transplanted tumor growth:An experimental study

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 177-181页

作者： Jian liu Jing liu Su-Yang Guo hong-li liu Sheng-Ze li Gynecological Oncology the First Affiliated Hospital of Bengbu Medical CollegeBengbu City 233004Anhui ProvinceChina

Objective:To study the regulating effect of HSP70 inhibitor(PES) combined with cisplatin on cervical cancer proliferation in vitro and transplanted tumor growth.Methods:Cervical cancer Hela cell lines were cultured and divided into control group,cisplatin group,PES group and cisplatin+PES group that were treated with serum-free DMEM,cisplatin with final concentration of 10 μmol/L,PES 20 μmol/L and cisplatin 10 μmol/L combined with PES with 20 μmol/L,respectively;animal models with cervical cancer xenografts were established and divided into control group,cisplatin group,PES group and cisplatin+PES group who received intra-tumor injection of normal saline,10 μmol/L cisplatin,20 μmol/L PES as well as 10 μmol/L cisplatin+20 μmol/L PES,respectively.Cell proliferation activity,transplanted tumor volume and mitochondria apoptosis molecule expression were detected.Results:Cell viability value and Bcl-2 mRNA expression in cells of cisplatin group,PES group and cisplatin+PES group were significantly lower than those of control group while Bax,Caspase-3 and Caspase-9 mRNA expression in cells were significantly higher than those of control group;transplanted tumor volume and the Bcl-2 mRNA expression in transplanted tumor tissue of cisplatin group,PES group and cisplatin+PES group were significantly lower than those of control group while Bax,Caspase-3 and Caspase-9 m RNA expression in transplanted tumor tissue were significantly higher than those of control group.Conclusions:HSP70 inhibitor combined with cislatin can inhibit cervical cancer cell proliferation in vitro and transplanted tumor growth through mitochondrial apoptosis pathway.

关键词： Cervical cancer Heat shock protein 70 Transplanted tumor Mitochondrial apoptosis pathway

Effectiveness and safety of human umbilical cord-mesenchymal stem cells for treating type 2 diabetes mellitus

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World Journal of Diabetes 2022年第10期13卷 877-887页

作者： Xiao-Fen lian Dong-Hui Lu hong-li liu Yan-Jing liu Xiu-Qun Han Yang Yang Yuan lin Qing-Xiang Zeng Zheng-Jie Huang Feng Xie Cai-Hao Huang hong-Mei Wu Ai-Mei Long ling-Ping Deng Fan Zhang Department of Endocrinology Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Department of Research&Development Zhejiang MaiDa Gene Tech Co.LtdZhoushan 316000Zhejiang ProvinceChina Department of Endocrinology Huizhou Central People's HospitalHuizhou 516000Guangdong ProvinceChina Department of Endocrinology Longgang District Central Hospital of ShenzhenShenzhen 518000Guangdong ProvinceChina

BACKGROUND Progressive pancreaticβ-cell dysfunction is a fundamental part of the pathology of type 2 diabetes mellitus(T2DM).Cellular therapies offer novel opportunities for the treatment of T2DM to improve the function of isletβ-cells.AIM To evaluate the effectiveness and safety of human umbilical cord-mesenchymal stem cell(hUC-MSC)infusion in T2DM treatment.METHODS Sixteen patients were enrolled and received 1×10^(6) cells/kg per week for 3 wk as intravenous hUC-MSC infusion.The effectiveness was evaluated by assessing fasting blood glucose,C-peptide,normal glycosylated hemoglobin A1c(HbA1c),insulin resistance index(homeostatic model assessment for insulin resistance),and isletβ-cell function(homeostasis model assessment ofβ-cell function).The dosage of hypoglycemic agents and safety were evaluated by monitoring the occurrence of any adverse events(AEs).RESULTS During the entire intervention period,the fasting plasma glucose level was significantly reduced[baseline:9.3400(8.3575,11.7725),day 14±3:6.5200(5.2200,8.6900);Pline:7.8000(7.5250,8.6750),day 84±3:7.150(6.600,7.925);Pline:29.90(16.43,37.40),day 28±3:40.97(19.27,56.36);Pliver damage or other side effects were reported.CONCLUSION The results of this study suggest that hUC-MSC infusion can improve glycemia,restore isletβ-cell function,and reduce the dosage of hypoglycemic agents without serious AEs.Thus,hUC-MSC infusion may be a novel option for the treatment of T2DM.

关键词： Type 2 diabetes Human umbilical cord mesenchymal stem cells Blood glucose Homeostasis model assessment ofβ-cell function Hypoglycemic agents

Expression and mechanism of action of miR-196a in epithelial ovarian cancer

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Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1082-1087页

作者： Bo Yang Sheng-Ze li ling Ma hong-li liu Jian liu Jun-Jun Shao Department of Female Tumor First Affiliated Hospital of Bengbu Medical College

Objective:To explore the expression,biological function and possible mechanism of action of microRNA molecular-196a(miR-196a) in epithelial ovarian cancer.Methods:RT-PCR was used to detect the expression quantities of epithelial ovarian tissue,benign ovarian tissue,normal ovary epithelial tissue,ovarian cancer cell lines and miR-196 a in normal ovarian epithelial cells to analyze the relationship between the expression of miR-196 a and the clinical pathologic parameters of ovarian cancer.Among those cell lines,the cell line of which miR-196 a expressed the most or least was selected and transfected the ovarian cancer cell line by using negative control plasma and miR-196 a inhibitor.After transfection,RT-PCR was used to test the expression quantity of miR-196 a,Transwell chamber method was applied to determine the migration and invasion abilities of ovarian carcinoma cells and Western blot was employed to detect the expression of HOXA10 protein.Results:The relative expression quantities of miR-196 a in ovarian cancer tissue and benign ovarian tissue were significantly higher than that in normal ovarian epithelial tissue,and the expression quantity of miR-196 a in ovarian cancer tissue was distinctively higher than that in benign ovarian tissue(P lial ovarian cancer,the expression quantities of miR-196 a in patients with low differentiation were all significantly higher than those in patients with high differentiation(Plinical stage and whether CA125 was positive or not in patients(P > 0.05).Compared with normal ovarian epithelial cell line IOSE80,the expression quantities of miR-196 a of all ovarian cancer cell lines increased obviously and differences were statistically significant(P line SKOV3 was the highest,while it decreased significantly(4.678 ± 0.785 vs.2.131 ± 0.345,t = 2.938,P line SKOV3 was

关键词： MiR-196a Epithelial ovarian cancer Migration Invasion HOXA 10

Banach空间中多值线性算子的集值度量广义逆及其单值选择

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数学学报(中文版) 2024年第4期67卷 719-731页

作者：刘宏丽刘冠琦王玉文哈尔滨师范大学数学科学学院哈尔滨石油学院学术委员会

本文利用Banach空间几何方法,特别是运用广义正交分解定理,给出了自反Banach空间中多值闭线性算子的集值度量广义逆的定义域、值域、表达式的精确表示.同时,给出了该度量广义逆的单值齐性选择的构造方法及其特征刻画,使得近期一些相关... 详细信息

本文利用Banach空间几何方法,特别是运用广义正交分解定理,给出了自反Banach空间中多值闭线性算子的集值度量广义逆的定义域、值域、表达式的精确表示.同时,给出了该度量广义逆的单值齐性选择的构造方法及其特征刻画,使得近期一些相关研究成果,可成为其直接推论.

关键词： Banach空间多值线性算子集值度量广义逆单值选择