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More attention should be paid to the treatment of male infertility with drugs---testosterone： to use it or not？

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Asian Journal of Andrology 2014年第2期16卷 270-273,I0010页

作者： hong-jun li Urological Department of the Peking Union Medical College Hospital (PUMCH) Peking Union Medical College Chinese Academy of Medical Sciences Beijing China

Testosterone replacement is strictly contraindicated for the treatment of male infertility was the advanced view from the ＇2013 European Association of Urology （EAU） guidelines on male infertility＇, and this view brings extensive concern and questions. Although sufficient numbers of well-performed and controlled clinical trials that provide evidence supporting drug treatment of male infertility are not available at present, the opportunity to prove that these drugs are effective should not be prevented, and rigorous examination of drug therapy should be encouraged and strengthened. Therefore, I believe the above conclusion in the EAU guidelines is poorly conceived.

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Detection and Location of a Target in Layered Media by Snapshot Time Reversal and Reverse Time Migration Mixed Method

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Chinese Physics Letters 2019年第11期36卷 31-34页

作者： hong-Juan Yang Jian li Xiang Gao jun Ma jun-hong li Wen Wang Cheng-Hao Wang Institute of Acoustics Chinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200 State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190 College of Mechanical Engineering and Application Electronics Technology Beijing University of TechnologyBeijing 100124

A target in layered medium can be located by the ridge-like distribution time reversal and reverse time migration(TR-RTM) mixed method. However, this method cannot distinguish between acoustic field distributions of the interface and target for the wider acoustic pulse signals, which may result in inaccurate location of the target. A snapshot TR-RTM mixed method is proposed to solve this problem. The principle of snapshot TR-RTM mixed method is first given. Experiments are then carried out, and a mountain-like acoustic field distribution is obtained by processing experimental data. The results show that the location of the peak is that of the target, and the ratio of the scattered signal and interface reflection signal(signal-to-interference ratio) is improved by about four times after processing. Furthermore, this method can effectively suppress the interface reflection signal and enhance the target scattering signal. Therefore, it can achieve effective detection and location of a target in a layered medium.

关键词： scattering interface layered

ON THE PROBLEM OF INSTABIliTY IN THE DIMENSIONS OF SPliNE SPACES OVER T-MESHES WITH T-CYCLES

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Journal of Computational Mathematics 2015年第3期33卷 248-262页

作者： Qing-Jie Guo Ren-hong Wang Chong-jun li School of Mathematical Sciences Dalian University of Technology Dalian 116024 China

The T-meshes are local modification of rectangular meshes which allow T-junctions. The splines over T-meshes are involved in many fields, such as finite element methods, CAGD etc. The dimension of a spline space is a basic problem for the theories and applications of splines. However, the problem of determining the dimension of a spline space is difficult since it heavily depends on the geometric properties of the partition. In many cases, the dimension is unstable. In this paper, we study the instability in the dimensions of spline spaces over T-meshes by using the smoothing cofactor-conformality method. The modified dimension formulas of spline spaces over T-meshes with T-cycles are also presented. Moreover, some examples are given to illustrate the instability in the dimensions of the spline spaces over some special meshes.

关键词： Spline space Smoothing cofactor-conformality method Instability in the dimension T-meshes.

Prognostic value of computed tomography derived skeletal muscle mass index in lung cancer:A meta-analysis

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World Journal of Clinical Cases 2022年第20期10卷 6927-6935页

作者： Xue-lin Pan hong-jun li Zhen li Zhen-lin li Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Hospital of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The prognostic role of the skeletal muscle mass index(SMI)derived from computed tomography(CT)imaging been well verified in several types of ***,whether the SMI could serve as a reliable and valuable predictor of long-term survival in lung cancer patients remains *** To identify the prognostic value of the CT-derived SMI in lung cancer *** The PubMed,Web of Science,and Embase electronic databases were searched up to November 5,2021 for relevant *** Reference Citation Analysis databases were used during the literature searching and *** ratios(HRs)and 95%confidence intervals(CIs)were calculated to assess the association of the SMI with the overall survival(OS)of lung cancer *** statistical analyses were performed with STATA 12.0 *** A total of 12 studies involving 3002 patients were *** pooled results demonstrated that a lower SMI was significantly related to poorer OS(HR=1.23,95%CI:1.11-1.37,Plinical management and treatment of lung cancer patients.

关键词： Skeletal muscle mass index Computed tomography Lung cancer Prognosis Meta-analysis

Transparent PVDF-based electrolyte enabled by lipophilic lithium magnesium silicate for solid-state lithium batteries

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Rare Metals 2024年第11期43卷 5625-5636页

作者： Yue Zhang jun-hong li Man Ge Yun-Hui Huang Heng-Hui Xu School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Solid-state batteries with solid polymer electrolytes are considered the most promising due to their high energy density and safety ***,their development is hindered by the limitations of polymer electrolytes,such as low ionic conductivity,poor mechanical strength and inadequate fire *** study presents a thin polyvinylidene fluoride-based composite solid electrolyte film(25μm incorporating twodimensional modified lipophilic lithium magnesium silicate(LLS)as additives with good *** incorporation of LLS promotes grain refinement in polyvinylidene fluoride(PVDF),enhances the densification of electrolyte films,increases the tensile strength to10.42 MPa and the elongation to 251.58%,improves ion transport interfac e,and facilitates uniform deposition of lithium ***,LLS demonstrates strong adsorption ability,promoting the formation of solvated molecules,resulting in high ionic conductivity(2.07×10^(-4)S·cm^(-1)at 30℃)and a stable lithium/electrolyte *** li//li cells assembled with the thin composite electrolytes exhibit stable cycling for2000 h at 0.1 mA·cm^(-2)and 0.05 mAh·cm^(-2).Additionally,the liFePO_(4)//li battery shows a capacity retention rate of99.9%after 200 cycles at 0.5C and room temperature.

关键词： Filler lithium magnesium silicate Polymer electrolytes Batteries

An analysis of treatment preferences and sexual quality of life outcomes in female partners of Chinese men with erectile dysfunction

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Asian Journal of Andrology 2016年第5期18卷 773-779页

作者： hong-jun li Wen-jun Bai Yu-Tian Dai Wen-Ping Xu Chia-Ning Wang Han-Zhong li Department of Urology Peking Union Medical College Hospital Beijing 100730 China Department of Urology Peking University People's Hospital Beijing 100044 China Department of Andrology Nanjing Drum Tower Hospital Jiangsu 210008 China Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai 200021 China

The impact of erectile dysfunction is distressing to both males and their female partners, but less attention has been paid to identify female partners＇ preferred treatment and sexual quality of life outcomes. The present analysis explores female partners＇ treatment preference for erectile dysfunction in Chinese Men. This was a phase 4, randomized, open-label, multicenter, crossover study in Chinese men with erectile dysfunction who were na＇fve to phosphodiesterase type 5 inhibitor treatments. Eligible patients were randomized to sequential 20-mg tadalafil/100-mg sildenafil or lO0-mg sildenafil/20-mg tadalafil for 8 weeks each. Of 418 patients, female partners of 64 patients agreed to enter the study; of 64 patients who entered the study with female partners, 63 were randomized, and 62 completed the study. Baseline demographics and disease characteristics were comparable between treatment groups. Significantly more couples preferred tadalafil compared with sildenafil overall （75.4% vs 24.6%; P〈 0.001）, and irrespective of erectile dysfunction severity at baseline （P 〈 0.005）. Significant improvements in sexual quality of life scores were reported at endpoint （Visit 8） in male patients and female partners in both tadalafil and sildenafil treatment groups （P 〈 0.001）. Significantly higher mean changes from baseline were observed for male patients in the tadalafil group compared with the sildenafil group for the erectile function （P = 0.013） and overall satisfaction （P = 0.019） International Index for Erectile Function domains and the spontaneity domain （P〈 0.001） of the Psychological and Interpersonal Relationship Scale. No major safety concerns were reported during the study. Though both treatments were effective, safe, and tolerable, more couples preferred tadalafil compared with sildenafil.

关键词： erectile dysfunction partners' preference sexual quality of life sildenafil tadalafil

Detection and Location of a Target in Layered Media without Prior Knowledge of Medium Parameters

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Chinese Physics Letters 2020年第6期37卷 40-43页

作者： Jian li hong-Juan Yang jun Ma Xiang Gao jun-hong li Jian-Zheng Cheng Wen Wang Cheng-Hao Wang School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China Institute of Acoustics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China College of Mechanical Engineering and Application Electronics Technology Beijing University of TechnologyBeijing 100124China

Without prior knowledge of medium parameters,a method is proposed to detect and locate a target in layered *** were carried out for liquid/liquid and solid/liquid layered media,and the location of a target in them was obtained using three methods combined,i.e.,the least-square method,the method of finding minimum dispersal degree of target distribution,and the snapshot time reversal and reverse time migration mixed *** medium parameters,i.e.,the acoustic velocities of upper and lower media as well as the thickness of the upper medium,were inversed *** results show that the position of target is consistent with its actual ***,the detection and location of a target in layered media are achieved without prior knowledge of medium parameters,and it overcomes the difficulty that the common time reversal method only detects the target,but cannot locate it.

关键词： media method overcome

A randomized clinical trial investigating treatment choice in Chinese men receiving sildenafil citrate and tadalafil for treating erectile dysfunction

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Asian Journal of Andrology 2017年第4期19卷 500-504页

作者： Wen-jun Bai hong-jun li Jian-jun Jin Wen-Ping Xu Sorsaburu Sebastian Xiao-Feng Wang Department of Urology Peking University People's Hospital Beijing 100044 China Department of Urology Peking Union Medical College Hospital Beijing 100730 China Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai 200021 China Eli lilly and Company Indianapolis Indiana 46285 USA

Sildenafil and tadalafil are efficacious and well tolerated in Chinese men with erectile dysfunction （ED）. Recent study results indicate that men with ED in China who were naive to phosphodiesterase inhibitor type 5 （PDE5） therapy prefer tadalafil 20-mg （on-demand） versus sildenafil 100-mg （on-demand）. Differences in psychosocial outcomes may help to explain treatment preference in favor of tadalafih This open-label, randomized, crossover study compared psychosocial outcomes and drug attribute choices between tadalafil and sildenafil in Chinese men with ED na＇（ve to PDE5 inhibitor therapy. Eligible patients were randomized to sequential 20-mg tadalafU/lOO-mg sildenafil （n = 190） or 100-mg sildenafil/20-mg tadalafil （n = 193） for 8 weeks each and were asked which treatment they preferred to take for the 8-week extension phase. Psychosocial outcomes were assessed using the Psychological and Interpersonal Relationship Scale （PAIRS）, Drug Attributes Questionnaire （DRAQ）, and Sexual life Quality Questionnaire （SLQQ）. When taking tadalafil versus sildenafil, men had a higher mean endpoint score on the PAIRS Spontaneity Domain （tadalafil = 2.86 vs sildenafil = 2.72; P 〈 0.001）, and a lower mean endpoint score on the Time Concerns Domain （tadalafil = 2.41 vs sildenafil = 2.55; P 〈 0.001）. A numerical increase in the Sexual Self-Confidence Domain was observed when taking tadalafil versus sildenafil （tadalafil -- 2.76 vs sildenafil = 2.72; P= 0.102）. The most frequently chosen drug attributes explaining treatment preference were able to get an erection long after having drug, and ability to get an erection every time. SLQQ results were comparable between treatment groups. These psychosocial outcomes may explain why more Chinese men preferred tadalafil versus sildenafil for the treatment of ED in this clinical trial.

关键词： drug attributes erectile dysfunction phosphodiesterase type 5 inhibitor psychological assessment of sexual dysfunction

Interaction of Photoactive[Fe(CN)_6]^(4-) with TiO_2 Anatase(101) Surface:A Periodic Density Functional Theory Study

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Chinese Journal of Structural Chemistry 2007年第3期26卷 361-366页

作者： XU Ying CHEN Wen-Kai CAO Mei-Juan liU Shu-hong li jun-Qian Department of Chemistry Fuzhou University Fuzhou Fujian 350002 China

The plane-wave pseudopotential function method, based on density-functional theory, has been used to calculate the adsorption, electronic band structures, orbitals and optical absorption spectrum of [Fe（CN）6]^4- on TiOz anatase（101） surface. Our calculations reveal that the surface-modified anatase system has large adsorption energy and a much narrower band gap. [Fe（CN）6]^4- adsorption on the （101） surface could lead to a large red shift of the anatase optical absorption threshold, which extends into a visible region significantly. The calculated results are in agreement with the experiment and other theoretical studies reasonably. It is very important for the understanding and further development ofphotovoltaic materials that are active under visible light.

关键词： density functional theory (DFT) [Fe(CN)6]^4- anatase(101) surface adsorption absorption