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Surgical management and molecular diagnosis of persistent Müllerian duct syndrome in Chinese patients

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Asian Journal of Andrology 2022年第1期24卷 78-84页

作者： hong-juan tian De-Hua Wu Wei Ru Ding-Wen Wu Chang Tao Guang-Jie Chen Jin-Na Yuan Jun-Fen Fu Da-Xing Tang Department of Urology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Genetics and Metabolism Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Persistent Müllerian duct syndrome(PMDS)is a rare clinically and genetically overlapping disorder caused by mutations in the anti-Müllerian hormone(AMH)gene or the anti-Müllerian hormone receptor type 2(AMHR2)*** individuals present uterus and tubes in normally virilized males and are discovered unexpectedly during other *** it is rare and complex,a definitive clinical diagnosis can be missed,and there are no guidelines regarding how to deal with the *** the present study,exome sequencing and Sanger verification were performed for causal variants in 12 PMDS *** diagnoses were made by positive exome sequencing in 8 *** them,7 patients evoked on the basis of ultrasound indicating bilateral testes on the same side of the *** different AMH variants(2 frameshift/nonsense,1 deletion,8 missense,and 1 in-frame)in 9 patients and 6 different AMHR2 variants(5 missense and 1 splicing)in 3 patients were *** variants were classified as“pathogenic”or“likely pathogenic”,and 4 of them were *** but two patients with AMH defects showed low serum AMH concentrations,but all patients with AMHR2 defects showed elevated AMH *** surgery,an abnormal vas deferens was observed in half of the *** patients underwent orchidopexy with uterine *** them,2 patients presented complications including irreducible cryptorchidism,and 3 patients developed Müllerian remnant *** patients underwent subtotal *** them,one patient had complication of injury to the vas deferens,and one had hemorrhage after *** is the first report of PMDS involving a large Chinese *** present study not only expands the variation spectrum but also provides clinical experience about the management of the uterus.

关键词： AMH AMHR2 disorders of sex development persistent Mullerian duct syndrome

The effect of age and gender on SD rats’ learning and memory abilities in Morris Water Maze

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The effect of age and gender on SD rats’ learning and memor...

Flexible Gradient Poly(ether-ester)from the Copolymerization of Epoxides and c-Caprolactone Mediated by a Hetero-bimetallic Complex

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ke-Rui GONG,She-Wei GUO,Ming-Gang LIU,Xiao-Yan ZHAO,Lai-hong YAN,Li-juan tian,Ying CHANG,Jun CHEN Institutes for Biomedical Sciences of Pain,Chinese Capital Medical University,Beijing 100069

＜正＞Aim The effects of age and gender on Sprague-Dawley（SD） rats’ learning and memory were studied with Morris Water *** By using Morris Water Maze monitoring and analyzing system,we evaluated the learning and memory abilities of neonatal and adult SD rats *** to the development rules of SD rats,we chose the rats 28 d old as neonatal rats and 2 months old as adult *** rats were divided into four groups by age and gender: 1) female SD rats of 28 d old,2) male SD rats of 28 d old,3) female SD rats of 2 months old and 4) male SD rats of 2 months *** experiment included the hidden platform test which lasted for the first four days and the probe test on the fifth day. Escape distance of the hidden platform test,time percentage spent in target quadrant and platform-crossing times of the probe test were chose to evaluate the performance of the rats in Morris Water *** 1) For the SD rats 28 d old,after the four days’ training,the escape distance in both groups decreased greatly,but there was no significant difference between the two groups（male ***）.In the probe test,the time percentage spent in the target quadrant for both groups was higher than the other quadrants,but there was still no significant difference between female and *** the platform-crossing times,there was also no difference between the two groups.2) For the SD rats 2 months old,there was no significant difference between male and female in the escape distance,time percentage spent in the target quadrant and platform-crossing times as well.3) For the rats in the same gender,male or female,there was no statistic difference between the two age groups（28 d vs.2 m） in the escape distance,time percentage spent in the target quadrant and platformcrossing ***:As for the SD rats of 28 d and 2 months old,the age and gender probably have no significant effects on the learning and memory abilities in Morris Water Maze.

关键词： Sprague-Dawley rat Morris Water Maze learning and memory gender age

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Chinese Journal of Polymer Science 2021年第8期39卷 1013-1019,I0007页

作者： Wei-Min Ren hong-juan Gao tian-Jun Yue State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

Copolymerization is a commonly employed method for optimizing the properties of polymer *** ether segments into polyesters main chain to obtain polyether-polyester copolymers is an effective strategy to realize the integration of multiple properties of polyester and polyether,and to develop more high-performance,multi-purpose polymer ***,the synthesis of poly(ether-ester)s is accessible by employing the biphenyl-linked heterodinuclear salen Cr-AI complex in the presence of PPNCI for the copolymerization of epoxides and£-caprolactone(CL).Monitoring the copolymerization process reveals that catalyst 1 exhibited good performance for the copolymerization of epoxides and CL,affording copolymers with a gradient sequence *** dynamic thermomechanical analysis(DMA)study indicates the obtained poly(ether-ester)s possess enhanced flexibility compared with the block copolymers or blend of PPO and PCL homopolymers with the same *** study provides a theoretical basis for the preparation of high-performance polymer materials.

关键词： Lactone Epoxide Copolymerization Poly(ether-ester)copolymer Dynamic mechanical analysis

Thermodynamic Calculation on the Formation of Titanium Hydride

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Chinese Journal of Chemical Physics 2008年第6期21卷 569-574页

作者： Jing-wei Zhaoa Hua Ding Xue-feng tian Wen-juan Zhao hong-liang Hou School of Materials and Metallurgy Northeastern University Shenyang 110004 China Beijing Aeronautical Manufacturing Technology Research Institute Beijing 100024 China

A modified Miedema model, using interrelationship among the basic properties of elements Ti and H, is employed to calculate the standard enthalpy of formation of titanium hydride TiHx （1≤x≤2）. Based on Debye theories of solid thermal capacity, the vibrational entropy, as well as electronic entropy, is acquired by quantum mechanics and statistic thermodynamics methods, and a new approach is presented to calculate the standard entropy of formation of TiH2. The values of standard enthalpy of formation of TiHx decrease linearly with increase of x. The calculated results of standard enthalpy, entropy, and free energy of formation of TiH2 at 298.16 K are -142.39 kJ/mol, -143.0 J/（mol·K） and -99.75 kJ/mol, respectively, which is consistent with the previously-reported data obtained by either experimental or theoretical calculation methods. The results show that the thermodynamic model for titanium hydride is reasonable.

关键词： Titanium hydride Thermodynamic calculation Modeling Enthalpy Entropy

N-Acetylenethio phthalimides: Sequential linkage for compositional click reaction

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Chinese Chemical Letters 2023年第2期34卷 183-187页

作者： Wen-Chao Gao Kai Feng Jun tian juan Zhang hong-hong Chang Xuefeng Jiang College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China

Click chemistry has become a useful tool for diverse molecular linkage and modification, and the development of new click strategy that enable reversibility and multifunctionality is of high demand for the multifunction and drug release. Herein, compositionally clicking combined regioselective iridium-catalyzed azide-alkynthio cycloaddition(Ir-AAC) and disulfuration has been developed for the sequential linkage from N-acetylenethio phthalimides, naturally occurring thiols and readily available azides. This method has been successfully applied to the construction of drug hybrids, peptide modification and glycosylation. Furthermore, by the design of diacetylenethio phthalimide as a platform molecule, trifunctional conjugants were sequentially linked through independent Ir-AAC, disulfuration and Cu-AAC reaction for hydrophobic tagging ternary PROTACs.

关键词： Diversity-oriented synthesis Compositional click Reversible linkage Iridium catalysis Hydrophobic tagging

A Bilinear Bcklund Transformation and N-Soliton-Like Solution of Three Coupled Higher-Order Nonlinear Schrdinger Equations with Symbolic Computation

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Communications in Theoretical Physics 2008年第9期50卷 689-695页

作者： ZHU hong-Wu tian Bo MENG Xiang-Hua LI juan XU Tao School of Science P.O. Box 122 Beijing University of Posts and Telecommunications Beijing 100876 China Key Laboratory of Optical Communication and Lightwave Technologies Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China Hunan Meteorological Observatory Changsha 410007 China

A bilinear Baecklund transformation is presented for the three coupled higher-order nonlinear Schroedinger equations with the inclusion of the group velocity dispersion, third-order dispersion and Kerr-law nonlinearity, which can describe the dynamics of alpha helical proteins in living systems as well as the propagation of ultrashort pulses in wavelength-division multiplexed system. Starting from the Baecklund transformation, the analytical soliton solution is obtained from a trivial solution. Simultaneously, the N-soliton-like solution in double Wronskian form is constructed, and the corresponding proof is also given via the Wronskian technique. The results obtained from this paper might be valuable in studying the transfer of energy in biophysics and the transmission of light pulses in optical communication systems.

关键词： coupled higher-order nonlinear Schroedinger equations Baecklund transformation soliton solution Wronskian technique symbolic computation

Interface property of dissimilar Ti-6Al-4V/AA1050 composite laminate made by non-equal channel lateral co-extrusion and heat treatment

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Defence Technology（防务技术） 2024年第3期33卷 197-208页

作者： juan Liao Mengmeng tian Xin Xue School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350116China

The purpose of this paper is to examine the effect of processing parameters and subsequent heat treatments on the microstructures and bonding strengths of Ti-6Al-4V/AA1050 laminations formed via a non-equal channel lateral co-extrusion *** microstructural evolution and growth mechanism in the diffusion layer were discussed further to optimize the bonding quality by appropriately adjusting process *** electron microscopes(SEM),energy dispersive spectrometer(EDS),and X-ray diffraction(XRD)were used to characterize interfacial diffusion *** shear test was used to determine the mechanical properties of the interfacial diffusion *** experimental results indicate that it is possible to co-extrusion Ti-6Al-4V/AA1050 compound profiles using non-equal channel lateral *** heat treatment processes affect the thickness of the diffusion *** the temperature and time of heat treatment increase,the thickness of the reaction layers increases ***,the shear strength of the Ti-6Al-4V/AA1050 composite interface is proportional to the diffusion layer *** is observed that a medium interface thickness results in superior mechanical performance when compared to neither a greater nor a lesser interface *** characterization of all heat treatments reveals that the only intermetallic compound observed in the diffusion layers is TiAl_(3).Due to the inter-diffusion of Ti and Al atoms,the TiAl_(3) layer grows primarily at AA1050/TiAl_(3) interfaces.

关键词： Shear strength Co-extrusion Heat treatment Microstructure Intermetallic compounds

Anatomical vs nonanatomical liver resection for solitary hepatocellular carcinoma:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1833-1846页

作者： Hu Liu Feng-juan Hu Hui Li tian Lan hong Wu Department of Liver Surgery Liver Transplantation DivisionLaboratory of Liver SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina The Center of Gerontology and Geriatrics West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The long-term survival of patients with solitary hepatocellular carcinoma(HCC)following anatomical resection(AR)vs non-anatomical resection(NAR)is still *** is necessary to investigate which approach is better for patients with solitary *** To compare perioperative and long-term survival outcomes of AR and NAR for solitary *** We performed a comprehensive literature search of PubMed,Medline(Ovid),Embase(Ovid),and Cochrane *** of any age and sex,who underwent liver resection,were considered following the following criteria:(1)Studies reporting AR vs NAR liver resection;(2)Studies focused on primary HCC with a solitary tumor;(3)Studies reporting the long-term survival outcomes(>5 years);and(4)Studies including patients without history of preoperative *** main results were overall survival(OS)and disease-free survival(DFS).Perioperative outcomes were also *** A total of 14 studies,published between 2001 and 2020,were included in our meta-analysis,including 9444 patients who were mainly from China,Japan,and *** was performed on 4260(44.8%)*** synthetic results showed that the 5-year OS[odds ratio(OR):1.19;P<0.001]and DFS(OR:1.26;P<0.001)were significantly better in the AR group than in the NAR *** was associated with longer operating time[mean difference(MD):47.08;P<0.001],more blood loss(MD:169.29;P=0.001),and wider surgical margin(MD=1.35;P=0.04)compared to *** was no obvious difference in blood transfusion ratio(OR:1.16;P=0.65)or postoperative complications(OR:1.24,P=0.18).CONCLUSION AR is superior to NAR in terms of long-term ***,AR can be recommended as a reasonable surgical option in patients with solitary HCC.

关键词： Hepatocellular carcinoma Anatomical resection Non-anatomical resection Meta-analysis Systematic review Solitary tumor

Characteristics and sources of polycyclic aromatic hydrocarbons in impervious surface run-off in an urban area in Shanghai, China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第10期14卷 751-759页

作者： juan HOU Lu BIAN tian LI State Key Laboratory of Pollution Control and Resource Reuse Tongji University

Rainwater and run-off from three kinds of impervious surface in the Shanghai urban area,China were *** aromatic hydrocarbons(PAHs) were measured in the samples,and their sources were *** mean sum of the 16 PAH concentrations measured in rainwater and run-offs from ceramic tiles,asphalt roofs,and asphalt roads were 873,1404,1743,and 4023 ng/L,*** PAH concentrations found in this study were moderate compared to PAH concentrations found in run-offs in other *** main PAH components in the rainwater,roof run-off,and asphalt road run-off samples were 3-ring PAHs,3–4-ring PAHs,and 4–6-ring PAHs,*** apportionment results indicated that combustion(47.4%–55.5%) and vehicular emissions(30.5%–33.0%) were the major contributors to PAHs in roof *** emissions were the most significant contributors to asphalt road run-off(47.2%),followed by combustion(23.5%),and petroleum(16.3%).Vehicular emissions and coal and natural gas combustion are therefore the most significant sources of PAHs in run-off from impervious surfaces in the Shanghai urban area.

关键词： Polycyclic aromatic hydrocarbons(PAHs) Impervious surface Run-off pollution Source apportionment