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Persistent SARS-CoV-2 infection in asymptomatic young adults

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Signal Transduction and Targeted Therapy 2022年第4期7卷 961-963页

作者： Mai-Juan Ma Shao-Fu Qiu Xiao-Ming Cui Ming Ni hong-jie liu Run-Ze Ye Lin Yao hong-Bo liu Wu-Chun Cao hong-Bin Song State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina Center for Disease Control and Prevention Chinese People’s Liberation ArmyBeijingChina Beijing Institute of Radiation Medicine BeijingChina School of Public Health Shandong UniversityJinanChina

Dear Editor,While most of the patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)cleared the virus within a few weeks of infection,some people have a persistent infection or persistent shedding viral RNA in the long *** persistent detection of viral RNA in clinical specimens is unlikely to reflect either relapse or reinfection in most cases because the replication-competent virus is generally not recoverable after ten days following symptom onset in mild to moderate cases of COVID-191 and after 20 days in severe or immunocompromised cases.

关键词： infection acute respiratory

Meritorious Role of Chinese Foster Parents

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Women of China 1996年第11期 20-22页

作者： GAO jie hong liu

The last contingent of Japanese war orphans remaining in China departed Fangzheng County, Heilongjiang Province, for Tokyo on June 13, 1996. Members of the group, the youngest of whom are now well into their fifties, are the offspring of Japanese civilians who settled in northeastern China fallowing the Japanese invasion in World War Ⅱ. The orphans were raised by Chinese foster parents.

关键词： Meritorious Role of Chinese Foster Parents

A Rare Case of Lupus Vulgaris with Papulonecrotic Tuberculid and Discoid Lupus Erythematosus

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Chinese Medical Journal 2017年第17期130卷 2134-2135页

作者： Ting-Ting Wang hong-jie liu Lin Wang Department of Dermatovenereology West China Hospital Sichuan University Chengdu Sichuan 610041 China

To the Editor：A 48-year-old woman presented with a plaque on her left helix that had persisted for 20 years,erythemas and scales on both earlobes present for 9 months,and papules on both thighs present for 6 *** she nor her family had any special *** examination revealed a well-circumscribed,dark-red plaque on her left helix,and red erythema on both her earlobes,with adherent scales and red papules symmetrically distributed on both thighs with crust and scale [Figure 1 a].Routine examinations showed no abnormal *** examination of the left helix showed that the epidermis was thin,with flattening of the rete ridges and many epithelioid granulomas with local caseous necrosis,accompanied by infiltration of lymphocytes into the dermis,multinucleated giant cells were not remarkable [Figure 1 b].In addition,acid-fast staining yielded negative *** earlobe biopsy showed epidermal hyperkeratosis and parakeratosis,liquefaction degeneration of the basal cells,and follicular keratotic plugging,and the blood vessels and skin appendages surrounded by lymphocytes in the dermis [Figure lc].The thigh biopsy showed epidermal hyperkeratosis and local parakeratosis,and palisading granuloma in the dermis,accompanied by progressive necrosis of the central collagen with mucin deposition [Figure 1 d].A tuberculin （purified protein derivative [PPD]） test performed on the forearm was strongly *** chain reaction for Mycobacterium tuberculosis in both the left helix plaque and the thigh papule was ***,a diagnosis of lupus vulgaris was made for the left helix;both earlobes were diagnosed with discoid lupus erythematosus,and both thighs with papulonecrotic tuberculid.

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Efficacy and Safety of Chinese Herbal Medicines Combined with Chemical Drugs for Alzheimer's Disease:A Systematic Review and Meta-Analysis

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 1-13页

作者： Li Xu Wen-Jun Chen Cai-Jun Tian Yan Zhang Yan Ma Tian-Hao Li hong-jie liu Zhe Zhang Department of the First College English College of Foreign LanguageShandong University of Traditional Chinese MedicineJinanChina Department of Oncology Linyi People's HospitalLinyiChina Department of Internal Medicine of Traditional Chinese Medicine The First Clinical CollegeShandong University of Traditional Chinese MedicineJinanChina Department of Chinese Materia Medica College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina Department of Medicinal Chemistry College of PharmacyShandong University of Traditional Chinese MedicineJinanChina Community Healthcare Center Shenzhen Traditional Chinese Medicine HospitalShenzhenChina Department of Fundamentals of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Shandong Co-Innovation Center of Classic TCM Formula College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina

Objective:To evaluate the efficacy and safety of Chinese herbal medicines(CHMs)combined with chemical drugs for the treatment of Alzheimer's disease(AD).Materials and Methods:Databases were searched to retrieve randomized controlled trials(RCTs)of CHMs combined with tacrine,galantamine,rivastigmine,donepezil,or memantine,following strict inclusion and exclusion *** research papers published in English,Chinese,and Japanese were *** primary outcome was the mini-mental state examination(MMSE)score and the secondary outcomes were AD assessment scale cognitive subscale(ADAS-Cog)score and safety ***-analysis was carried out using Rev Man 5.3 and subgroup analysis was conducted to identify the sources of ***:A total of 15 RCTs with 1386 participants were included in this *** donepezil was used in the retrieved ***-analyses showed that the combination of CHMs with donepezil led to significant improvement in the MMSE score(Z=9.45;P<0.00001;weighted mean difference[WMD]=2.68,95%confidence interval[CI]:2.12-3.24)and a significant decrease in the ADAS-Cog score(Z=5.53;P<0.00001;WMD=-3.79;95%CI:-5.13--2.44).Safety evaluation demonstrated that these combination treatments relieved adverse events such as insomnia(risk ratio[RR]=0.20,95%CI:0.06-0.68;P=0.01)and hive(RR=0.10;95%CI:0.01-0.73;P=0.02).Conclusions:The combination of CHMs with a chemical drug like donepezil led to significant improvements in patient cognition as well as a better safety profile when compared to the application of a chemical drug alone.

关键词： Alzheimer's disease Chinese herbal medicine donepezil memantine meta-analysis randomized controlled trials rivastigmine

Microstructure and corrosion behavior of as-homogenized and as-extruded Mg-xLi-3Al-2Zn-0.5Y alloys(x=4,8,12)

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Transactions of Nonferrous Metals Society of China 2022年第1期32卷 134-146页

作者： Xiang PENG Jia-wei SUN hong-jie liu Guo-hua WU Wen-cai liu National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The microstructure and corrosion behavior of the as-homogenized and as-extruded Mg-xLi-3Al-2Zn-0.5Y alloys(x=4,8,12,wt.%)were *** results show that as the Li content increases from 4%to 12%,the matrix transfers from singleα-Mg phase,(α-Mg+β-Li)dual phase to singleβ-Li phase.A mixed corrosion feature of intergranular corrosion and pitting corrosion occurs in the Mg-4Li-3Al-2Zn-0.5Y and Mg-12Li-3Al-2Zn-0.5Y *** former is related to the precipitated AlLi phase along the grain boundaries,and the latter is related to the high potential difference between the second phase and the *** corrosion resistance of the as-extruded alloys is better than that of the as-homogenized *** superior corrosion resistance of the as-extruded Mg-8Li-3Al-2Zn-0.5Y alloy with the lowest corrosion rate(P_(W)=(0.63±0.26)mm/a)is attributed to the more uniform distribution of second phases,the protectiveα-Mg phase via sacrificing theβ-Li phase and the relatively integrated oxide film.

关键词： Mg-xLi-3Al-2Zn-0.5Y alloys microstructure corrosion behavior homogenization extrusion second phase oxide film

Jianpi Bushen Recipe affects epithelial-mesenchymal transition in hepatocellular carcinoma through TGF-β and Twist

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Drug Combination Therapy 2020年第1期2卷 1-6页

作者： hong-jie liu You—Ying Lai Zhi-Fen Han Jian-jie Chen Xin-Wen Ma Department of Oncotogy Shuguang Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatotogy Shuguang Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

Backgroud:To explore the effects of Jianpi Bushen Recipe on the epithelial-mesenchymal transition(EMT)of nude mice with transplanted human liver cancer SK-HEP-1 ***:To establish models with transplanted liver cancer cells,nude mice were divided randomly into three groups:blank group,traditional Chinese medicine(TCM)group and control *** were given normal saline,Jianpi Bushen Recipe and solafeni through administration by gavage for four *** expression of TGF-β and twist mRNA were detected by real-time *** expression of E-cadherin was detected by Western ***:Compared with the blank group,the expression of transforming growth factor-P(TGF-β)mRNA and twist mRNA in the TCM group and the control group decreased significantly(P0.05).The expression of E-cadherin protein in TCM group and control group increased significantly(P0.05).Conclusion:Jianpi Bushen Recipe can inhibit the EMT of liver cancer SK-HEP-1 cells in vivo by down-regulating the expression of TGF-β/twist signaling and indirectly up-regulating E-cadherin expression in transplanted liver cancer tissue,indicating the potential of Jianpi Bushen Recipe to inhibit invasion and metastasis of liver cancer.

关键词： Jianpi Bushen Recipe Liver cancer Epithelial-mesenchymal transition TGF-β Twist E-cadherin

Predicting the nephrotoxicity of Chinese herbal medicines based on a Bayesian network model

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TMR Pharmacology Research 2022年第1期2卷 22-29页

作者： Li-Juan Tan Liang Chen Jia-Hui Huang Ze-Hai Fang hong-jie liu School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine(Futian) Shenzhen 518034China School of Nursing Zibo Vocational InstituteZibo 255300China

Objective:Based on a Bayesian network model(BNM),we constructed and evaluated a predictive model of Chinese herbal medicines(CHMs)nephrotoxicity,explored its influencing factors,and provided a reference for the prevention and control of ***:We searched for CHMs with nephrotoxicity through academic journals and academic works,screened non-nephrotoxic CHMs,and then tested the correlation between nephrotoxic and non-nephrotoxic CHMs and their four properties,five flavours,and channel *** screened variables were used to construct the Bayesian network model(BNM),predict important factors affecting the nephrotoxicity of Chinese herbal medicines(CHMs),draw the receiver operating characteristic(ROC)curve of the model,and calculate the area under the curve(AUC)to evaluate the forecasting effect of the ***:Medicinal property theory(four properties and five flavours)are important factors affecting the nephrotoxicity of *** and non-nephrotoxic CHMs are related to their four propertiesand five flavours(P<0.05).BNM showed that sweetness and flatness wereimportant protective factors for nephrotoxicity of CHMs;the prediction accuracy was 77.92%,the AUC result of the model ROC curve was 0.661(95%CI:0.620-0.701),and the best sensitivity(0.736)and specificity(0.571)were obtained at ***:Modern mathematical statistics and modeling methods have certain reference significance and application value for the prediction of CHMs nephrotoxicity and toxicology research.

关键词： Chinese herbal medicines four properties five flavours channel tropism prediction of nephrotoxicity Bayesian network model

基于实测冲击响应字典稀疏表示的齿轮系统侧隙故障特征提取

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振动与冲击 2017年第11期36卷 86-91页

作者：高洪波刘杰李允公东北大学机械工程与自动化学院沈阳110819 辽宁省交通高等专科学校机电工程系沈阳110122

为了从齿轮系统振动信号中提取由于齿侧间隙故障产生的瞬态冲击成分,提出了基于稀疏表示的故障特征提取方法,将特征提取转化为稀疏字典的构造和稀疏表示系数的求解。根据侧隙故障瞬态冲击的响应特性,提出采用与其更相似的系统实测冲击... 详细信息

为了从齿轮系统振动信号中提取由于齿侧间隙故障产生的瞬态冲击成分,提出了基于稀疏表示的故障特征提取方法,将特征提取转化为稀疏字典的构造和稀疏表示系数的求解。根据侧隙故障瞬态冲击的响应特性,提出采用与其更相似的系统实测冲击响应构造稀疏字典,继而利用正交匹配追踪算法优化求解稀疏表示向量,获得表征瞬态冲击发生时刻的稀疏系数,并重构故障冲击序列。通过冲击成分的包络解调分析,进一步获得瞬态冲击的调制频率。仿真和实验表明,提出的方法能够有效提取齿轮系统齿侧间隙故障特征。

关键词：故障特征提取稀疏表示实测冲击响应齿侧间隙

To set up a logistic regression prediction model for hepatotoxicity of Chinese herbal medicines based on the efficacy of Chinese herbal medicines

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TMR Pharmacology Research 2021年第1期1卷 35-61页

作者： Tian-Hao Li Hui-jie Shi Peng Qing Li-Sheng Peng Shui-Yu Liao Ze-Wen Ding hong-jie liu Zhe Zhang Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033China Department of Pharmacy Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China The First Affiliated Hospital of Jinan University Guangzhou 510630China Shenzhen Longhua District Central Hospital Shenzhen 518110China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China Shandong University of Traditional Chinese Medicine Jinan 250355China

In our previous research,a logistic regression prediction model for hepatotoxicity of Chinese herbal medicines based on the four properties,five flavors and channel tropism has been successfully ***,could Chinese herbal medicines efficacy also be applied to predict the hepatotoxicity of Chinese herbal medicines?Therefore,a logistic regression prediction model for hepatotoxicity of Chinese herbal medicines based on Chinese herbal medicines efficacy has been tentatively set up to study the correlations of hepatotoxic and nonhepatotoxic Chinese herbal medicines with efficacy by using a chi-square test for two-way unordered categorical *** regression prediction model was established and the accuracy of the prediction by this model was *** has been found that the hepatotoxicity and nonhepatotoxicity of Chinese herbal medicines were weakly related to the efficacy,and the coefficient was *** were 20 variables from Chinese herbal medicines efficacy analyzed with unconditional logistic regression,and 6 variables,rectifying Qi and relieving pain,clearing heat and disinhibiting dampness,invigorating blood and stopping pain,invigorating blood and relieving swelling,killing worms and relieving fright were chosen to establish the logistic regression prediction model,with the optimal cutoff value being *** cold and relieving pain(DCRP),clearing heat and disinhibiting dampness,invigorating blood and relieving pain(IBRP),invigorating blood and relieving swelling,killing worms,and relieving fright were the variables to affect the hepatotoxicity and the established logistic regression prediction model had predictive power for hepatotoxicity of Chinese herbal medicines to a certain degree.

关键词： Efficacy of Chinese herbal medicines Hepatotoxicity prediction Logistic regression prediction model