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Success rate of current human-derived gastric cancer organoids establishment and influencing factors:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1626-1646页

作者： Kai-Lin jiang Xiang-Xiang Wang Xue-Jiao Liu Li-Kun Guo Yong-Qi chen Qing-Ling Jia Ke-Ming Yang jiang-hong Ling Department of Gastroenterology Shuguang HospitalShanghai 200021China Department of Pathology Shuguang HospitalShanghai 200021China

BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally *** To explore the potential influencing factors,and the literature on successful culture rates of GCOs was reviewed using *** PubMed,Web of Science,and EMBASE were searched for *** trained researchers selected the studies and extracted *** 17.0 software was used for meta-analysis of the incidence of each outcome *** adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included *** plots and Egger’s test were used to detect publication *** analyses were conducted for sex,tissue source,histo-logical classification,and the pathological tumor-node-metastasis(pTNM)cancer staging *** Eight studies with a pooled success rate of 66.6%were *** derived from women and men had success rates of 67%and 46.7%,*** from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9%and 53.7%,*** of poorly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,*** with pTNM stages I-II and III-IV showed success rates of 38.3%and 65.2%,respectively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,*** generated with collagenase were more successful than those constructed with Liberase TH and TrypLE(72.1%vs 71%,respectively).EDTA digestion showed a 50%lower success rate than other methods(P=0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological type,and pTNM *** Y-27632,and using Liberase TH,TrypLE,or collagenase yields greater success than EDTA.

关键词： Gastric cancer organoids Human-derived organoids Gastric cancer Cell lines In vitro research models

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Energy-Efficient Traffic Offloading for RSMA-Based Hybrid Satellite Terrestrial Networks with Deep Reinforcement Learning

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China Communications 2024年第2期21卷 49-58页

作者： Qingmiao Zhang Lidong Zhu Yanyan chen Shan jiang National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China The Higher Educational Key Laboratory for Flexible Manufacturing Equipment Integration of Fujian Province Xiamen Institute of TechnologyXiamen 361021China China Mobile(jiangxi)Communications Group Co. LtdYichun 336000China

As the demands of massive connections and vast coverage rapidly grow in the next wireless communication networks, rate splitting multiple access(RSMA) is considered to be the new promising access scheme since it can provide higher efficiency with limited spectrum resources. In this paper, combining spectrum splitting with rate splitting, we propose to allocate resources with traffic offloading in hybrid satellite terrestrial networks. A novel deep reinforcement learning method is adopted to solve this challenging non-convex problem. However, the neverending learning process could prohibit its practical implementation. Therefore, we introduce the switch mechanism to avoid unnecessary learning. Additionally, the QoS constraint in the scheme can rule out unsuccessful transmission. The simulation results validates the energy efficiency performance and the convergence speed of the proposed algorithm.

关键词： deep reinforcement learning energy efficiency hybrid satellite terrestrial networks rate splitting multiple access traffic offloading

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Sum-Rate Maximization in Active RIS-Assisted Multi-Antenna WPCN

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China Communications 2024年第6期21卷 23-39页

作者： jiang Jie Lyu Bin chen Pengcheng Yang Zhen School of Communications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China jiangsu Provincial Key Laboratory of Photonic and Electronic Materials Sciences and Technology Nanjing UniversityNanjing 210003China

In this paper,we propose an active reconfigurable intelligent surface(RIS)enabled hybrid relaying scheme for a multi-antenna wireless powered communication network(WPCN),where the active RIS is employed to assist both wireless energy transfer(WET)from the power station(PS)to energyconstrained users and wireless information transmission(WIT)from users to the receiving station(RS).For further performance enhancement,we propose to employ both transmit beamforming at the PS and receive beamforming at the *** formulate a sumrate maximization problem by jointly optimizing the RIS phase shifts and amplitude reflection coefficients for both the WET and the WIT,transmit and receive beamforming vectors,and network resource *** solve this non-convex problem,we propose an efficient alternating optimization algorithm with the linear minimum mean squared error criterion,semidefinite relaxation(SDR)and successive convex approximation ***,the tightness of applying the SDR is *** results demonstrate that our proposed scheme with 10 reflecting elements(REs)and 4 antennas can achieve 17.78%and 415.48%performance gains compared to the single-antenna scheme with 10 REs and passive RIS scheme with 100 REs,respectively.

关键词： active reconfigurable intelligent surface beamforming sum-rate maximization wireless powered communication network

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Reactive Transport Process of Earthquake-induced Hydrochemical Changes in Guanding Thermal Spring,Western Sichuan,China

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 241-249页

作者： NA Jin jiang Xue SHI Zheming chen Yanmei Hubei Key Laboratory of Petroleum Geochemistry and Environment(Yangtze University) Wuhan 430100China School of Environmental Studies China University of GeosciencesWuhan 430074China School of Water Resources and Environment China University of GeosciencesBeijing 100083China State Key Laboratory of Water Resource Protection and Utilization in Coal Mining Beijing 100000China

Earthquake-related hydrochemical changes in thermal springs have been widely observed;however,quantitative modeling of the reactive transport process is *** the present study,we apply reactive transport simulation to capture the hydrochemical responses in a thermal spring following the Wenchuan Ms 8.0 and Lushan Ms 7.0 *** first constrain deep reservoir geothermal fluid compositions and temperature by multicomponent geothermometry,and then a reactive geochemical transport model is constructed to reproduce the hydrochemical evolution *** results show that the recharge from the shallow aquifer increases gradually until it reaches a peak because of the permeability enhancement caused by the Lushan earthquake,which may be the mechanism to explain the earthquake-related hydrochemical *** contrast to the postseismic effect of the Wenchuan earthquake,the chemical evolution can be considered as hydrochemical anomalies related to the Lushan *** study proves that the efficient simulation of reactive transport processes is useful for investigating earthquake-related signals in hydrochemical time series.

关键词： earthquake hydrochemical changes reactive geochemical transport model Kangding area

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In situ crosslink polymerization induced long-lived multicolor supramolecular hydrogel based on modifiedβ-cyclodextrin

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Chinese Chemical Letters 2024年第2期35卷 374-379页

作者： Yonghui Sun Linnan jiang Yong chen Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

The construction of hydrogels with good mechanical properties and phosphorescent properties is full of ***,we report a supramolecular phosphorescent hydrogel with long lifetime,high tensile strength and self-healing property,which can be easily constructed through in-situ thermalinitiated polymerization of isocyanatoethyl acrylate-modifiedβ-cyclodextrin(β-CD-DA)and acrylatemodified adamantane(Ad-DA),acrylic acid(AA),followed by the non-covalent association with carbon dots(CNDs).The lifetime of phosphorescent hydrogel can reach 1261 ms at room temperature,and the quantum yield is 11%.Importantly,through the efficient triplet to singlet Förster resonance energy transfer(TS-FRET),the phosphorescent hydrogel shows the good phosphorescence energy transfer property for organic dyes Rhodamine B and Eosin Y with the delayed fluorescence lifetime up to 730 ms and 585 ms as well as the energy transfer efficiency(Φ_(ET))up to 99.9%and 99.3%,***,owing to the host-guest interactions betweenβ-CD-DA and Ad-DA,the three-dimensional cross-linked network phosphorescent hydrogel can be easily stretched to 18 times of its original length,and can achieve self-healing of the cut surfaces within 30 *** results will expand the scope of phosphorescent materials and provide new ideas and opportunities for materials science.

关键词： Room temperature phosphorescence Hydrogel Phosphorescence energy transfer Cyclodextrin Supramolecular interaction

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Gravel hardness effect on compaction characteristics of gravelly soil

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Journal of Mountain Science 2024年第4期21卷 1432-1443页

作者： SHI Yunfang LI Shengang jiang chen LIU Jinning School of Resources and Civil Engineering Northeastern UniversityShenyang 110004China

The compaction characteristics of gravelly soil are affected by gravel *** investigate the evolution and influencing mechanism of different gravel hardness on the compaction characteristics of gravelly soil,heavy compaction tests and crushing tests were conducted on gravelly soils with gravels originated from hard,soft and extremely soft *** to orthogonal experiments and variance analysis,it was found that hardness has a significant impact on the maximum dry density of gravelly soil,followed by gravel content,and lastly,moisture *** gravel compositions with an average saturated uniaxial compressive strength less than 60 MPa,the order of compacted maximum dry density is soft gravels>hard gravels>extremely soft *** type of gravelly soil has a threshold for gravel content,with 60%for hard and soft gravels and 50%for extremely soft *** these thresholds,the compacted dry density decreases *** is a certain interaction between hardness,gravel content,and moisture *** hardness increases the influence of gravel content,whereas lower hardness increases the influence of moisture *** soils with the coarse aggregate(CA)between 0.7 and 0.8 typically achieve higher dry densities after *** addition,the prediction equations for the particle breakage rate and CA ratio in the Bailey method were proposed to estimate the compaction performance of gravelly soil *** results further revealed the compaction mechanism of different gravelly soils and can provide reference for subgrade filling construction.

关键词： Gravelly soil Hardness Compaction characteristics Crushing characteristics Particle breakage rate Bailey method

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Resveratrol combats chronic diseases through enhancing mitochondrial quality

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Food Science and Human Wellness 2024年第2期13卷 597-610页

作者： Weichu Tao Hu Zhang Xia jiang Ning chen Tianjiu Research and Development Center for Exercise Nutrition and Foods Hubei Key Laboratory of Exercise Training and MonitoringCollege of Sports MedicineWuhan Sports UniversityWuhan 430079China The University Hospital of Wuhan Sports University Wuhan 430079China

Resveratrol(RSV),as a functional food component extracted from natural plants,has been widely studied and recognized in preventing and treating various diseases,with major mechanisms including executing anti-inflammation and anti-oxidation functions,and improving mitochondrial *** diseases as non-communicable diseases are mainly caused by multiple factors,such as physiological decline and dysfunction in the body,and have become a significant challenge on public health *** is worth noting that chronic diseases such as Alzheimer's disease(AD),Parkinson's disease(PD),muscle atrophy,cardiovascular disease,obesity,and cancer are accompanied by abnormal mitochondrial ***,targeted regulation of mitochondria may be a meaningful way to prevent and treat chronic *** evidence has confirmed that RSV is actively involved in regulating mitochondria,and it has become an essential consideration to prevent and treat chronic diseases through targeting mitochondria and improving corresponding *** this article,current studies on RSV to optimize mitochondrial quality for preventing and alleviating chronic disease are systematically summarized,which can provide a theoretical reference for the development of functional foods or drugs to combat chronic diseases.

关键词： Resveratrol Functional food Mitochondrial quality Chronic disease Anti-inflammation Anti-oxidation

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Colloid-facilitated release of polybrominated diphenyl ethers at an e-waste recycling site: evidence from undisturbed soil core leaching experiments

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 91-101页

作者： Zebin Huo Mengjun Xi Lianrui Xu Chuanjia jiang Wei chen College of Environmental Science and Engineering Ministry of Education Key Laboratory of Pollution Processes and Environmental CriteriaTianjin Key Laboratory of Environmental Remediation and Pollution ControlNankai UniversityTianjin 300350China

Polybrominated diphenyl ethers (PBDEs), a class of persistent organic pollutants, have been frequently detected in soil at e-waste recycling sites. However, the key factors controlling the transport of PBDEs from surface soil to the vadose zone and groundwater are unclear. Here, colloid-enhanced leaching of PBDEs from undisturbed soil cores collected at an e-waste recycling site in Tianjin, China, is reported. Spatially heterogeneous release of colloids and PBDEs was observed in all the tested soil cores under chemical and hydrodynamic perturbations, indicating the presence of preferential flow paths. Colloid concentration in the effluent significantly increased as ionic strength decreased (from 10 to 0.01 mmol/L), probably due to the stronger electrostatic repulsion between colloidal particles and the soil matrix at lower ionic strength. In contrast, colloid mobilization was not significantly affected by the changes in pH of the influent (from 4.0 to 10.0) and flow rate (from a Darcy velocity of 1.5 to 6.0 cm/h). The concentrations of 2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether (BDE-209), the predominant PBDE congener at the site, detected in the leachate (ranging from 1.09 to 3.43 ng/L) were much lower than previously reported results from packed column leaching tests, and were positively correlated with colloid concentrations. This indicates that remobilization of colloids at e-waste recycling sites can promote the leaching and downward migration of PBDEs from surface soil. The findings highlight the potential risk of surface soil PBDE contamination to groundwater quality and call for further understanding of colloid-facilitated transport for predicting the fate of PBDEs at e-waste recycling sites.

关键词： Polybrominated diphenyl ether Colloid-facilitated transport E-waste recycling site Undisturbed soil core Groundwater quality

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Experimental investigation about the incipient velocity of spherical particles on a hemispherical bed surface

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Particuology 2024年第5期88卷 49-61页

作者： Chuannan Li Jie chen Changbo jiang Xie Li Zhiyuan Wu School of Hydraulic and Environmental Engineering Changsha University of Science & TechnologyChangsha 410114China Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province Changsha 410114China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China

The sediment particles play a huge role in shaping the bed load *** this research,240 water-tunnel experiments are carried out to investigate the incipient velocity of the observation particles in two particle *** accurately predict the incipient velocity of the observation particles,the equation is conceived by the rolling instability *** incipient velocity equations and experimental data are used to analyze the trend of dispersive pressure and the effect of arrangement position on *** find that it is appropriate to choose the coefficient of drag as 0.261 and the coefficient of lift as 0.198 for the incipient velocity equation of spherical particles on the hemispherical bed ***,the dispersive pressure is closely related to the flow state,particle size,and particle arrangement,which leads to the incipient velocity of the observation particle being at a minimum when the interference particle angle is 45°.Finally,the particle spacing and the projected area changed with the arrangements,directly affecting the incipient velocity of the observed *** analysis of four aspects for the coefficients,dispersive pressure,different particle spacing,and projected area will facilitate the prediction of particle incipient velocity,especially on hemispherical beds.

关键词： Hemispherical bed surface Observed particle Interference particle Dispersive pressure Incipient velocity

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Photocatalyzed ditrifluoromethylthiolation of alkenes with CF_(3)SO_(2)Na

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Science China Chemistry 2024年第2期67卷 587-594页

作者： Fangming chen Lvqi jiang Chunyang Hu Jie Liu Wenbin Yi School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Organofluorine Chemistry Shanghai Institute Organic ChemistryChinese Academy of SciencesShanghai200032China

Since the first report of sodium trifluoromethanesulfinate(CF_(3)SO_(2)Na) as an electrophilic trifluoromethylthiolation reagent in 2015,there has been no breakthrough in research in this ***,we disclose an unprecedented usage of CF_(3)SO_(2)Na as a radical trifluoromethylthiolation reagent.A photocatalyzed ditrifluoromethylthiolation of alkenes with CF_(3)SO_(2)Na in the presence of PPh_(3) and catalytic copper has been ***,either Ir[(p-Fppy)_(2)(bpy)]PF_6 or Ir(ppy)_(3) could facilitate this *** studies indicate that initiation of the radical chain proceeded via two different photocatalytic quenching *** protocol provides a practical method for the construction of diverse vicinal ditrifluoromethylthiolated compounds.

关键词： trifluoromethylthiolation photocatalysis radical difunctionalization alkenes

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