检索结果-南通市图书馆

Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism

Asian Journal of Andrology 2005年第4期7卷 375-380,页

作者： Yong Wang Chen Shao Chang-hong Shi Lei Zhang hong-hong yue Peng-Fei Wang Bo Yang Yun-Tao Zhang Fan Liu Wei-Jun Qin He Wang Guo-Xing Shao Department of Urology Tangdu Hospital Department of Urology Department of Microbiology Department of Epidemiology Department of Nephrology Xijing Hospital Fourth Military Medical University Xi＇an 710032 Shaanxi China

Aim： To explore the effect of androgen receptor （AR） on the expression of the cell cycle-related genes, such as CDKNIA and BTG1, in prostate cancer cell line LNCaP. Methods： After AR antagonist flutamide treatment and confirmation of its effect by phase contrast microscope and flow cytometry, the differential expression of the cell cycle-related genes was analyzed by a cDNA microarray. The flutamide treated cells were set as the experimental group and the LNCaP cells as the control. We labeled cDNA probes of the experimental group and control group with Cy5 and Cy3 dyes, respectively, through reverse transcription. Then we hybridized the cDNA probes with cDNA microarrays, which contained 8 126 unique human cDNA sequences and the chip was scanned to get the fluorescent values of Cy5 and Cy3 on each spot. After primary analysis, reverse transcription polymerase chain reaction （RT- PCR） tests were carried out to confirm the results of the chips. Results：After AR antagonist flutamide treatment, three hundred and twenty-six genes （3.93 %） expressed differentially, 97 down-regulated and 219 up-regulated. Among them, eight up-regulated genes might be cell cycle-related, namely CDCIO, NRAS, BTG1, Wee1, CLK3, DKFZP564A122, CDKNIA and BTG2. The CDKNIA and BTG1 gene mRNA expression was confirmed to be higher in the experimental group by RT-PCR, while p53 mRNA expression had no significant changes. Conclusion： Flutamide treatment might up-regulate CDKN1A and BTG1 expression in prostate cancer cells. The protein expressions of CDKN1A and BTG1 play an important role in inhibiting the proliferation of cancer cells. CDKN1A has a great impact on the cell cycle of prostate cancer cells and may play a role in the cancer cells in a p53-independent pathway. The prostate cancer cells might affect the cell cycle-related genes by activating AR and thus break the cell cycle control.

关键词： prostate cancer LNCaP p21 androgen receptor CDKN1A BTG1 cell cycle genes flutamide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo hong-Bo Jin Cong-Feng Qiao yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Output stochastic distribution control for nonlinear systems

Output stochastic distribution control for nonlinear systems

引用

第二十一届中国控制会议

作者： WANG hong, yue hong (UMIST, Manchester, UK , and Institute of Automation, Chinese Academy of Sciences P O Box 2728, Beijing, P R China)

＜正＞The paper presents a summary on the recent developments on the control algorithm design for nonlinear stochastic control systems subjected to non-Gaussian inputs. This new research area was motivated in 1996 when we investigated problem formulation for a number of practical systems included in chemical engineering, food processing, paper-making, material composition processing, manufacturing, and combustion flames control. The aim of the control for these systems is to make the output probability density function of the system to follow a target distribution that is characterized by a probability density function. This demand is certainly different from all the existing stochastic control that only deals with the control of system output （i. e. , mean values and variance）. An outline of several control algorithms has been given when B - spline models are used to represent the system. It has been shown that these control algorithms can guarantee the closed loop stability and the target tracking.

关键词： Nonlinear systems proability density function B-spline models passivity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

氮掺杂的介-微孔碳/硫复合材料的性能

引用

电池 2016年第5期46卷 247-250页

作者：杨书廷田拴宝尹艳红岳红云河南师范大学化学化工学院河南新乡453007 动力电源及关键材料国家地方联合工程实验室河南新乡453007

在真空高温条件下,通过热处理甘氨酸、碳纳米管（CNT）和单质硫,一步制备氮掺杂的介-微孔碳/硫复合材料。采用XRD、SEM、循环伏安和恒流充放电等方法,分析复合材料的结构、形貌及电化学性能。制备的复合材料用作锂/硫电池正极,与普通热... 详细信息

在真空高温条件下,通过热处理甘氨酸、碳纳米管（CNT）和单质硫,一步制备氮掺杂的介-微孔碳/硫复合材料。采用XRD、SEM、循环伏安和恒流充放电等方法,分析复合材料的结构、形貌及电化学性能。制备的复合材料用作锂/硫电池正极,与普通热熔法制备的硫/CNT相比,电化学阻抗降低了38.1%,在1.6~2.8 V循环,0.2 C首次放电比容量增加了24.4%,不同倍率下的循环性能平均提高21.4%。

关键词：单质硫氮掺杂硫/碳纳米管锂硫电池

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

慢性阻塞性肺疾病患者抑郁情况及其影响因素研究

引用

实用心脑肺血管病杂志 2016年第6期24卷 42-45页

作者：洪丽月洪原城黄种杰金润女中国人民解放军第180医院呼吸内科福建省泉州市362000

目的探讨慢性阻塞性肺疾病(COPD)患者抑郁情况及其影响因素。方法选取2013年3月—2016年1月在中国人民解放军第180医院呼吸内科住院部和门诊部就诊的COPD患者206例,通过电子病历系统记录其一般资料〔包括性别、年龄、吸烟史、受教育程... 详细信息

目的探讨慢性阻塞性肺疾病(COPD)患者抑郁情况及其影响因素。方法选取2013年3月—2016年1月在中国人民解放军第180医院呼吸内科住院部和门诊部就诊的COPD患者206例,通过电子病历系统记录其一般资料〔包括性别、年龄、吸烟史、受教育程度、体质指数(BMI)和COPD分级〕,采用肺功能仪检查患者肺功能〔包括第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)和第1秒用力呼气容积占预计值百分比(FEV_1%pred)〕,采用医院焦虑抑郁量表(HAD)评估患者抑郁情况,采用多因素logistic回归分析筛选COPD患者抑郁的影响因素。结果本组患者抑郁发生率为41.3%(85/206)。抑郁患者和非抑郁患者FEV1/FVC比较,差异无统计学意义(P>0.05);抑郁患者和非抑郁患者性别、年龄、有无吸烟史、受教育程度、BMI、COPD分级及FEV1%pred比较,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,性别〔OR=0.457,95%CI(0.210,0.993)〕、年龄〔OR=0.617,95%CI(0.428,0.890)〕、受教育程度〔OR=1.455,95%CI(1.099,1.927)〕、BMI〔OR=0.492,95%CI(0.291,0.833)〕、COPD分级〔OR=1.946,95%CI(1.003,3.779)〕及FEV1%pred〔OR=2.337,95%CI(1.523,3.587)〕为COPD患者抑郁的影响因素(P<0.05)。结论 COPD患者抑郁发生率较高,而性别、年龄、受教育程度、BMI、COPD分级及FEV1%pred为COPD患者抑郁的影响因素。

关键词：肺疾病,慢性阻塞性抑郁影响因素分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental Investigation of Vibration Response of A Free-Hanging Flexible Riser Induced by Internal Gas-Liquid Slug Flow

引用

China Ocean Engineering 2018年第6期32卷 633-645页

作者： ZHU hong-jun ZHAO hong-lei GAO yue State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University

The vibration response of a free-hanging flexible riser induced by internal gas-liquid slug flow was studied experimentally in a small-diameter tube model based on Froude number criterion. The flow regime in a curved riser model and the response displacements of the riser were simultaneously recorded by high speed cameras. The gas superficial velocity ranges from 0.1 m/s to 0.6 m/s while the liquid superficial velocity from 0.06 m/s to 0.3 m/*** slugging type 3, unstable oscillation flow and relatively stable slug flow were observed in the considered flow rates. Severe slugging type 3 characterized by premature gas penetration occurs at relatively low flow rates. Both the cycle time and slug length become shorter as the gas flow rate increases. The pressure at the riser base undergoes a longer period and larger amplitude of fluctuation as compared with the other two flow regimes. Additionally, severe slugging leads to the most vigorous in-plane vibration. However, the responses in the vertical and horizontal directions are not synchronized. The vertical vibration is dominated by the second mode while the horizontal vibration is dominated by the first mode. Similar to the vortex-induced vibration, three branches are identified as initial branch, build-up branch and descending branch for the response versus the mixture velocity of gas-liquid flow.

关键词： gas-liquid two-phase flow severe slugging liquid slug flexible riser flow-induced vibration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Editorial:Bilingual (multilingual) publications and duplicate publications: for or against?

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 687-690页

作者： yue-hong (Helen) ZHANG Journals of Zhejiang University-SCIENCE (A/B/C)

From the professional perspective of journal publishing, whether a bilingual (multilingual) publication is suspicious from an ethical point of view has been a topic of debate. Indeed this problem has

关键词：出版物多语言双语期刊编辑期刊出版作者出版业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Heteroatom-doped porous carbon-supported single-atom catalysts for electrocatalytic energy conversion

引用

Journal of Energy Chemistry 2021年第12期30卷 54-73,I0002页

作者： yue Shao Zhengtai Zha hong Wang Key Laboratory of Functional Polymer Materials Ministry of EducationInstitute of Polymer ChemistryCollege of ChemisttyNankai University.Tianjin 300071China

Electrocatalysts play a crucial role in the development of renewable energy conversion and storage *** unique advantages of heteroatom-doped porous carbon-supported single-atom electrocatalysts(SAC-HDPCs)are *** SAC-HDPCs exhibit outstanding activity,selectivity and stability due to their distinct electronic structure,satisfactory conductivity,controllable porosity and heteroatomdoping *** and significant developments involving the synthesis,characterization,and structure-property-function relationship of SAC-HDPCs have been made in recent *** this review,we describe recent research efforts involving advanced(in situ)characterization techniques,innovative synthetic strategies,and electrochemical energy conversion examples of *** electrocatalytic performance of SAC-HDPCs is further considered at an atomic level,and the mechanisms underlying this performance are also discussed in *** expect that these analyses and deductions will be useful for the design of new materials and may help to establish a foundation for the design of future SAC-HDPCs.

关键词： Carbon material Heteroatom doping Single-atom electrocatalyst Electrocatalytic energy conversion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new rotating black hole in quintessential dark energy and its thermodynamics

引用

Science China(Physics,Mechanics & Astronomy) 2019年第11期62卷 63-68页

作者： yue Wang Chen-Hao Wu Rui-hong yue Center for Gravitation and Cosmology College of Physical Science and Technology Yangzhou University

The spacetime metric for a rotating black hole in a quintessential field can take various forms owing to the ambiguity of the state equation for quintessential dark energy in rotating spacetime. Herein, to provide a more physical solution, the metric is determined by imposing the laws of thermodynamics of a black hole, which is typically valid in most systems. The new metric ensures the validity of the first and second laws of thermodynamics and can degenerate to the known non-rotating metric in the quintessential field. Moreover, we set an upper limit for the black hole rotation parameter, a, in our metric according to the weak energy condition(WEC).

关键词： rotating black holes in quintessential field thermodynamics weak energy condition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bending behavior of double-row stabilizing piles with constructional time delay

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第8期13卷 596-609页

作者： Yang YU yue-quan SHANG hong-yue SUN College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China Department of Ocean Science and Engineering Zhejiang UniversityHangzhou 310058China

The bending behavior of double-row stabilizing plies is associated with the constructional time delay(CTD),which can be defined as the time interval between the installations of the front stabilizing pile and the rear stabilizing *** paper investigates the effect of CTD on the bending moments of double-row stabilizing piles and a method for determining the optimal CTD is *** stabilizing pile is modeled as a cantilever pile embedded in the Winkler elastic foundation.A triangular distributed earth pressure is assumed on the pile segment in the sliding *** front stabilizing pile and the rear stabilizing pile are connected by a beam with pinned *** analytical solutions of bending moments on the front and the rear stabilizing piles are derived and the accuracy of bending moment solutions is validated by comparing the tensile strain measured from the hongyan landslide project,Taizhou,Zhejiang,*** is concluded that CTD has a significant influence on the bending moments of double-row stabilizing *** optimal CTD can be obtained when the maximum tensile stress in the front stabilizing pile is equal to that in the rear stabilizing pile,which is 1.4 months for the hongyan landslide project.

关键词： Subgrade reaction Landslide Stabilizing pile Constructional time delay (CTD) Bending moment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：