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Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis:A Systematic Review

Biomedical and Environmental Sciences 2024年第1期37卷 85-95页

作者： WANG Han Lin XUE yan Feng CUI Bao Qiu LIU hong SHEN Xin Xin Shandong Provincial Research Center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049ShandongChina Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013ShanxiChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective This study explored the potentially modifiable factors for depression and major depressive disorder(MDD)from the MR-Base database and further evaluated the associations between drug targets with *** We analyzed two-sample of Mendelian randomization(2SMR)using genetic variant depression(n=113,154)and MDD(n=208,811)from Genome-Wide Association Studies(GWAS).Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 *** MR analysis was performed by screening drug targets with MDD in the DrugBank database to explore the therapeutic targets for *** variance weighted(IVW),fixed-effect inverse variance weighted(FE-IVW),MR-Egger,weighted median,and weighted mode were used for complementary *** The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for ***,the associations between drug targets and MDD showed that SLC6A4,GRIN2A,GRIN2C,SCN10A,and IL1B expression are associated with an increased risk of *** contrast,ADRB1,CHRNA3,HTR3A,GSTP1,and GABRG2 genes are candidate protective factors against *** This study identified the risk factors causally associated with depression and MDD,and estimated 10 drug targets with significant impact on MDD,providing essential information for formulating strategies to prevent and treat depression.

关键词： Risk factors Drug targets Depression Major depressive disorder Two-sample Mendelian randomization

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Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis

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Current Medical Science 2024年第4期44卷 809-819页

作者： Chen-guang YAO Zi-jia ZHAO Ting TAN Jiang-ning yan Zhong-wei CHEN Jun-tao XIONG Han-luo LI yan-hong WEI Kang-hong HU Sino-German Biomedical Center Hubei Provincial Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)Key Laboratory of Fermentation Engineering(Ministry of Education)National“111”Center for Cellular Regulation and Molecular PharmaceuticsHubei University of TechnologyWuhan430068China Center for Evaluation of Hubei Medical Products Administration Wuhan430068China

Objective Lindqvist-type polyoxometalates(POMs)exhibit potential antitumor *** study aimed to examine the effects of Lindqvist-type POMs against breast cancer and the underlying *** Using different cancer cell lines,the present study evaluated the antitumor activities of POM analogues that were modified at the body skeleton based on molybdenum-vanadium-centered negative oxygen ion polycondensations with different side *** colony formation assay,autophagy detection,mitochondrial observation,qRT-PCR,Western blotting,and animal model were used to evaluate the antitumor activities of POMs against breast cancer cells and the related *** MO-4,a Lindqvist-type POM linking a proline at its side strain,was selected for subsequent experiments due to its low half maximal inhibitory concentration in the inhibition of proliferation of breast cancer *** was found that MO-4 induced the apoptosis of multiple types of breast cancer ***,MO-4 activated intracellular mitophagy by elevating mitochondrial reactive oxygen species(ROS)levels and resulting in *** vivo,breast tumor growth and distant metastasis were significantly reduced following MO-4 *** Collectively,the results of the present study demonstrated that the novel Lindqvist-type POM MO-4 may exhibit potential in the treatment of breast cancer.

关键词： antitumor breast cancer polyoxometalate mitochondria mitophagy

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Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： Shan-Shan Jin Si-Nong Wang yan-yan Huang Jing-Yu Zhang Peng Liu Hui Yu hong-Dong Zhang Yu-Liang yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

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Regioselective C-C bond cleavage/aminocarbonylation cascade under copper catalysis

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Science China Chemistry 2024年第11期67卷 3798-3806页

作者： Qi-Chao Shan yan Zhao Yong Wu hong-Fei Liu Xin-Hua Duan Li-Na Guo Department of Chemistry School of Chemistry Energy Research Center of Energy Storage Materials and Devices Ministry of EducationXi'an Jiaotong University State Key Laboratory of Applied Organic Chemistry Lanzhou University

A regioselective C-C bond cleavage/aminocarbonylation cascade is presented. In recent years, tremendous progress has been made in the alkoxyl radical-mediated C-C bond cleavage of unstrained monocarbocycles. In contrast, the deconstruction and functionalization of bicyclic skeletons has been less developed and has mainly focused on the ring expansion process. Inspired by the aromatization-driven C-C bond cleavage, here we demonstrate a ring-opening/aminocarbonylation cascade under copper catalysis, in which the formation of a stable γ-lactam or succinimide skeleton reverses the selectivity of C-C cleavage. Remarkably, the photo and thermal assistance is not required when the succinimide skeleton is formed during the ring opening process. DFT calculations revealed that this unexpected ring-opening process is thermodynamically and kinetically favourable.

关键词： C-C bond cleavage controllable regioselectivity aminocarbonylation bicyclic alkoxy radical

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Numerical and experimental study of the effects of wind turbine operation on sand-dust transport characteristics

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 97-113页

作者： Gaosheng Ma hong Han Ye Li Deshun Li yan Wang Ning Fu Quan Zheng Rennian Li School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Gansu Provincial Technology Center for Wind Turbines Lanzhou 730050China Key Laboratory of Fluid Machinery and Systems Lanzhou 730050China Multiple Function Towing Tank Laboratory State Key Laboratory of Ocean EngineeringSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Given factors such as reduced land availability for onshore wind farms,wind resource enrichment levels,and costs,there is a growing trend of establishing wind farms in deserts,the Gobi,and other arid ***,the relationship between sanddust weather environments and wind turbine operations has garnered significant *** investigate the impact of wind turbine wakes on sand-dust transportation,this study employs large eddy simulation to model flow fields,coupled with an actuator line model for simulating rotating blades and a multiphase particle in cell model for simulating sand *** research focuses on a horizontal axis wind turbine model and examines the motion and spatiotemporal distribution characteristics of four typical sizes of sand particles in the turbine *** findings reveal that sand particles of varying sizes exhibit a spiral settling pattern after traversing the rotating plane of wind turbine blades,influenced by blade shedding vortex and *** particles tend to cluster in the peripheries of the vortex cores of low vorticity in the wind turbine *** rotation of wind turbines generates a wake vortex structure that causes a significant clustering of sand particles at the tip *** the wake distance increases,the particles that cluster at the turbine's tip gradually spread outward to approximately twice the rotor diameter and then begin to mix with the incoming flow *** turbines have a noticeable impact on sand-dust transportation,hindering their movement to a significant *** average sand-blocking rate exhibits a trend of initially increasing and then decreasing as the wake distance *** its peak,the sand-blocking rate reaches an impressive 67.55%.The presence of wind turbines induces the advanced settling of sand particles,resulting in a“triangular”distribution of the deposition within the ground projection area of the wake.

关键词： wind turbine particle transportation actuator line model dry deposition particle clustering

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RGB oralscan video-based orthodontic treatment monitoring

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Science China(Information Sciences) 2024年第1期67卷 124-139页

作者： yan TIAN Hanshi FU Hao WANG Yuqi LIU Zhaocheng XU hong CHEN Jianyuan LI Ruili WANG School of Computer Science and Technology Zhejiang Gongshang University Shining3D Tech Co. Ltd. School of Information and Technology Monash University School of Mathematical and Computational Sciences Massey University Department of Stomatology Zhejiang Provincial People's HospitalHangzhou Medical College School of Computer and Computing Science Zhejiang University City College

Orthodontic treatment monitoring involves using current images and previous 3D models to estimate the relative position of individual teeth before and after orthodontic *** process differs from image-based object 6D pose estimation due to the gingiva deformation and varying pose offsets for each tooth during *** by the fact that the poses of molars remain relatively fixed in implicit orthodontics,we design an approach that employs multiview pose evaluation and bidirectional temporal propagation for jaw pose estimation and then employs an iteration-based method for tooth *** handle changes in tooth appearance or location with weak texture across frames,we also introduce an instance propagation module that leverages positional and semantic information to explore instance relations in the temporal *** evaluated the performance of our approach using both the Shining3D tooth pose dataset and the Aoralscan3 tooth registration *** experimental results demonstrate remarkable accuracy improvements compared with existing methods.

关键词： digital dentistry object 6D pose estimation deep learning computer vision

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Fully relativistic energies,transition properties,and lifetimes of lithium-like germanium

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Chinese Physics B 2024年第10期33卷 52-61页

作者： Shuang Li Jing Zhou Liu-hong Zhu Xiu-Fei Mei Jun yan School of Electrical and Optoelectronic Engineering West Anhui UniversityLu’an 237012China Institute of Applied Physics and Computational Mathematics Beijing 100088China Shanghai EBIT Laboratory Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China

Employing two fully relativistic methods,the multi-reference configuration Dirac-Hartree-Fock(MCDHF)methodand the relativistic many-body perturbation theory(RMBPT)method,we report energies and lifetime values for the lowest35 energy levels of the(1s^(2))nl configurations(where the principal quantum number n=2-6 and the angular quantum numberl=0,...,n-1)of lithium-like germanium(Ge XXX),as well as complete data on the transition wavelengths,radiativerates,absorption oscillator strengths,and line strengths between the *** the allowed(E1)and forbidden(magneticdipole M1,magnetic quadrupole M2,and electric quadrupole E2)ones are *** results from the two methodsare consistent with each other and align well with previous accurate experimental and theoretical *** assess theoverall accuracies of present RMBPT results to be likely the most precise ones to *** present fully relativistic resultsshould be helpful for soft x-ray laser research,spectral line identification,plasma modeling and *** datasetspresented in this paper are openly available at https://***/10.57760/sciencedb.j00113.00135.

关键词： multi-reference Dirac-Hartree-Fock relativistic many-body perturbation radiative rate lifetime

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High photoluminescence Ag-In-Ga-S quantum dots based on ZnX_(2)-treated surface passivation

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Nano Research 2024年第8期17卷 7533-7541页

作者： Danni yan Yuhui Dong Naiwei Wei Shuai yang hong Zhu Wanzhong Gu Yousheng Zou Haibo Zeng MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics&NanomaterialsSchool of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

Quaternary Ag-In-Ga-S(AIGS)quantum dot(QD)is considered a promising,spectral-tunable,and environmentally friendly luminescent display ***,the more complex surface defect states of AIGS QDs resulting from the coexistence of multiple elements lead to a low(<60%)photoluminescence quantum yield(PLQY).Here,we develop a novel convenient method to introduce Z-type ligands ZnX_(2)(X=Cl,Br,I)for passivating the surface defects of AIGS QDs to dramatically enhance the PLQY and stability without affecting the crystalline structure and *** show that the addition of ZnCl_(2) during the purified process of AIGS QDs leads to a 3-fold increase of PLQY(from 28.5% to 87%).Impressively,the highest PLQY is up to a recorded value of 92%,which is comparable to typical heavy metal *** dynamics studies have shown that the rapid annihilation process of excitons in treated QDs is *** also confirm that the improvement in PLQY is a result of the effective passivation of the non-coordinating atom on the QD surface by building a new bonding between sulfur dangling and Zn2+.The realization of high PLQY will further promote the application of AIGS QDs in luminescent displays.

关键词： I-III-VI quantum dots Ag-In-Ga-S surface defect passivation Z-type ligand photoluminescence quantum yield

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Identification and immune analysis of antimicrobial peptides from the cigarette beetle(Lasioderma serricorne)

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Insect Science 2024年第4期31卷 1121-1134页

作者： Yue Zhang Yi yan Guy Smagghe hong yang Ren-huai Dai Wen-jia yang Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

Antimicrobial peptides(AMPs)in insects are endogenous peptides that are effector components of the innate defense system of the *** may serve as antimicrobial agents because of their small molecular weight and broad-spectrum antimicrobial *** this study,we performed transcriptome analysis of cigarette beetle(Lasioderma serricorne)larvae,parasitized by the ectoparasitic wasp,Anisopteromalus *** AMP genes were significantly upregulated following *** parasitism,postulating the hypothesis that the parasitization enhanced the host's resistance against pathogenic microorganisms through the regulation of host AMP ***,3 AMP genes(LsDef1,LsDef2,and LsCole)were significantly upregulated and we studied their immune function in *** challenge and functional analysis showed that LsCole was responsible for the immune response against Gram-negative and Gram-positive bacteria,while LsDef1 and LsDef2 were involved in insect defense against Gram-positive *** recombinant LsCole exhibited antimicrobial activities against the Gram-negative bacterium Escherichia coli and the Gram-positive bacterium Staphylococcus ***2 showed an antibacterial effect against *** and LsDef2 exhibited antibiofilm activity against *** 2 AMPs disrupted cell membranes and caused leakage of *** cell *** results indicated that the 3 AMPs in *** are involved in the innate immunity of this pest *** AMPs may have potential as antimicrobial agents for bacterial infection ***,data are discussed in relation to new control strategies with greater biosafety against pest insects with use of microbial biocontrol agents in combination with RNA interference against the insect's defensive AMP genes.

关键词： antimicrobial activity antimicrobial peptides innate immune response Lasioderma serricorne RNA interference

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Breeding Asian seabass to increase survival against big belly disease and growth

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Aquaculture and Fisheries 2024年第5期9卷 731-738页

作者： Peng Liu Jun hong Xia Fei Sun Le Wang Zituo yang May Lee hong yan Pang yan Fei Wen Gen Hua Yue Temasek Life Sciences Laboratory National University of Singapore1 Research Link117604Singapore Department of Biological Sciences National University of Singapore14 Science Drive117543Singapore

Asian seabass(Lates calcarifer)is an important foodfish *** has been cultured in Singapore since the 1980s.A selective breeding program to improve growth,meat quality and disease resistance has been ongoing in Singapore since *** 2012,outbreaks of the big belly disease(BBD)occurred in two batches of offspring generated by a mass-cross among F1 brooders in a *** the outbreaks,only 437 survived in 6000 F2 *** parentage analysis with 10 microsatellites revealed that four parents(F1)produced high percentage of offspring that survived the BBD ***-two BBD survivor offspring(F2)were selected based on their growth performance at 90 days post hatch(dph),family origin and allelic *** were used as brooders to generate *** a period of five years,these F2 brooders produced six batches of offspring,where no outbreak of BBD *** the same period,outbreaks of BBD occurred in 4 out of 18 batches produced by F2 brooders selected for growth,with mortality rates ranging from 85.1%to 95.4%.In F3,the average body weight(57.1±1.09 g,n=3068)of the line for BBD survival was slightly lower than that(60.6±2.29 g,n=4280)of the line for growth at 90 *** both lines,the body weight of F3 was much higher than that(46.90±0.19 g,n=12117)of *** genetic diversity in the line for BBD survival(F3)was much lower than that in F3 line for growth due to small founder *** data indicate that the selection of BBD survival during BBD outbreaks using molecular parentage analysis is effective to reduce BBD *** further reduction of genetic diversity is essential in the line selected for increased survival against BBD.

关键词： Barramundi Infection Resistance Growth Marker Diversity

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