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Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1268-1280页

作者： xu-xu He Bang Du Tao Wu hao Shen Department of Surgery Fudan University Affiliated Zhongshan Hospital(Qingpu Branch)Shanghai 201700China Department of Surgery Anhui Provincial Red Cross Society HospitalHefei 230031Anhui ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Immunotherapy for advanced gastric cancer has attracted widespread attention in recent ***,the adverse reactions of immunotherapy and its relationship with patient prognosis still need further *** order to determine the association between adverse reaction factors and prognosis,the aim of this study was to conduct a systematic prognostic *** comprehensively evaluating the clinical data of patients with advanced gastric cancer treated by immunotherapy,a nomogram model will be established to predict the survival status of patients more *** To explore the characteristics and predictors of immune-related adverse reactions(irAEs)in advanced gastric cancer patients receiving immunotherapy with programmed death protein-1(PD-1)inhibitors and to analyze the correlation between irAEs and patient *** A total of 140 patients with advanced gastric cancer who were treated with PD-1 inhibitors in our hospital from June 2021 to October 2023 were *** were divided into the irAEs group and the non-irAEs group according to whether or not irAEs *** features,manifestations,and prognosis of irAEs in the two groups were collected and analyzed.A multivariate logistic regression model was used to analyze the related factors affecting the occurrence of irAEs,and the prediction model of irAEs was *** receiver operating characteristic(ROC)curve was used to evaluate the ability of different indicators to predict irAEs.A Kaplan-Meier survival curve was used to analyze the correlation between irAEs and *** Cox proportional risk model was used to analyze the related factors affecting the prognosis of *** A total of 132 patients were followed up,of whom 63(47.7%)developed *** looked at the two groups’clinical features and found that the two groups were statistically different in age≥65 years,Ki-67 index,white blood cell count,neutrophil count,and regulatory T cell(Treg)count

关键词： Advanced gastric cancer Prognostic analysis Immunotherapy Nomogram model

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Selective oxidation using in-situ generated hydrogen peroxide over titanosilicates

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Chinese Journal of Structural Chemistry 2024年第6期43卷 12-14页

作者： Zhipeng Wan hao xu Peng Wu State Key Laboratory of Petroleum Molecular&Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal UniversityShanghai200062China Institute of Eco-Chongming Shanghai202162China

Titanosilicates are a class of heteroatom-containing zeolitic materials with tetrahedrally coordinated Ti^(4+)ions incorporated into crystalline zeolite frameworks,with TS-1,Ti-MWW and Ti-MOR as representative and attractive selective oxidation *** liquid-phase oxidations of a variety of substrates such as olefins and ketones with the green oxidant of H_(2)O_(2)over titanosilicates under mild conditions have attracted considerable research interests in the clean production of fine and bulk chemicals,among which propylene epoxidation and cyclohexanone ammoximation have been industrialized[1].

关键词： silicate zeolite propylene

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Analytical libration control law for electrodynamic tether system with current constraint

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Astrodynamics 2024年第2期8卷 237-246页

作者： Shidong xu Ti Chen hao Wen Dongping Jin State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

This study focuses on stabilizing the libration dynamics of an electrodynamic tether system(EDTS)using generalized torques induced by the Lorentz *** contrast to existing numerical optimization methods,a novel analytical feedback control law is developed to stabilize the in-plane and out-of-plane motions of a tether by modulating the electric current *** saturation constraint on the current is accounted for by adding an auxiliary dynamic system to the *** enhance the robustness of the proposed controller,multiple perturbations of the orbital dynamics,modeling uncertainties,and external disturbances are approximated using a neural network in which the weighting matrix and approximation error are estimated simultaneously,such that these perturbations are well compensated for during the control design of the ***,a dynamically scaled generalized inverse is utilized to address the singular matrix in the control *** closed-loop system is proven to be ultimately bounded based on Lyapunov stability ***,numerical simulations are performed to demonstrate the effectiveness of the proposed analytical control law.

关键词： electrodynamic tether system(EDTS) libration dynamics analytical control current constraint

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Oral delivery of ferroptosis inducers for effective treatment of hepatic fibrosis

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Nano Research 2024年第8期17卷 7621-7630页

作者： Yinglan Yu Shunlong Zhang Yongfeng xu hao Shao Lei Luo College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China

Liver fibrosis is characterized by the excessive accumulation of extracellular matrix(ECM),which is primarily produced by activated hepatic stellate cells(HSCs).However,effective therapies for hepatic fibrosis are currently *** is a promising anti-fibrotic drug candidate,but its clinical application is hindered by limited ***,we present a novel oral delivery platform that enhances the HSCs uptake of artesunate and induces potent *** platform is vitamin Adecorated nanoparticles encapsulated with *** multifunctional ligand vitamin A interacts with retinol-binding proteins that are highly expressed on the intestinal epithelium to promote transcytosis,highly expressed on the surface of HSCs but lowly expressed in normal *** oral administration,this oral delivery platform enhances transepithelial transport in the intestine,improves drug accumulation in the liver,and continuously increases HSCs uptake of *** drug release in HSCs,artesunate depletes glutathione peroxidase 4 and glutathione,effectively initiating *** vivo experiments demonstrate that this strategy induces pronounced ferroptosis,efficiently relieving liver *** work provides a proof-ofconcept demonstration that an oral delivery strategy for ferroptosis inducers may be beneficial for liver fibrosis treatment.

关键词： liver fibrosis hepatic stellate cells oral delivery intestinal epithelium ferroptosis

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Surface roughness classification using light scattering matrix and deep learning

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Science China(Technological Sciences) 2024年第2期67卷 520-535页

作者： SUN hao TAN Wei RUAN YiXiao BAI Long xu JianFeng State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Wuhan Digital Design and Manufacturing Innovation Center Co. LtdWuhan 430074China

High-quality optical components have been widely used in various applications;thus,extremely high beam quality is ***,surface roughness is a key indicator of the surface *** this study,the angular distribution of light scattering field intensity was obtained for surfaces having different roughness profiles based on the finite difference time domain(FDTD)method,and the results were compared with those obtained using the generalized Harvey-Shack(GHS)*** was shown that the FDTD approach can be used for an accurate simulation of the scattered field of a rough surface,and the superposition of results obtained from many surfaces that have the same roughness level was in good agreement with the result given by the analytic GHS model.A light scattering matrix(LSM)method was proposed based on the FDTD simulation results that could obtain rich surface roughness *** classification effect of LSM was compared with that of the single-incidence scattering distribution(SISD)based on a ResNet-50 deep learning *** classification accuracy of the model trained with the LSM dataset was obtained as 95.74%,which was 23.40%higher than that trained using the SISD ***,the effects of different noise types and filtering methods on the classification performance were analyzed,and the LSM was also shown to improve the robustness and generalizability of the trained surface roughness ***,the proposed LSM method has important implications for improving the data acquisition scheme of current light scattering measurement systems,and it also has the potential to be used for detection and characterization of surface defects of optical components.

关键词： surface roughness FDTD simulation GHS theory deep learning light scattering matrix

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GPU-accelerated OCT imaging: Real-time data processing and artifact suppression for enhanced monitoring of 3D bioprinted tissues and vascular-like networks

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 67-82页

作者： Shanshan Yang Jinhao Zhou hao Guo Ling Wang Mingen xu Hangzhou Dianzi University Automation College HangzhouZhejiangP.R.China Zhejiang Provincial Key Laboratory of Medical Information and Biological 3D Printing Hangzhou ZhejiangP.R.China

Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological ***,it still faces the following challenges:including data processing speed,image quality,and improvements in three-dimensional(3D)visualization *** technology,especially functional imaging techniques like optical coherence tomography angiography(OCTA),requires a long acquisition time and a large data *** the substantial increase in the acquisition speed of swept source optical coherence tomography(SS-OCT),it still poses significant challenges for data ***,during in situ acquisition,image artifacts resulting from interface reflections or strong reflections from biological tissues and culturing containers present obstacles to data visualization and further ***,a customized frequency domainfilter with anti-banding suppression parameters was designed to suppress artifact ***,this study proposed a graphics processing unit(GPU)-based real-time data processing pipeline for SS-OCT,achieving a measured line-process rate of 800 kHz for 3D fast and high-quality data ***,a GPU-based realtime data processing for CC-OCTA was integrated to acquire dynamic ***,a vascular-like network chip was prepared using extrusion-based 3D printing and sacrificial materials,with sacrificial material being printed at the desired vascular network locations and then removed to form the vascular-like *** imaging technology was used to monitor the progression of sacrificial material removal and vascular-like network ***,GPU-based OCT enables real-time processing and visualization with artifact suppression,making it particularly suitable for in situ noninvasive longitudinal monitoring of 3D bioprinting tissue and vascular-like networks in microfluidic chips.

关键词： SS-OCT GPU acceleration artifact noise 3D bioprinted microfluidic chip.

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Remote copper-catalyzed enantioselective substitution of yne-thiophene carbonates

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Science China Chemistry 2024年第4期67卷 1175-1180页

作者： hao-Dong Qian Xiang Li Tingrui Yin Wei-Feng Qian Chunhui Zhao Cuiju Zhu hao xu CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology of Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Here,we describe a strategy for the copper-catalyzed asymmetric heteroarylation of yne-thiophene carbonates with indoles via remote *** key to the success of this strategy lies in the design of the alkynyl group at the ortho-position of the heterocycle thiophene,enabling the formation of a triarylmethane moiety via very remote ***,the concept of remote copper-catalyzed asymmetric transformation extends not only to yne-allylic esters but also to yne-aryl *** reaction readily provides a diverse array of chiral triarylmethanes with high efficiency,enantioselectivity,and excellent functional group ***,facile follow-up transformations underscore their potential utility in the synthesis of various enantioenriched building *** mechanistic studies support the plausibility of the remote substitution pathway.

关键词： remote substitution copper catalyst asymmetric catalysis triaryl methanes

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Heat distribution model under hydrogen-rich low-carbon conditions in blast furnace

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Journal of Iron and Steel Research International 2024年第3期31卷 584-594页

作者： Gang Wang Jun xu Kun He Zhong-ping Zou hao Bai School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China CISDI Low-Carbon Blast Furnace Research Office MCC Low-Carbon Technology Research InstituteChongqing 401122China

Low carbon development of blast furnaces is one of the key technological directions in the current development of *** to the differences in the physical and chemical properties of hydrogen and carbon,hydrogen-rich media entering a blast furnace will change the heat distribution,thus affecting the stability of ***,a heat distribution model was proposed to study the temperature distribution in a blast furnace,simultaneously considering gas-solid heat exchange,slag and iron melting,and chemical *** model was used to analyze the temperature distribution of a 2300 m^(3) blast furnace and was verified via comparison with actual production ***,the effects of the injection rate of hydrogen-rich media,H2 concentration,and oxygen enrichment rate of the blast on the temperature distribution were *** indicated that the increase in the injection rate of the hydrogen-rich media decreased the amount of direct reduction and led to an increase in the furnace ***,an increase in the oxygen enrichment rate led to a decrease in the furnace temperature,but could reduce the solid fuel ratio,while the change in H2 concentration had less effect on the temperature *** combination of hydrogen-rich media injection and the increase in the oxygen enrichment rate would help to adjust the temperature distribution to the same level as the conventional blast furnace conditions.

关键词： Heat distribution Blast furnace Low-carbon condition Hydrogen enrichment Calculation model

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A COMPACT EMBEDDING RESULT FOR NONLOCAL SOBOLEV SPACES AND MULTIPLICITY OF SIGN-CHANGING SOLUTIONS FOR NONLOCAL SCHRÖDINGER EQUATIONS

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Acta Mathematica Scientia 2024年第5期44卷 1853-1876页

作者： xu ZHANG hao ZHAI Fukun Zhao Department of Mathematics Wuhan University of TechnologyWuhan430070China Department of Mathematics Yunnan Normal UniversityKunming650500China

For any s∈(0,1),let the nonlocal Sobolev space X^(s)(ℝ^(N))be the linear space of Lebesgue measure functions fromℝN toℝsuch that any function u in X^(s)(ℝ^(N))belongs to L2(ℝN)and the function(x,y)\longmapsto\big(u(x)-u(y)\big)\sqrt{K(x-y)}is in L2(ℝN,ℝN).First,we show,for a coercive function V(x),the subspace E:=\bigg\{u\in X^s(\mathbb{R}^N):\int_{\mathbb{R}^N}V(x)u^2{\rm d}x<+\infty\bigg\}of X^(s)(ℝ^(N))is embedded compactly into L^(p)(ℝ^(N))for p\in[2,2_s^*),where 2_s^*is the fractional Sobolev critical *** terms of applications,the existence of a least energy sign-changing solution and infinitely many sign-changing solutions of the nonlocal Schrödinger equation-{\cal{L}_K}u+V(x)u=f(x,u),\x\in\\mathbb{R}^N are obtained,where-{\cal{L}_K}is an integro-differential operator and V is coercive at infinity.

关键词： sign-changing solution integro-differential operator least energy variational method

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Research on the Working Mechanism and Virtual Design for Cleaning Element in Brush Shape of the Sugarcane Harvester

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厦门大学学报（自然科学版） 2002年第S1期41卷 137-138页

作者： LI Shang-ping, MENG Yan-mei, MA Fang-lan, TAN hong-hao, CHEN Wei-xu (College of Mechanical Engineering, Guangxi University, Nanning 530004 , China)

The cleaning element is the key part to the small w ho le-stall sugarcane harvester, which is suitable to the highland. And it is the bottleneck of the design of the small sugarcane harvester. The working mechanism of centrifugal cleaning method of the cleaning element in brush shape is based on the high speed rotating cleaning element that push, scrub, and strike the sta lk to separate the leaves from the sugarcane. The paper elaborated the worki ng mechanism of cleaning element in brush shape of the sugarcane harvester, and analyzed the state of cleaning procedure and the reacting force that the cleanin g element was subjected. Combined with the earlier stage experiments and researc hes, it was found out that the factors, which affect the cleaning efficiency and fatigue life of cleaning element, were quite many, and the factors were complex and random. So it was difficult to analyze and design cleaning element in theor y. Moreover, if the design parameters were got from experiment it would be time consuming, laborious, and costly. The method of numerical value simulation ortho gonal experiment is used to analyze the reacting force by means of establishing finite element analysis model for cleaning element on ANSYS. According to orthog onal experiment principle, the different parameter groups were made to do finite element calculation. And then orthogonal experiment analysis and regression ana lysis were made to find out the effect on the calculated result that was caused by the changes of different parameter groups, and get optimal design parameters of cleaning element. In conclusion, this virtual design method is a quick and ef ficient way in innovative mechanical product design. This method economizes mate rial, labor, and time, and then it is the right way of high efficiency and speed to reduce the development period, and increase the quality of product and the r atio of successful development at once.

关键词： cleaning element finite element analysis orthog onal experiment regression analysis

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