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Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1647-1659页

作者： Ju-Hang Chu Lu-Yao Huang Ya-Ru Wang Jun Li shi-Long Han hao Xi Wen-Xue Gao Ying-Yu Cui Ming-Ping Qian Department of General Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Interventional and Vascular Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Pathology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Clinical Research Management Office Shanghai Tenth People’s HospitalShanghai 200072China Department of Cell Biology Institute of Medical GeneticsState Key Laboratory of CardiologyTongji University School of MedicineShanghai 200331China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical *** demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced *** SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal *** computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/***,he was judged to have advanced *** treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of *** the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be *** pathological diagnosis indicated a complete *** patient recovered well after the operation,and no tumor recurrence was *** Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant *** drug adjustments should be made during any treatment according to the patient's tolerance to treatment.

关键词： Hepatocellular therapy Conversion hepatectomy Interventional therapy Epclusa Lenvatinib Sintilimab Case report

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Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study

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World Journal of Gastroenterology 2024年第11期30卷 1572-1587页

作者： shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-Ta Cui Yi-hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Microbiota Medicine&Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina

BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical ***,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been *** To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to *** We conducted a prospective,open-label,single-center clinical *** CD patients underwent *** clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the *** Seven of the 11 patients(63.6%)showed an optimal clinical response three months *** microbiome diversity significantly increased after WMT,consistent with improved clinical *** of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as Faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia *** addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the ***,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after *** WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s ***-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.

关键词： Crohn’s disease Clinical trials Fecal microbiota transplant Metagenome Metatranscriptome Metabolome

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Multifunctional solar-blind ultraviolet photodetectors based on p-PCDTBT/n-Ga_(2)O_(3)heterojunction with high photoresponse

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InfoMat 2024年第2期6卷 118-130页

作者： Yifei Wang Zhenhua Lin Jingli Ma Yongyi Wu Haidong Yuan Dongsheng Cui Mengyang Kang XingGuo Jie Su Jinshui Miao Zhifeng shi Tao Li Jincheng Zhang Yue hao Jingjing Chang State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi'anthe People's Republic of China School of Physics and Microelectronics Key Laboratory of Material PhysicsMinistry of EducationZhengzhou UniversityZhengzhouthe People's Republic of China Center for Spintronics and Quantum Systems State Key Laboratory for Mechanical Behavior of MaterialsDepartment of Materials Science and EngineeringXi'an Jiaotong UniversityXi'anthe People's Republic of China Advanced Interdisciplinary Research Center for Flexible Electronics Xidian UniversityXi'anthe People's Republic of China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghaithe People's Republic of China

Solar-blind ultraviolet(UV)photodetectors based on p-organic/n-Ga_(2)O_(3) hybrid heterojunctions have attracted extensive attention ***,the multifunctional solar-blind photodetector based on p-type poly[N-90-heptadecanyl-2,7-carbazole-alt-5,5-(40,70-di-2-thienyl-20,10,30-benzothiadiazole)](PCDTBT)/n-type amorphous Ga_(2)O_(3)(a-Ga_(2)O_(3))is fabricated and investigated,which can work in the phototransistor mode coupling with self-powered *** the introduction of PCDTBT,the dark current of such the a-Ga_(2)O_(3)-based photodetector is decreased to 0.48 ***,the photoresponse parameters of the a-Ga_(2)O_(3)-based photodetector in the phototransistor mode to solar-blind UV light are further increased,that is,responsivity(R),photo-detectivity(D*),and external quantum efficiency(EQE)enhanced to 187 A W^(-1),1.3×10^(16) Jones and 9.1×10^(4)% under the weak light intensity of 11μW cm^(-2),*** to the formation of the built-in field in the p-PCDTBT/n-Ga_(2)O_(3) type-Ⅱ heterojunction,the PCDTBT/Ga_(2)O_(3) multifunctional photodetector shows self-powered *** responsivity of p-PCDTBT/n-Ga_(2)O_(3) multifunctional photodetector is 57.5 mA W^(-1) at zero *** multifunctional p-n hybrid heterojunction-based photodetectors set the stage for realizing high-performance amorphous Ga_(2)O_(3) heterojunction-based photodetectors.

关键词： amorphous Ga_(2)O_(3) heterojunction multifunctional PCDTBT solar-blind photodetectors

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IR-YOLO: Real-Time Infrared Vehicle and Pedestrian Detection

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Computers, Materials & Continua 2024年第2期78卷 2667-2687页

作者： Xiao Luo hao Zhu Zhenli Zhang Department of Electrical Engineering and Automation Jiangxi University of Science and TechnologyGanzhou341000China Jiangxi Provincial Key Laboratory of Maglev Technology Ganzhou341000China Graduate School of Information Production and SystemsWaseda UniversityKitakyushu-shiFukuoka808-0135Japan

Road traffic safety can decrease when drivers drive in a low-visibility *** application of visual perception technology to detect vehicles and pedestrians in infrared images proves to be an effective means of reducing the risk of *** tackle the challenges posed by the low recognition accuracy and the substan-tial computational burden associated with current infrared pedestrian-vehicle detection methods,an infrared pedestrian-vehicle detection method A proposal is presented,based on an enhanced version of You Only Look Once version 5(YOLOv5).First,A head specifically designed for detecting small targets has been integrated into the model to make full use of shallow feature information to enhance the accuracy in detecting small ***,the Focal Generalized Intersection over Union(GIoU)is employed as an alternative to the original loss function to address issues related to target overlap and category ***,the distribution shift convolution optimization feature extraction operator is used to alleviate the computational burden of the model without significantly compromising detection *** test results of the improved algorithm show that its average accuracy(mAP)reaches 90.1%.Specifically,the Giga Floating Point Operations Per second(GFLOPs)of the improved algorithm is only *** contrast,the improved algorithms outperformed the other algorithms on similar GFLOPs,such as YOLOv6n(11.9),YOLOv8n(8.7),YOLOv7t(13.2)and YOLOv5s(16.0).The mAPs that are 4.4%,3%,3.5%,and 1.7%greater than those of these algorithms show that the improved algorithm achieves higher accuracy in target detection tasks under similar computational resource *** the other hand,compared with other algorithms such as YOLOv8l(91.1%),YOLOv6l(89.5%),YOLOv7(90.8%),and YOLOv3(90.1%),the improved algorithm needs only 5.5%,2.3%,8.6%,and 2.3%,respectively,of the *** improved algorithm has shown significant advancements in balancing accuracy and computati

关键词： Traffic safety infrared image pedestrians and vehicles focal GIoU distributed shift convolution

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NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 153-164页

作者： Bo shi Cheng-Jie Lyu Zhen-Kai Le hao-Sen Ji Yi Xiao Yuan-Yuan Zhang Shou-Jiang Huang Lin-Jun Yu Qiang Shu Jin-Fa Tou Deng-Ming Lai Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Thoracic and Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Background Macrophages are involved in various immune inflammatory disease *** study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis(NEC).Methods CD68,nucleotide-binding oligomerization domain,leucine-rich repeat,and pyrin domain-containing 3(NLRP3),cysteine aspartate-specific protease-1(caspase-1),and interleukin-1β(IL-1β)in paraffin sections of intestinal tissues from NEC and control patients were detected with immunohistochemistry,immunofluorescence,and western *** pet milk,hypoxia and cold stimulation were used to establish a mouse(wild type and Nlrp3^(-/-))model of *** mouse macrophage(RAW 264.7)and rat intestinal epithelial cell-6 lines were also cultured followed by various ***,intestinal epithelial cell injuries,and IL-1β release were *** Compared to the gut“healthy”patients,the intestinal lamina propria of NEC patients had high macrophage infiltration and high NLRP3,caspase-1,and IL-1β ***,in vivo,the survival rate of Nlrp3^(-/-)NEC mice was dramatically improved,the proportion of intestinal macrophages was reduced,and intestinal injury was decreased compared to those of wild-type NEC ***3,caspase-1,and IL-1β derived from macrophages or supernatant from cocultures of macrophages and intestinal epithelial cells also caused intestinal epithelial cell *** Macrophage activation may be essential for NEC ***3/caspase-1/IL-1β cellular signals derived from macrophages may be the underlying mechanism of NEC development,and all these may be therapeutic targets for developing treatments for NEC.

关键词： Caspase-1 Interleukin-1β Macrophage Necrotizing enterocolitis NLRP3

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Study on the long period ordered（LPO）phase in the Mg-TM（TM=Cu,Ni,Zn）-Y systems

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材料与冶金学报 2010年第4期9卷 282-284页

作者： JIANG Min ZHANG Jun-feng LI hong-xiao hao shi-ming School of Materials and Metallurgy Northeastern University Shenyang 110004 China

In this work, a systemic study has been performed to the Mg-TM(TM=Cu, Ni, Zn)-Y alloys. It has been proved that a long period ordered (LPO) phase is stable in all these systems with limited solubility ranges of Cu, Ni, Zn and Y. The equilibrium composition of the LPO phase has been determined accurately, and the phase relationships concerning the LPO phase have been established. Based on this, ideal n(TM)/n(Y) ratios for getting the LPO phase have been obtained, which are important for the composition design of the LPO Mg-based alloys.

关键词： long period ordered phase phase equilibrium Mg-TM-RE

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Association between composite dietary antioxidant index and stroke among individuals with diabetes

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World Journal of Diabetes 2024年第8期15卷 1742-1752页

作者： hong-Qiang Zhang Jie shi Tong Yue Jia-hao Weng Xu-Lin Wang hao Wang Xiao-Yu Su Xue-Ying Zheng Si-Hui Luo Yu Ding Chao-Fan Wang Department of Cardiology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of DiabetologyGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and *** composite dietary antioxidant index(CDAI),which reflects the overall intake of key dietary antioxidants,has been identified as a crucial metric for exploring this *** previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals,there remains a substantial gap in understanding this association among individuals with diabetes,who are at an inherently greater risk for cerebrovascular *** To investigate the association between CDAI and stroke risk in individuals with *** Using a cross-sectional study design,this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with *** CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants:Vitamins A,C,and E;carotenoids;selenium;and *** logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke *** The participant cohort,with an average age of 59.5 years and a slight male majority,reflected the broader demographic characteristics of individuals with *** analysis revealed a strong inverse relationship between CDAI levels and stroke ***,those in the highest quintile of CDAI demonstrated a 43%lower prevalence of stroke compared to those in the lowest quintile,even after adjustments for various *** finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with *** Our findings suggested that CDAI was inversely associated with stroke prevalence among pa

关键词： Stroke Diabetes Composite dietary antioxidant index National Health and Nutrition Examination Survey Crosssectional study

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Omental fibroma combined with right indirect inguinal hernia masquerades as a scrotal tumor: A case report

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World Journal of Clinical Cases 2024年第5期12卷 988-994页

作者： Ping Zhou Chan-Hui Jin Ying shi Guo-Qing Ma Wen-hao Wu Yu Wang Kun Cai Wu-Feng Fan Tian-Bao Wang Department of Gastrointestinal Surgery South China Hospital of Shenzhen UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND The most common causes of scrotal enlargement in patients include primary tumor of the scrotum,inflammation,hydrocele of the tunica vaginalis,and indirect inguinal hernia;scrotal enlargement caused by external tumors of the scrotum is *** patient had both a greater omentum tumor and an inguinal hernia,and the tumor protruded into the scrotum through the hernia sac,which is even ***,omental tumors are mostly metastatic,and primary omental fibroma is *** SUMMARY Here,we report a rare case of a 25-year-old young man with scrotal enlargement and pain for 3 *** examination and multidisciplinary discu-ssions considered intra-abdominal tumor displacement and inguinal hernia,and intraoperative exploration confirmed that the greater omentum tumor protruded into the ***,tumor resection and tension-free inguinal hernia repair were *** final diagnosis was benign fibroma of the greater omentum accompanied by an indirect inguinal *** This unusual presentation of a common inguinal hernia disease illustrates the necessity of performing detailed history taking,physical examination,and imaging before surgery.

关键词： Hernia Indirect inguinal hernia Fibroma Omental tumor Scrotal tumor Greater omentum Case report

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“Hepatic hilum area priority,liver posterior first”:An optimized strategy in laparoscopic resection for type Ⅲ-Ⅳ hilar cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2167-2174页

作者： Xiao-Si Hu Yong Wang hong-Tao Pan Chao Zhu shi-Lei Chen Shuai Zhou Hui-Chun Liu Qing Pang hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People's HospitalHefei 230041Anhui ProvinceChina

BACKGROUND In recent years,pure laparoscopic radical surgery for Bismuth-Corlette type Ⅲ and Ⅳ hilar cholangiocarcinoma(HCCA)has been preliminarily explored and applied,but the surgical strategy and safety are still worthy of further improvement and *** To summarize and share the application experience of the emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”in pure laparoscopic radical resection for patients with HCCA of Bismuth-Corlette types Ⅲ and *** The clinical data and surgical videos of 6 patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ who underwent pure laparoscopic radical resection in our department from December 2021 to December 2023 were retrospectively *** Among the 6 patients,4 were males and 2 were *** average age was 62.2±11.0 years,and the median body mass index was 20.7(19.2-24.1)kg/m^(2).The preoperative median total bilirubin was 57.7(16.0-155.7)μmol/*** patient had Bismuth-Corlette type Ⅲa,4 patients had Bismuth-Corlette type Ⅲb,and 1 patient had Bismuth-Corlette type Ⅳ.All patients successfully underwent pure laparoscopic radical resection following the strategy of“hepatic hilum area dissection priority,liver posterior separation first”.The operation time was 358.3±85.0 minutes,and the intraoperative blood loss volume was 195.0±108.4 *** of the patients received blood transfusions during the perioperative *** median length of stay was 8.3(7.0-10.0)*** bile leakage occurred in 2 patients,and all patients were discharged without serious surgery-related *** The emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”is safe and feasible in pure laparoscopic radical surgery for patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ.This strategy is helpful for promoting the modularization and process of pure laparoscopic radical surgery for complicated HCCA,shortens the learning curve,and

关键词： Hilar cholangiocarcinoma Bismuth-Corlette types Ⅲ and Ⅳ Laparoscopy Radical resection Strategy

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Geological conditions and reservoir characteristics of various shales in major shalehosted regions of China

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China Geology 2024年第1期7卷 138-149页

作者： Shu-jing Bao Tian-xu Guo Jin-tao Yin Wei-bin Liu Sheng-jian Wang hao-han Li Zhi Zhou shi-zhen Li Xiang-lin Chen The Key Laboratory of Unconventional Petroleum Geology China Geological SurveyMinistry of Natural Resources100083 BeijingChina Oil and Gas Survey China Geological Survey100083 BeijingChina Research Institute of Yanchang Petroleum(Group)CO.LTD 710076 Xi’anChina

China is home to shales of three facies:Marine shale,continental shale,and marine-continental transitional *** types of shale gas are associated with significantly different formation conditions and major controlling *** study compared the geological characteristics of various shales and analyzed the influences of different parameters on the formation and accumulation of shale *** general,shales in China’s several regions exhibit high total organic carbon(TOC)contents,which lays a sound material basis for shale gas *** strata generally show high degrees of thermal *** contrast,continental shales manifest low degrees of thermal evolution,necessitating focusing on areas with relatively high degrees of thermal evolution in the process of shale gas surveys for these *** shales of the Wufeng and Silurian formations constitute the most favorable shale gas reservoirs since they exhibit the highest porosity among the three types of *** shales are followed by those in the Niutitang and Longtan *** contrast,the shales of the Doushantuo,Yanchang,and Qingshankou formations manifest low ***,the shales of the Wufeng and Longmaxi formations exhibit high brittle mineral *** a low siliceous mineral content,the shales of the Doushantuo Formation feature a high carbonate mineral content,which can increase the shales’brittleness to some *** marine-continental transitional shales,where thin interbeds of tight sandstone with unequal thicknesses are generally found,it is recommended that fracturing combined with drainage of multiple sets of lithologic strata should be employed to enhance their shale gas production.

关键词： Shale gas Marine shale Continental shale Marine-continental transitional shale Neoproterozoic-Cretaceous strata Geological conditions Reservoir characteristics Petroleum geological survey engineering

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