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Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4014-4027页

作者： li Wang Zhe Zhang hai-Zhang Ma Department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Emergency Medicine The First People’s Hospital of Linping District HangzhouHangzhou 311100Zhejiang ProvinceChina Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)is a lethal malignancy with limited treatment options and poor *** PEA3 subfamily of E26 transformation specific genes:ETV1,ETV4,and ETV5 are known to play significant roles in various cancers by influencing cell proliferation,invasion,and *** To analyze PEA3 subfamily gene expression levels in CCA and their correlation with clinical parameters to determine their prognostic value for *** The expression levels of PEA3 subfamily genes in pan-cancer and CCA data in the cancer genome atlas and genotype-tissue expression project databases were analyzed with R language *** curve and receiver operating characteristic analyses were performed using the SurvMiner,Survival,and Procr language *** gene expression profiling interactive analysis 2.0 database was used to analyze the expression levels of PEA3 subfamily genes in different subtypes and stages of *** Gestalt was used to perform the gene ontology/Kyoto encyclopedia of genes and genomes(GO/KEGG)analysis,and STRING database analysis was used to determine the genes and proteins related to PEA3 subfamily *** ETV1,ETV4,and ETV5 expression levels were significantly increased in *** were significant differences in ETV1,ETV4,and ETV5 expression levels among the different subtypes of CCA,and predictive analysis revealed that only high ETV1 and ETV4 expression levels were significantly associated with shorter overall survival in patients with ***/KEGG analysis revealed that PEA3 subfamily genes were closely related to transcriptional misregulation in *** vitro and in vivo experiments revealed that PEA3 silencing inhibited the invasion and metastasis of CCA *** The expression level of ETV4 may be a predictive biomarker of survival in patients with CCA.

关键词： PEA3 subfamily Cholangiocarcinoma The cancer genome atlas ETV4 The prognosis Prognostic biomarker

Computed tomography-based radiomics combined with machine learning allows differentiation between primary intestinal lymphoma and Crohn's disease

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World Journal of Gastroenterology 2024年第25期30卷 3155-3165页

作者： Meng-Jun Xiao Yu-Teng Pan Jia-He Tan hai-Ou li hai-Yan Wang Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250000Shandong ProvinceChina University of California DavisCA 95616United States Qilu Hospital Cheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Due to similar clinical manifestations and imaging signs,differential diagnosis of primary intestinal lymphoma(PIL)and Crohn's disease(CD)is a challenge in clinical *** To investigate the ability of radiomics combined with machine learning methods to differentiate PIL from *** We collected contrast-enhanced computed tomography(CECT)and clinical data from 120 patients form center 1.A total of 944 features were extracted singlephase images of CECT *** the last absolute shrinkage and selection operator model,the best predictive radiographic features and clinical indications were *** from 54 patients were collected at center 2 as an external validation set to verify the robustness of the *** area under the receiver operating characteristic curve,accuracy,sensitivity and specificity were used for *** A total of five machine learning models were built to distinguish PIL from *** on the results from the test group,most models performed well with a large area under the curve(AUC)(>0.850)and high accuracy(>0.900).The combined clinical and radiomics model(AUC=1.000,accuracy=1.000)was the best model among all *** Based on machine learning,a model combining clinical data with radiologic features was constructed that can effectively differentiate PIL from CD.

关键词： Primary intestinal lymphoma Crohn's disease Radiomics Machine learning Diagnosis

A giant Ce-containing poly(tungstobismuthate): Synthesis, structure and catalytic performance for the decontamination of a sulfur mustard simulant

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Chinese Chemical Letters 2024年第10期35卷 465-468页

作者： Chen lian Si-Han Zhao hai-Lou li Xinhua Cao College of Chemistry and Chemical Engineering Xinyang Normal UniversityXinyang 464000China MOE Key Laboratory of Cluster Science School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 102488China

A novel Ce-containing poly(tungstobismuthate)Cs18Na8H_(2)0[Ce3(H_(2)O)10W8Bi4O_(2)8(B-α-Bi W9O_(3)3)4]2·64H_(2)O(1)has been synthesized by a facile one-pot self-assembly reaction *** structural characterization is realized by virtue of single-crystal X-ray diffraction,infrared spectroscopy,powder X-ray diffraction and thermogravimetric *** polyoxoanion of 1 is an octameric architecture consisting of two tetrameric entities[Ce3(H_(2)O)10W8Bi4O_(2)8(B-α-Bi W9O_(3)3)4]23-linked by two Ce–O–W bonds,and adjacent polyoxoanions are further combined together by means of Ce3+linkers,resulting in an infinite 1D chain *** 1 is the currently largest tungstobismuthate,and also represents the first example of lanthanide-encapsulated tungstobismuthate exhibiting an extended ***,compound 1 as a heterogeneous catalyst,exhibits high activity for the oxidative decontamination of a sulfur mustard simulant,2-chloroethyl ethyl sulfide(CEES)into 2-chloroethyl ethyl sulfoxide(CEESO).

关键词： Polyoxometalates Tungstobismuthate Cluster Lanthanide Oxidation

Consensus on glycemic management for patients with coronary heart disease and type 2 diabetes

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Journal of Geriatric Cardiology 2024年第7期21卷 689-702页

作者： li-Nong JI Yun-Dai CHEN Jing liU Xiang-hai ZHOU Cardiovascular Subcommittee of Chinese International Exchange and Promotion Association for Medical and Healthcare Peking University People's Hospital Chinese PLA General Hospital

The prevalence of patients with coronary heart disease(CHD)and diabetes mellitus is notably high,posing sig-nificant residual cardiovascular risks even after routine interventions such as antihypertensive,lipid-lowering,and antithrombot-ic *** studies have demonstrated that certain glucose-lowering medications confer cardiovascular benefits for pa-tients with type 2 ***,a survey indicates that cardiologists may not be fully acquainted with the optimal screen-ing timing,indicators,and diagnostic criteria for type 2 diabetes,and there is insufficient awareness and a low rate of prescrip-tion of novel glucose-lowering medications with proven cardiovascular efficacy,such as glucagon-like peptide-1 receptor agon-ists(GLP-1 RAs)and sodium-glucose co-transporter-2 inhibitors(SGLT-2i).In this context,based on domestic and international guidelines or consensus and the latest evidence-based evidence,this consensus aims to standardize the glycemic management for patients with acute coronary syndrome,chronic coronary syndrome,and perioperative management for percutaneous coronary *** highlights the key points of screening and diagnosis of type 2 diabetes,and the comprehensive management of cardiovascular risk in patients with *** consensus elaborates on the principles and algorithms of glycemic management for CHD patients,without involving acute complications of diabetes,clarifies the clinical practice of glucose-lowering medications with cardiovascular benefits,and promotes the standardized use of these medications in cardiovascular and other related spe-cialty ***,it addresses the glucose-lowering treatment to comprehensively reduce cardiovascular risks.

关键词： coronary patients routine

Precise control of page cache for containers

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Frontiers of Computer Science 2024年第2期18卷 17-30页

作者： Kun WANG Song WU Shengbang li Zhuo HUANG Hao FAN Chen YU hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Container-based virtualization isbecoming increasingly popular in cloud computing due to its efficiency and *** isolation is a fundamental property of *** works have indicated weak resource isolation could cause significant performance degradation for containerized applications and enhanced resource ***,current studies have almost not discussed the isolation problems of page cache which is a key resource for *** leverage memory cgroup to control page cache ***,existing policy introduces two major problems in a container-based ***,containers can utilize more memory than limited by their cgroup,effectively breaking memory ***,the Os kernel has to evict page cache to make space for newly-arrived memory requests,slowing down containerized *** paper performs an empirical study of these problems and demonstrates the performance impacts on containerized *** we propose pCache(precise control of page cache)to address the problems by dividing page cache into private and shared and controlling both kinds of page cache separately and *** do so,pCache leverages two new technologies:fair account(f-account)and evict on demand(EoD).F-account splits the shared page cache charging based on per-container share to prevent containers from using memory for free,enhancing memory *** EoD reduces unnecessary page cache evictions to avoid the performance *** evaluation results demonstrate that our system can effectively enhance memory isolation for containers and achieve substantial performance improvement over the original page cache management policy.

关键词： page cache memory cgroup container isolation cloud computing

High-temperature wetting behavior between slag and refractory

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Journal of Iron and Steel Research International 2024年第6期31卷 1304-1319页

作者： Yong-xin Wang Ya-ge li Ya-bo Gao Zhong Huang hai-jun Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Slag corrosion is one of the main factors of the damage of refractory,and its primary manifestations involve the melting of refractory in slag and the slag penetration into refractory,both of which are highly related to the wetting behavior between slag and *** high-temperature wettability could be characterized by parameters including the surface tension,adhesion work,and spreading coefficient of the slag on refractory surface,and it could be suppressed by altering the slag/refractory interface,thus resulting in an improved anti-corrosion *** this,the key knowledges of the slag corrosion,theory of wetting behavior and test of high-temperature contact angle were firstly ***,the major factors influencing the high-temperature slag wetting behavior were discussed based on the aspects of slag composition,refractory composition,and surface ***,the future research direction was proposed in this field.

关键词： High-temperature wetting Refractory Slag corrosion Surface tension

Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial

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Neural Regeneration Research 2024年第4期19卷 923-928页

作者： Xiangjun li Chunyan li hai Huang Dan Bai Jingyi Wang Anqi Chen Yu Gong Ying Leng Department of Ophthalmology Affiliated Hospital of Beihua University Department of Endocrinology Affiliated Hospital of Beihua University

The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting *** major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser ***,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many *** might result from the incomplete recovery of retinal ganglion cell ***,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision *** this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their *** patients will be followed up for 12 *** primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after *** secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after *** measure is the incidence of adverse events at 1,3,6,9,and 12 months after *** study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up *** trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal

关键词： choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity

Planning and construction of Xiong’an New Area(city of over 5 million people):Contributions of China’s geologists and urban geology

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China Geology 2024年第3期7卷 382-408页

作者： Bo Han Zhen Ma liang-jun lin hong-wei liu Yi-hang Gao Yu-bo Xia hai-tao li Xu Guo Feng Ma Yu-shan Wang Ya-long Zhou hong-qiang li Tianjin Center China Geological Survey(North China Center of Geoscience Innovation)Ministry of Natural ResourcesTianjin 300170China Xiong’an Urban Geological Research Center China Geological SurveyMinistry of Natural ResourcesTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China China Institute of Geo-Environment Monitoring Beijing 100081China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Center for Hydrogeology and Environmental Geology China Geological SurveyMinistry of Natural ResourcesBaoding 071051China Institute of Geophysical&Geochemical Exploration Chinese Academy of Geological SciencesLangfang 065000China Chinese Academy of Geological Sciences Beijing 10037China

China established Xiong’an New Area in Hebei Province in 2017,which is planned to accommodate about 5 million people,aiming to relieve Beijing City of the functions non-essential to its role as China’s capital and to expedite the coordinated development of the Beijing-Tianjin-Hebei *** 2017 to 2021,the China Geological Survey(CGS)took the lead in multi-factor urban geological surveys involving space,resources,environments,and disasters according to the general requirements of“global vision,international standards,distinctive Chinese features,and future-oriented goals”in Xiong’an New Area,identifying the engineering geologic conditions and geologic environmental challenges of this *** achievements also include a 3D engineering geological structure model for the whole area,along with“one city proper and five clusters”,insights into the ecology and the background endowment of natural resources like land,geothermal resources,groundwater,and wetland of the area before engineering construction,a comprehensive monitoring network of resources and environments in the area,and the“Transparent Xiong’an”geological information platform that is open,shared,dynamically updated,and three-dimensionally ***’s geologists and urban geology have played a significant role in the urban planning and construction of Xiong’an New Area,providing whole-process geological solutions for urban planning,construction,operation and *** future urban construction of Xiong’an New Area will necessitate the theoretical and technical support of earth system science(ESS)from various aspects,and the purpose is to enhance the resilience of the new type of city and to provide support for the green,low-carbon,and sustainable development of this area.

关键词： Low Carbon New City Planning and construction Land Geothermal resources Groundwater Wetland Underground space Geologic disasters Site stability Natural resource Ecosystem Geological safety Transparent Xiong’an Resilient city Xiong’an New Area

Layered oxide cathodes for sodium-ion batteries:microstructure design,local chemistry and structural unit

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Science China Chemistry 2024年第1期67卷 191-213页

作者： ling-Yi Kong Han-Xiao liu Yan-Fang Zhu Jia-Yang li Yu Su hong-Wei li hai-Yan Hu Yi-Feng liu Ming-Jing Yang Zhuang-Chun Jian Xin-Bei Jia Shu-Lei Chou Yao Xiao Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Because of the low price and abundant reserves of sodium compared with lithium,the research of sodium-ion batteries(SIBs)in the field of large-scale energy storage has returned to the research *** oxides distinguish themselves from the mains cathode materials of SIBs owing to their advantages such as high specific capacity,simple synthesis route,and environmental ***,the commercial development of the layered oxides is limited by sluggish kinetics,complex phase transition and poor air *** on the research ideas from macro-to micro-scale,this review systematically summarizes the current optimization strategies of sodium-ion layered oxide cathodes(SLOC)from different dimensions:microstructure design,local chemistry regulation and structural unit *** the dimension of microstructure design,the various structures such as the microspheres,nanoplates,nanowires and exposed active facets are prepared to improve the slow kinetics and electrochemical ***,from the view of local chemistry regulation by chemical element substitution,the intrinsic electron/ion properties of SLOC have been enhanced to strengthen the structural ***,the optimization idea of endeavors to regulate the physical and chemical properties of cathode materials essentially is put forward from the dimension of structural unit *** opinions and strategies proposed in this review will provide some inspirations for the design of new SLOC in the future.

关键词： sodium-ion batteries layered oxide cathodes microstructure design local chemistry structural unit