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低剂量放疗缓解骨关节炎

生物化学与生物物理进展 2024年第6期51卷 1382-1392页

作者：马国榕杨永泽孟欣高玉婷李树直郭洪章金晓东甘肃中医药大学第一临床医学院兰州730000 中国科学院近代物理研究所兰州730030 甘肃省人民医院骨科兰州730099 西安交通大学第二附属医院急诊科西安710004 西北师范大学生命科学学院兰州730070

骨关节炎(osteoarthritis,OA)是一种慢性退行性关节疾病,也是最常见的关节炎类型,几乎涉及任何关节,可导致患者慢性疼痛和残疾。19世纪末期伦琴发现了X射线,到20世纪80年代Luckey认为低水平辐射(LDRT)对生物可能有益,逐步应用于一些疾... 详细信息

骨关节炎(osteoarthritis,OA)是一种慢性退行性关节疾病,也是最常见的关节炎类型,几乎涉及任何关节,可导致患者慢性疼痛和残疾。19世纪末期伦琴发现了X射线,到20世纪80年代Luckey认为低水平辐射(LDRT)对生物可能有益,逐步应用于一些疾病的治疗,但目前LDRT的运用并未得到普及。本文介绍了OA的流行病学、危险因素、临床表现、治疗方法以及发病机制,重点讨论了LDRT缓解OA的可能机制以及临床研究进展,还探讨了LDRT治疗OA引起的不良反应(急性反应和致癌风险)。在临床上,LDRT本身具有非侵入性、不良反应较小等优势,在治疗OA展现出疼痛缓解、运动改善等疗效,因此LDRT在治疗OA中有广阔的应用前景。

关键词：低剂量放疗骨关节炎炎症抑制临床研究不良反应

Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China

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World Journal of Gastroenterology 2010年第47期16卷 6020-6025页

作者： guo-hong zhang Bo Huang Rui-Qin Mai Department of Pathology Medical College of Shantou University Shantou 515031 Guangdong Province China Department of Laboratory Medicine the FirstAfliated HospitalMedical CollegeShantou UniversityShantou 515041Guangdong ProvinceChina

AIM: To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population. METHODS: Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 controls were included for meta-analysis. Stratified analyses were carried out to determine the genealcohol and gene-gene interaction with ESCC risk. Potential sources of heterogeneity between studies were explored, and publication bias was also evaluated. RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence in- terval (CI): 2.76-5.67]. Signif icant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00,95% CI: 1.54-2.61]. Compared with the non-alcoholics, Arg/Arg (OR = 25.20, 95% CI: 10.87-53.44) and Glu/ Lys + Lys/Lys (OR = 21.47, 95% CI: 6.44-71.59) were found to interact with alcohol drinking to increase the ESCC risk. ADH1B Arg+ and ALDH2 Lys+ had a higher risk for ESCC (OR = 7.09, 95% CI: 2.16-23.33). CONCLUSION: The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption. The individuals carrying both risky genotypes have a higher baseline risk of ESCC.

关键词： Esophageal cancer Alcohol metabolizing enzyme genes Polymorphism Susceptibility

Evolution of Hydrogen Storage Alloys Prepared by Special Methods

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Journal of Rare Earths 2004年第Z1期22卷 222-227页

作者： guo hong zhang Ximin Jing Hai Li Chengdong Xu Jun National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China

Microstructure characteristics and electrochemical properties of hydrogen storage alloys prepared by gas atomization, melt spinning and strip casting respectively were *** advantages, disadvantages and research development of the above methods for preparing hydrogen storage alloys were *** strip casting is a new special means for preparing AB5 rare earth hydrogen storage alloys of high performance and low cost, and the study of the strip casting for preparing hydrogen storage alloys is presented specially.

关键词： hydrogen storage alloys gas atomization melt spinning strip casting rare earths

Micromagnetism simulation on effects of soft phase size on Nd2Fe14B/α-Fe nanocomposite magnet with soft phase imbedded in hard phase

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Chinese Physics B 2018年第8期27卷 529-534页

作者： Yu-Qing Li Ming Yue Yi Pen hong-guo zhang College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China

In this study, micromagnetism simulation by using timte dltterence method is cameo out on the Ncl21-el415/a-Fe nanocomposite magnet with soft phase imbedded in hard phase. The effects of soft magnetic phase size （S） on the magnetic properties and magnetic reversal modes are systematically analyzed. As S increases from 1 nm to 48 nm, the remanence （Jr） increases, while the coercivity （Hci） decreases, leading to the result that the magnetic energy prod- uct [（BH）max] first increases slowly, and then decreases rapidly, peaking at S = 24 nm with the （BH）max of 72.9 MGOe （1 MGOe = 7.95775 kJ.m-3）. Besides, with the increase of S, the coercivity mechanism of the nanocomposite magnet changes from nucleation to pinning. Furthermore, by observing the magnetic moment evolution in demagnetization pro- cess, the magnetic reversal of the soft phase in the nanocomposite magnet can be divided into three modes with the increase of S： coherent rotation （S 〈 3 nm）, quasi-coherent rotation （3 nm≤S 〈 36 nm）, and the vortex-like rotation （S ≥36 nm）.

关键词： micromagnetism simulation magnetization dynamics, Nd2Fe14B/a-Fe nanocomposite magnets

Growth Kinetics of Proeutectoid Ferrite in an Fe-0.09C-1.5Mn-0.2Si Steel

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Journal of Iron and Steel Research International 2014年第10期21卷 964-968页

作者： Lin CHENG Kai-ming WU Xiang-liang WAN guo-hong zhang The State Key Laboratory of Refractories and Metallurgy Hubei Collaborative Innovation Center for Advanced SteelsInternational Research Institute for Steel TechnologyWuhan University of Science and Technology

Growth kinetics of proeutectoid ferrite, including grain boundary face nucleated ferrite, grain boundary edge nucleated ferrite allotriomorph and intragranular ferrite idiomorph, were experimentally measured in an Fe- 0.09C-1.5Mn-0.2Si steel and compared with theoretical calculation in local equilibrium and paraequilibrium modes. Grain boundary edge nucleated ferrite exhibited larger growth rate than grain boundary face nucleated ferrite and in- tragranular ferrite idiomorph. Experimental kinetics of proeutectoid ferrite was within the window defined by the lo- cal equilibrium and paraequilibrium limits. A transition of growth kinetics from paraequilibrium to local equilibrium was observed in the temperature range of 650--750 ℃, which can be explained in terms of solute drag.

关键词： steel proeutectoid ferrite kinetics solute drag

Density functional theory study of B- and Si-doped carbons and their adsorption interactions with sulfur compounds

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Carbon Energy 2024年第2期6卷 195-208页

作者： Peng guo hong zhang Shuliang Dong Libao An College of Mechanical Engineering North China University of Science and TechnologyTangshanHebeiChina College of Life Sciences North China University of Science and TechnologyTangshanHebeiChina

Understanding the adsorption interactions between carbon materials and sulfur compounds has far-reaching impacts,in addition to their well-known important role in energy storage and conversion,such as lithium-ion *** this paper,properties of intrinsic B or Si single-atom doped,and B-Si codoped graphene(GR)and graphdiyne(GDY)were investigated by using density functional theory-based calculations,in which the optimal doping configurations were explored for potential applications in adsorbing sulfur *** showed that both B or Si single-atom doping and B-Si codoping could substantially enhance the electron transport properties of GR and GDY,improving their surface ***,B and Si atoms displayed synergistic effects for the codoped configurations,where B-Si codoped GR/GDY exhibited much better performance in the adsorption of sulfurcontaining chemicals than single-atom doped *** addition,results demonstrated that,after B-Si codoping,the adsorption energy and charge transfer amounts of GDY with sulfur compounds were much larger than those of GR,indicating that B-Si codoped GDY might be a favorable material for more effectively interacting with sulfur reagents.

关键词： adsorption density functional theory doping graphdiyne graphene sulfur compounds

Construction of recombinant industrial Saccharomyces cerevisiae strain with bglS gene insertion into PEP4 locus by homologous recombination

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第7期9卷 527-535页

作者： Qiang zhang Qi-he CHEN Ming-liang FU Jin-ling WANG hong-bo zhang guo-qing HE Department of Food Science and Nutrition Zhejiang University Hangzhou 310029 China

The bglS gene encoding endo-1,3-1,4-β-glucanase from Bacillus subtil＆ was cloned and sequenced in this study. The bglS expression cassette, including PGK1 promoter, bglS gene fused to the signal sequence of the yeast mating pheromone a-factor （MFals）, and ADH1 terminator with G418-resistance as the selected marker, was constructed. Then one of the PEP4 allele of Saccharomyces cerevisiae WZ65 strain was replaced by bglS expression cassette using chromosomal integration of polymerase chain reaction （PCR）-mediated homologous recombination, and the bglS gene was expressed simultaneously. The recombinant strain S. cerevisiae （SC-βG） was preliminarily screened by the clearing hydrolysis zone formed after the barley β-glucan was hydrolyzed in the plate and no proteinase A （PrA） activity was measured in fermenting liquor. The results of PCR analysis of genome DNA showed that one of the PEP4 allele had been replaced and bglS gene had been inserted into the locus of PEP4 gene in recombinant strains. Different endo-1,3-1,4-β-glucanase assay methods showed that the recombinant strain SC-βG had high endo-1,3-1,4-β-glucanase expression level with the maximum of 69.3 U/（h·ml） after 60 h of incubation. Meanwhile, the Congo Red method was suitable for the determination of endo-1,3-1,4-β-glucanase activity during the actual brewing process. The current research implies that the constructed yeast strain could be utilized to improve the industrial brewing property of beer.

关键词： Endo-1 3-1 4-β-glucanase (bglS) Gene replacement Homologous recombination Bacillus subtilis PEP4 gene Saccharomyces cerevisiae

Effect of 1,25-dihydroxyvitamin D3 on mast cells tryptase in asthmatic guinea pigs

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Asian Pacific Journal of Tropical Medicine 2015年第6期8卷 493-496页

作者： Xiao-He Zheng Gui-Dong zhang guo-hong zhang Rui-Qin Mai Ling Shen Department of Respiratory Medicine 1st Affiliated Hospital of Medical College of Shantou University

Objective:To explore the effect of 1,25-dihydroxyvitamin D3 on the mast cell tryptase(MCT) in asthmatic guinea ***:A total of 60 male or female healthy guinea pigs were randomly divided into control group(group A),asthmatic group(group B).and 1,25-dihydroxyvitamin D3 group(group C),with 20 cases in each *** establish asthmatic guinea pig models,1ml peanut oil was tilled into stomach in the morning in group A and group *** 1 ml peanut oil with 1,25-dihydroxyvitamin D3 was filled into stomach in group *** resistance(Re) of asthmatic guinea pigs was detected,and the bronchoalveolar lavage fluid(BALF) cells were *** tissue with HE and MCT immunohistochemical staining were used to observe the pathological changes in lung tissue and the distribution of ***:After injection of different concentration of acetylcholine chloride,the Re in group B and group C were increased significantly compared with group A(P<0.05):compared with group *** Re in group C were decreased significantly(t=-5.385.-5.761.-6.184.-13.574.P<0.05):the total number of BALF cells and eosinophils were increased significantly in group B and C(t=19.618.9.598.10.854.5.388.P<0.05);compared with group *** total number of BALF cells and eosinophils in group C was decreased significantly(t=-5.555.-5.392.P<0.05):the number of tryptase positive cells in group B was increased significantly than that in group A(t=21.312,P<0.05),and in addition to the alveolar septum and submucosa,the cells were also distributed around blood vessels and outside the cells:the number of tryptase positive cells in group C was decreased significantly compared with group *** the difference was statistically significant(t=5.043.P<0.05).Conclusions:After the asthmatic guinea pigs arc treated with 1,25-dihydroxyvitamin D3,their *** degree of inflammatory cells in the trachea and lung tissue and airway inflammatory reaction are reduced significantly.1,25-dihydroxyvitamin D3 has a cert

关键词： 1,25-dihydroxyvitamin D3 Asthmatic guinea pigs Expiratory airway resistance Mast cell tryptase

Associations of sex hormone levels with body mass index(BMI)in men:a cross-sectional study using quantile regression analysis

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Asian Journal of Andrology 2023年第1期25卷 98-102页

作者： Xin Lv Yu-Ting Jiang Xin-Yue zhang Lei-Lei Li hong-guo zhang Rui-Zhi Liu Center of Reproductive Medicine and Center of Prenatal Diagnosis The First Hospital of Jilin UniversityChangchun 130021China

Body mass index(BMI)has been increasing globally in recent *** studies reported that BMI was associated with sex hormone levels,but the results were generated via linear regression or logistic regression,which would lose part of *** regression analysis can maximize the use of variable *** study compared the associations among different regression *** participants were recruited from the Center of Reproductive Medicine,The First Hospital of Jilin University(Changchun,China)between June 2018 and June *** used linear,logistic,and quantile regression models to calculate the associations between sex hormone levels and *** total,448 men were included in this *** average BMI was 25.7(standard deviation[s.d.]:3.7)kg m^(-2);29.7%(n=133)of the participants were normal weight,45.3%(n=203)of the participants were overweight,and 23.4%(n=105)of the participants were *** levels of testosterone and estradiol significantly differed among BMI groups(all P<0.05).In linear regression and logistic regression,BMI was associated with testosterone and estradiol levels(both P<0.05).In quantile regression,BMI was negatively associated with testosterone levels in all quantiles after adjustment for age(all P<0.05).BMI was positively associated with estradiol levels in most quantiles(≤80^(th))after adjustment for age(all P<0.05).Our study suggested that BMI was one of the influencing factors of testosterone and *** note,the quantile regression showed that BMI was associated with estradiol only up to the 80^(th) percentile of estradiol.

关键词： body mass index estradiol obesity overweight testosterone