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Electroacupuncture-induced neuroprotection against focal cerebral ischemia in the rat is mediated by adenosine A1 receptors

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Neural Regeneration Research 2017年第2期12卷 228-234页

作者： Qin-xue Dai Wu-jun Geng Xiu-xiu Zhuang hong-fa wang Yun-chang Mo He Xin Jiang-fan Chen Jun-lu wang Department of Anesthesiology First Affiliated Hospital of Wenzhou Medical University Department of Neurology Boston University School of Medicine

The activation of adenosine A1 receptors is important for protecting against ischemic brain injury and pretreatment with electroacupuncture has been shown to mitigate ischemic brain insult. The aim of this study was to test whether the adenosine A1 receptor mediates electroacupuncture pretreatment-induced neuroprotection against ischemic brain injury. We first performed 30 minutes of electroacupuncture pretreatment at the Baihui acupoint（GV20）, delivered with a current of 1 mA, a frequency of 2/15 Hz, and a depth of 1 mm. High-performance liquid chromatography found that adenosine triphosphate and adenosine levels peaked in the cerebral cortex at 15 minutes and 120 minutes after electroacupuncture pretreatment, respectively. We further examined the effect of 15 or 120 minutes electroacupuncture treatment on ischemic brain injury in a rat middle cerebral artery-occlusion model. We found that at 24 hours reperfusion,120 minutes after electroacupuncture pretreatment, but not for 15 minutes, significantly reduced behavioral deficits and infarct volumes. Last, we demonstrated that the protective effect gained by 120 minutes after electroacupuncture treatment before ischemic injury was abolished by pretreatment with the A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine（1 mg/kg, intraperitoneally）. Our results suggest that pretreatment with electroacupuncture at the Baihui acupoint elicits protection against transient cerebral ischemia via action at adenosine A1 receptors.

关键词： nerve regeneration adenosine adenosine triphosphate adenosine A1 receptor cerebral ischemia electroacupuncture pretreatment 8-cyclopentyl-1 3-dipropylxanthine high-performance liquid chromatography neural regeneration

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ERG11 mutations associated with azole resistance in Candida albicans isolates from vulvovaginal candidosis patients

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Asian Pacific Journal of Tropical Biomedicine 2015年第11期5卷 909-914页

作者： Bin wang Li-Hua Huang Ji-Xue Zhao Man Wei Hua fang Dan-Yang wang hong-fa wang Ji-Gang Yin Mei Xiang The Second Hospital of Jilin University Key Lab of ZoonosisMinistry of Education The First Hospital of Jilin University Shandong Institute of Parasitic Diseases Key Lab of Zoonosis Ministry of EducationInstitute of ZoonosisJilin University

Objective: To investigate the azole susceptibility of Candida albicans(***)from vulvovaginal candidosis patients and to analyze the relationship between ERG11 gene mutations in these isolates and azole ***: Three hundred and two clinical isolates of Candida species were *** susceptibility was tested in vitro in microdilution studies. The ERG11 genes of 17 isolates of C. albicans(2 susceptibles, 5 dose-dependent resistants and 10 resistants) were amplified and ***: Of the 302 isolates collected, 70.2% were C. albicans, of which 8.5%, 3.8% and4.2% were resistant to fluconazole, itraconazole and voriconazole, respectively. In total,27 missense mutations were detected in ERG11 genes from resistant/susceptible dosedependent isolates. Among them, Y132 H, A114 S, and Y257 H substitutions were most prevalent and were known to cause fluconazole resistance. G464 S and F72 S also have been proved to cause fluconazole resistance. Two novel substitutions(T285A, S457P) in hotspot regions were ***: Twenty seven mutations in the ERG11 gene were identified in azoleresistant C. albicans isolates, which indicated a possible relation with the increase in resistance to azole drugs and the recurrence of vulvovaginal candidosis. The relationship of two novel substitutions(T285A, S457P) with fluconazole resistance needs to be further verified by site-directed mutagenesis.

关键词： Candida albicans Azoles resistance ERG11 gene Muta

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Biodiversity variability of macrobenthic in the Yellow Sea and East China Sea between 2001 and 2011

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Zoological Systematics 2014年第4期39卷 459-484页

作者： Xin-Zheng Li hong-fa wang Jin-Bao wang Dong Dong Lin Ma Qi Kou Ji-Xing Sui Zhi-Bin Gan Bao-Lin Zhang Institute of Oceanology Chinese Academy of Sciences

In this study, we compared the biodiversity and ecological status of macrobenthos between 2001 and 2011 in terms of species composition, dominant species, abundance, biomass, diversity, and secondary productivity of macrobenthos in the Yellow Sea and East China Sea. The results indicate that the species abundances, biomass, and diversity in spring 2011 were all lower than those in autumn 2000 and spring of 2001. Most of the dominant species have changed from 2001 to 2011, with the exception of the echinoderm Ophiura sarsii vadicola that was dominant in these years. Small-sized animal species have increased possibly due to gradual environment deterioration such as the pollution and the climate warmer.

关键词： Yellow Sea East China Sea macrobenthos ecology biodiversity secondary productivity

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Simulations of electron zebra stripes in the inner radiation belt using a composite empirical electric field model

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Science China Earth Sciences 2025年第1期68卷 27-38页

作者： Ziyang wang Ying LIU Qiugang ZONG hong ZOU Yuguang YE Xuzhi ZHOU Chao YUE Shan wang Institute of Space Physics and Applied Technology Peking University State Key Laboratory of Lunar and Planetary Science Macau University of Science and Technology

The phenomenon termed “zebra stripes” manifests as regular patterns in the energy-space(L shell) spectrum of energetic electrons(ranging from tens to hundreds ke V) within the inner radiation belt. These structures exhibit drift-periodic behavior and commonly arise from large-scale electric field perturbations near the substorm onsets. In this study, we introduce a composite electric field model and replicate the formation, structure, and evolution of zebra stripes using a bounce-averaged test particle code under this electric field model. High-resolution measurements of energetic electrons obtained from the Van Allen Probes and the recently launched Macao Science Satellites-1 are used as initial conditions and served to validate our test particle simulations. Comparative analyses between observed data and simulations demonstrate our test particle method's efficacy in capturing zebra stripes' general behavior. Moreover, the composite model proves capable of reproducing realistic variations in the electric field within the inner radiation belt to a certain extent. Nevertheless, subtle differences emerge in the flux strength and the positions of stripes. These disparities primarily stem from limitations inherent in the electric field model and the initial conditions of the simulation. Acknowledging that the model represents an average case, it is conceivable that real-world scenarios may deviate from the average, thereby introducing variations in the observed phenomena.

关键词： Zebra stripes Inner radiation belt Large-scale electric fields Van Allen Probes Macao Science Satellite

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双挂汽车列车高速阶跃横向失稳能量分析

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吉林大学学报（工学版） 2017年第1期47卷 71-75页

作者：张义花许洪国刘宏飞王发继吉林大学交通学院长春130022

采用图论方法,并结合各个车辆单元的链接关系,得到了双挂汽车列车各个车辆单元3种可能的失稳顺序。基于TruckSim建立包括非线性轮胎模型的多体动力学双挂汽车列车模型,通过仿真高速阶跃响应下各个车辆单元状态变量的变化趋势,可知侧倾... 详细信息

采用图论方法,并结合各个车辆单元的链接关系,得到了双挂汽车列车各个车辆单元3种可能的失稳顺序。基于TruckSim建立包括非线性轮胎模型的多体动力学双挂汽车列车模型,通过仿真高速阶跃响应下各个车辆单元状态变量的变化趋势,可知侧倾角速度是影响车辆失稳的首要因素。结合能量方程求解不同车速下各个车辆单元在阶跃响应中的最大能量,得到了各个车辆单元的失稳顺序,同时对图论法中提出的失稳顺序进行了验证和能量分析。

关键词：车辆工程车辆动力学双挂汽车列车图论横向失稳能量分析

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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai wang Yanbo Liang Chao wang Yunhong Zhang hong Liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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Pb^(2+)、Cd^(2+)和Ce^(3+)对猪胰α-淀粉酶活性的影响

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生物化学与生物物理进展 2002年第1期29卷 74-77页

作者：洪法水王雪峰沈颂东苏国兴潘新法苏州大学生物科学系苏州215006

分别研究了Pb2 + 、Cd2 + 和Ce3 + 对Ca (Ⅱ )α 淀粉酶活性影响及对其Ca2 + 的竞争作用 .结果表明三种金属离子低浓度情况下 (0 5～ 5mmol/L)对α 淀粉酶具有激活现象 ,而较高浓度则抑制酶活力 .Pb2 + 、Cd2 + 和Ce3 + 竞争置换α 淀... 详细信息

分别研究了Pb2 + 、Cd2 + 和Ce3 + 对Ca (Ⅱ )α 淀粉酶活性影响及对其Ca2 + 的竞争作用 .结果表明三种金属离子低浓度情况下 (0 5～ 5mmol/L)对α 淀粉酶具有激活现象 ,而较高浓度则抑制酶活力 .Pb2 + 、Cd2 + 和Ce3 + 竞争置换α 淀粉酶中Ca2 + 能力的大小是 :Pb2 + >Cd2 + >Ce3 + ,其抑制酶活作用大小 :Pb2 + >Cd2 + >Ce3 + .

关键词： α-淀粉酶重金属离子抑制常数竞争结合猪胰酶活性毒害作用

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基质矿化特性与生化性状协同效应的研究

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干旱区地理 2017年第1期40卷 114-121页

作者：张帆王晨冰王鸿王发林甘肃省农业科学院林果花卉研究所甘肃兰州730070

研究不同配方基质矿化特性与生化性状协同效应,探索其养分释放规律,以期合理高效利用,为戈壁非耕地合理使用基质提供可靠的理论依据。实验以初选的三种不同配方基质为试材(T1:草炭+秸秆+牛粪+蛭石=2∶2∶4∶2;T2:草炭+秸秆+鸡粪+蛭石=5... 详细信息

研究不同配方基质矿化特性与生化性状协同效应,探索其养分释放规律,以期合理高效利用,为戈壁非耕地合理使用基质提供可靠的理论依据。实验以初选的三种不同配方基质为试材(T1:草炭+秸秆+牛粪+蛭石=2∶2∶4∶2;T2:草炭+秸秆+鸡粪+蛭石=5∶2∶2∶1;T3:草炭+秸秆+羊粪+蛭石=3∶2∶3∶2),按一定温/湿度,采用室内培养法,测定养分指标和生化特性变化。结果表明,不同基质碳、氮、磷的矿化量、矿化率、残留率及生物化学性状等指标在不同培养期动态变化存在明显差异,其中,培养末期,T3有机碳矿化率最大、残留率最小,其净矿化量分别较T1和T2高41.9%和22.2%;T3在整个培养期氮矿化率和矿质氮含量最大,而残留率最小,其氮净矿化量分别较T1和T2高25.8%和71.8%;T1有机磷矿化率、净矿化量和残留率最大,T3则相反。T3多酚氧化酶、脲酶、碱性磷酸酶、蛋白酶在整个培养期内变幅最大,T1最小。基质配料和比例不同,其矿化特性和生物性状不同。T3更能充分发挥物料组合的促进效应,为微生物活动提供更加丰富的碳源和生长物质,是适合非耕地使用的基质配方。

关键词：基质矿化生物酶协同效应

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Achieving ultralow leakage current in Schottky-MIS cascode anode lateral field-effect diode based on AlGaN/GaN HEMT

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Science China(Information Sciences) 2025年第1期68卷 379-385页

作者： fangzhou wang Changhong GAO Guojian DING Cheng YU Zhuocheng wang Xiaohui wang Qi FENG Ping YU Peng ZUO Wanjun CHEN Yang wang Haiqiang JIA hong CHEN Bo ZHANG Zeheng wang Songshan Lake Materials Laboratory School of Microelectronics Southern University of Science and Technology State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Manufacturing Commonwealth Scientific and Industrial Research Organisation

In this paper,we design and fabricate a Schottky-metal-insulator-semiconductor（MIS） cascode anode GaN lateral field-effect diode（CA-LFED） to achieve ultralow reverse leakage current(ILEAK).The device based on AlGaN/GaN highelectron-mobility-transistor（HEMT） includes a normally-off MIS-controlled channel that is cascoded with a high barrier height Schottky *** reverse bias,the high electric-field is effectively prevented by the normally-off MIS-controlled channel *** with the high barrier height Schottky contact,this feature significantly suppresses the *** by the device fabrication,the CA-LFED with high breakdown voltage（BV）>600 V shows an ultralow ILEAKof 3.6×10-9A/mm as well as a low forward voltage drop（VF） of 2.2 *** performance suggests that the CA-LFED can be a promising candidate for ultralow ILEAKand better VF-ILEAKtrade-off GaN power diode applications.

关键词： Schottky-MIS cascode anode lateral field-effect diode (LFED) ultralow reverse leakage current ($I_{\rm{LEAK}}$) forward drop and reverse leakage trade-off AlGaN/GaN HEMTs

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Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期7卷 80-87页

作者： fang-Qian wang Yin Zhang Wei-Wei wang Mei-Qian Fu hong-Bing Mo Wei-Dong Yu Chao Liu Jun Yan College of Chemistry and Chemical Engineering Central South University Junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

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