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Experimental study of reservoir damage of water-based fracturing fluids prepared by different polymers

Petroleum Science 2024年第5期21卷 3298-3306页

作者： Guo-Dong Wu Li-Kun Wang Chun-Yan Zhao Ze-Jun Zhang Jian-Yu Yin Maryamgul Anwaier hong-da ren dan Yang Shu-Li Yin Zhuo-Lin Cai dao-Yi Zhu Engineering Technology Research Institute Xinjiang Oilfield CompanyKaramay834000XinjiangChina Luliang Oilfield Operation Area Xinjiang Oilfield CompanyKaramay834000XinjiangChina China University of Petroleum-Beijing at Karamay Karamay834000XinjiangChina

Fracturing operations can effectively improve the production of low-permeable reservoirs. The performance of fracturing fluids directly affects the fracturing efficiency and back flow capacity. As polymerbased fracturing fluids(such as guar gum(GG), polyacrylamide(HPAM), etc.) are high-viscosity fluids formed by viscosifiers and crosslinking agents, the degree of gel breakage after the fracturing operation directly influences the damage degree to the reservoir matrix and the mobility of oil angd gas produced from the reservoir into the wellbore. This study compared the viscosity, molecular weight, and particle size of the fracturing fluid after gel breakage prepared by GG and HPAM as viscosifiers, as well as evaluate their damage to the core. Results show that the viscosities of the gel-breaking fluid increased with the concentration of the viscosifier for both the HPAM-based and GG-based fracturing fluids. For the breaking fluid with the same viscosity, the molecular weight in the HPAM-based gel-breaking fluid was much larger than that in the GG-based system. Moreover, for the gel-breaking fluid with the same viscosity, the molecular particle size of the residual polymers in the HPAM-based system was smaller than that in the GG-based system. The damage to the core with the permeability of 1 × 10^(-3)μm^(2) caused by both the HPAM-based and GG-based gel-breaking fluids decreased with the increase in the solution viscosity. For the gel-breaking fluid systems with the same viscosity(i.e., 2-4 mPa s), the damage of HPAM-based fracturing fluid to low-permeability cores was greater than the GG-based fracturing fluid(45.6%-80.2%) since it had a smaller molecular particle size, ranging from 66.2% to 77.0%. This paper proposed that the damage caused by hydraulic fracturing in rock cores was related to the partilce size of residual polymers in gel-breaking solution, rather than its molecular weight. It was helpful for screening and optimizing viscosifiers used in hydraulic f

关键词： Fracturing fluid Guar gum HPAM Gel-breaking fluid Formation damage

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Detection of germline mutations of hMLH1 and hMSH2 based on cDNA sequencing in China

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World Journal of Gastroenterology 2005年第42期11卷 6620-6623页

作者： Chao-Fu Wang, Xiao-Yan Zhou, Tai-Ming Zhang, Meng-hong Sun, da-ren Shi, Laboratory of Molecular Pathology, Cancer Hospital of Fudan University Department of Oncology, Shanghai Medical College of Fudan University, Shanghai 200032, China Laboratory of Molecular Pathology Cancer Hospital of Fudan University Shanghai 20032 China.

AIM： TO detect the germline mutations Of hMLH1 and hMSH2 based on mRNA sequencing to identify hereditary non polyposis oolorectal cancer （HNPCC） families. METHODS： Total RNA was extracted from peripberal blood of 14 members from 12 different families fulfilling Amsterdam criteria II. mRNA of hMLH1 and hMSH2 was reversed with special primers and heat-resistant reverse tmnscriptase, cDNA was amplified with expand long template PCR and cDNA sequendng analysis was followed. RESULT： Seven germline mutations were found in 6 families （6/12, 50%）, in 4 hMLH1 and 3 hMSH2 mutations （4/12, 33.3%）; （3/12, 25%）. The mutation types involved 4 missense, 1 silent and 1 frame shift mutations as well as 1 mutation in the non-coding area. Four out of the seven mutations have not been reported previously. The 4 hMLH1 mutations were distributed in exons 8, 12, 16, and 19. The 3 hMSH2 mutations were distributed in exons 1 and 2. Six out of the 7 mutations were pathological, which were dislTibuted in 5 HNPCC families. CONCLUSION： Germline mutations of hMLH1 and hMSH2 can be found based on cDNA sequencing so as to identify HNPCC family, which is highly sensitive and has the advantages of cost and time saving.

关键词： hMLH1 hMSH2 Colorectal cancer Hereditarynon-polyposis Reverse transcription Germline mutation

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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li hong Zhou Zhihao ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan ren Fei Zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation data assimilation Machine learning

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构建体外错配修复功能分析模型及其在人类结直肠癌细胞株及肿瘤组织中的应用

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复旦学报（医学版） 2004年第3期31卷 284-289,296,F004页

作者：王怡 Clark Alan 王家训孙孟红施达仁复旦大学附属肿瘤医院病理科上海200032 Laboratory of Molecular Genetics National Institute of Environmental Health 中国科学院上海植物生理生态研究所上海200032

目的　构建体外错配修复 (mismatchrepair,MMR)功能分析模型 ,应用于人类结直肠癌细胞株及肿瘤组织 ,分析其整体的MMR功能状态 ;并与微卫星稳定性 (microsatellitestability ,MSS)检测结果比较 ,评价这两种检测方法在结直肠癌基础研究... 详细信息

目的　构建体外错配修复 (mismatchrepair,MMR)功能分析模型 ,应用于人类结直肠癌细胞株及肿瘤组织 ,分析其整体的MMR功能状态 ;并与微卫星稳定性 (microsatellitestability ,MSS)检测结果比较 ,评价这两种检测方法在结直肠癌基础研究和临床诊断治疗中的价值。方法　以噬菌体M 13mp2为材料 ,以lacZα为报告基因 ,构建含有单碱基错配及双碱基缺失的异源双链DNA分子 ;以其为待修复模板和细胞株TK6 (作为MMR功能完整表型 )共同组成体外MMR功能分析模型。提取结肠癌细胞株Lovo及 1例遗传性非腺瘤病性结直肠癌(hereditarynon polyposiscolorectalcancer ,HNPCC) ,1例散发性直肠癌 (sporadicrectalcancer,SRC)肿瘤组织的总蛋白 ,经大T抗原依赖性SV 4 0DNA复制证实其生物学活性保持良好后与构建成功的异源双链DNA共同作用 ,通过作用前后噬斑的变化 ,计算修复效率 ,从而了解其错配修复系统功能状态。采用国际HNPCC合作小组推荐的 5个位点分析细胞及病人正常及肿瘤组织的微卫星稳定性。结果　TK6细胞株微卫星稳定 ,对双碱基缺失del(2 )的修复效率超过 6 0 % ,对单碱基错配G·G的修复效率超过 5 0 % ;而Lovo细胞株微卫星不稳 ,对双碱基缺失del(2 )的修复效率低于 2 0 % ,对单碱基错配G·G的修复效率低于 10 %。 1?

关键词：错配修复功能分析微卫星稳定性遗传性非腺瘤性结直肠癌

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Thermodynamics of the System of Massive Dirac Fermions in a Uniform Magnetic Field

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Chinese Physics Letters 2021年第9期38卷 22-29页

作者： ren-hong Fang ren-da Dong De-Fu Hou Bao-Dong Sun Key Laboratory of Particle Physics and Particle Irradiation(MOE) Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOS) Central China Normal UniversityWuhan 430079China

We construct the grand partition function of the system of massive Dirac fermions in a uniform magnetic field from Landau levels,through which all thermodynamic quantities can be *** use of the Abel–Plana formula,these thermodynamic quantities can be expanded as power series with respect to the dimensionless variable𝑏b=2eB/T^(2).The zero-field magnetic susceptibility is expanded at zero mass,and the leading order term is *** also calculate scalar,vector current,axial vector current and energy-momentum tensor of the system through ensemble average *** correction to chiral separation effect is *** massless chiral fermions,our results recover the chiral magnetic effect for right-and left-handed fermions,as well as chiral separation effect.

关键词： chiral Dirac expanded

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Motivational interviewing in postoperative rehabilitation and chronic disease management: Current findings and future research directions

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World Journal of Psychiatry 2025年第1期15卷 26-31页

作者： Bing-ren Zhang Xiao Yang Affiliated Hospital(School of Clinical Medicine) Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina Mental Health Education and Counseling Center Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina

This editorial highlights a recently published study examining the effectiveness of music therapy combined with motivational interviewing(MI)in addressing an-xiety and depression among young and middle-aged patients following percuta-neous coronary *** further explores existing evidence and potential future research directions for MI in postoperative rehabilitation and chronic disease *** aims to facilitate behavioral change and promote healthier lifestyles by fostering a trusting relationship with patients and enhan-cing intrinsic *** has demonstrated its effectiveness in posto-perative recovery for oncological surgery,stroke,organ transplants,and gastroin-testinal procedures,as well as in managing chronic conditions such as diabetes,obesity,and periodontal *** approach is patient-centered,adaptable,cost-effective,and easily replicable,though its limitations include reliance on the therapist’s expertise,variability in individual responses,and insufficient long-term follow-up *** research could focus on developing individualized and precise intervention models,exploring applications in digital health management,and confirming long-term outcomes to provide more compre-hensive support for patient rehabilitation.

关键词： Chronic disease management Motivational interviewing Patient-centered Postoperative rehabilitation Treatment adherence

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Chiral magnetic effect for chiral fermion system

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Chinese Physics C 2020年第7期44卷 126-134页

作者： ren-da Dong ren-hong Fang De-Fu Hou Duan She Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOS) Central China Normal UniversityWuhan 430079China

The chiral magnetic effect is concisely derived by employing the Wigner function approach in the chiral fermion ***,the chiral magnetic effect is derived by solving the Landau levels of chiral fermions in *** second quantization and ensemble average leads to the equation of the chiral magnetic effect for righthand and lefthand fermion *** chiral magnetic effect arises uniquely from the contribution of the lowest Landau *** carefully analyze the lowest Landau level and find that all righthand(chirality is+1)fermions move along the direction of the magnetic field,whereas all lefthand(chirality is-1)fermions move in the opposite direction of the magnetic ***,the chiral magnetic effect can be explained clearly using a microscopic approach.

关键词： CME Landau levels chiral fermions

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Influence of pump brightness,self-Kerr and cross-Kerr effects on the entanglement of partially degenerate triple-photon state

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Communications in Theoretical Physics 2023年第10期75卷 45-50页

作者： da Zhang Zhihong ren School of Physics and Information Engineering Shanxi Normal UniversityTaiyuan 030031China

Recently,partially degenerate triple-photon states(TPS)generated by the third-order spontaneous parametric down-conversion have been observed in a superconducting cavity(2020,***.X 10,011011).Their non-Gaussian entanglement properties,characterized by a series of high-order covariance matrices,have also been theoretically ***,we use the non-Gaussian entanglement criterion proposed in(2021,***.127,150502)and the logarithmic negativity to study the effect of pump brightness,self-Kerr and cross-Kerr interactions on the entanglement of partially degenerate TPS(PDTPS).We find that the brighter the pump,the easier the entanglement of PDTPS leap to higher-order covariance *** both self-Kerr and cross-Kerr interactions induce nonlinear phase shifts and weaken the entanglement of PDTPS,cross-Kerr interactions can effectively raise the threshold of entanglement loaded on the third-order covariance *** results can contribute to our understanding of the mechanism of the generation of unconditional non-Gaussian entanglement.

关键词： non-Gaussian entanglement triple-photon states high-order covariance matrices cross-Kerr effect

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