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chinese herbal medicines for prevention and treatment of colorectal cancer: From molecular mechanisms to potential clinical applications

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Journal of Integrative Medicine 2020年第5期18卷 369-384页

作者： Mu-yan Kong Le-yan Li yan-mei Lou hong-yu chi Jin-jun Wu Joint Laboratoiy for Translational Cancer Research of chinese Medicine of the Ministry of Education of the People's Republic of china.International Institute for Translational chinese Medicine.Guangzhou University of chinese Medicine Guangzhou 510006Guangdong ProvinceChina

Worldwide, colorectal cancer(CRC) is one of the most common malignant tumors, leading to immense social and economic burdens. Currently, the main treatments for CRC include surgery, chemotherapy,radiotherapy and immunotherapy. Despite advances in the diagnosis and treatment of CRC, the prognosis for CRC patients remains poor. Furthermore, the occurrence of side effects and toxicities severely limits the clinical use of these therapies. Therefore, alternative medications with high efficacy but few side effects are needed. An increasing number of modern pharmacological studies and clinical trials have supported the effectiveness of chinese herbal medicines(CHMs) for the prevention and treatment of *** may be able to effectively reduce the risk of CRC, alleviate the adverse reactions caused by chemotherapy, and prolong the survival time of patients with advanced CRC. Studies of molecular mechanisms have provided deeper insight into the roles of molecules from CHMs in treating CRC. This paper summarizes the current understanding of the use of CHMs for the prevention and treatment of CRC, the main molecular mechanisms involved in these processes, the role of CHMs in modulating chemotherapyinduced adverse reactions, and CHM's potential role in epigenetic regulation of CRC. The current study provides beneficial information on the use of CHMs for the prevention and treatment of CRC in the clinic,and suggests novel directions for new drug discovery against CRC.

关键词： Colorectal neoplasms Herbal medicine Preventive medicine Medicine chinese traditional Molecular mechanisms of pharmacological action Epigenesis genetic

Radical rejuvenates the click-clip reaction

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Science china Chemistry 2025年

作者： Jiong Zhou Miaomiao yan Yuanxin Zhang Department of Chemistry College of Sciences Northeastern University

With the widespread attention paid to the construction of functional molecular systems, chemical synthesis is increasingly pursuing the accurate and efficient combination and dissociation of molecular units to achieve specific functions [1]. Carolyn R. Bertozzi, Morten Meldal, and *** Sharpless, winners of the 2022 Nobel Prize in Chemistry, found that click chemistry works like LEGO bricks, using the basic block to build infinitely changing shape, which allows the molecular building block to be combined quickly and efficiently [2].

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尕斯库勒砂西区块N1-N2^1储层特征研究

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岩性油气藏 2007年第4期19卷 34-39页

作者：何会牟中海朱玉洁迟洪岩刘冬玺西南石油大学中国石油青海油田分公司

根据岩石薄片、铸体薄片、扫描电镜、X-射线衍射、压汞等资料,结合地质、物性分析资料,对尕斯库勒砂西区块N1—N21储层特征及Ⅱ号断层上、下盘的差异进行了综合分析。研究认为:研究区的储层为一套碎屑岩储层,经历了以压实、胶结作用为... 详细信息

根据岩石薄片、铸体薄片、扫描电镜、X-射线衍射、压汞等资料,结合地质、物性分析资料,对尕斯库勒砂西区块N1—N21储层特征及Ⅱ号断层上、下盘的差异进行了综合分析。研究认为:研究区的储层为一套碎屑岩储层,经历了以压实、胶结作用为主的破坏性成岩作用和以溶蚀、构造作用为主的建设性成岩作用,储层成岩阶段处于早成岩B亚期—晚成岩A1亚期;储层孔隙类型有粒间孔、粒内孔、裂缝、贴粒缝等4类,并以粒间孔为主;N1—N21储层属中孔、低渗储层,储集性能中—差;分流河道砂体是该区最主要的储集砂体,其物性也明显好于其它微相砂体。Ⅱ号断层上盘成分成熟度明显小于下盘、胶结物平均含量低于下盘;上盘以长石岩屑砂岩为主,下盘以长石砂岩为主;上盘粒间孔较下盘发育,而下盘裂缝较上盘发育;上盘主要为中孔、中渗储层类型,下盘主要为低孔、低渗储层类型。

关键词：成岩作用储集层孔隙结构孔喉参数尕斯库勒砂西区块柴达木盆地

Measured overall effusion cooling effectiveness over a wide blowing ratio range using infrared imaging

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航空动力学报 2010年第7期25卷 1454-1463页

作者： ZHANG chi SONG Bo LIN Yu-zhen XU Quan-hong LIU yan National Key Laboratory of Science and Technology on Aero-Engines School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100191 China Jiangsu chinfan Compressor Incorporation Changshu Economic Development Zone Jiangsu 215513 China china North Vehicle Research Institute China North Industries Group Corporation Beijing 100072 China

Experimental investigations were performed on the overall cooling effectiveness η of a flat effusion wall over a wide range of blowing ratio(M=0.47～5.27).The effusion wall had a staggered multi-hole pattern typical of gas turbine combustor application,with a ratio of hole pitch to row spacing P/S=1∶2,a porosity PS/d2=72,and an inclination angle α=30°.The current paper documented distribution of the overall cooling effectiveness on the wall surface,based on infrared imaging of the 2-D surface temperature *** results indicate:(1) The overall η increases along with the streamwise distance for the wide range of M due to the superposition effect of the multi-row film cooling.(2) The overall η substantially benefits from the multi-hole inside convective *** hole convective cooling not only complements the weakest film protection at initial rows but also helps mitigate the temperature gradient.(3) The overall η increases asymptotically with increasing M,unlike adiabatic η mostly published in the past,which decreased after M reached a specific *** current work showcased the end cooling outcome jointly driven by the filming cooling mechanism and the hole inside convective cooling mechanism.

关键词： gas turbine effusion cooling overall cooling effectiveness blowing ratio infrared imaging

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang yan Li Libo Chen Handong Jiao Zhijing Yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Semiconductor doping

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： Jia-Hui Li Qing Zhao Dong-Ao Mao Kun Zhou Bao-Kuan Chen yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

A Verifiable Trust-Based CP-ABE Access Control Scheme for Cloud-Assisted Renewable Energy Systems

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Computers, Materials & Continua 2025年第1期82卷 1211-1232页

作者： Jiyu Zhang Kehe Wu Ruomeng yan Zheng Tian Yizhen Sun Yuxi Wu Yaogong Guo Department of Control and Computer Engineering North China Electric Power UniversityBeijing102206China State Grid Information&Communication Company of Hunan Electric Power Corporation Changsha410118China State Grid Hunan Electric Power Corporation Chenzhou Power Supply Branch Chenzhou423000China

Renewable Energy Systems(RES)provide a sustainable solution to climate warming and environmental pollution by enhancing stability and reliability through status acquisition and analysis on cloud platforms and intelligent processing on edge servers(ES).However,securely distributing encrypted data stored in the cloud to terminals that meet decryption requirements has become a prominent research ***,managing attributes,including addition,deletion,and modification,is a crucial issue in the access control scheme for *** address these security concerns,a trust-based ciphertext-policy attribute-based encryption(CP-ABE)device access control scheme is proposed for RES(TB-CP-ABE).This scheme effectivelymanages the distribution and control of encrypted data on the cloud through robust attribute key *** introducing trust management mechanisms and outsourced decryption technology,the ES system can effectively assess and manage the trust worthiness of terminal devices,ensuring that only trusted devices can participate in data exchange and access sensitive ***,the ES system dynamically evaluates trust scores to set decryption trust thresholds,thereby regulating device data access permissions and enhancing the system’s *** validate the security of the proposed TB-CP-ABE against chosen plaintext attacks,a comprehensive formal security analysis is conducted using the widely accepted random oraclemodel under the decisional q-Bilinear Diffie-Hellman Exponent(q-BDHE)***,comparative analysis with other schemes demonstrates that the TB-CP-ABE scheme cuts energy/communication costs by 43%,and scaleswell with rising terminals,maintaining average latency below 50ms,ensuring real-time service *** proposed scheme not only provides newinsights for the secure management of RES but also lays a foundation for future secure energy solutions.

关键词： Access control renewable energy systems(RES) ciphertext-policy attribute-based encryption(CP-ABE) security

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science china Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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Spatiotemporal characteristics and influencing factors of vegetation water use efficiency on the Tibetan Plateau in 2001–2020

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Journal of Geographical Sciences 2025年第1期35卷 39-64页

作者： HE Chenyang WANG yanjiao yan Feng LU Qi School of Ecological and Environmental Science East China Normal University Institute of Ecological Conservation and Restoration Chinese Academy of Forestry National Climate Center China Meteorological Administration

Water use efficiency （WUE）,as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ***,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain *** study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–*** indicated an annual mean WUE of 0.8088 gC/mm·m2across the plateau,with a spatial gradient reflecting decrease from the southeast toward the *** manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,***,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of *** factors accounted for 70.79%of the variability in *** leaf area index and temperature served as the major driving forces of WUE variation.

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