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Exogeneous metal ions as therapeutic agents in cardiovascular disease and their delivery strategies

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Regenerative Biomaterials 2024年第2期3卷 1-16页

作者： Xiaoqian hong Geer tian Yang Zhu Tanchen Ren Department of Cardiology of the Second Affliated Hospital and State Key Laboratory of Transvascular Implantation Devices Cardiovascular Key Laboratory of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310o09China Binjiang Institute of Zhejiang University Hangzhou 310053China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Metal ions participate in many metabolic processes in the human body,and their homeostasis is crucial for *** cardiovascular diseases(CVDs),the equilibriums of metal ions are frequently interrupted,which are related to a variety of disturbances of physiological processes leading to abnormal cardiac *** supplement of metal ions has the potential to work as therapeutic strategies for the treatment of *** with other therapeutic drugs,metal ions possess broad availability,good stability and safety and diverse drug delivery *** delivery strategies of metal ions are important to exert their ther-apeutic effects and reduce the potential toxic side effects for cardiovascular applications,which are also receiving increasing *** local delivery strategies for metal ions based on various biomaterials are constantly being *** this review,we comprehensively summarized the positive roles of metal ions in the treatment of cVDs from three aspects:protecting cells from oxidative stress,inducing angiogenesis,and adjusting the functions of ion *** addition,we introduced the transferability of metal ions in vascular reconstruction and cardiac tissue repair,as well as the currently available engineered strategies for the precise delivery of metal ions,such as integrated with nanoparticles,hydrogels and scaffolds.

关键词： metal ions cardiovascular disease tissue engineering oxidative stress angiogenesis ion channel

Spin-polarized transport in a normal/ferromagnetic/normal zigzag graphene nanoribbon junction

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chinese Physics B 2012年第1期21卷 433-437页

作者： tian hong-Yu Wang Jun Department of Physics Southeast UniversityNanjing 210096China

We investigate the spin-dependent electron transport in single and double normal/ferromagnetic/normal zigzag graphene nanoribbon （NG/FG/NG） junctions. The ferromagnetism in the FG region originates from the spontaneous magnetization of the zigzag graphene nanoribbon. It is shown that when the zigzag-chain number of the ribbon is even and only a single transverse mode is actived, the single NG/FG/NG junction can act as a spin polarizer and/or a spin analyzer because of the valley selection rule and the spin-exchange field in the FG, while the double NG/FG/NG/FG/NG junction exhibits a quantum switching effect, in which the on and the off states switch rapidly by varying the cross angle between two FG magnetizations. Our findings may shed light on the application of magnetized graphene nanoribbons to spintronics devices.

关键词： spontaneous magnetization zigzag graphene nanoribbon spin polarizer quantumswitching effect

锐钛矿相TiO_(2)吸附柴油中典型碱性氮化物的模拟计算

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石油炼制与化工 2025年第1期56卷 66-75页

作者：王聚财唐克孙潇镝富添洪新辽宁工业大学化学与环境工程学院辽宁锦州121001

为了探究锐钛矿相TiO_(2)(a-TiO_(2))对柴油中典型氮化物(吡啶、苯胺、喹啉)及非氮化物的吸附行为和选择性,利用模拟计算方法研究了吡啶、苯胺、喹啉及非氮化物在a-TiO_(2)(101)晶面吸附过程中的吸附构型、吸附能、Mulliken电荷、电荷... 详细信息

为了探究锐钛矿相TiO_(2)(a-TiO_(2))对柴油中典型氮化物(吡啶、苯胺、喹啉)及非氮化物的吸附行为和选择性,利用模拟计算方法研究了吡啶、苯胺、喹啉及非氮化物在a-TiO_(2)(101)晶面吸附过程中的吸附构型、吸附能、Mulliken电荷、电荷密度、差分电荷密度和态密度等。结果表明:吡啶、苯胺、喹啉吸附于a-TiO_(2)(101)晶面的吸附能分别为-188.59,-100.99,-201.63 kJ mol,3种氮化物均能稳定吸附于a-TiO_(2)(101)晶面,其吸附稳定性由大到小的顺序为喹啉>吡啶>苯胺;在吸附过程中,氮化物将自身一定量的电荷转移到a-TiO_(2)(101)晶面,形成氮化物→a-TiO_(2)(101)晶面的电荷转移通道;吡啶和喹啉在a-TiO_(2)(101)晶面吸附时形成N—Ti化学键,苯胺的氨基H和a-TiO_(2)(101)晶面的O形成氢键。芳烃、烷烃、环烷烃等非氮化物在a-TiO_(2)(101)晶面的吸附强度相近,均弱于氮化物。a-TiO_(2)对氮化物有较好的吸附脱除效果,能选择性去除柴油中的碱性氮化物。

关键词： TiO_(2) 吸附氮化物柴油模拟计算

The Spectrum for Overlarge Sets of Hybrid Triple Systems

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Acta Mathematicae Applicatae Sinica 2014年第3期30卷 635-646页

作者： Mei-hui CHENG Zi-hong tian Huihua College of Hebei Normal University College of Mathematics and Information Science Hebei Normal University

A hybrid triple system of order v and index A, denoted by HTS（v, λ）, is a pair （X,B） where X is a v-set and B is a collection of cyclic triples and transitive triples on X, such that every ordered pair of X belongs to A triples of B. An overlarge set of disjoint HTS（v, λ）, denoted by OLHTS（v, λ）, is a collection {（Y／{y}, .Ai）}i, such that Y is a （v ＋ 1）-set, each （Y／{y}, Ai） is an HTS（v, λ,） and all Ais form a partition of all cyclic triples and transitive triples on Y. In this paper, we shall discuss the existence problem of OLHTS（v, A） and give the following conclusion： there exists an OLHTS（v, λ） if and only if λ= 1, 2, 4, v = 0, 1 （rood 3） and v ≥ 4.

关键词： overlarge set hybrid triple system hybrid candelabra system

Pyramid Bayesian Method for Model Uncertainty Evaluation of Semantic Segmentation in Autonomous Driving

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Automotive Innovation 2022年第1期5卷 70-78页

作者： Yang Zhao Wei tian hong Cheng School of Automation Engineering University of Electronic Science and Technology of ChinaChengduChina

With the fast-developing deep learning models in the field of autonomous driving,the research on the uncertainty estima-tion of deep learning models has also ***,a pyramid Bayesian deep learning method is proposed for the model uncertainty evaluation of semantic *** segmentation is one of the most important perception problems in understanding visual scene,which is critical for autonomous *** study to optimize Bayesian SegNet for uncertainty *** paper first simplifies the network structure of Bayesian SegNet by reducing the number of MC-Dropout layer and then introduces the pyramid pooling module to improve the performance of Bayesian *** and mPAvPU are used as evaluation matrics to test the proposed method on the public Cityscapes *** experimental results show that the proposed method improves the sampling effect of the Bayesian SegNet,shortens the sampling time,and improves the network performance.

关键词： Semantic Segmentation Bayesian SegNet Uncertainty Evaluation

Large Sets and Overlarge Sets of Triangle-Decomposition

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 123-132页

作者： Zi-hong tian Qing-de Kang Institute of Mathematics Hebei Normal University Shijiazhuang 050016 China

There are six types of triangles： undirected triangle, cyclic triangle, transitive triangle, mixed-1 triangle, mixed-2 triangle and mixed-3 triangle. The triangle-decompositions for the six types of triangles have already been solved. For the first three types of triangles, their large sets have already been solved, and their overlarge sets have been investigated. In this paper, we establish the spectrum of LTi（v,λ）, OLTi（v）（i = 1, 2）, and give the existence of LT3（v, λ） and OLT3（v, λ） with λ even.

关键词： Triangle-decomposition large set overlarge set

Decomposing Triples of Z_(p^n) and Z_(3p^n) into Cyclic Designs

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Acta Mathematica Sinica,English Series 2013年第11期29卷 2111-2128页

作者： Zi hong tian Rui Zhong WEI College of Mathematics and Information Science Hebei Normal University Department of Computer Science Lakehead University

In this paper, we give some decompositions of triples of Zp^n or Z3p^n into cyclic triple systems. New constructions of difference families are given. Some infinite classes of simple cyclic triple systems are obtained... 详细信息

关键词： Decomposition cyclic designs triple systems simple designs difference families

Indecomposable Large Sets of Steiner Triple Systems with Indices 5, 6

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Acta Mathematica Sinica,English Series 2012年第11期28卷 2169-2184页

作者： Mei Hui CHENG Zi hong tian Institute of Mathematics Hebei Normal University

A family （X, B1）,（X, B2）,..., （X, Bq） of q STS（v）s is a λ-fold large set of STS（v） and denoted by LSTSλ（v） if every 3-subset of X is contained in exactly A STS（v）s of the collection. It is indecomposable and denoted by IDLSTSx（v） if there does not exist an LSTSx, （v） contained in the collection for any λ 〈 λ. In this paper, we show that for λ = 5, 6, there is an IDLSTSλ（v） for v ≡ 1 or 3 （rood 6） with the exception IDLSTS6（7）.

关键词： Steiner triple system, large set, candelabra system indecomposable

The Existence of LHMTS(m^v) and LHDTS(m^v)

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Acta Mathematica Sinica,English Series 2018年第11期34卷 1703-1717页

作者： Xiang Qian LI Ru hong HU Zi hong tian Institute of Mathematics Beijing Jiaotong University Beijing 100044 P. R. China College of Mathematics and Information Science Hebei Normal University Shijiazhuang 050024 P. R. China

In this article, we establish the existence of an LHMTS（mv） for v ≡ 2 （mod 6） and m≡ 3 （mod 6）. Thus there exists an LHMTS（mv） if and only if v（v-1）m2 ≡ 0 （mod 3） except possibly for v=6, m≡ 1, 5 （mod 6） and m≠1. In the similar way, the existence of LHDTS（mv） is completely determined, i.e., there exists an LHDTS（mv） if and only if v（v-1）m2 ≡ 0 （mod 3）.

关键词： Holey Mendelsohn triple system holey directed triple system large set