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Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： Fang, Lei Lin, Xiaoqi Xu, Ruian Liu, Lu Zhang, Yu tian, Feng Li, Jiao Jiao Xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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Superlinear Elliptic Equation with Mixed Boundary Value in Annular Domain

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Acta Mathematica Sinica,English Series 2021年第10期37卷 1549-1559页

作者： Jian tian Yuan hong WEI School of Mathematics Jilin UniversityChangchun 130012P.R.China

In this paper,we study superlinear elliptic equations with mixed boundary value conditions in annular *** is assumed that the nonlinearities depend on the derivative *** results about existence of solutions are establ... 详细信息

关键词： Mixed boundary value annular domain radial solution gradient term iterative method

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Diagnosing SST Error Growth during ENSO Developing Phase in the BCC_CSM1.1(m) Prediction System

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Advances in Atmospheric Sciences 2022年第3期39卷 427-442页

作者： Ben tian hong-Li REN Laboratory for Climate Studies&CMA-NJU Joint Laboratory for Climate Prediction Studies National Climate CenterChina Meteorological AdministrationBeijing 100081China State Key Laboratory of Severe Weather Institute of Tibetan Plateau&Polar MeteorologyChinese Academy of Meteorological SciencesBeijing 100081China Department of Atmospheric Science School of Environmental StudiesChina University of GeoscienceWuhan 430074China

In this study, the predictability of the El Nino-South Oscillation(ENSO) in an operational prediction model from the perspective of initial errors is diagnosed using the seasonal hindcasts of the Beijing Climate Center System Model,BCC;SM1.1(m). Forecast skills during the different ENSO phases are analyzed and it is shown that the ENSO forecasts appear to be more challenging during the developing phase, compared to the decay phase. During ENSO development, the SST prediction errors are significantly negative and cover a large area in the central and eastern tropical Pacific, thus limiting the model skill in predicting the intensity of El Nino. The large-scale SST errors, at their early stage, are generated gradually in terms of negative anomalies in the subsurface ocean temperature over the central-western equatorial Pacific,featuring an error evolutionary process similar to that of El Nino decay and the transition to the La Nina growth ***, for short lead-time ENSO predictions, the initial wind errors begin to play an increasing role, particularly in linking with the subsurface heat content errors in the central-western Pacific. By comparing the multiple samples of initial fields in the model, it is clearly found that poor SST predictions of the Nino-3.4 region are largely due to contributions of the initial errors in certain specific locations in the tropical Pacific. This demonstrates that those sensitive areas for initial fields in ENSO prediction are fairly consistent in both previous ideal experiments and our operational predictions,indicating the need for targeted observations to further improve operational forecasts of ENSO.

关键词： ENSO prediction initial errors error evolution SST

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Effect of Hf and Zr Contents on Stress-rupture and Fatigue Crack Growth Rate Performances in FGH96PM Superalloy

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Journal of Iron and Steel Research International 2014年第3期21卷 382-388页

作者： tian XIA Yi-wen ZHANG Yue chi High Temperature Materials Research Institute Central Iron and Steel Research Institute Beijing Key Laboratory of Advanced High Temperature Materials

Four experimental FGH96 alloys with various contents of Hf and Zr （0 and 0.04%, 0.3% and 0.04%, 0.6% and 0. 04%, 0. 3% and 0.06%, respectively） were produced using PREP （plasma rotating electrode process）＋ HIP （hot isostatic pressing） route. The unnotched and notched stress-rupture properties and fatigue crack growth rate （FCGR） of all the experimental alloys were investigated to study the effect of Hf and Zr. Relevant fracture morphol ogy and microstructure were observed by scanning electron microscopy and transmission electron microscopy. The results revealed that appropriate content of Hf could lengthen stress-rupture life, eliminate notch sensitivity and slo wer FCGR. Microstructure analysis showed that the amount of ＂f phase should be increased or decreased by adjusting Hf and Zr contents, and MC carbide and oxide coupled growth should be increased by adding Hf content, which caused oxycarbide to precipitate along grain boundary and strengthen the alloy. It was found that excessive Zr in Hf- containing FGH96 alloy had certain deleterious effects on stress-rupture property because there was strong Zr segre- gation at prior particle boundary, leaving a long chain of large-size oxides along the boundary. The optimal content of Hf and Zr in FGH96 alloy was 0.6% and 0. 04%, respectively.

关键词： PM superalloy FGH96 HI Zr stress rupture carbide oxide

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Review of research on high-speed railway aerodynamics in china

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Transportation Safety and Environment 2019年第1期1卷 1-21页

作者： hong-qi tian Key Laboratory of Traffic Safety on Track of Ministry of Education Central South UniversityChangshaHunan 410075China Joint International Research Laboratory of Key Technology for Rail Traffic Safety ChangshaHunan 410075China School of Traffic&Transportation Engineering Central South UniversityChangshaHunan 410075China

High-speed railway aerodynamics is the key basic science for solving the bottleneck problem of high-speed railway *** paper systematically summarizes the aerodynamic research relating to china’s high-speed railway *** key research advances are comprehensively discussed,including train aerodynamic drag-reduction technology,train aerodynamic noise-reduction technology,train ventilation technology,train crossing aerodynamics,train/tunnel aerodynamics,train/climate environment aerodynamics,and train/human body *** types of railway aerodynamic test platform built by Central South University are *** major systems for a high-speed railway network—the aerodynamics theoretical system,the aerodynamic shape(train,tunnel,and so on)design system,the aerodynamics evaluation system,the 3D protection system for operational safety of the high-speed railway network,and the high-speed railway aerodynamic test/computation/analysis platform system—are also ***,eight future development directions for the field of railway aerodynamics are *** over 30 years,railway aerodynamics has been an important supporting element in the development of china’s high-speed railway network,which has also promoted the development of high-speed railway aerodynamics throughout the world.

关键词： aerodynamics high-speed railway drag reduction noise reduction train ventilation train crossing aerodynamics train/tunnel aerodynamics train/climate environment aerodynamics train/human body aerodynamics aerodynamic test platforms

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Age,growth,and mortality rate of the yellow goosefish Lophius litulon(Jordan,1902)in the Yellow Sea

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Journal of Oceanology and Limnology 2021年第2期39卷 732-740页

作者： Yu SUN chi ZHANG Yongjun tian Yoshiro WATANABE College of Fisheries Ocean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and TechnologyQingdao 266003China Atmosphere and Ocean Research Institute University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8564Japan

With the decline in the most fisheries resources in the Yellow Sea,the yellow goosefish Lophius litulon has increased in commercial and ecological importance in recent *** studied the length distribution,length-weight relationship,age composition,growth pattern,mortality,and exploitation rates of the yellow goosefish in the Yellow *** length(TL)of females and males ranged from 173 to 582 mm and 178 to 500 mm,*** length-weight relationships were also estimated for females and *** classes from 2 to 4 years predominated in the *** von Bertalanffy growth function(VBGF),estimated based on non-linear least-squares methodology,showed significant differences between *** attained a greater estimated asymptotic total length(765 mm TL)compared to males(579 mm TL).The VBGF did not differ significantly between stocks of the northern Yellow Sea and the southern Yellow *** natural instantaneous mortality rate(M)ranged from 0.25/a to 0.33/a based on four age-and length-based *** instantaneous mortality rate(Z)of total samples calculated by the age-based catch curve method was 0.591/a and the average fishing mortality(F)was 0.30/*** exploitation rate(E)was approximately 0.5,indicating that the population of *** in the Yellow Sea may be *** results provide a reference for the present status of *** and information for the management.

关键词： Lophius litulon Yellow Sea age growth mortality rate

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Water temperature induced interannual variation in spawning of Japanese Spanish mackerel Scomberomorus niphonius in the northern Yellow Sea

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Journal of Oceanology and Limnology 2023年第4期41卷 1620-1627页

作者： Mengzhen PAN chi ZHANG Yongjun tian Qinghuan ZHU Frontiers Science Center for Deep Ocean Multispheres and Earth System(FDOMES) and Key Laboratory of MaricultureMinistry of EducationOcean University of ChinaQingdao 266100China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Graduate School of Agricultural Science Tohoku UniversitySendai 9808572Japan

Japanese Spanish mackerel Scomberomorus niphonius is a pelagic,neritic species that occurs in the Yellow Sea in high commercial *** spawning period of this fast-growing species is controlled by water *** on microstructural analysis of otoliths from 145 young-of-the-year(YoY)*** collected by trawl in 2017,2018,and 2020,and the temporal variation in the spawning period in the northern Yellow Sea,and its relationship to water temperature were *** found that the spawning lasted from late April to late June but differed in year:in 2017 it occurred from April 23 to June 1 and peaked in early May,in 2018 it extended later from May 7 to June 29,and in 2020 from May 6 to June 22 and peaked later from late May to *** highest temperature in 2017 corresponds with the earliest end of the spawning period and a lower growing degree-day(GDD,℃·day)of 383℃·*** 2018,slower warming corresponds with a longer spawning period,and a GDD spawning period of 506℃·*** warming in late 2020 corresponds with a spawning peak,and a GDD spawning temperature of 448℃·*** differences in spawning period,the water temperature when spawning commenced was 10-12℃.Therefore,water temperature is the major determinant of the spawning period,affecting both the starting and the ending of *** study improved our understanding of the spawning dynamics and environmental adaptation of ***,and how these might change in environments subject to increased warming.

关键词： otolith microstructure Scomberomorus niphonius spawning period yellow sea water temperature

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Review of the Configuration and Transient Stability of Large-scale Renewable Energy Generation through Hybrid DC Transmission

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 115-126页

作者： Xinshou tian Yongning chi Longxue Li hongzhi Liu Institute of Energy Power Innovation North China Electric Power UniversityBeijing 102206China china Electric Power Research Institute No.15Xiaoying East RoadQingheHaidian DistrictBeijing 100192China.

Based on the complementary advantages of Line Commutated Converter(LCC)and Modular Multilevel Converter(MMC)in power grid applications,there are two types of hybrid DC system topologies:one is the parallel connection of LCC converter stations and MMC converter stations,and the other is the series connection of LCC and MMC converter stations within a single *** hybrid DC transmission system faces broad application prospects and development potential in large-scale clean energy integration across regions and the construction of a new power system dominated by new energy sources in *** paper first analyzes the system forms and topological characteristics of hybrid DC transmission,introducing the forms and topological characteristics of converter-level hybrid DC transmission systems and system-level hybrid DC transmission ***,it analyzes the operating characteristics of LCC and MMC inverter-level hybrid DC transmission systems,provides insights into the transient stability of hybrid DC transmission systems,and typical fault ride-through control ***,it summarizes the networking characteristics of the LCC-MMC series within the converter station hybrid DC transmission system,studies the transient characteristics and fault ridethrough control strategies under different fault types for the LCC-MMC series in the receiving-end converter station,and investigates the transient characteristics and fault ride-through control strategies under different fault types for the LCC-MMC series in the sending-end converter station.

关键词： Hybrid DC transmission Transient stability Configuration Control system

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Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction

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Earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun Yu PengHao tian XiangHui Xue Christopher JScott HaiLun Ye JianFei Wu Wen Yi TingDi Chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China CAS Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence

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锆基金属有机框架捕获黄连中的生物碱类药物活性成分

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分析测试学报 2025年第1期44卷 188-194页

作者：司甜甜赵薇王慧张红玉刘小烨容蓉冯娟娟山东中医药大学药学院济南大学化学化工学院

采用溶剂热法制备了锆基MOF-808，利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获，并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件，对黄连粗提液中药根碱... 详细信息

采用溶剂热法制备了锆基MOF-808，利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获，并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件，对黄连粗提液中药根碱的回收率达到85.78%，结合高效液相色谱技术建立了检测黄连粗提液中5种生物碱类活性成分的方法。方法的线性范围为0.1～300μg·L-1，检出限为0.02～0.05μg·L-1，相对标准偏差为0.40%～4.7%，加标回收率达到69.7%～128%。该研究实现了中药黄连中生物碱类活性成分的高效、快速富集与捕获，为MOFs材料在选择性捕获与富集中药有效成分等领域的研究提供了新思路。

关键词：金属有机框架选择性富集色谱分离生物碱活性成分黄连

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